M. Kearney

发表

Age-dependent impairment of angiogenesis.

J. Isner, T. Murohara, T. Asahara, 1999, Circulation.

Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells (*)

Atsushi Namiki, Edi Brogi, Thierry Couffinhal, 1995, The Journal of Biological Chemistry.

Mouse model of angiogenesis.

J. Isner, T. Couffinhal, B. Witzenbichler, 1998, The American journal of pathology.

One-year follow-up in the Coronary Angioplasty Versus Excisional Atherectomy Trial (CAVEAT I)

R. Califf, E. Topol, J. Isner, 1995, Circulation.

Synergistic Effect of Bone Marrow Mobilization and Vascular Endothelial Growth Factor-2 Gene Therapy in Myocardial Ischemia

Douglas Losordo, S. Shintani, T. Murayama, 2004, Circulation.

Estrogen-Mediated, Endothelial Nitric Oxide Synthase–Dependent Mobilization of Bone Marrow–Derived Endothelial Progenitor Cells Contributes to Reendothelialization After Arterial Injury

J. Isner, T. Asahara, R. Aikawa, 2003, Circulation.

Estrogen Receptor–Mediated, Nitric Oxide–Dependent Modulation of the Immunologic Barrier Function of the Endothelium: Regulation of Fas Ligand Expression by Estradiol

Douglas Losordo, M. Kearney, Shu-hua Xu, 2001, Circulation.

In Vivo Assessment of Vascular Pathology Resulting From Laser Irradiation: Analysis of 23 Patients Studied by Directional Atherectomy Immediately After Laser Angioplasty

J. Isner, C. White, K. Rosenfield, 1992, Circulation.

Divergence of Angiogenic and Vascular Permeability Signaling by VEGF: Inhibition of Protein Kinase C Suppresses VEGF-Induced Angiogenesis, but Promotes VEGF-Induced, NO-Dependent Vascular Permeability

J. Isner, T. Murohara, I. Spyridopoulos, 2002, Arteriosclerosis, thrombosis, and vascular biology.

Apoptosis in human atherosclerosis and restenosis.

J. Isner, M. Kearney, J. Passeri, 1995, Circulation.

Time course of increased cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency.

J. Isner, C. Bauters, S. Bunting, 1995, The American journal of pathology.

Hyperhomocyst(e)inemia impairs angiogenesis in a murine model of limb ischemia

Y. Yoon, J. Isner, T. Asahara, 2005, Vascular medicine.

Effect of subintimal resection on initial outcome and restenosis for native coronary lesions and saphenous vein graft disease treated by directional coronary atherectomy. A report from the CAVEAT I and II investigators. Coronary Angioplasty Versus Excisional Atherectomy Trial.

R. Califf, E. Topol, R. Schwartz, 1996, Journal of the American College of Cardiology.

Intramyocardial Transplantation of Autologous CD 34 Stem Cells for Intractable Angina

K. Poh, F. Welt, T. Henry, 2007 .

Epidermal growth factor receptor-targeted cytotoxin inhibits neointimal hyperplasia in vivo. Results of local versus systemic administration.

J. Isner, J. Pickering, M. Kearney, 1995, Circulation Research.

Pathology of unstable angina: Analysis of biopsies obtained by directional coronary atherectomy

E. Topol, J. Isner, Douglas Losordo, 2005, Journal of Thrombosis and Thrombolysis.

CD34-Positive Cells Exhibit Increased Potency and Safety for Therapeutic Neovascularization After Myocardial Infarction Compared With Total Mononuclear Cells

T. Asahara, Douglas Losordo, T. Murayama, 2006, Circulation.

Animal Model Mouse Model of Angiogenesis

T. Couffinhal, B. Witzenbichler, M. Silver, 2007 .

Vascular endothelial growth factor/vascular permeability factor (VEGF/VPF) in normal and atherosclerotic human arteries.

J. Isner, T. Murohara, T. Couffinhal, 1997, The American journal of pathology.

Model of Lower Limb Vascular Insufficiency

J. Isner, C. Bauters, S. Bunting, 2007 .

Functional disruption of α4 integrin mobilizes bone marrow–derived endothelial progenitors and augments ischemic neovascularization

Y. Yoon, D. Goukassian, T. Asahara, 2006, The Journal of experimental medicine.

Postnatal Recapitulation of Embryonic Hedgehog Pathway in Response to Skeletal Muscle Ischemia

J. Isner, Douglas Losordo, R. Pola, 2003, Circulation.

Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia.

K Walsh, J. Isner, K. Walsh, 1998, Circulation.

VEGF-C gene therapy augments postnatal lymphangiogenesis and ameliorates secondary lymphedema.

Y. Yoon, J. Isner, D. Jackson, 2003, The Journal of clinical investigation.

Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA.

J. Isner, Douglas Losordo, P. Vale, 2002, Human gene therapy.

Synergistic effect of combined intramyocardial CD34+ cells and VEGF2 gene therapy after MI

Masaaki, T. Murohara, Douglas Losordo, 2006, Nature Clinical Practice Cardiovascular Medicine.

Time course of recombinant protein secretion after liposome-mediated gene transfer in a rabbit arterial organ culture model.

J. Isner, Douglas Losordo, S. Takeshita, 1994, Laboratory investigation; a journal of technical methods and pathology.

Histochemical staining following LacZ gene transfer underestimates transfection efficiency.

J. Isner, T. Couffinhal, M. Silver, 1997, Human gene therapy.

In Vivo Blockade of Tumor Necrosis Factor-&agr; Accelerates Functional Endothelial Recovery After Balloon Angioplasty

I. Spyridopoulos, Douglas Losordo, M. Kearney, 2001, Circulation.

Engineering the Response to Vascular Injury Divergent Effects of Deregulated E2F1 Expression on Vascular Smooth Muscle Cells and Endothelial Cells Result in Endothelial Recovery and Inhibition of Neointimal Growth

Y. Yoon, J. Isner, D. Goukassian, 2003, Circulation research.

Reduced Intimal Thickening Following αvβ 3 Blockade is Associated with Smooth Muscle Cell Apoptosis

J. Isner, T. Murohara, D. Cheresh, 1998 .

EXPERIMENTAL STUDIES Passivation of Metallic Stents After Arterial Gene Transfer of phVEGF 165 Inhibits Thrombus Formation and Intimal Thickening

Belle, J. Isner, L. Maillard, 2016 .

Identification of 92-kD gelatinase in human coronary atherosclerotic lesions. Association of active enzyme synthesis with unstable angina.

J. Isner, D. Brown, J M Isner, 1995, Circulation.

Proliferative activity in peripheral and coronary atherosclerotic plaque among patients undergoing percutaneous revascularization.

J. Isner, J. Pickering, J. Jekanowski, 1993, The Journal of clinical investigation.

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

Haruchika Masuda, Takayuki Asahara, J. Isner, 1999, Nature Medicine.

Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions.

J. Isner, S. Nikol, J. Pickering, 1992, The Journal of clinical investigation.

Impaired collateral vessel development associated with reduced expression of vascular endothelial growth factor in ApoE-/- mice.

J. Isner, T. Couffinhal, K. Peters, 1999, Circulation.

Accelerated restitution of endothelial integrity and endothelium-dependent function after phVEGF165 gene transfer.

J. Isner, T. Asahara, J. Symes, 1996, Circulation.

Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy

J. Alroy, J. Isner, L. Adelman, 2000, Nature Medicine.

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

J. Isner, H. Masuda, T. Asahara, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.

P. Huang, M. Fishman, J. Isner, 1998, The Journal of clinical investigation.

Therapeutic Potential of Ex Vivo Expanded Endothelial Progenitor Cells for Myocardial Ischemia

J. Isner, H. Masuda, T. Asahara, 2001, Circulation.

Antibody blockade of thrombospondin accelerates reendothelialization and reduces neointima formation in balloon-injured rat carotid artery.

J. Isner, T. Asahara, B. Witzenbichler, 1999, Circulation.

Vascular endothelial growth factor-C (VEGF-C/VEGF-2) promotes angiogenesis in the setting of tissue ischemia.

J. Isner, T. Murohara, I. Spyridopoulos, 1998, The American journal of pathology.

Age-dependent Defect in Vascular Endothelial Growth Factor Expression Is Associated with Reduced Hypoxia-inducible Factor 1 Activity*

G. Semenza, J. Isner, D. Branellec, 2000, The Journal of Biological Chemistry.

Direct intramuscular gene transfer of naked DNA encoding vascular endothelial growth factor augments collateral development and tissue perfusion.

J. Isner, S. Takeshita, J. Symes, 1996, Circulation.

Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model.

E. Brogi, J. Isner, S. Bunting, 1994, The Journal of clinical investigation.

The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors

Takayuki Asahara, J. Isner, D. Baker, 2001, Nature Medicine.

Clonogenic analysis reveals reserve stem cells in postnatal mammals. II. Pluripotent epiblastic-like stem cells.

Stephanie R. Jackson, T. Steele, C. Duplàa, 2004, The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology.

Effect of percutaneous adenovirus-mediated Gax gene delivery to the arterial wall in double-injured atheromatous stented rabbit iliac arteries

J. Isner, E. Belle, P. Steg, 2000, Gene Therapy.

Effects of poloxamer 407 on transfection time and percutaneous adenovirus-mediated gene transfer in native and stented vessels.

J. Isner, E. Belle, K. Walsh, 1998, Human gene therapy.

Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization.

J. Isner, G. Yancopoulos, T. Asahara, 1998, Circulation research.

Low-efficiency of percutaneous adenovirus-mediated arterial gene transfer in the atherosclerotic rabbit.

M. Perricaudet, J. Barry, M. Kearney, 1995, The Journal of clinical investigation.

Variable expression of the estrogen receptor in normal and atherosclerotic coronary arteries of premenopausal women.

J. Isner, Douglas Losordo, J. Jekanowski, 1994, Circulation.

Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling

Masaaki, Y. Yoon, D. Goukassian, 2005, Nature Medicine.

Constitutive Expression of phVEGF 165 After Intramuscular Gene Transfer Promotes Collateral Vessel Development in Patients With Critical Limb Ischemia Clinical Investigation and Reports

J. Isner, K. Walsh, I. Baumgartner, 1998 .

Temporally and spatially coordinated expression of cell cycle regulatory factors after angioplasty.

K. Walsh, V. Andrés, M. Kearney, 1997, Circulation research.

Local Gene Transfer of phVEGF-2 Plasmid by Gene-Eluting Stents: An Alternative Strategy for Inhibition of Restenosis

Y. Yoon, J. Isner, D. Walter, 2004, Circulation.

Local delivery of vascular endothelial growth factor accelerates reendothelialization and attenuates intimal hyperplasia in balloon-injured rat carotid artery.

J. Isner, C. Bauters, T. Asahara, 1995, Circulation.

Intramyocardial Transplantation of Autologous Endothelial Progenitor Cells for Therapeutic Neovascularization of Myocardial Ischemia

Y. Yoon, J. Isner, T. Asahara, 2003, Circulation.

Reciprocal relation between VEGF and NO in the regulation of endothelial integrity

J. Isner, T. Murohara, T. Couffinhal, 1997, Nature Medicine.

Lower-Extremity Edema Associated with Gene Transfer of Naked DNA Encoding Vascular Endothelial Growth Factor

J. Isner, I. Baumgartner, M. Kearney, 2000, Annals of Internal Medicine.

Passivation of metallic stents after arterial gene transfer of phVEGF165 inhibits thrombus formation and intimal thickening.

J. Isner, E. Belle, L. Maillard, 1997, Journal of the American College of Cardiology.

Elevated levels of basic fibroblast growth factor in patients with limb ischemia.

J. Isner, K. Rosenfield, M. Kearney, 1996, American heart journal.

Cell cycle regulator E2F1 modulates angiogenesis via p53-dependent transcriptional control of VEGF.

F. Martelli, D. Goukassian, R. Kishore, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Sonic Hedgehog Induces Arteriogenesis in Diabetic Vasa Nervorum and Restores Function in Diabetic Neuropathy

K. Allendoerfer, Y. Yoon, T. Asahara, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Restoration of E2F expression rescues vascular endothelial cells from tumor necrosis factor-alpha-induced apoptosis.

J. Isner, I. Spyridopoulos, Douglas Losordo, 1998, Circulation.

Evidence Implicating Nonmuscle Myosin in Restenosis: Use of In Situ Hybridization to Analyze Human Vascular Lesions Obtained by Directional Atherectomy

D. Baim, J. Isner, L. Weir, 1992, Circulation.

Vascular endothelial growth factor inhibits endothelial cell apoptosis induced by tumor necrosis factor-alpha: balance between growth and death signals.

C. Cetrulo, E. Brogi, J. Isner, 1997, Journal of molecular and cellular cardiology.

Intramyocardial Transplantation of Autologous CD34+ Stem Cells for Intractable Angina: A Phase I/IIa Double-Blind, Randomized Controlled Trial

K. Poh, F. Welt, T. Henry, 2007, Circulation.

Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor.

J. Isner, I. Spyridopoulos, Douglas Losordo, 1997, Circulation.

Rescue of diabetes-related impairment of angiogenesis by intramuscular gene therapy with adeno-VEGF.

J. Isner, K. Peters, B. Annex, 1999, The American journal of pathology.

Differential expression of nonmuscle myosin II isoforms in human atherosclerotic plaque.

J. Isner, S. Nikol, J. Pickering, 1997, Atherosclerosis.

Use of human tissue specimens obtained by directional atherectomy to study restenosis.

C. Bauters, S. Nikol, J. Pickering, 1994, Trends in cardiovascular medicine.

In situ hybridization of human atherosclerotic material from coronary arteries and saphenous vein graft biopsied with an atherectomy catheter

D. Baim, J. Isner, L. Weir, 1991 .

Differential expression of 92-kDa gelatinase in primary atherosclerotic versus restenotic coronary lesions.

J. Isner, D. Brown, M. Kearney, 1997, American Journal of Cardiology.

Expression of 92 KDA Gelatinase in Human Atherosclerotic Lesions Following Recent Plaque Rupture

E. Topol, J. Isner, David L. Brown, 1995 .

Hypoxia up‐regulates the angiogenic cytokine secretoneurin via an HIF‐1α‐ and basic FGF‐dependent pathway in muscle cells

G. Gurtner, Johannes Leierer, Douglas Losordo, 2007, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Safety and efficacy of peripheral blood progenitor cell mobilization and collection in patients with advanced coronary heart disease

K. Poh, R. Weinstein, Douglas Losordo, 2006, Journal of clinical apheresis.

Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene.

J. Isner, S. Takeshita, J. Symes, 1997, Circulation.

Transcutaneous ultrasound augments naked DNA transfection of skeletal muscle.

J. Isner, Douglas Losordo, M. Silver, 2002, Molecular therapy : the journal of the American Society of Gene Therapy.

Use of the Rabbit Ear Artery to Serially Assess Foreign Protein Secretion After Site‐Specific Arterial Gene Transfer In Vivo: Evidence That Anatomic Identification of Successful Gene Transfer May Underestimate the Potential Magnitude of Transgene Expression

J. Isner, Douglas Losordo, J. Pickering, 1994, Circulation.

Immunolocalization of thrombospondin-1 in human atherosclerotic and restenotic arteries.

J. Isner, J. Lawler, R. Riessen, 1998, American heart journal.

Histopathology of in-stent restenosis in patients with peripheral artery disease.

J. Isner, Douglas Losordo, V. Andrés, 1997, Circulation.

Improved efficiency of arterial gene transfer by use of poloxamer 407 as a vehicle for adenoviral vectors

M. Perricaudet, P. Steg, M. Kearney, 1997, Gene Therapy.

Accelerated re-endothelialization and reduced neointimal thickening following catheter transfer of phVEGF165

J. Isner, T. Asahara, J. Symes, 1996 .

Transplantation of ex vivo expanded endothelial progenitor cells for therapeutic neovascularization.

J. Isner, H. Masuda, T. Asahara, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Hypoxia up‐regulates the angiogenic cytokine secretoneurin via an HIF‐1α‐ and basic FGF‐dependent pathway in muscle cells

G. Gurtner, Johannes Leierer, Douglas Losordo, 2007, The FASEB Journal.

Reduced intimal thickening following alpha(v)beta3 blockade is associated with smooth muscle cell apoptosis.

J. Isner, T. Murohara, D. Cheresh, 1998, Cell Adhesion and Communication.