I. Sircar

发表

Synthesis and SAR of N-benzoyl-L-biphenylalanine derivatives: discovery of TR-14035, a dual alpha(4)beta(7)/alpha(4)beta(1) integrin antagonist.

E. Lazarides, Elias Lazarides, D. Nowlin, 2002, Bioorganic & medicinal chemistry.

Discovery and structure-activity relationship studies of indole derivatives as liver X receptor (LXR) agonists.

Chiaki Fukushima, Kei Takedomi, K. Takedomi, 2007, Bioorganic & medicinal chemistry letters.

2-Aryl-N-acyl indole derivatives as liver X receptor (LXR) agonists.

J. Zapf, I. Sircar, F. Bakir, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and structure-activity relationship of 4-(2-aryl-cyclopropylamino)-quinoline-3-carbonitriles as EGFR tyrosine kinase inhibitors.

I. Sircar, S. Kher, M. Pannala, 2007, Bioorganic & medicinal chemistry letters.

Identification of novel series of human CCR1 antagonists.

J. Li, I. Sircar, Kui Xu, 2008, Bioorganic & medicinal chemistry letters.

Chapter 9 Agents for the Treatment of Congestive Heart Failure

I. Sircar, R. Steffen, Michael D. Taylor, 1987 .

Design and synthesis of potent, selective, and orally active fluorine-containing renin inhibitors.

A. Doherty, M. J. Ryan, M. Taylor, 1992, Journal of medicinal chemistry.

Cardiotonic agents. 10. Cardiovascular evaluation of dihydropyridazinone ring open analogues of imazodan

W. Moos, I. Sircar, R. Potoczak, 1989 .

Cardiotonic agents. 2. Synthesis and structure-activity relationships of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones: a new class of positive inotropic agents.

D. B. Evans, I. Sircar, J. Bristol, 1985, Journal of medicinal chemistry.

Cardiotonic agents. 9. Synthesis and biological evaluation of a series of (E)-4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]ethenyl]-3 (2H)-pyridazinones: a novel class of compounds with positive inotropic, antithrombotic, and vasodilatory activities for the treatment of congestive heart failure.

D. B. Evans, I. Sircar, S. Burke, 1989, Journal of medicinal chemistry.

Cardiotonic agents. 5. 1,2-Dihydro-5-[4-(1H-imidazol-1-yl)phenyl]-6-methyl-2-oxo-3- pyridinecarbonitriles and related compounds. Synthesis and inotropic activity.

D. B. Evans, I. Sircar, J. Bristol, 1987, Journal of medicinal chemistry.

Cardiotonic agents. 1. 4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3 (2H)-pyridazinones: novel positive inotropic agents for the treatment of congestive heart failure.

D. B. Evans, W. Moos, I. Sircar, 1984, Journal of medicinal chemistry.

Cardiotonic agents. 8. Selective inhibitors of adenosine 3',5'-cyclic phosphate phosphodiesterase III. Elaboration of a five-point model for positive inotropic activity.

C. Humblet, A. McPhail, W. Moos, 1987, Journal of medicinal chemistry.

Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors.

A. Doherty, H. W. Hamilton, B. Steinbaugh, 1992, Journal of medicinal chemistry.

Synthesis and biological activity of 4-(diphenylmethyl)-alpha-[(4-quinolinyloxy)methyl]-1-piperazineethanol and related compounds.

I. Sircar, S. Burke, H. Barth, 1992, Journal of medicinal chemistry.

Cardiotonic agents. 7. Inhibition of separated forms of cyclic nucleotide phosphodiesterase from guinea pig cardiac muscle by 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinones and related compounds. Structure-activity relationships and correlation with in vivo positive inotropic activit

W. Moos, I. Sircar, J. Bristol, 1987, Journal of medicinal chemistry.

Cardiotonic agents. 4. Synthesis and biological evaluation of N-substituted 2,4,4a,5-tetrahydro-3H-indeno[1,2-c]pyridazin-3-ones: rigid structures derived from CI-930 and analogues.

I. Sircar, M. Cain, S. Burke, 1986, Journal of medicinal chemistry.

CARDIOTONIC AGENTS. 1. 4,5-DIHYDRO-6-(4-(1H-IMIDAZOL-1-YL)PHENYL)-3(2H)-PYRIDAZINONES: NOVEL POSITIVE INOTROPIC AGENTS FOR THE TREATMENT OF CONGESTIVE HEART FAILURE

W. Moos, I. Sircar, J. Bristol, 1985 .

An improved and efficient synthesis of 2-substituted 1,4-dihydropyridine derivatives via regiospecific bromination

I. Sircar, K. R. Anderson, L. Bonadies, 1988 .

Cardiotonic agents. 3. Synthesis and biological activity of novel 6-(substituted 1H-imidazol-4(5)-yl)-3(2H)-pyridazinones.

D. B. Evans, I. Sircar, J. Bristol, 1986, Journal of medicinal chemistry.

New inhibitors of human renin that contain novel replacements at the P2 site.

A. Doherty, M. Taylor, J. C. Hodges, 1991, Journal of medicinal chemistry.

Renin inhibitors containing esters at the P2-position. Oral activity in a derivative of methyl aminomalonate.

C. Humblet, E. Lunney, J. C. Hodges, 1991, Journal of medicinal chemistry.

Calcium channel blocking and positive inotropic activities of ethyl 5-cyano-1,4-dihydro-6-methyl-2-[(phenylsulfonyl)methyl]-4-aryl-3- pyridine-carboxylate and analogues. Synthesis and structure-activity relationships.

M. Taylor, I. Sircar, T. Pugsley, 1991, Journal of medicinal chemistry.

Calcium Channel Blocking and Positive Inotropic Activities of Ethyl 5- Cyano-1,4-dihydro-6-methyl-2-((phenylsulfonyl)methyl)-4-aryl-3- pyridinecarboxylate and Analogues. Synthesis and Structure-Activity Relationships.

M. Taylor, I. Sircar, T. Pugsley, 1991 .

Derivatives of 5-[[1-(4'-carboxybenzyl)imidazolyl]methylidene]hydantoins as orally active angiotensin II receptor antagonists.

J. M. Hamby, R. Panek, J. C. Hodges, 1995, Journal of medicinal chemistry.

Nonpeptide angiotensin II receptor antagonists. 1. Synthesis and in vitro structure-activity relationships of 4-[[[(1H-pyrrol-1-ylacetyl)amino]phenyl]methyl]imidazole derivatives as angiotensin II receptor antagonists.

R. Panek, G. Lu, T. Major, 1993, Journal of medicinal chemistry.

A family-based and case–control association study of trace amine receptor genes on chromosome 6q23 in bipolar affective disorder

S. Cichon, M. Rietschel, M. Nöthen, 2005, Molecular Psychiatry.

PD 122860: a novel dihydropyridine with sodium channel stimulating and calcium channel blocking properties.

T. Major, M. Taylor, I. Sircar, 1989, The Journal of pharmacology and experimental therapeutics.

Pharmacologic characterization of CI-996, a new angiotensin receptor antagonist.

R. Panek, J. Keiser, J. C. Hodges, 1995, The Journal of pharmacology and experimental therapeutics.

Identification of novel series of human CCR1 antagonists.

J. Li, I. Sircar, Kui Xu, 2008, Bioorganic & medicinal chemistry letters.