Kevin R. Mott

发表

Binding of Herpes Simplex Virus 1 UL20 to GODZ (DHHC3) Affects Its Palmitoylation and Is Essential for Infectivity and Proper Targeting and Localization of UL20 and Glycoprotein K

Shaohui Wang, K. Kousoulas, K. Wawrowsky, 2017, Journal of Virology.

Binding of HSV-1 Glycoprotein K (gK) to Signal Peptide Peptidase (SPP) Is Required for Virus Infectivity

Yoshiharu Matsuura, Y. Matsuura, K. Kousoulas, 2014, PloS one.

B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer

David L. Marron, C. Perou, Xiaping He, 2019, Cell.

Herpes simplex virus type 1 immediate-early protein ICP0 diffuses out of infected rabbit corneas.

G. Perng, Kevin R. Mott, Ling Jin, 2005, The Journal of general virology.

Macrophage IL-12 p 70 Signaling Prevents HSV-1 – Induced CNS Autoimmunity Triggered by Autoaggressive CD 4

R. Flavell, B. Rouse, Shuang Chen, 2011 .

Macrophage IL-12p70 signaling prevents HSV-1-induced CNS autoimmunity triggered by autoaggressive CD4+ Tregs.

R. Flavell, B. Rouse, Shuang Chen, 2011, Investigative ophthalmology & visual science.

A role for the JAK-STAT1 pathway in blocking replication of HSV-1 in dendritic cells and macrophages

S. Wechsler, D. Underhill, T. Town, 2009, Virology Journal.

Immunization with Different Viral Antigens Alters the Pattern of T Cell Exhaustion and Latency in Herpes Simplex Virus Type 1-Infected Mice

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2010, Journal of Virology.

Coregulatory Interactions among CD8α Dendritic Cells, the Latency-Associated Transcript, and Programmed Death 1 Contribute to Higher Levels of Herpes Simplex Virus 1 Latency

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2014, Journal of Virology.

S. Wechsler, D. Underhill, H. Ghiasi, 2008, Journal of Virology.

Ocular infection of mice with an avirulent recombinant HSV-1 expressing IL-4 and an attenuated HSV-1 strain generates virulent recombinants in vivo

S. Wechsler, H. Ghiasi, Kevin R. Mott, 2010, Molecular vision.

A comparative study of experimental mouse models of central nervous system demyelination

O. Dumitrascu, H. Ghiasi, Kevin R. Mott, 2014, Gene Therapy.

Center for Neurobiology & Vaccine Development, Ophthalmology Research

H. Ghiasi, Kevin R. Mott, C. Burns, 2008 .

A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits

A. Nesburn, S. Wechsler, L. BenMohamed, 2002, Journal of Virology.

Inhibitors of signal peptide peptidase (SPP) affect HSV-1 infectivity in vitro and in vivo.

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2014, Experimental eye research.

Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency

S. Wechsler, C. Ware, J. Rodriguez-Barbosa, 2013, Journal of Virology.

Adaptive and Innate Transforming Growth Factor (cid:1) Signaling Impact Herpes Simplex Virus 1 Latency and Reactivation (cid:1)

S. Wechsler, R. Flavell, T. Town, 2011 .

Exacerbation of corneal scarring in HSV-1 gK-immunized mice correlates with elevation of CD8+CD25+ T cells in corneas of ocularly infected mice.

A. Ljubimov, H. Ghiasi, Kevin R. Mott, 2010, Virology.

Inclusion of CD80 in HSV Targets the Recombinant Virus to PD-L1 on DCs and Allows Productive Infection and Robust Immune Responses

G. Freeman, S. Wechsler, A. Sharpe, 2014, PloS one.

Small Noncoding RNA (sncRNA1) within the Latency-Associated Transcript Modulates Herpes Simplex Virus 1 Virulence and the Host Immune Response during Acute but Not Latent Infection

Shaohui Wang, H. Ghiasi, Kevin R. Mott, 2022, Journal of virology.

CD8α Dendritic Cells Drive Establishment of HSV-1 Latency

S. Wechsler, B. Konda, T. Town, 2014, PloS one.

A Recombinant Herpes Simplex Virus Type 1 Expressing Two Additional Copies of gK Is More Pathogenic than Wild-Type Virus in Two Different Strains of Mice

K. Kousoulas, G. Perng, H. Ghiasi, 2007, Journal of Virology.

The Role of LAT in Increased CD8 (cid:1) T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1 (cid:1)

G. Freeman, S. Wechsler, L. BenMohamed, 2011 .

Optic neuritis in different strains of mice by a recombinant HSV-1 expressing murine interleukin-2.

F. Hofman, H. Ghiasi, Kevin R. Mott, 2009, Investigative ophthalmology & visual science.

Expression of Murine CD80 by Herpes Simplex Virus 1 in Place of Latency-Associated Transcript (LAT) Can Compensate for Latency Reactivation and Anti-apoptotic Functions of LAT

Shaohui Wang, H. Ghiasi, Kevin R. Mott, 2019, Journal of Virology.

Glycoprotein C of herpes simplex virus type 1 is required to cause keratitis at low infectious doses in intact rabbit corneas

S. Wechsler, G. Perng, Kevin R. Mott, 2004, Current eye research.

CD8+ T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1

T. Town, D. Gate, H. Ghiasi, 2016, Journal of Virology.

CD 8 T Cells Play a Bystander Role in Mice Latently Infected with Herpes Simplex Virus 1

T. Town, D. Gate, H. Ghiasi, 2016 .

1 CD 8 + T cells play a bystander role in HSV-1 latently infected mice 1 2

T. Town, D. Gate, H. Ghiasi, 2016 .

Level of Herpes Simplex Virus Type 1 Latency Correlates with Severity of Corneal Scarring and Exhaustion of CD8+ T Cells in Trigeminal Ganglia of Latently Infected Mice

S. Wechsler, L. BenMohamed, C. Bresee, 2008, Journal of Virology.

Mutations within the Pathogenic Region of Herpes Simplex Virus 1 gK Signal Sequences Alter Cell Surface Expression and Neurovirulence

Joshua J. Breunig, H. Ghiasi, Kevin R. Mott, 2014, Journal of Virology.

The Absence of DHHC3 Affects Primary and Latent Herpes Simplex Virus 1 Infection

Shaohui Wang, A. Ljubimov, K. Kousoulas, 2017, Journal of Virology.

Interrelationship of Primary Virus Replication, Level of Latency, and Time to Reactivation in the Trigeminal Ganglia of Latently Infected Mice

S. Wechsler, Shaohui Wang, T. Town, 2016, Journal of Virology.

Adaptive and Innate Transforming Growth Factor β Signaling Impact Herpes Simplex Virus 1 Latency and Reactivation

S. Wechsler, R. Flavell, T. Town, 2011, Journal of Virology.

Involvement of STAT4 in IgG subtype switching and ocular HSV-1 replication in mice

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2010, Molecular vision.

Role of Dendritic Cells in Enhancement of Herpes Simplex Virus Type 1 Latency and Reactivation in Vaccinated Mice

H. Ghiasi, Kevin R. Mott, 2008, Clinical and Vaccine Immunology.

Role of anti-glycoproteins D (anti-gD) and K (anti-gK) IgGs in pathology of herpes stromal keratitis in humans.

A. Nesburn, A. Wittek, H. Ghiasi, 2007, Investigative ophthalmology & visual science.

The Role of LAT in Increased CD8+ T Cell Exhaustion in Trigeminal Ganglia of Mice Latently Infected with Herpes Simplex Virus 1

G. Freeman, S. Wechsler, L. BenMohamed, 2011, Journal of Virology.

ICAM-5 modulates cytokine/chemokine production in the CNS during the course of herpes simplex virus type 1 infection

G. Perng, Kevin R. Mott, N. Onlamoon, 2009, Journal of Neuroimmunology.

Role of Interleukin-2 and Herpes Simplex Virus 1 in Central Nervous System Demyelination in Mice

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2013, Journal of Virology.

Herpes simplex virus type 1 mutants containing the KOS strain ICP34.5 gene in place of the McKrae ICP34.5 gene have McKrae-like spontaneous reactivation but non-McKrae-like virulence.

A. Nesburn, S. Wechsler, G. Perng, 2002, The Journal of general virology.

A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse

S. Wechsler, Clinton Jones, G. Perng, 2005, Journal of Virology.

A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels

A. Nesburn, S. Wechsler, Clinton Jones, 2002, Journal of Virology.

Macrophages are important determinants of acute ocular HSV-1 infection in immunized mice.

N. Van Rooijen, H. Ghiasi, Kevin R. Mott, 2007, Investigative ophthalmology & visual science.

Overexpression of herpes simplex virus glycoprotein K (gK) alters expression of HSV receptors in ocularly-infected mice.

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2014, Investigative ophthalmology & visual science.

CD11c Controls Herpes Simplex Virus 1 Responses To Limit Virus Replication during Primary Infection

S. Wechsler, L. BenMohamed, C. Ballantyne, 2011, Journal of Virology.

Role of Dendritic Cells in Enhancement of Hsv-1 Latency and Reactivation In

H. Ghiasi, Kevin R. Mott, 2022 .

The role of a glycoprotein K (gK) CD8+ T-cell epitope of herpes simplex virus on virus replication and pathogenicity.

S. Wechsler, L. BenMohamed, H. Ghiasi, 2009, Investigative ophthalmology & visual science.

Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits

A. Nesburn, S. Wechsler, D. Esmaili, 2001, Journal of Virology.

Epitope mapping of HSV-1 glycoprotein K (gK) reveals a T cell epitope located within the signal domain of gK.

A. Moreno, T. Foster, K. Kousoulas, 2007, Virus research.

A mouse model featuring tissue-specific deletion of p53 and Brca1 gives rise to mammary tumors with genomic and transcriptomic similarities to human basal-like breast cancer

C. Perou, David B. Darr, J. Usary, 2018, Breast Cancer Research and Treatment.

Suppression of IL-12p70 formation by IL-2 or following macrophage depletion causes T-cell autoreactivity leading to CNS demyelination in HSV-1-infected mice

Shuang Chen, M. Arditi, H. Ghiasi, 2017, PLoS pathogens.

IL-2 Suppression of IL-12p70 by a Recombinant HSV-1 Expressing IL-2 Induces T-Cell Auto-Reactivity and CNS Demyelination

Shuang Chen, M. Arditi, H. Ghiasi, 2011, PloS one.

Use of cytokine immunotherapy to block CNS demyelination induced by a recombinant HSV-1 expressing IL-2

O. Dumitrascu, H. Ghiasi, Kevin R. Mott, 2010, Gene Therapy.

Role of CD8+ T Cells and Lymphoid Dendritic Cells in Protection from Ocular Herpes Simplex Virus 1 Challenge in Immunized Mice

H. Ghiasi, Kevin R. Mott, H. Matundan, 2014, Journal of Virology.

Integrated Metabolic Profiling and Transcriptional Analysis Reveals Therapeutic Modalities for Targeting Rapidly Proliferating Breast Cancers.

C. Fan, C. Perou, R. Deberardinis, 2021, Cancer research.

The MMTV-Wnt1 murine model produces two phenotypically distinct subtypes of mammary tumors with unique therapeutic responses to an EGFR inhibitor

C. Perou, David B. Darr, B. Calhoun, 2019, Disease Models & Mechanisms.

Reactivation phenotype in rabbits of a herpes simplex virus type 1 mutant containing an unrelated antiapoptosis gene in place of latency-associated transcript

S. Wechsler, Clinton Jones, G. Perng, 2011, Journal of NeuroVirology.

The bovine herpesvirus-1 LR ORF2 is critical for this gene's ability to restore the high wild-type reactivation phenotype to a herpes simplex virus-1 LAT null mutant.

S. Wechsler, J. Cooper, Clinton Jones, 2003, The Journal of general virology.

Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer

C. Fan, C. Perou, David B. Darr, 2018, Genome Medicine.

The corneas of naive mice contain both CD4+ and CD8+ T cells.

J. Jester, Donald J. Brown, N. Morishige, 2007, Molecular vision.

The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection

H. Ghiasi, Kevin R. Mott, Sariah J. Allen, 2019, Journal of Virology.

Batf3 deficiency is not critical for the generation of CD8α⁺ dendritic cells.

D. Underhill, O. Akbari, B. Sharifi, 2015, Immunobiology.

FGFR4 regulates tumor subtype differentiation in luminal breast cancer and metastatic disease.

Sara R. Selitsky, David L. Marron, C. Fan, 2020, The Journal of clinical investigation.

Identification of a protein encoded in the herpes simplex virus type 1 latency associated transcript promoter region.

N. Fraser, G. Perng, Kevin R. Mott, 2005, Virus research.

Identification of Jun loss promotes resistance to histone deacetylase inhibitor entinostat through Myc signaling in luminal breast cancer

C. Fan, C. Perou, David B. Darr, 2018, Genome Medicine.

A mutant deleted for most of the herpes simplex virus type 1 (HSV-1) UOL gene does not affect the spontaneous reactivation phenotype in rabbits

S. Wechsler, Clinton Jones, N. Fraser, 2006, Journal of NeuroVirology.

Binding of herpesvirus entry mediator (HVEM) and HSV-1 gD affect reactivation but not latency levels

Shaohui Wang, H. Ghiasi, Kevin R. Mott, 2023, PLoS pathogens.