L. Pennington

发表

Structure-activity relationships of selective estrogen receptor modulators: modifications to the 2-arylbenzothiophene core of raloxifene.

H W Cole, C. D. Jones, K. Matsumoto, 1997, Journal of medicinal chemistry.

The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization.

D. Moustakas, L. Pennington, Lewis D Pennington, 2017, Journal of medicinal chemistry.

A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design.

B. Beno, N. Meanwell, K. Yeung, 2015, Journal of medicinal chemistry.

Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase-Glucokinase Regulatory Protein (GK-GKRP) Binding: Strategic Use of a N → S (nN → σ*S-X) Interaction for Conformational Constraint.

Kristin L. Andrews, Jiandong Zhang, S. Chmait, 2015, Journal of medicinal chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 2. Leveraging structure-based drug design to identify analogues with improved pharmacokinetic profiles.

R. Kunz, Jiandong Zhang, S. Chmait, 2014, Journal of medicinal chemistry.

A new strategy for synthesis of attached rings

L. Overman, L. Pennington, 2000 .

Enantioselective total synthesis of briarellins E and F: the first total syntheses of briarellin diterpenes.

L. Overman, L. Pennington, Olivier Corminboeuf, 2003, Journal of the American Chemical Society.

Total synthesis of the reputed structure of alcyonin and reassignment of its structure.

L. Overman, L. Pennington, Olivier Corminboeuf, 2003, Organic letters.

Optimization of a Potent, Orally Active S1P1 Agonist Containing a Quinolinone Core.

Matthew R. Lee, A. Tasker, K. Sham, 2012, ACS medicinal chemistry letters.

Quinolinone-based agonists of S1P₁: use of a N-scan SAR strategy to optimize in vitro and in vivo activity.

Matthew R. Lee, A. Tasker, M. Horner, 2012, Bioorganic & medicinal chemistry letters.

4-Methoxy-N-[2-(trifluoromethyl)biphenyl-4-ylcarbamoyl]nicotinamide: A Potent and Selective Agonist of S1P1.

Matthew R. Lee, M. Horner, K. Sham, 2011, ACS medicinal chemistry letters.

Homogeneity of Passively Ventilated National Laboratory

Wilmarth, L. L. Buckley, Š., 2008 .

Seasonal changes in the composition of passively ventilated waste tank headspaces

J. L. Huckaby, L. L. Buckley, J. Hayes, 1997 .

Strategic use of pinacol-terminated Prins cyclizations in target-oriented total synthesis.

L. Overman, L. Pennington, 2003, The Journal of organic chemistry.

A general strategy for the synthesis of cladiellin diterpenes: enantioselective total syntheses of 6-acetoxycladiell-7(16),11-dien-3-ol (deacetoxyalcyonin acetate), cladiell-11-ene-3,6,7-triol, sclerophytin A, and the initially purported structure of sclerophytin A.

L. Overman, D. MacMillan, L. Pennington, 2001, Journal of the American Chemical Society.

NOVEL METHODOLOGY FOR THE SYNTHESIS OF ESTROGENIC AND ANTIESTROGENIC ISOFLAV-3-ENES

T. Grese, L. Pennington, 1995 .

Enantioselective syntheses of authentic sclerophytin A, sclerophytin B, and cladiell-11-ene-3,6,7-triol.

L. Overman, L. Paquette, F. Gallou, 2001, Organic letters.

Total synthesis of the supposed structure of (-)-sclerophytin A and an improved route to (-)-7-deacetoxyalcyonin acetate.

L. Overman, L. Pennington, 2000, Organic letters.

Structure-brain exposure relationships.

S. Hitchcock, L. Pennington, Lewis D Pennington, 2006, Journal of medicinal chemistry.

Design and preparation of a potent series of hydroxyethylamine containing β-secretase inhibitors that demonstrate robust reduction of central β-amyloid.

Yuan Cheng, Wenge Zhong, Michael D Bartberger, 2012, Journal of medicinal chemistry.

Synthesis and pharmacology of conformationally restricted raloxifene analogues: highly potent selective estrogen receptor modulators.

H W Cole, M. Sato, L. Short, 1998, Journal of medicinal chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 3. Structure-activity relationships within the aryl carbinol region of the N-arylsulfonamido-N'-arylpiperazine series.

R. Kunz, S. Chmait, M. Bartberger, 2014, Journal of medicinal chemistry.

Versatile raloxifene triflates

L. Short, A. Glasebrook, T. Grese, 1997 .

Holistic Drug Design for Multiparameter Optimization in Modern Small Molecule Drug Discovery.

I. Muegge, L. Pennington, 2021, Bioorganic & medicinal chemistry letters.

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.

I. Muegge, B. Aquila, L. Pennington, 2020, Journal of medicinal chemistry.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 1. Discovery of a novel tool compound for in vivo proof-of-concept.

R. Wahl, Jiandong Zhang, S. Chmait, 2014, Journal of medicinal chemistry.

Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors

R. Wahl, Jiandong Zhang, S. Chmait, 2013, Nature.

Hydroxyethylamine-based inhibitors of BACE1: P₁-P₃ macrocyclization can improve potency, selectivity, and cell activity.

R. Wahl, S. Hitchcock, M. Citron, 2013, Bioorganic & medicinal chemistry letters.

Structure guided P1' modifications of HEA derived β-secretase inhibitors for the treatment of Alzheimer's disease.

S. Hitchcock, H. Monenschein, M. Bartberger, 2012, Bioorganic & medicinal chemistry letters.

A Potent and Orally Efficacious, Hydroxyethylamine-Based Inhibitor of β-Secretase.

Yuan Cheng, Yi Luo, Wenge Zhong, 2012, ACS medicinal chemistry letters.

Design and synthesis of potent, orally efficacious hydroxyethylamine derived β-site amyloid precursor protein cleaving enzyme (BACE1) inhibitors.

R. Wahl, S. Hitchcock, Yuan Cheng, 2012, Journal of medicinal chemistry.

Structure—Brain Exposure Relationships

S. Hitchcock, L. Pennington, 2007 .

A unified strategy for enantioselective total synthesis of cladiellin and briarellin diterpenes: total synthesis of briarellins E and F and the putative structure of alcyonin and revision of its structure assignment.

L. Overman, L. Pennington, Olivier Corminboeuf, 2009, The Journal of organic chemistry.

Harnessing the necessary nitrogen atom in chemical biology and drug discovery

Eamon Comer, L. Pennington, Philip N. Collier, 2023, Medicinal Chemistry Research.