M. D. Díaz-de-Villegas

发表

Highly convergent stereoselective synthesis of chiral key intermediates in the synthesis of Palinavir from imines derived from l-glyceraldehyde

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2002 .

Diastereoselective synthesis of (1S,2S,3R,4R) and (1R,2S,3R,4S)-bicyclo[2.2.1]hept-2-amino-2,3-dicarboxylic acids: New conformationally-constrained (S)-aspartic acid analogues

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 1996 .

Alchemical Design of Pharmacological Chaperones with Higher Affinity for Phenylalanine Hydroxylase

Bruno L. Victor, A. Velázquez‐Campoy, J. Sancho, 2022, International journal of molecular sciences.

Diastereoselective Strecker reaction of imines derived from D-glyceraldehyde. A new route to β-hydroxy-α-amino acids

C. Cativiela, M. D. Díaz-de-Villegas, J. A. Galvez, 1995 .

Vascular Reactivity Profile of Novel KCa3.1‐Selective Positive‐Gating Modulators in the Coronary Vascular Bed

H. Wulff, R. Köhler, L. Rivera, 2016, Basic & clinical pharmacology & toxicology.

tert-Butyl (7R)-7-[(4S)-2,2-dimethyl-[1,3]dioxolan-4-yl]-1,4-dioxa-8-azaspiro[4.5]decane-8-carboxylate

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2002 .

Efficient resolution of rac-2-cyano-2-methyl-3-phenylpropanoic acid. An appropriate starting material for the enantioconvergent synthesis of (S)-α-methylphenylalanine on a large laboratory scale

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2003 .

Efficient stereodivergent synthesis of 1,4-dideoxy-1,4-iminohexitols from an (S)-glyceraldimine

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2004 .

Debenzylative cycloetherification as synthetic tool in the diastereoselective synthesis of 3,6-disubstituted hexahydro-2H-furo[3,2-b]pyrroles, PDE1 enzyme inhibitors with antiproliferative effect on melanoma cells.

J. Kehler, C. Christoffersen, R. Badorrey, 2020, The Journal of organic chemistry.

STEREOCONTROLLED SYNTHESIS OF ALL FOUR STEREOISOMERS OF FULLY PROTECTED 2-AMINO-3-HYDROXYPENTANOIC ACID FROM IMINES DERIVED FROM D-GLYCERALDEHYDE

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1999 .

Synthesis of (S)-N-tert-butoxycarbonyl-N,O-isopropylidene-α-methylserinal: A potential building block for the asymmetric synthesis of non-natural amino acids

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1998 .

Stereoselective amination of chiral enolates: Synthesis of enantiomerically pure α,β-diamino acids, chiral key compounds in the synthesis of conformationally constrained peptido- and non-peptidomimetics

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1995 .

Allylation and propargylation of chiral cyanopropanoates: an efficient route to long chain alpha-substituted alpha-methyl alpha-amino acids.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 2004, Chirality.

Design, synthesis and structure-activity evaluation of novel 2-pyridone-based inhibitors of α-synuclein aggregation with potentially improved BBB permeability.

J. Sancho, S. Ventura, I. Pallarès, 2021, Bioorganic chemistry.

Asymmetric synthesis of (1R,5S)-2-methyl-6,7-benzomorphan via Aza-Prins reaction.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2021, Chirality.

Stereoselective synthesis and biological evaluation as inhibitors of hepatitis C virus RNA polymerase of GSK3082 analogues with structural diversity at the 5-position.

O. Abián, A. Velázquez‐Campoy, J. Sancho, 2019, European journal of medicinal chemistry.

Stereoselective synthesis of quaternary a-amino acids. Part 2: Cyclic compounds

C. Cativiela, M. D. Díaz-de-Villegas, 1998 .

Synthesis of (R)-quinuclidine-2-carboxylic acid in enantiomerically pure form

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2008 .

Diastereoselective Strecker Reaction of D‐Glyceraldehyde Derivatives. A Novel Route to (2S,3S)‐ and (2R,3S)‐2‐Amino‐3,4‐dihydroxybutyric Acid.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1996 .

A chiral hydrazone derived from d-glyceraldehyde: a convenient starting material for the stereoselective synthesis of α-hydrazino acids

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1997 .

Stereoselective synthesis of α-hydroxy-β-amino acids using D-glyceraldehyde as the homochiral source

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1996 .

Olefination of methyl (1S,2R,4R)-N-benzoyl-2-formyl-7-azabicyclo[2.2.1]heptane-1-carboxylate, a synthetic approach to new conformationally constrained prolines

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 2003 .

Diastereoselective reduction of ketimines derived from (R)-3,4-dihydroxybutan-2-one: an alternative route to key intermediates for the synthesis of anticancer agent ES-285

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2010 .

Highly Stereoselective Synthesis of Stereochemically Defined Polyhydroxylated Propargylamines by Alkynylation of N-Benzylimines Derived from (R)-Glyceraldehyde

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2007 .

Organocatalysis in Enantioselective α-Functionalization of 2-Cyanoacetates

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2014 .

Diastereoselective Construction of the 6-Oxa-2-azabicyclo[3.2.1]octane Scaffold from Chiral α-Hydroxyaldehyde Derivatives by the Aza-Prins Reaction.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2017, The Journal of organic chemistry.

Organocatalyzed enantioselective desymmetrization of diols in the preparation of chiral building blocks.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2012, Chemistry.

Asymmetric Synthesis of ES-285, an Anticancer Agent Isolated from Marine Sources

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2009 .

Synthesis and chemical resolution of unique α,β-didehydroamino acids with a chiral axis

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1999 .

A simple synthesis of (−)-(1S,2R)-allocoronamic acid in its enantiomerically pure form

C. Cativiela, A. Jiménez, M. D. Díaz-de-Villegas, 1995 .

Study of the Lewis acid-promoted addition of silylenol ethers to imines derived from glyceraldehyde

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2003 .

Asymmetric Hetero Diels-Alder Reaction of N-Benzylimines Derived from R-Glyceraldehyde: A New Approach to Homochiral Piperidine Building Blocks and its Application to the Synthesis of (2R)-4-Oxopipecolic Acid

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

Synthesis of (R)- 3-alkyl-3-benzyl-2-azetidinones in enantiomerically pure form

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1993 .

Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form

C. Cativiela, M. D. Díaz-de-Villegas, J. A. Galvez, 1992 .

1,3-Dipolar cycloaddition of diazomethane to chiral azlactones. Experimental and theoretical studies

C. Cativiela, A. Jiménez, J. García, 1997 .

Synthesis, resolution, and absolute configuration determination of a vicinal amino alcohol with axial chirality. Application to the synthesis of new box and pybox ligands

M. D. Díaz-de-Villegas, J. Gálvez, P. López‐Ram‐de‐Viu, 2022, Chirality.

Z-2-phenyl-4-[(S)-2,2-dimethyl-1,3-dioxolan-4-ylmethylen]-5(4H)-oxazolone as the dienophile in asymmetric diels-alder reactions. II

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 1996 .

Z -2-Phenyl-4-[(S)- 2,2-dimethyl-1,3-dioxolan-4-ylmethylen]-5(4H)-oxazolone as the Dienophile in Asymmetric Diels-Alder Reactions

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 1995 .

STUDY OF THE REACTION OF A CHIRAL OXAZOLONE WITH OXOSULPHONIUM METHYLIDES AS CYCLOPROPANATING AGENTS

C. Cativiela, A. Jiménez, M. D. Díaz-de-Villegas, 1995 .

New α,β-didehydroamino acid derivatives as precursors in the synthesis of 1-aminocyclopropanecarboxylic acids

C. Cativiela, A. Jiménez, M. D. Díaz-de-Villegas, 1994 .

Efficient asymmetric synthesis of amino acids through hydrogenation of the didehydroamino acid residue in cyclic imino-ester derivatives

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1992 .

Synthesis and conformational properties of model dipeptides containing novel axially chiral α,β-didehydroamino acids at the (i+1) position of a β-turn conformation

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 2004 .

Study of the asymmetric diels-alder reaction of a chiral azlactone

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 1994 .

Stereoselective amination of chiral enolates : synthesis of chiral key intermediates for β-lactam antibiotics

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1994 .

Chiral Amino Diol Derivatives as New Modular Organocatalysts for the Enantioselective α-Chlorination of Cyclic β-Keto Esters

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2010 .

Two new conformationally restricted 4,5-dihydroxynorvaline analogues with a norbornane skeleton.

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 2000, Acta crystallographica. Section C, Crystal structure communications.

Chiral iminoesters derived from D-glyceraldehyde in [3 + 2] cycloaddition reactions. Asymmetric synthesis of a key intermediate in the synthesis of neuramidinase inhibitors.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2013, The Journal of organic chemistry.

1,3-Dipolar cycloaddition of diazomethane with a chiral azlactone

C. Cativiela, A. Jiménez, F. Lahoz, 1994 .

Michael addition of carbonyl compounds to nitroolefins under the catalysis of new pyrrolidine-based bifunctional organocatalysts.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2018, Organic & biomolecular chemistry.

Metal complexes of biologically important ligands: Synthesis of amino acidato complexes of PdII containing a C,N-cyclometallated group as an ancillary ligand

C. Cativiela, J. García, M. D. Díaz-de-Villegas, 1995 .

Asymmetric Synthesis of a Novel Conformationally Constrained D‐Lysine Analogue with a Piperidine Skeleton

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2008 .

Stereoselective Synthesis of Chiral 2,3‐Disubstituted 2,3‐Dihydro‐4(1H)‐pyridones

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2008 .

Synthesis of new conformationally rigid phenylalanine analogues.

C. Cativiela, M. D. Díaz-de-Villegas, A. Avenoza, 1994 .

Chiral 2-Cyanocinnamates in Conjugate Addition Asymmetric Enolate Trapping Reactions

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1992 .

High-performance liquid chromatographic enantioseparation of unusual amino acid derivatives with axial chirality on polysaccharide-based chiral stationary phases.

M. D. Díaz-de-Villegas, J. Gálvez, P. López‐Ram‐de‐Viu, 2015, Journal of chromatography. A.

Asymmetric synthesis of (2R,3S)-4-halo-3-benzyloxy-2-(N-methoxycarbonyl-N-benzylamino)butyronitriles as precursors for the synthesis of β-hydroxy-α-amino acids

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2000 .

Reversal of the stereochemical course of the addition of phenylmagnesium bromide to N-benzylimines derived from R-glyceraldehyde depending on the O-protecting group and its application to the synthesis of both enantiomers of phenylglycine

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

(alphaMe)Nva: stereoselective syntheses and preferred conformations of selected model peptides.

C. Toniolo, F. Formaggio, M. Crisma, 2000, The journal of peptide research : official journal of the American Peptide Society.

Chiral Pd organometallic complexes as catalysts in cyclopropanation reactions

C. Cativiela, R. Navarro, M. D. Díaz-de-Villegas, 1996 .

Synthesis of constrained prolines by Diels–Alder reaction using a chiral unsaturated oxazolone derived from (R)-glyceraldehyde as starting material

C. Cativiela, E. Buñuel, M. D. Díaz-de-Villegas, 2001 .

Efficient enantioconvergent synthesis of (S)-α-benzyl-α-methyl-β-alanine from (R)- and (S)-2-cyano-2-methyl-3-phenylpropanoic acid

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2003 .

Asymmetric Synthesis of .beta.-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1994 .

Synthesis of Chiral 2-Chloroacrylic Esters.

C. Cativiela, M. D. Díaz-de-Villegas, J. A. Galvez, 1992 .

Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2017, Beilstein journal of organic chemistry.

New Efficient Synthesis of 1-Aminocyclopropanecarboxylic Acid (ACC)

C. Cativiela, A. Jiménez, M. D. Díaz-de-Villegas, 1992 .

A straightforward synthesis of (−)-(1S,2R)-Allonorcoronamic acid using D-mannitol as the chiral source

C. Cativiela, A. Jiménez, M. D. Díaz-de-Villegas, 1995 .

Stereoselective synthesis and biological evaluation of D-fagomine, D-3-epi-fagomine and D-3,4-epi-fagomine analogs from D-glyceraldehyde acetonide as a common building block.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2012, Organic & biomolecular chemistry.

Study of the Reactions between Vinylmagnesium Bromide and Imines Derived from (R)‐Glyceraldehyde − The Key Step in the Stereodivergent Synthesis of Conveniently Protected, Enantiopure syn‐ and anti‐2‐Amino‐1,3,4‐butanetriol Derivatives

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2003 .

A Convenient Synthesis of L-a-Vinylglycine from D-Mannitol

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

A practical method for the absolute configuration assignment of α-amino acids using their Pd(dmba) amino acidato complexes

C. Cativiela, M. D. Díaz-de-Villegas, R. Navarro, 1996 .

Recent Progress on the Stereoselective Synthesis of Acyclic Quaternary α-Amino Acids

C. Cativiela, M. D. Díaz-de-Villegas, 2007 .

Study of the Reactions Between Vinylmagnesium Bromide and Imines Derived from (R)-Glyceraldehyde — The Key Step in the Stereodivergent Synthesis of Conveniently Protected, Enantiopure syn- and anti-2-Amino-1,3,4-butanetriol Derivatives.

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2003 .

A Convenient Synthesis of L‐α‐Vinylglycine from D‐Mannitol.

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

Synthesis of Cyanocinnamic Esters by the Knoevenagel Reaction

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1990 .

A Chiral Oxazolone Derived from D-Glyceraldehyde as an Intermediate in the Synthesis of Enantiomerically Pure Cyclic Amino Acids

C. Cativiela, A. Jiménez, E. Buñuel, 2003 .

Stereocontrolled synthesis of orthogonally protected 2-substituted 4-aminopiperidines.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2009, Organic & biomolecular chemistry.

The synthesis of enantiomerically pure (2R)-α-methylisoserine

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1996 .

Synthesis of Cyanocinnamic Esters by the Knoevenagel Reaction.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1991 .

Stereodivergent Addition of Allylmetal Reagents to Imines Derived from (R)‐2,3‐Di‐O‐benzylglyceraldehyde by Appropriate Selection of Metal and Double Stereodifferentiation

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 2002 .

Asymmetric synthesis of 3,3-diphenyl-2-methylalanine, a new unusual α-amino acid for peptides of biological interest

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1994 .

On the synthesis of (S)-α-methylaspartic acid by diastereoselective alkylation of a chiral 2-cyanopropanoate

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1997 .

A new approach to the stereoselective synthesis of conveniently protected α-allyl substituted amino acids; chiral key compounds in the synthesis of constrained peptide isostere constituents

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

Asymmetric Synthesis of 3,3-Diphenyl-2-methylalanine, a New Unusual . alpha.-Amino Acid for Peptides of Biological Interest.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1995 .

New approaches to the asymmetric synthesis of α-methylphenylalanine

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1994 .

Chiral 2-cyano esters as synthetic intermediates in the synthesis of R and S α-methylvaline

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1995 .

Synthesis of (S)-α-Methylaspartic Acid by Diastereoselective Alkylation of a Chiral 2-Cyanopropanoate.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1997 .

Synthesis of (R)- and (S)-2-amino-2-methylbutanoic acid (Iva) in enantiomerically pure form

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1993 .

A New Approach to the Stereoselective Synthesis of Conveniently Protected α-Allyl Substituted Amino Acids; Chiral Key Compounds in the Synthesis of Constrained Peptide Isostere Constituents.

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1997 .

First asymmetric synthesis of an acyclic β,β-dialkylated-γ-aminobutyric acid

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 2006 .

New Approaches to the Asymmetric Synthesis of α- Methylphenylalanine.

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1994 .

First Stereoselective Synthesis of (1R,2R,4R)‐ and (1S,2R,4S)‐2‐Substituted‐1‐azabicyclo[2.2.1]heptanes

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2009 .

Lipopeptaibol metabolites of tolypocladium geodes: total synthesis, preferred conformation, and membrane activity.

C. Toniolo, F. Formaggio, A. Moretto, 2003, Chemistry.

Design, Synthesis, and Efficacy Testing of Nitroethylene- and 7-Nitrobenzoxadiazol-Based Flavodoxin Inhibitors against Helicobacter pylori Drug-Resistant Clinical Strains and in Helicobacter pylori-Infected Mice.

A. Velázquez‐Campoy, J. Carrodeguas, Á. Lanas, 2019, Journal of medicinal chemistry.

Selective Targeting of Human and Animal Pathogens of the Helicobacter Genus by Flavodoxin Inhibitors: Efficacy, Synergy, Resistance and Mechanistic Studies

A. Velázquez‐Campoy, J. Sancho, U. Schaible, 2021, International journal of molecular sciences.

A pyrene-inhibitor fluorescent probe with large Stokes shift for the staining of Aβ1–42, α-synuclein, and amylin amyloid fibrils as well as amyloid-containing Staphylococcus aureus biofilms

J. Sancho, S. Ventura, I. Pallarès, 2018, Analytical and Bioanalytical Chemistry.

Study of the reaction of imines derived from (R)-glyceraldehyde with Danishefsky's diene

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1999 .

Efficient stereoselective synthesis of enantiopure cis-and trans-1,2,4-trisubstituted piperidines

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2007 .

Unexpected epimerization at C2 in the Horner-Wadsworth-Emmons reaction of chiral 2-substituted-4-oxopiperidines.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2006, Chemical communications.

Study of the Reaction of Imines Derived from (R)‐Glyceraldehyde with Danishefsky′s Diene.

C. Cativiela, R. Badorrey, M. D. Díaz-de-Villegas, 1999 .

Base-controlled diastereodivergent synthesis of (R)- and (S)-2-substituted-4-alkylidenepiperidines by the Wadsworth-Emmons reaction.

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2007, Journal of Organic Chemistry.

Chiral 2-acetamidoacrylates in conjugate addition – asymmetric enolate trapping reactions. Asymmetric synthesis of phenylalanine

C. Cativiela, M. D. Díaz-de-Villegas, J. Gálvez, 1992 .

A Novel Pan-Negative-Gating Modulator of KCa2/3 Channels, Fluoro-Di-Benzoate, RA-2, Inhibits Endothelium-Derived Hyperpolarization–Type Relaxation in Coronary Artery and Produces Bradycardia In Vivo

Brandon M. Brown, H. Wulff, R. Köhler, 2015, Molecular Pharmacology.

Expedient asymmetric synthesis of (2S,3S)-Boc-phenylalanine epoxide, a key intermediate for the synthesis of biologically active compounds

R. Badorrey, M. D. Díaz-de-Villegas, J. Gálvez, 2009 .

Stereoselective Synthesis of Quaternary α-Amino Acids. Part 1. Acyclic Compounds

C. Cativiela, M. D. Díaz-de-Villegas, 2010 .

Crystal structure of (1S,2S,3R,4R)-3-[(S)-2,2-dimethyl-1,3-dioxolan-4-yl]- bicyclo[2.2.1]-hept-5-en-2-spiro-{4'[2'-phenyl-5'(4'H)-oxazolone]}, C20H21NO4

M. D. Díaz-de-Villegas, J. Gálvez, E. Buñuel, 1998 .