Peter I Boross

Potent new antiviral compound shows similar inhibition and structural interactions with drug resistant mutants and wild type HIV-1 protease.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2007, Journal of medicinal chemistry.

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 Å resolution crystal structures of HIV‐1 protease mutants with substrate analogs

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2005, The FEBS journal.

Mechanism of drug resistance revealed by the crystal structure of the unliganded HIV-1 protease with F53L mutation.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2006, Journal of molecular biology.

Kinetic, stability, and structural changes in high-resolution crystal structures of HIV-1 protease with drug-resistant mutations L24I, I50V, and G73S.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2005, Journal of molecular biology.

A Novel Bis-Tetrahydrofuranylurethane-Containing Nonpeptidic Protease Inhibitor (PI), GRL-98065, Is Potent against Multiple-PI-Resistant Human Immunodeficiency Virus In Vitro

Irene T Weber, Masayuki Amano, Yuan-Fang Wang, 2007, Antimicrobial Agents and Chemotherapy.

Crystal structures of HIV protease V82A and L90M mutants reveal changes in the indinavir-binding site.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, European journal of biochemistry.

High resolution crystal structures of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017) active against multi-drug-resistant clinical strains.

Irene T Weber, Robert W Harrison, Yuan-Fang Wang, 2004, Journal of molecular biology.