Ling Qi

发表

A Phos-Tag-Based Approach Reveals the Extent of Physiological Endoplasmic Reticulum Stress

Liu Yang, Zhen Xue, Yin He, 2010, PloS one.

SUMO modification regulates the transcriptional activity of XBP1.

Hui Chen, Ling Qi, 2010, The Biochemical journal.

Lipoprotein Lipase and Its Regulators: An Unfolding Story

S. Kersten, Ling Qi, Shuangcheng Wu, 2020, Trends in Endocrinology & Metabolism.

The obesity-induced adipokine sST2 exacerbates adipose Treg and ILC2 depletion and promotes insulin resistance

Jiandie D. Lin, Si-ming Li, Linkang Zhou, 2020, Science Advances.

Tipping the Balance in Metabolic Regulation: Regulating Regulatory T Cells by Costimulation

Ling Qi, 2014, Diabetes.

Activation of Natural Killer T Cells Promotes M2 Macrophage Polarization in Adipose Tissue and Improves Systemic Glucose Tolerance via Interleukin-4 (IL-4)/STAT6 Protein Signaling Axis in Obesity*

S. Kersten, A. Xu, Chih-Hao Lee, 2012, The Journal of Biological Chemistry.

Gr-1+ CD11b+ Myeloid-derived Suppressor Cells Suppress Inflammation and Promote Insulin Sensitivity in Obesity*

S. Ostrand-Rosenberg, Liu Yang, Ling Qi, 2011, The Journal of Biological Chemistry.

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

R. Kulkarni, S. Kersten, Bethany A. Carboneau, 2019, Nature Immunology.

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes

P. Arvan, Anoop Arunagiri, Ming Liu, 2018, Annals of the New York Academy of Sciences.

Endoplasmic Reticulum Protein Quality Control in β Cells.

N. Shrestha, Rachel B Reinert, Ling Qi, 2020, Seminars in cell & developmental biology.

TRB 3 Links the E 3 Ubiquitin Ligase COP 1 to Lipid Metabolism

J. Yates, R. Evans, Sherry L. Niessen, 2009 .

Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.

L. Goodyear, H. Koh, D. An, 2014, American journal of physiology. Regulatory, integrative and comparative physiology.

ER-stress-associated functional link between Parkin and DJ-1 via a transcriptional cascade involving the tumor suppressor p53 and the spliced X-box binding protein XBP-1

A. Brice, H. Ariga, E. Duplan, 2013, Journal of Cell Science.

PERK and XBP1 differentially regulate CXCL10 and CCL2 production

D. Gao, Ling Qi, Hua Liu, 2017, Experimental eye research.

Endoplasmic reticulum quality control in cancer: Friend or foe.

Ling Qi, Hana Kim, Asmita Bhattacharya, 2015, Seminars in cancer biology.

Stressed out about obesity: IRE1α–XBP1 in metabolic disorders

Liu Yang, Yin He, Ling Qi, 2011, Trends in Endocrinology & Metabolism.

Hepatic Sel1L‐Hrd1 ER‐associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH

S. Kersten, L. Yin, Kezhong Zhang, 2018, The EMBO journal.

A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death.

Ling Qi, Yonggan Wu, Jang-Gi Choi, 2015, Cell reports.

Intrinsic Structural Features of the Human IRE1α Transmembrane Domain Sense Membrane Lipid Saturation.

A. Sum, Christina Chan, G. Kim, 2019, Cell reports.

Brief description of insulin mRNA quantity and quality

R. Kaufman, P. Arvan, Anoop Arunagiri, 2021 .

Landscape of Intercellular Crosstalk in Healthy and NASH Liver Revealed by Single-Cell Secretome Gene Analysis.

Jiandie D. Lin, Jun Z. Li, K. Kurabayashi, 2019, Molecular cell.

Kinase (AMPK)-dependent Manner Response in an AMP-activated Protein Phenformin Activates the Unfolded Protein

Liu Yang, Ling Qi, R. Davisson, 2014 .

The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism.

S. Kersten, B. Xue, Hang Shi, 2014, Cell metabolism.

The Transcriptional Co-Regulator HCF-1 Is Required for INS-1 β-cell Glucose-Stimulated Insulin Secretion

Siu Sylvia Lee, Ling Qi, Yewei Ji, 2013, PloS one.

Epithelial Sel1L is required for the maintenance of intestinal homeostasis

Angela C. Poole, R. Ley, Julia Goodrich, 2016, Molecular biology of the cell.

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

M. Concha, C. Hetz, E. Chevet, 2018, Nature Cell Biology.

Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes

D. Beard, S. Kersten, T. Sanderson, 2020, Science.

Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages.

N. Tan, G. Hooiveld, S. Kersten, 2010, Cell metabolism.

The Full Capacity of AICAR to Reduce Obesity-Induced Inflammation and Insulin Resistance Requires Myeloid SIRT1

Zhenggang Yang, B. Xue, Hang Shi, 2012, PloS one.

ER-associated degradation in health and disease – from substrate to organism

Ling Qi, Asmita Bhattacharya, 2019, Journal of Cell Science.

High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet*

J. Locasale, Xiaojing Liu, M. Hirschey, 2015, Molecular & Cellular Proteomics.

Adipocyte Spliced Form of X-Box–Binding Protein 1 Promotes Adiponectin Multimerization and Systemic Glucose Homeostasis

F. Liu, S. Kersten, Liu Yang, 2014, Diabetes.

Short Term High Fat Diet Challenge Promotes Alternative Macrophage Polarization in Adipose Tissue via Natural Killer T Cells and Interleukin-4*

Liu Yang, Shengyi Sun, Ling Qi, 2012, The Journal of Biological Chemistry.

Endoplasmic reticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.

J. Hodgin, M. Bitzer, E. Otto, 2021, The Journal of clinical investigation.

Hypothalamic ER–associated degradation regulates POMC maturation, feeding, and age-associated obesity

M. Low, P. Arvan, G. Kim, 2018, The Journal of clinical investigation.

The Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Complex Manages a Key Checkpoint in B Cell Development.

Liu Yang, Ling Qi, Q. Long, 2016, Cell reports.

The IRE1alpha-XBP1 pathway of the unfolded protein response is required for adipogenesis.

Xinmin Zhang, Xiaoyong Yang, Hang Shi, 2009, Cell metabolism.

Deficiency of Suppressor Enhancer Lin12 1 Like (SEL1L) in Mice Leads to Systemic Endoplasmic Reticulum Stress and Embryonic Lethality*

I. Biunno, J. Schimenti, R. Munroe, 2010, The Journal of Biological Chemistry.

Detecting and quantitating physiological endoplasmic reticulum stress.

Liu Yang, Hui Chen, Ling Qi, 2011, Methods in enzymology.

Proteasomal degradation of WT proinsulin in pancreatic beta cells

P. Arvan, Anoop Arunagiri, Billy Tsai, 2022, The Journal of biological chemistry.

Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β−selection

Yuning Hong, Xi Chen, S. Adoro, 2021, eLife.

Notch-Induced Endoplasmic Reticulum-Associated Degradation Governs Thymocyte β−Selection

Yuning Hong, Xi Chen, S. Adoro, 2021, bioRxiv.

SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer

Juncheng Wei, Ling Qi, Beixue Gao, 2022, iScience.

Journal Pre-proof SEL1L-HRD1 ER-associated degradation suppresses hepatocyte hyperproliferation and liver cancer

Juncheng Wei, Ling Qi, Beixue Gao, 2022 .

XBP-1 Couples Endoplasmic Reticulum Stress to Augmented IFN-β Induction via a cis-Acting Enhancer in Macrophages

Hui Chen, Ling Qi, Judith A. Smith, 2010, The Journal of Immunology.

The ATP-P2X7 Signaling Axis Is Dispensable for Obesity-Associated Inflammasome Activation in Adipose Tissue

S. Kersten, Shengyi Sun, Ling Qi, 2012, Diabetes.

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways.

Ling Qi, Jiwon Hwang, 2018, Trends in biochemical sciences.

New Insights into the Physiological Role of Endoplasmic Reticulum-Associated Degradation.

P. Arvan, Billy Tsai, Ling Qi, 2017, Trends in cell biology.

The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism

M. Montminy, S. Koo, L. Flechner, 2005, Nature.

Haploid Insufficiency of Suppressor Enhancer Lin12 1-like (SEL1L) Protein Predisposes Mice to High Fat Diet-induced Hyperglycemia*

Rajni Singh, Ling Qi, Q. Long, 2011, The Journal of Biological Chemistry.

Emerging roles for XBP1, a sUPeR transcription factor.

Ziying Liu, Liu Yang, Zhen Xue, 2010, Gene expression.

Pyroptosis, a new bridge to tumor immunity

Yanjing Li, Ling Qi, Y. Bai, 2021, Cancer science.

ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis.

P. Arvan, G. Kim, M. Spiess, 2017, The Journal of clinical investigation.

Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival

J. Yates, J. Locasale, S. Kersten, 2014, Proceedings of the National Academy of Sciences.

A Conserved Structural Determinant Located at the Interdomain Region of Mammalian Inositol-requiring Enzyme 1α*

K. Ye, Y. Mao, Zhen Xue, 2011, The Journal of Biological Chemistry.

SAM68 promotes tumorigenesis in lung adenocarcinoma by regulating metabolic conversion via PKM alternative splicing

Ling Qi, Z. Feng, Jizhong Wang, 2021, Theranostics.

Normal and defective pathways in biogenesis and maintenance of the insulin storage pool.

R. Kaufman, P. Arvan, Anoop Arunagiri, 2021, The Journal of clinical investigation.

IRE1α governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A

M. Concha, C. Hetz, T. Iwawaki, 2018, Nature Cell Biology.

The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic beta-cell dysfunction.

Tsonwin Hai, E. Zmuda, M. Montminy, 2010, Molecular endocrinology.

TRB3 Links the E3 Ubiquitin Ligase COP1 to Lipid Metabolism

J. Yates, R. Evans, Sherry L. Niessen, 2006, Science.

Mechanisms of inflammatory responses in obese adipose tissue.

Ling Qi, Sander Kersten, S. Kersten, 2012, Annual review of nutrition.

Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice.

Angela C. Poole, R. Ley, Julia Goodrich, 2014, Cell reports.

Adipocyte CREB promotes insulin resistance in obesity.

Tsonwin Hai, E. Zmuda, M. Montminy, 2009, Cell metabolism.

Cell Metabolism Role of CREB in Obesity active

Tsonwin Hai, E. Zmuda, M. Montminy, 2009 .

Integration of ER protein quality control mechanisms defines β cell function and ER architecture

P. Arvan, Billy Tsai, Yu-Jie Chen, 2022, The Journal of clinical investigation.

Transcription- and phosphorylation-dependent control of a functional interplay between XBP1s and PINK1 governs mitophagy and potentially impacts Parkinson disease pathophysiology

T. Goiran, E. Duplan, Wejdane El Manaa, 2021, Autophagy.

Requirement for TRanslocon-Associated Protein (TRAP) α in insulin biogenesis

S. Flibotte, Ming Liu, P. Arvan, 2019, bioRxiv.

ER associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity.

Y. Dou, K. Inoki, Fengbiao Mao, 2020, Blood.

Selective EMC subunits act as molecular tethers of intracellular organelles exploited during viral entry

Billy Tsai, P. Bagchi, Ling Qi, 2020, Nature Communications.

Nonmuscle myosin IIB links cytoskeleton to IRE1α signaling during ER stress.

K. Kemphues, J. Yates, R. Adelstein, 2012, Developmental cell.

-Acting Enhancer in Macrophages cis Induction via a b Stress to Augmented IFN-XBP-1 Couples Endoplasmic Reticulum

Hui Chen, Ling Qi, Judith A. Smith, 2010 .

Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion*

R. Zechner, S. Herzig, S. Kersten, 2014, The Journal of Biological Chemistry.

Target Involved in Hepatic Triglyceride Proliferator-activated Receptor ( PPAR ) ( HILPDA ) Is a Novel Peroxisome Hypoxia-inducible Lipid Droplet-associated Metabolism :

S. Herzig, C. Heier, Ling Qi, 2014 .

IRE1α is an endogenous substrate of endoplasmic reticulum-associated degradation

S. Kersten, Pengcheng Bu, T. Iwawaki, 2015, Nature Cell Biology.

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

A. Cuervo, V. Shakkottai, A. Lieberman, 2018, Nature Communications.

The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.

K. Wanic, M. Małecki, Jiang Hu, 2010, The Journal of clinical investigation.

Feeding Angptl4−/− mice trans fat promotes foam cell formation in mesenteric lymph nodes without leading to ascites[S]

N. Tan, S. Kersten, S. Brodesser, 2017, Journal of Lipid Research.

Genome-wide screens identify SEL1L as an intracellular rheostat controlling collagen turnover

Michael T. McManus, Michael J. Podolsky, P. Wolters, 2024, Nature communications.

Direct control of hepatic glucose production by interleukin-13 in mice.

Kristopher J. Stanya, Hang Shi, A. McKenzie, 2013, The Journal of clinical investigation.

Medullary thymic epithelial NF–kB-inducing kinase (NIK)/IKKα pathway shapes autoimmunity and liver and lung homeostasis in mice

M. Omary, L. Rui, Y. Shah, 2019, Proceedings of the National Academy of Sciences.

Hypoxia-Inducible Lipid Droplet–Associated Is Not a Direct Physiological Regulator of Lipolysis in Adipose Tissue

S. Mandrup, E. Kalkhoven, S. Kersten, 2017, Endocrinology.

Endoplasmic reticulum associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity

Y. Dou, K. Inoki, Fengbiao Mao, 2019, bioRxiv.

Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity

R. Kulkarni, S. Kersten, Bethany A. Carboneau, 2019, Nature Immunology.

SEL1L-HRD1 ER-associated degradation is a new ataxia gene 1

M. Hatten, Hong Wang, E. Govek, 2023 .

Protein Quality Control Through Endoplasmic Reticulum-Associated Degradation Maintains Hematopoietic Stem Cell Identity and Niche Interactions

X. Zhang, J. Rosen, Xi Chen, 2020, Nature Cell Biology.

Sel1L-Hrd1 ER-associated degradation maintains β-cell identity via TGFβ signaling.

Jiandie D. Lin, P. Arvan, S. Kersten, 2020, The Journal of clinical investigation.

SEL1L–HRD1 endoplasmic reticulum-associated degradation controls STING-mediated innate immunity by limiting the size of the activable STING pool

T. Liang, Yuan Luo, C. Hu, 2023, Nature Cell Biology.

The mechanisms to dispose of misfolded proteins in the endoplasmic reticulum of adipocytes

M. Ivanova, Yi-jia Lin, Shengyi Sun, 2023, Nature communications.

Dentin defects caused by a Dspp−1 frameshift mutation are associated with the activation of autophagy

J. Simmer, Ling Qi, Chuhua Zhang, 2023, Scientific reports.

SEL1L-HRD1 interaction is prerequisite for the formation of a functional HRD1 ERAD complex

Hong Wang, Shengyi Sun, Ling Qi, 2023, bioRxiv.

Phenformin Activates the Unfolded Protein Response in an AMP-activated Protein Kinase (AMPK)-dependent Manner*

Liu Yang, Ling Qi, R. Davisson, 2013, The Journal of Biological Chemistry.

Requirement for translocon-associated protein (TRAP) α in insulin biogenesis

S. Flibotte, P. Arvan, Jialu Xu, 2019, Science Advances.

PKA phosphorylation couples hepatic inositol-requiring enzyme 1α to glucagon signaling in glucose metabolism

Yong Liu, J. Han, Mengle Shao, 2011, Proceedings of the National Academy of Sciences.

Coordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD

Ling Qi, Ana Maria Cuervo, A. Cuervo, 2018, Nature Communications.

Muscle-specific ER-associated degradation maintains postnatal muscle hypertrophy and systemic energy metabolism

S. Kersten, N. Shrestha, Ling Qi, 2023, JCI insight.

Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland

P. Arvan, Y. Tomer, S. Refetoff, 2023, JCI insight.