D. Donahue

发表

Unexpected role of anticoagulant protein C in controlling epithelial barrier integrity and intestinal inflammation

F. Castellino, V. Ploplis, S. Danese, 2011, Proceedings of the National Academy of Sciences.

Abrogation of Plasminogen Activator Inhibitor-1-Vitronectin Interaction Ameliorates Acute Kidney Injury in Murine Endotoxemia

F. Castellino, V. Ploplis, M. Sandoval-Cooper, 2015, PloS one.

Translational Research in Acute Lung Injury and Pulmonary Fibrosis Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury

F. Castellino, V. Ploplis, M. Walsh, 2016 .

Plasminogen Deficiency Significantly Reduces Vascular Wall Disease in a Murine Model of Type IIa Hypercholesterolemia

F. Castellino, V. Ploplis, T. Iwaki, 2021, Biomedicines.

Group A Streptococcus-Induced Activation of Human Plasminogen Is Required for Keratinocyte Wound Retraction and Rapid Clot Dissolution

F. Castellino, V. Ploplis, Shaun W. Lee, 2021, Frontiers in Cardiovascular Medicine.

Direct Host Plasminogen Binding to Bacterial Surface M-protein in Pattern D Strains of Streptococcus pyogenes Is Required for Activation by Its Natural Coinherited SK2b Protein*

F. Castellino, V. Ploplis, Kristofor Glinton, 2015, The Journal of Biological Chemistry.

A Natural Inactivating Mutation in the CovS Component of the CovRS Regulatory Operon in a Pattern D Streptococcal pyogenes Strain Influences Virulence-associated Genes*

Yueling Zhang, R. Balsara, F. Castellino, 2013, The Journal of Biological Chemistry.

In situ metabolite and lipid analysis of GluN2D−/− and wild-type mice after ischemic stroke using MALDI MSI

R. Balsara, F. Castellino, A. Hummon, 2020, Analytical and Bioanalytical Chemistry.

An accompanying genetic severe deficiency of tissue factor protects mice with a protein C deficiency from lethal endotoxemia.

F. Castellino, V. Ploplis, R. Navari, 2011, Blood.

Mutations in the Control of Virulence Sensor Gene from Streptococcus pyogenes after Infection in Mice Lead to Clonal Bacterial Variants with Altered Gene Regulatory Activity and Virulence

F. Castellino, V. Ploplis, Shaun W. Lee, 2014, PloS one.

The Streptococcal Protease SpeB Antagonizes the Biofilms of the Human Pathogen Staphylococcus aureus USA300 through Cleavage of the Staphylococcal SdrC Protein

F. Castellino, V. Ploplis, Mijoon Lee, 2020, Journal of bacteriology.

Stable genetic integration of a red fluorescent protein in a virulent Group A Streptococcus strain

F. Castellino, V. Ploplis, Shaun W. Lee, 2019, Access microbiology.

Neutralization of Streptolysin S-Dependent and Independent Inflammatory Cytokine IL-1β Activity Reduces Pathology During Early Group A Streptococcal Skin Infection

F. Castellino, V. Ploplis, Rebecca A. Flaherty, 2018, Front. Cell. Infect. Microbiol..

A Key Role for the Urokinase Plasminogen Activator (uPA) in Invasive Group A Streptococcal Infection

V. Nizet, Yueling Zhang, F. Castellino, 2013, PLoS pathogens.

severe protein C deficiency Acute inflammation is exacerbated in mice genetically predisposed to a

F. Castellino, D. Donahue, A. Lay, 2013 .

Activation of band 3 mediates group A Streptococcus streptolysin S-based beta-haemolysis

Charles R. Tessier, F. Castellino, V. Ploplis, 2016, Nature Microbiology.

Streptolysin S targets the sodium-bicarbonate cotransporter NBCn1 to induce inflammation and cytotoxicity in human keratinocytes during Group A Streptococcal infection

F. Castellino, V. Ploplis, B. Ashfeld, 2022, Frontiers in Cellular and Infection Microbiology.

Characterizing the role of tissue-type plasminogen activator in a mouse model of Group A streptococcal infection.

J. McArthur, F. Castellino, V. Ploplis, 2019, Microbes and infection.

The vitronectin‐binding domain of plasminogen activator inhibitor‐1 plays an important functional role in lipopolysaccharide‐induced lethality in mice

F. Castellino, V. Ploplis, D. Donahue, 2012, Journal of thrombosis and haemostasis : JTH.

Abnormal Whole Blood Thrombi in Humans with Inherited Platelet Receptor Defects

R. Balsara, F. Castellino, V. Ploplis, 2012, PloS one.

A deficiency of the GluN2C subunit of the N-methyl-D-aspartate receptor is neuroprotective in a mouse model of ischemic stroke.

R. Balsara, F. Castellino, N. Zhou, 2018, Biochemical and biophysical research communications.

Conantokin-G Attenuates Detrimental Effects of NMDAR Hyperactivity in an Ischemic Rat Model of Stroke

R. Balsara, F. Castellino, D. Donahue, 2015, PloS one.

Acute inflammation is exacerbated in mice genetically predisposed to a severe protein C deficiency.

F. Castellino, D. Donahue, A. Lay, 2007, Blood.

Systemic platelet dysfunction is the result of local dysregulated coagulation and platelet activation in the brain in a rat model of isolated traumatic brain injury.

F. Castellino, V. Ploplis, M. Walsh, 2014, Journal of neurotrauma.

Genomic Characterization of a Pattern D Streptococcus pyogenes emm53 Isolate Reveals a Genetic Rationale for Invasive Skin Tropicity

F. Castellino, V. Ploplis, Shaun W. Lee, 2016, Journal of Bacteriology.

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

F. Castellino, V. Ploplis, M. Sandoval-Cooper, 2017, Scientific Reports.

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats

E. Moore, F. Castellino, V. Ploplis, 2014, The journal of trauma and acute care surgery.

Early platelet dysfunction in a rodent model of blunt traumatic brain injury reflects the acute traumatic coagulopathy found in humans.

F. Castellino, V. Ploplis, M. Walsh, 2014, Journal of neurotrauma.

High levels of LDL‐cholesterol rescue the neonatal mortality associated with afibrinogenemia in mice

F. Castellino, T. Iwaki, D. Donahue, 2007, Journal of thrombosis and haemostasis : JTH.

Probing NMDA receptor GluN2A and GluN2B subunit expression and distribution in cortical neurons

Ashley N. Ferreira, R. Balsara, F. Castellino, 2014, Neuropharmacology.

Enhanced in Vitro Proliferation of Aortic Endothelial Cells from Plasminogen Activator Inhibitor-1-deficient Mice*

R. Balsara, F. Castellino, V. Ploplis, 2004, Journal of Biological Chemistry.

Plasminogen Activator Inhibitor-1 Protects Mice Against Cardiac Fibrosis by Inhibiting Urokinase-type Plasminogen Activator-mediated Plasminogen Activation

F. Castellino, V. Ploplis, M. Sandoval-Cooper, 2017, Scientific Reports.

Altered Smooth Muscle Cell Histone Acetylome by the SPHK2/S1P Axis Promotes Pulmonary Hypertension

V. Ploplis, D. Donahue, Francis J. Castellino, 2023, Circulation research.

Early coagulation events induce acute lung injury in a rat model of blunt traumatic brain injury.

V. Ploplis, D. Donahue, Francis J. Castellino, 2016, American journal of physiology. Lung cellular and molecular physiology.

Severe deficiency of coagulation Factor VII results in spontaneous cardiac fibrosis in mice

V. Ploplis, D. Donahue, H. Xu, 2009, The Journal of pathology.

Traumatic brain injury causes platelet adenosine diphosphate and arachidonic acid receptor inhibition independent of hemorrhagic shock in humans and rats

E. Moore, F. Castellino, V. Ploplis, 2014, The journal of trauma and acute care surgery.

Antimicrobial peptide-conjugated phage-mimicking nanoparticles exhibit potent bactericidal action against Streptococcus pyogenes in murine wound infection models

V. Ploplis, Shaun W. Lee, D. Donahue, 2024, Nanoscale advances.