M. Eastwood

发表

Endothelin-1 promotes myofibroblast induction through the ETA receptor via a rac/phosphoinositide 3-kinase/Akt-dependent pathway and is essential for the enhanced contractile phenotype of fibrotic fibroblasts.

Yunliang Chen, R. D. du Bois, J. Pearson, 2004, Molecular biology of the cell.

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts

D. Abraham, C. Denton, Shangxin Liu, 2009, PloS one.

Effect of precise mechanical loading on fibroblast populated collagen lattices: morphological changes.

M Eastwood, R A Brown, R. Brown, 1998, Cell motility and the cytoskeleton.

Mechanical loading regulates protease production by fibroblasts in three‐dimensional collagen substrates

Robert A. Brown, M. Eastwood, D. Herbage, 2000, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Activation of Key Profibrotic Mechanisms in Transgenic Fibroblasts Expressing Kinase-deficient Type II Transforming Growth Factor-β Receptor (TβRIIΔk)*

D. Abraham, C. Denton, E. Renzoni, 2005, Journal of Biological Chemistry.

Heart valve and arterial tissue engineering

A. McCulloch, A. Harris, C. Sarraf, 2003, Cell proliferation.

Thrombospondin 1 is a key mediator of transforming growth factor β-mediated cell contractility in systemic sclerosis via a mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK)-dependent mechanism

Yunliang Chen, D. Abraham, C. Denton, 2011, Fibrogenesis & tissue repair.

Loss of protein kinase Cϵ results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2008, Journal of Cell Science.

Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts.

Yunliang Chen, S. Parapuram, D. Abraham, 2009, Arthritis and rheumatism.

FAK is required for TGFbeta-induced JNK phosphorylation in fibroblasts: implications for acquisition of a matrix-remodeling phenotype.

Yunliang Chen, Shiwen Xu, D. Abraham, 2007, Molecular biology of the cell.

CCN2 is necessary for the function of mouse embryonic fibroblasts.

Yunliang Chen, K. Lyons, D. Abraham, 2007, Experimental cell research.

Rosiglitazone alleviates the persistent fibrotic phenotype of lesional skin scleroderma fibroblasts.

D. Abraham, C. Denton, A. Leask, 2010, Rheumatology.

Post‐transcriptional regulation of α‐smooth muscle actin determines the contractile phenotype of Dupuytren's nodular cells

J. Nanchahal, K. Midwood, M. Eastwood, 2010, Journal of cellular physiology.

Contribution of activin receptor-like kinase 5 (transforming growth factor beta receptor type I) signaling to the fibrotic phenotype of scleroderma fibroblasts.

Yunliang Chen, D. Abraham, C. Denton, 2006, Arthritis and rheumatism.

Heparan sulfate-dependent ERK activation contributes to the overexpression of fibrotic proteins and enhanced contraction by scleroderma fibroblasts.

Yunliang Chen, A. Pitsillides, D. Abraham, 2008, Arthritis and rheumatism.

Matrix contraction by dermal fibroblasts requires transforming growth factor-beta/activin-linked kinase 5, heparan sulfate-containing proteoglycans, and MEK/ERK: insights into pathological scarring in chronic fibrotic disease.

Yunliang Chen, D. Abraham, E. Renzoni, 2005, The American journal of pathology.

Evidence for sequential utilization of fibronectin, vitronectin, and collagen during fibroblast‐mediated collagen contraction

I. Yannas, Robert A. Brown, V. Mudera, 2002, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Loss of protein kinase C&egr; results in impaired cutaneous wound closure and myofibroblast function

Yunliang Chen, D. Abraham, C. Denton, 2014, Journal of Cell Science.

Tensional homeostasis in dermal fibroblasts: Mechanical responses to mechanical loading in three‐dimensional substrates

M Eastwood, R A Brown, I. Yannas, 1998, Journal of cellular physiology.

Ultrastructural changes during contraction of collagen lattices by ocular fibroblasts

N. Occleston, P. Khaw, R. Brown, 1998, Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.

Phenytoin reduces the contraction of recessive dystrophic epidermolysis bullosa fibroblast populated collagen gels.

R. Brown, Robert A. Brown, M. Eastwood, 1997, The international journal of biochemistry & cell biology.

Inducible lineage-specific deletion of TbetaRII in fibroblasts defines a pivotal regulatory role during adult skin wound healing.

Yunliang Chen, D. Abraham, C. Denton, 2009, The Journal of investigative dermatology.

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

D. Hamilton, Shiwen Xu, J. Guan, 2012, Journal of Cell Science.

The effect of burn blister fluid on fibroblast contraction.

A. Wilson, R. Brown, Robert A. Brown, 1997, Burns : journal of the International Society for Burn Injuries.

In vitro mesenchymal stem cell differentiation after mechanical stimulation

C. Sarraf, M. Eastwood, W. Otto, 2011, Cell proliferation.

Expression of integrin β1 by fibroblasts is required for tissue repair in vivo

D. Abraham, C. Denton, T. Krieg, 2010, Journal of Cell Science.

Dynamic protrusive cell behaviour generates force and drives early matrix contraction by fibroblasts

P. Khaw, M. Bailly, A. Dahlmann-Noor, 2007, Experimental cell research.

Duration and orientation of mechanical loads determine fibroblast cyto‐mechanical activation: Monitored by protease release

Robert A. Brown, M. Eastwood, R. Prajapati, 2000, Wound Repair and Regeneration.

Fibroblast responses to mechanical forces

M Eastwood, R A Brown, R. Brown, 1998, Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine.

Tissue engineering of biological cardiovascular system surrogates.

Andrew D McCulloch, Mark Eastwood, Andrew B Harris, 2002, Heart, lung & circulation.

Molecular responses of human dermal fibroblasts to dual cues: contact guidance and mechanical load.

M Eastwood, R A Brown, R Pleass, 2000, Cell motility and the cytoskeleton.

A culture force monitor for measurement of contraction forces generated in human dermal fibroblast cultures: evidence for cell-matrix mechanical signalling.

M Eastwood, R A Brown, R. Brown, 1994, Biochimica et biophysica acta.

Aortic Root Characteristics of Human Pulmonary Autografts

Magdi H. Yacoub, M. Yacoub, S. Edwards, 2000, Circulation.

Balanced mechanical forces and microtubule contribution to fibroblast contraction

M Eastwood, R A Brown, D. McGrouther, 1996, Journal of cellular physiology.

Quantitative analysis of collagen gel contractile forces generated by dermal fibroblasts and the relationship to cell morphology

Mark Eastwood, Robert A. Brown, M. Eastwood, 1996, Journal of cellular physiology.

Enhanced fibroblast contraction of 3D collagen lattices and integrin expression by TGF-beta1 and -beta3: mechanoregulatory growth factors?

Robert A. Brown, V. Mudera, K. Sethi, 2002, Experimental cell research.

Identification of a novel stretch-responsive skeletal muscle gene (Smpx).

T. Kemp, D. Sassoon, M. Simon, 2001, Genomics.

New multi-cue bioreactor for tissue engineering of tubular cardiovascular samples under physiological conditions.

Mark Eastwood, Andrew D McCulloch, Andrew B Harris, 2004, Tissue engineering.

Cell proliferation rates in an artificial tissue‐engineered environment

A D McCulloch, M Eastwood, A. McCulloch, 2005, Cell proliferation.

Matrix Contraction by Dermal Fibroblasts Requires Transforming Growth Factor-β/Activin-Linked Kinase 5, Heparan Sulfate-Containing Proteoglycans, and MEK/ERK

Yunliang Chen, D. Abraham, E. Renzoni, 2005 .

Periostin modulates myofibroblast differentiation during full-thickness cutaneous wound repair

D. Hamilton, Shiwen Xu, J. Guan, 2012, Journal of Cell Science.