Richard A. Houghten

发表

Multitarget Structure-Activity Relationships Characterized by Activity-Difference Maps and Consensus Similarity Measure

Austin B. Yongye, José L. Medina-Franco, Jaime Pérez-Villanueva, 2011, J. Chem. Inf. Model..

Figure 1, Key SAR for our first library

Darren Finlay, Kristiina Vuori, Robert Ardecky, 2011 .

First Japanese Conference on Combinatorial Chemistry and High Throughput Screening

Richard A. Houghten, 2005, Molecular Diversity.

Integrating computational and mixture-based screening of combinatorial libraries

Clemencia Pinilla, Austin B. Yongye, Richard A. Houghten, 2011, Journal of molecular modeling.

Conditional Probabilistic Analysis for Prediction of the Activity Landscape and Relative Compound Activities

José L. Medina-Franco, Richard A. Houghten, Marc A. Giulianotti, 2013, J. Chem. Inf. Model..

From Tens to Trillions - Advances in Synthetic Combinatorial Chemistry of Peptides, Peptidomimetics and Heterocyclic Compounds Derived from Peptides

Richard A. Houghten, R. Houghten, 2006 .

Chemoinformatic Analysis of Combinatorial Libraries, Drugs, Natural Products, and Molecular Libraries Small Molecule Repository

Rajarshi Guha, José L. Medina-Franco, Richard A. Houghten, 2009, J. Chem. Inf. Model..

Modeling of peptides containing D-amino acids: implications on cyclization

Austin B. Yongye, Richard A. Houghten, Yongping Yu, 2009, J. Comput. Aided Mol. Des..

A large scale classification of molecular fingerprints for the chemical space representation and SAR analysis

José L. Medina-Franco, Austin B. Yongye, Fabian López-Vallejo, 2012, Journal of Cheminformatics.

Activity-difference maps and consensus similarity measure characterize structure-activity relationships

José L. Medina-Franco, Jaime Pérez-Villanueva, Austin B. Yongye, 2012, Journal of Cheminformatics.

Table 5, Submission of Probe and analogs

Darren Finlay, Kristiina Vuori, Robert Ardecky, 2011 .

Libraries from libraries: The generation of peptidomimetic combinatorial diversities

Richard A. Houghten, J. M. Ostresh, G. M. Husar, 1995 .

Conformational landscape of platinum(II)-tetraamine complexes: DFT and NBO studies

Austin B. Yongye, Richard A. Houghten, Karina Martínez-Mayorga, 2010, J. Comput. Aided Mol. Des..

Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries

Clemencia Pinilla, Richard A. Houghten, Jon R. Appel, 2003, Nature Medicine.

Figure 2, Key SAR for our second library

Darren Finlay, Kristiina Vuori, Robert Ardecky, 2011 .

Characterization of Activity Landscapes Using 2D and 3D Similarity Methods: Consensus Activity Cliffs

José L. Medina-Franco, Andreas Bender, Richard A. Houghten, 2009, J. Chem. Inf. Model..

Rapid Scanning Structure-Activity Relationships in Combinatorial Data Sets: Identification of Activity Switches

Clemencia Pinilla, Bruce S. Edwards, Larry A. Sklar, 2013, J. Chem. Inf. Model..

Table 1, PubChem Assay Summaries for Probe project

Darren Finlay, Robert Ardecky, Thomas D.Y. Chung, 2010 .

Use of combinatorial library screening to identify inhibitors of a bacterial two-component signal transduction kinase

Christian N. Parker, Richard A. Houghten, Sylvie E. Blondelle, 2004, Molecular Diversity.

Mixture-Based Synthetic Combinatorial Libraries

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 1999 .

Protection against foot-and-mouth disease by immunization with a chemically synthesized peptide predicted from the viral nucleotide sequence

Richard A. Houghten, Richard A. Lerner, Fred Brown, 1982, Nature.

The Current Status of Heterocyclic Combinatorial Libraries

Richard A. Houghten, Adel Nefzi, R. Houghten, 1997 .

Solid-phase synthesis of trisubstituted bicyclic guanidines via cyclization of reduced N-acylated dipeptides

Richard A. Houghten, Adel Nefzi, R. Houghten, 1998 .

In vitro and direct in vivo testing of mixture-based combinatorial libraries for the identification of highly active and specific opiate ligands

Richard A. Houghten, Colette T. Dooley, Jon R. Appel, 2006, The AAPS Journal.

Mapping the Prion Protein Using Recombinant Antibodies

Clemencia Pinilla, Richard A. Houghten, Stanley B. Prusiner, 1998, Journal of Virology.

Identification of candidate T-cell epitopes and molecular mimics in chronic Lyme disease

Yingdong Zhao, Clemencia Pinilla, Bernhard Hemmer, 1999, Nature Medicine.

Mixture-Based Heterocyclic Combinatorial Positional Scanning Libraries: Discovery of Bicyclic Guanidines Having Potent Antifungal Activities against Candida albicans andCryptococcus neoformans

Richard A. Houghten, Sylvie E. Blondelle, R. Houghten, 1999, Antimicrobial Agents and Chemotherapy.

Identification of Tetrapeptides from a Mixture Based Positional Scanning Library That Can Restore nM Full Agonist Function of the L106P, I69T, I102S, A219V, C271Y, and C271R Human Melanocortin-4 Polymorphic Receptors (hMC4Rs)

Clemencia Pinilla, Michael A. Walters, Richard A. Houghten, 2014, Journal of medicinal chemistry.

Solid-Phase Synthesis of Substituted 2,3-Diketopiperazines from Reduced Polyamides

Richard A. Houghten, Marc A. Giulianotti, Adel Nefzi, 2000 .

Increased Diversity of Libraries from Libraries: Chemoinformatic Analysis of Bis‐Diazacyclic Libraries

José L. Medina-Franco, Andreas Bender, Ian T. Nabney, 2011, Chemical biology & drug design.

Identification of novel antitumor agents from mixture-based synthetic combinatorial libraries using cell-based assays

Richard A. Houghten, Jon R. Appel, R. Houghten, 1998, Molecular Diversity.

Solid-Phase Synthesis, Characterization, and Screening of a 43,000- Compound Tetrahydroisoquinoline Combinatorial Library.

M. C. Griffith, Richard A. Houghten, R. Houghten, 1997 .

The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein

Arthur J. Olson, John A. Tainer, Richard A. Houghten, 1984, Nature.

The Versatility of Nonsupport‐Bound Combinatorial Libraries

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 2007 .

The structure of an antigenic determinant in a protein

Andrew R. Cherenson, Richard A. Houghten, Richard A. Lerner, 1984, Cell.

Solid phase synthesis of 1,4-benzothiazepin-5-one derivatives

Richard A. Houghten, Marc A. Giulianotti, Adel Nefzi, 1999 .

Membrane Protecting Sequences and New Antimicrobial Peptides Identified through the Screening of Synthetic Peptide Combinatorial Libraries

Richard A. Houghten, Sylvie E. Blondelle, R. Houghten, 1994 .

Versatility of positional scanning synthetic combinatorial libraries for the identification of individual compounds

Clemencia Pinilla, Richard A. Houghten, Colette T. Dooley, 1994 .

Soluble Combinatorial Libraries: Extending the Range and Repertoire of Chemical Diversity

Richard A. Houghten, 1994 .

Combinatorial Chemistry: Libraries from Libraries, the Art of the Diversity‐Oriented Transformation of Resin‐Bound Peptides and Chiral Polyamides to Low Molecular Weight Acyclic and Heterocyclic Compounds

Richard A. Houghten, Adel Nefzi, John M. Ostresh, 2004 .