S. Clarke

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Evidence for a Ligand-Mediated Positive Selection Signal in Differentiation to a Mature B Cell 1

Hongsheng Wang, S. Clarke, 2003, The Journal of Immunology.

Molecular characterization of anti-DNA antibodies induced in normal mice by immunization with bacterial DNA. Differences from spontaneous anti-DNA in the content and location of VH CDR3 arginines.

D. Pisetsky, G. Gilkeson, S. Clarke, 1993, Journal of immunology.

BCL‐2 levels do not predict azathioprine treatment response in inflammatory bowel disease, but inhibition induces lymphocyte apoptosis and ameliorates colitis in mice

G. Rogler, M. Hausmann, M. Mozaffari, 2018, Clinical and experimental immunology.

BCL2 Regulates Differentiation of Intestinal Fibroblasts.

G. Rogler, M. Hausmann, S. Clarke, 2018, Inflammatory bowel diseases.

Identification of a Precursor to Phosphatidyl Choline-Specific B-1 Cells Suggesting That B-1 Cells Differentiate from Splenic Conventional B Cells In Vivo: Cyclosporin A Blocks Differentiation to B-11

C. Tatu, S. Clarke, L. Arnold, 2000, The Journal of Immunology.

Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

R. Tisch, S. Clarke, Carmen P. Wong, 2005, The Journal of experimental medicine.

regulatory T cells during autoimmune diabetes

R. Tisch, S. Clarke, Carmen P. Wong, 2005 .

EBV Latent Membrane Protein 2A Induces Autoreactive B Cell Activation and TLR Hypersensitivity1

R. Tisch, Hongsheng Wang, K. Conway, 2006, The Journal of Immunology.

V region gene usage and somatic mutation in the primary and secondary responses to influenza virus hemagglutinin.

L. Staudt, M. Weigert, W. Gerhard, 1990, Journal of immunology.

A shared kappa reciprocal fragment and a high frequency of secondary Jk5 rearrangements among influenza hemagglutinin specific B cell hybridomas.

S. Clarke, S. McCray, 1991, Journal of immunology.

Treatment with a CD40 Antagonist Antibody Reverses Severe Proteinuria and Loss of Saliva Production and Restores Glomerular Morphology in Murine Systemic Lupus Erythematosus

S. Westmoreland, J. Seagal, S. Clarke, 2019, The Journal of Immunology.

Immune cells and type 1 IFN in urine of SLE patients correlate with immunopathology in the kidney.

B. Vilen, S. Clarke, M. Dooley, 2016, Clinical immunology.

T. Kepler, C. Mohan, D. Bunch, 2006, Journal of Clinical Immunology.

IgG-Immune Complexes Promote B Cell Memory by Inducing BAFF

J. Rathmell, B. Vilen, A. Caro-Maldonado, 2016, The Journal of Immunology.

Polymorphism in anti-phosphocholine antibodies reflecting evolution of immunoglobulin families

S. Rudikoff, M. Potter, S. Clarke, 1983, The Journal of experimental medicine.

Staphylococcus aureus Protein A Disrupts Immunity Mediated by Long-Lived Plasma Cells

R. Tisch, A. Richardson, B. Vilen, 2017, The Journal of Immunology.

This information is current as Cells Immunity Mediated by Long-Lived Plasma Protein A Disrupts Staphylococcus aureus

R. Tisch, A. Richardson, B. Vilen, 2016 .

Early Preplasma Cells Define a Tolerance Checkpoint for Autoreactive B Cells1

B. Vilen, K. Conway, S. Clarke, 2006, The Journal of Immunology.

Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance.

Xiangdong Lu, K. Conway, G. Matsushima, 2006, Blood.

Btk regulates multiple stages in the development and survival of B-1 cells.

A. Satterthwaite, R. Hinman, S. Clarke, 2007, Molecular immunology.

Mature B Cell Selection Signal in Differentiation to a Evidence for a Ligand-Mediated Positive

Hongsheng Wang, S. Clarke, 2003 .

Anti-Sm B Cell Differentiation in Ig Transgenic MRL/Mp-lpr/lpr Mice: Altered Differentiation and an Accelerated Response1

S. Clarke, S. Santulli-Marotto, S. Ferguson, 2001, The Journal of Immunology.

Differentiation and an Accelerated Response Mice : Altered lpr / lpr Transgenic MRL / Mp-Anti-Sm B Cell Differentiation in Ig

S. Clarke, S. Santulli-Marotto, S. Ferguson, 2001 .

Splenic and peritoneal B-1 cells differ in terms of transcriptional and proliferative features that separate peritoneal B-1 from splenic B-2 cells.

G. M. Fischer, R. Gerstein, L. Solt, 2001, Cellular immunology.

Blocks Differentiation to B-1 Conventional B Cells In Vivo: Cyclosporin A B-1 Cells Differentiate from Splenic Choline-Specific B-1 Cells Suggesting That Identification of a Precursor to Phosphatidyl

C. Tatu, S. Clarke, L. Arnold, 2000 .

Selective maturation of VH12 B cells in the spleen enriches for anti-phosphatidyl choline B cells: evidence for receptor editing.

C. Tatu, S. Clarke, 2000, Current topics in microbiology and immunology.

Restricted Ig variable region gene expression among Ly-1+ B cell lymphomas.

S. Clarke, C. Pennell, G. Haughton, 1988, Journal of immunology.

Sm and DNA binding by dual reactive B cells requires distinct VH, V kappa, and VH CDR3 structures.

M. Retter, R. Eisenberg, P. Cohen, 1995, Journal of immunology.

The majority of murine VH12‐expressing B cells are excluded from the peripheral repertoire in adults

Jian Ye, S. Clarke, S. McCray, 1995, European journal of immunology.

V region gene analysis of anti-Sm hybridomas from MRL/Mp-lpr/lpr mice.

D. Pisetsky, M. Retter, M. Shlomchik, 1993, Journal of immunology.

A VH12 Transgenic Mouse Exhibits Defects in Pre-B Cell Development and Is Unable to Make IgM+ B Cells1

Jian Ye, Hongsheng Wang, S. Clarke, 2001, The Journal of Immunology.

The transition of pre‐BI to pre‐BII cells is dependent on the VH structure of the mu/surrogate L chain receptor.

S. Clarke, S. McCray, J. Ye, 1996, The EMBO journal.

Cutting Edge: Low-Affinity, Smith Antigen-Specific B Cells Are Tolerized by Dendritic Cells and Macrophages1

B. Vilen, S. Clarke, M. Kilmon, 2005, The Journal of Immunology.

CD19 signaling is impaired in murine peritoneal and splenic B-1 B lymphocytes.

V. Sindhava, S. Clarke, S. Bondada, 2009, Molecular immunology.

A novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLE.

J. Anolik, S. Hogan, S. Clarke, 2008, Clinical immunology.

Coagulopathy and platelet activation in Kawasaki syndrome: identification of patients at high risk for development of coronary artery aneurysms.

J. Burns, M. Glodé, S. Clarke, 1984, The Journal of pediatrics.

B-1 Cell Development: Evidence for an Uncommitted Immunoglobulin (Ig)M+ B Cell Precursor in B-1 Cell Differentiation

S. Clarke, L. Arnold, 1998, The Journal of experimental medicine.

T cell autoimmunity in Ig transgenic mice.

L. Bockenstedt, M. Mamula, S. Clarke, 1999, Journal of immunology.

T Cell Autoimmunity in Ig Transgenic Mice Materials and Methods

L. Bockenstedt, M. Mamula, S. Clarke, 1998 .

STAT3 activation, chemokine receptor expression, and cyclin-Cdk function in B-1 cells.

G. M. Fischer, D. Tanguay, T. Chiles, 2000, Current topics in microbiology and immunology.

Low-Affinity Anti-Smith Antigen B Cells Are Regulated by Anergy as Opposed to Developmental Arrest or Differentiation to B-11

S. Clarke, M. Borrero, 2002, The Journal of Immunology.

B-1Developmental Arrest or Differentiation to Regulated by Anergy as Opposed to Low-Affinity Anti-Smith Antigen B Cells Are

S. Clarke, M. Borrero, 2001 .

Lupus-Specific Antiribonucleoprotein B Cell Tolerance in Nonautoimmune Mice Is Maintained by Differentiation to B-1 and Governed by B Cell Receptor Signaling Thresholds1

T. Tedder, S. Clarke, C. Santiago, 2001, The Journal of Immunology.

Assessment of methods for serum extracellular vesicle small RNA sequencing to support biomarker development

V. Kaimal, S. Clarke, C. Cuff, 2019, Journal of extracellular vesicles.

Autoreactive B cell regulation: peripheral induction of developmental arrest by lupus-associated autoantigens.

M. Retter, M. Mamula, S. Clarke, 1998, Immunity.

B-1 cells are made, not born.

A. Whitmore, S. Clarke, L. Arnold, 1993, Immunology today.

Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity

Jian Ye, C. Tatu, S. Clarke, 1999, The Journal of experimental medicine.

Impaired Clearance of Apoptotic Cells Induces the Activation of Autoreactive Anti-Sm Marginal Zone and B-1 B Cells 1

Hongsheng Wang, S. Clarke, Y. Qian, 2004, The Journal of Immunology.

Anti-Sm Marginal Zone and B-1 B Cells Induces the Activation of Autoreactive Impaired Clearance of Apoptotic Cells

Hongsheng Wang, S. Clarke, Y. Qian, 2003 .

Effect of intravenous immune globulin on the coagulopathy of Kawasaki syndrome.

M. Glodé, S. Clarke, W. Hathaway, 1989, The Journal of pediatrics.

Polymorphism in immunoglobulin heavy chains suggesting gene conversion.

S. Rudikoff, S. Clarke, J. Claflin, 1982, Proceedings of the National Academy of Sciences of the United States of America.

VH12 Rearrangements in Adult Peritoneal B Cells

S. Clarke, C. Pennell, S. McCray, 1992, Annals of the New York Academy of Sciences.

Restriction in Vκ Gene Use and Antigen Selection in Anti-Myeloperoxidase Response in Mice

Y. Itoh-Lindstrom, R. Falk, J. Jennette, 2000, The Journal of Immunology.

Antigen selection of anti-DSG1 autoantibodies during and before the onset of endemic pemphigus foliaceus.

S. Clarke, V. Aoki, L. Diaz, 2009, The Journal of investigative dermatology.

Dissecting the Anti-Desmoglein Autoreactive B Cell Repertoire in Pemphigus Vulgaris Patients1

Jian Ye, S. Clarke, L. Diaz, 2007, The Journal of Immunology.

Patients B Cell Repertoire in Pemphigus Vulgaris Dissecting the Anti-Desmoglein Autoreactive

Jian Ye, S. Clarke, L. Diaz, 2007 .

Two types of BCR interactions are positively selected during leukemia development in the Eμ-TCL1 transgenic mouse model of CLL.

C. Croce, S. Iacovelli, H. Jumaa, 2015, Blood.

Organization and expression of vh gene families preferentially expressed by ly‐1+ (cd5) b cells

S. Clarke, C. Pennell, K. Sheehan, 1989, European journal of immunology.

MTA2/NuRD Regulates B Cell Development and Cooperates with OCA-B in Controlling the Pre-B to Immature B Cell Transition

A. Melnick, F. Papavasiliou, R. Roeder, 2019, Cell reports.

Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus

Andrew J Monteith, B. Vilen, Y. Truong, 2016, The Journal of Immunology.

Apoptotic debris accumulates on hematopoietic cells and promotes disease in murine and human SLE 1

John, Yuri, B. Vilen, 2016 .

Development of B-1 cells: segregation of phosphatidyl choline-specific B cells to the B-1 population occurs after immunoglobulin gene expression

S. Clarke, L. Arnold, C. Pennell, 1994, The Journal of experimental medicine.

VH CDR3‐dependent positive selection of murine VH12‐expressing B cells in the neonate

S. Clarke, S. McCray, 1993, European journal of immunology.

Mechanisms that limit the diversity of antibody: three sequentially acting mechanisms that favor the spontaneous production of germline encoded anti-phosphatidyl choline.

D. Spencer, S. Clarke, G. Haughton, 1993, International immunology.

Specific H chain junctional diversity may be required for non-T15 antibodies to bind phosphorylcholine.

D E Mosier, A. Feeney, D. Mosier, 1988, Journal of immunology.

Association of the pre-B cell receptor (BCR) expression level with the quality of pre-BII cell differentiation reveals hierarchical pre-BCR function.

Hongsheng Wang, S. Clarke, 2007, Molecular immunology.

Maintenance of tolerance by regulation of anti-myeloperoxidase B cells.

D. Alcorta, J. Silver, D. Bunch, 2008, Journal of the American Society of Nephrology : JASN.

Inter- and intraclonal diversity in the antibody response to influenza hemagglutinin

L. Staudt, M. Weigert, W. Gerhard, 1985, The Journal of experimental medicine.

ANTIINFLUENZA HEMAGGLUTININ ANTIBODY DIVERSITY secondary immunizat ion with influenza virus

L. Staudt, M. Weigert, W. Gerhard, 2003 .

Evidence for gene conversion among immunoglobulin heavy chain variable region genes

S. Rudikoff, S. Clarke, 1984, The Journal of experimental medicine.

B Cell Receptor Affinity and B Cell Subset Identity Integrate to Define the Effectiveness, Affinity Threshold, and Mechanism of Anergy1

S. Clarke, S. McCray, Ramiro Diz, 2008, The Journal of Immunology.

Anergy Affinity Threshold, and Mechanism of Identity Integrate to Define the Effectiveness, B Cell Receptor Affinity and B Cell Subset

S. Clarke, S. McCray, Ramiro Diz, 2008 .

Regulation of B-cell development by antibody specificity.

Hongsheng Wang, S. Clarke, 2004, Current opinion in immunology.

Positive selection focuses the VH12 B‐cell repertoire towards a single B1 specificity with survival function

Hongsheng Wang, S. Clarke, 2004, Immunological reviews.

Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages.

B. Vilen, S. Clarke, M. Kilmon, 2005, Journal of immunology.

Safety and pharmacodynamics of venetoclax (ABT-199) in a randomized single and multiple ascending dose study in women with systemic lupus erythematosus

K. Grebe, S. Wong, R. Fleischmann, 2018, Lupus.

The Nature of the Antigen Determines Leukemia Development and Behavior in the Eμ-TCL1 Transgenic Mouse Model of CLL

C. Croce, S. Iacovelli, Hongsheng Wang, 2012 .

Biased immunoglobulin variable region gene expression by Ly‐1 B cells due to clonal selection

S. Clarke, L. Arnold, T. Mercolino, 1989, European journal of immunology.

Both Sm and DNA are selecting antigens in the anti-Sm B cell response in autoimmune MRL/lpr mice.

M. Retter, R. Eisenberg, P. Cohen, 1996, Journal of immunology.

Overlap of the anti-Sm and anti-DNA responses of MRL/Mp-lpr/lpr mice.

R. Eisenberg, J. Davignon, P. Cohen, 1993, Journal of immunology.

High frequency expression of S107 VH genes by peritoneal B cells of B10.H-2aH-4bP/WTS mice.

E. Maynard, S. Clarke, L. Arnold, 1990, Journal of Immunology.

Transitional B Cells Lose Their Ability to Receptor Edit but Retain Their Potential for Positive and Negative Selection1

Chen-feng Qi, Hongsheng Wang, H. Morse, 2007, The Journal of Immunology.

Disrupted B‐lymphocyte development and survival in interleukin‐2‐deficient mice

R. Sartor, S. Clarke, L. Arnold, 2001, Immunology.

The influence of variable-region somatic mutations on the specificity and pathogenicity of murine monoclonal anti-DNA antibodies.

D. Pisetsky, G. Gilkeson, J. Lefkowith, 1995, Clinical immunology and immunopathology.

The anti‐La response of a single MRL/Mp‐lpr/lpr mouse: Specificity for DNA and VH gene usage

D. Pisetsky, E. Clair, S. Clarke, 1994, European journal of immunology.

Receptor Cross-Talk Spatially Restricts p-ERK during TLR4 Stimulation of Autoreactive B Cells

Andrew J Monteith, B. Vilen, S. Clarke, 2012, The Journal of Immunology.

Interdependence of N Nucleotide Addition and Recombination Site Choice in V(D)J Rearrangement

Thomas B. Kepler, T. Kepler, S. Clarke, 1996, The Journal of Immunology.

The BALB/c secondary response to the Sb site of influenza virus hemagglutinin. Nonrandom silent mutation and unequal numbers of VH and Vk mutations.

L. Staudt, R. Rickert, M. Weigert, 1990, Journal of immunology.

Anti-Sm B cell tolerance and tolerance loss in systemic lupus erythematosus

S. Clarke, 2008, Immunologic research.

Influence of VH CDR3 arginine and light chain pairing on DNA reactivity of a bacterial DNA-induced anti-DNA antibody from a BALB/c mouse.

G. Gilkeson, S. Clarke, M. Wloch, 1997, Journal of immunology.

Single cell analysis shows decreasing FoxP3 and TGFβ1 coexpressing CD4+CD25+ regulatory T cells during autoimmune diabetes

R. Tisch, S. Clarke, D. Culton, 2005, The Journal of experimental medicine.

Selection at Multiple Checkpoints Focuses VH12 B Cell Differentiation toward a Single B-1 Cell Specificity

Jian Ye, C. Tatu, S. Clarke, 1999, The Journal of experimental medicine.

Evidence for gene conversion among immunoglobulin heavy chain variable region genes

S. Rudikoff, S. Clarke, 1984, The Journal of experimental medicine.