L. Roumenina

L. Vergoz, C. Hue, V. Frémeaux-Bacchi, 2013, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Genetics of hemolytic uremic syndromes.

T. Seeman, F. Schaefer, V. Frémeaux-Bacchi, 2012, Presse medicale.

Hemopexin as an Inhibitor of Hemolysis-Induced Complement Activation

L. Roumenina, Dandan Luo, G. Tuffin, 2020, Frontiers in Immunology.

Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

S. Watson, J. Dimitrov, Y. Di, 2020, Haematologica.

P-selectin drives complement attack on endothelium during intravascular hemolysis in TLR-4/heme-dependent manner

J. Dimitrov, V. Frémeaux-Bacchi, N. Merle, 2019, Proceedings of the National Academy of Sciences.

Heme Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

J. Dimitrov, S. Satchell, P. Mathieson, 2018, Front. Immunol..

Drives Susceptibility of Glomerular Endothelium to Complement Overactivation Due to Inefficient Upregulation of Heme Oxygenase-1

J. Dimitrov, S. Satchell, P. Mathieson, 2018 .

Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

V. Frémeaux-Bacchi, L. Roumenina, F. Pourcine, 2020, Frontiers in Immunology.

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome.

J. Dimitrov, V. Frémeaux-Bacchi, L. Halbwachs‐Mecarelli, 2013, Blood.

hemolytic uremic syndrome Complement activation by heme as a secondary hit for atypical

J. Dimitrov, V. Frémeaux-Bacchi, L. Halbwachs‐Mecarelli, 2013 .

Circulating FH Protects Kidneys From Tubular Injury During Systemic Hemolysis

V. Frémeaux-Bacchi, M. Pickering, Samantha Knockaert, 2020, Frontiers in Immunology.

Uremic Syndrome: One Target, Two Diseases Glomerulopathies and in Atypical Hemolytic Factor H Autoantibodies in C3 - Anti

T. Jokiranta, M. Büchler, B. Moulin, 2015 .

C3‐dependent effector functions of complement

L. Roumenina, A. Zarantonello, A. Grunenwald, 2022, Immunological reviews.

Ex Vivo Complement Activation on Endothelial Cells: Research and Translational Value.

V. Frémeaux-Bacchi, L. Roumenina, S. Chauvet, 2021, Trends in molecular medicine.

Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency.

S. Tavernier, P. Stordeur, F. Haerynck, 2020, The Journal of allergy and clinical immunology.

Complement System Part I – Molecular Mechanisms of Activation and Regulation

V. Frémeaux-Bacchi, S. Church, N. Merle, 2015, Front. Immunol..

Terminal complement without C5 convertase?

L. Roumenina, 2021, Blood.

Complement C3 is a novel modulator of the anti-factor VIII immune response

S. Kaveri, S. Lacroix-Desmazes, V. Frémeaux-Bacchi, 2017, Haematologica.

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation.

V. Frémeaux-Bacchi, L. Halbwachs‐Mecarelli, P. Lesavre, 2011, Blood.

C1q+ macrophages: passengers or drivers of cancer progression.

C. Sautès-Fridman, W. Fridman, L. Roumenina, 2022, Trends in cancer.

Context-dependent roles of complement in cancer

C. Sautès-Fridman, F. Petitprez, W. Fridman, 2019, Nature Reviews Cancer.

Tumor Cells Hijack Macrophage-Produced Complement C1q to Promote Tumor Growth

P. Validire, C. Sautès-Fridman, F. Petitprez, 2019, Cancer Immunology Research.

of Birmingham Heme induces human and mouse platelet activation through C-type-lectin-like receptor-2

S. Watson, J. Dimitrov, L. Roumenina, 2020 .

Complement System: Promoter or Suppressor of Cancer Progression?

C. Sautès-Fridman, W. Fridman, L. Roumenina, 2020, Antibodies.

B cells and cancer: To B or not to B?

C. Sautès-Fridman, F. Petitprez, W. Fridman, 2020, The Journal of experimental medicine.

B cells and complement at the forefront of chemotherapy

C. Sautès-Fridman, L. Roumenina, 2020, Nature Reviews Clinical Oncology.

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

L. Vergoz, M. Noris, C. Hue, 2014, Journal of the American Society of Nephrology : JASN.

Complement factor H related proteins (CFHRs).

C. Skerka, V. Frémeaux-Bacchi, L. Roumenina, 2013, Molecular immunology.

Interaction of C1q with IgG1, C-reactive protein and pentraxin 3: mutational studies using recombinant globular head modules of human C1q A, B, and C chains.

A. Mantovani, A. Agrawal, M. Gadjeva, 2006, Biochemistry.

Pregnancy-associated hemolytic uremic syndrome revisited in the era of complement gene mutations.

E. Rondeau, M. Essig, F. Provôt, 2010, Journal of the American Society of Nephrology : JASN.

The receptor for advanced glycation end products is a sensor for cell‐free heme

S. Lancel, J. Dimitrov, M. Billamboz, 2020, The FEBS journal.

A role for complement blockade in kidney transplantation

L. Roumenina, D. Karpman, Zivile Bekassy, 2022, Cellular & Molecular Immunology.

Endothelial cells: source, barrier, and target of defensive mediators

V. Frémeaux-Bacchi, L. Roumenina, J. Rayes, 2016, Immunological reviews.

A novel CFHR1-CFHR5 hybrid leads to a familial dominant C3 glomerulopathy.

F. Gonnet, R. Daniel, V. Kher, 2017, Kidney international.

Use of eculizumab for atypical haemolytic uraemic syndrome and C3 glomerulopathies

V. Frémeaux-Bacchi, J. Zuber, F. Fakhouri, 2012, Nature Reviews Nephrology.

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies.

J. Grünfeld, P. Niaudet, A. Servais, 2012, Kidney international.

The Benefits of Complement Measurements for the Clinical Practice.

L. Roumenina, A. Grunenwald, Anne Grunenwald, 2021, Methods in molecular biology.

Alternative complement pathway assessment in patients with atypical HUS.

C. Sautès-Fridman, V. Frémeaux-Bacchi, C. Loirat, 2011, Journal of immunological methods.

Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions.

V. Frémeaux-Bacchi, N. Merle, L. Roumenina, 2019, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

Antibodies Use Heme as a Cofactor to Extend Their Pathogen Elimination Activity and to Acquire New Effector Functions*

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2007, Journal of Biological Chemistry.

Mutations in Complement Regulatory Proteins Predispose to Preeclampsia: A Genetic Analysis of the PROMISSE Cohort

J. Atkinson, D. Branch, J. Salmon, 2011, PLoS medicine.

Analysis of protein missense alterations by combining sequence‐ and structure‐based methods

Maria A Miteva, Bruno O Villoutreix, Nathalie Lagarde, 2020, Molecular genetics & genomic medicine.

C1q and its growing family.

M. Gadjeva, Robert B Sim, K. Reid, 2007, Immunobiology.

Functional Complement C1q Abnormality Leads to Impaired Immune Complexes and Apoptotic Cell Clearance

W. Fridman, D. Sène, V. Frémeaux-Bacchi, 2011, The Journal of Immunology.

Apoptotic Cell Clearance Leads to Impaired Immune Complexes and Functional Complement C 1 q Abnormality

W. Fridman, D. Sène, V. Frémeaux-Bacchi, 2011 .

Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome.

C. Sautès-Fridman, W. Fridman, J. Dimitrov, 2009, Blood.

Hyperfunctional C 3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome

C. Sautès-Fridman, W. Fridman, J. Dimitrov, 2009 .

Mechanism and functional implications of the heme-induced binding promiscuity of IgE.

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2015, Biochemistry.

Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN.

G. Deschênes, S. Burtey, M. Delahousse, 2017, Journal of the American Society of Nephrology : JASN.

Anti-Factor B Antibodies and Acute Postinfectious GN in Children.

B. Villoutreix, M. Miteva, E. Thervet, 2020, Journal of the American Society of Nephrology : JASN.

Factor D Inhibition Blocks Complement Activation Induced by Mutant Factor B Associated With Atypical Hemolytic Uremic Syndrome and Membranoproliferative Glomerulonephritis

R. Palsson, L. Roumenina, D. Karpman, 2021, Frontiers in Immunology.

Detection of Anti-C3b Autoantibodies by ELISA.

L. Roumenina, M. Radanova, V. Vasilev, 2021, Methods in molecular biology.

Autoantibodies Against C3b—Functional Consequences and Disease Relevance

V. Frémeaux-Bacchi, L. Roumenina, M. Radanova, 2019, Front. Immunol..

Detection of Autoantibodies to Complement Components by Surface Plasmon Resonance-Based Technology.

V. Frémeaux-Bacchi, Rémi Noé, L. Roumenina, 2018, Methods in molecular biology.

C5 nephritic factors drive the biological phenotype of C3 glomerulopathies.

F. Petitprez, G. Deschênes, C. Legendre, 2017, Kidney international.

Anti–Factor H Autoantibodies in C3 Glomerulopathies and in Atypical Hemolytic Uremic Syndrome: One Target, Two Diseases

T. Jokiranta, M. Büchler, B. Moulin, 2015, The Journal of Immunology.

Overall Neutralization of Complement Factor H by Autoantibodies in the Acute Phase of the Autoimmune Form of Atypical Hemolytic Uremic Syndrome

C. Sautès-Fridman, W. Fridman, A. Bagga, 2012, The Journal of Immunology.

Anti-factor H autoantibodies assay.

V. Frémeaux-Bacchi, L. Roumenina, S. Ngo, 2014, Methods in molecular biology.

The role of Complement in Post-Transfusion Hemolysis and Hyperhemolysis Reaction.

F. Pirenne, P. Bartolucci, L. Roumenina, 2019, Transfusion medicine reviews.

Anti-inflammatory activity of intravenous immunoglobulin through scavenging of heme

S. Kaveri, M. Lecerf, J. Dimitrov, 2019, Molecular immunology.

Antibody Polyreactivity in Health and Disease: Statu Variabilis

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2013, Journal of Immunology.

Minimal-size Functional Factor H Surface-recognition Domains Represents a Complement Regulatory and an Engineered Construct Combining

P. Sánchez-Corral, S. Reuter, T. Jokiranta, 2022 .

the Autoimmune Form of Atypical Hemolytic H by Autoantibodies in the Acute Phase of Overall Neutralization of Complement Factor

C. Sautès-Fridman, W. Fridman, A. Bagga, 2013 .

Functional characterization of mutations in complement C3 that predispose to aHUS

J. Atkinson, V. Frémeaux-Bacchi, L. Roumenina, 2010 .

Complement activation in sickle cell disease: Dependence on cell density, hemolysis and modulation by hydroxyurea therapy

L. Kiger, E. Audureau, G. Bodivit, 2020, American journal of hematology.

Distal Angiopathy and Atypical Hemolytic Uremic Syndrome: Clinical and Functional Properties of an Anti-Factor H IgAλ Antibody.

S. Lepreux, C. Combe, J. Goujon, 2015, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[Atypical hemolytic-uremic syndrome related to abnormalities within the complement system].

V. Frémeaux-Bacchi, F. Fakhouri, C. Loirat, 2011, La Revue de medecine interne.

Oxidized hemoglobin triggers polyreactivity and autoreactivity of human IgG via transfer of heme

S. Kaveri, S. Lacroix-Desmazes, M. Lecerf, 2023, Communications Biology.

Heme-Exposed Pooled Therapeutic IgG Improves Endotoxemia Survival

J. Dimitrov, T. Stefanova, T. Vassilev, 2017, Inflammation.

Von Willebrand Factor Interacts with Surface-Bound C1q and Induces Platelet Rolling

B. Kaufmann, J. K. Kremer Hovinga, H. Hopfer, 2016, The Journal of Immunology.

Hemolytic uremic syndrome associated with Bordetella pertussis infection in a 2-month-old infant carrying a pathogenic variant in complement factor H

V. Frémeaux-Bacchi, L. Roumenina, J. Harambat, 2019, Pediatric Nephrology.

Complement C1s and C4d as Prognostic Biomarkers in Renal Cancer: Emergence of Noncanonical Functions of C1s

P. Validire, C. Sautès-Fridman, Guillaume Lacroix, 2021, Cancer Immunology Research.

Glomerulonephritis With Isolated C3 Deposits as a Manifestation of Subtotal Factor I Deficiency

A. Moktefi, J. Goujon, V. Frémeaux-Bacchi, 2019, Kidney International Reports.

Complement biomarkers as predictors of disease outcome in C3 glomerulopathy

Richard J. H. Smith, V. Frémeaux-Bacchi, L. Roumenina, 2018, Molecular Immunology.

Kinetics and thermodynamics of interaction of coagulation factor VIII with a pathogenic human antibody.

B. Atanasov, S. Kaveri, S. Lacroix-Desmazes, 2009, Molecular immunology.

Hemopexin and Albumin inhibit heme-induced macrophage activation while also enabling heme-LPS synergistic promotion of TNF production

L. Travassos, M. Bozza, G. C. Henderson, 2023, Advances in Redox Research.

IgG Subclass-Dependent Pulmonary Antigen Retention during Acute IgG-Dependent Systemic Anaphylaxis in Mice

L. Macdonald, A. Murphy, P. Bruhns, 2022, The Journal of Immunology.

Functional evaluation of factor H genetic and acquired abnormalities: application for atypical hemolytic uremic syndrome (aHUS).

V. Frémeaux-Bacchi, L. Roumenina, S. Ngo, 2014, Methods in molecular biology.

Complement factor H: a guardian within?

L. Roumenina, I. Boudhabhay, 2021, Kidney international.

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

S. Thiel, A. Hansen, P. Kristensen, 2018, Front. Immunol..

Aalborg Universitet A Single-Domain Antibody Targeting Complement Component C 5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL 7 Protein

S. Thiel, A. Hansen, P. Kristensen, 2018 .

Intracellular Factor H Drives Tumor Progression Independently of the Complement Cascade

P. Validire, C. Sautès-Fridman, W. Fridman, 2021, Cancer Immunology Research.

Site-specific N-glycosylation analysis of soluble Fcγ receptor IIIb in human serum

C. Sautès-Fridman, W. Fridman, Koichi Kato, 2018, Scientific Reports.

ATVB IN FOCUS: Thromboinflammation and Infection

J. Dimitrov, K. Suzuki-Inoue, L. Roumenina, 2023 .

Heme: driver of erythrocyte elimination.

J. Dimitrov, L. Roumenina, 2021, Blood.

Hemolysis is associated with altered heparan sulfate of the endothelial glycocalyx and with local complement activation in thrombotic microangiopathies.

S. Lancel, F. Glowacki, V. Gnemmi, 2023, Kidney international.

Complement C3 Deposition on Endothelial Cells Revealed by Flow Cytometry.

L. Roumenina, I. Boudhabhay, A. Grunenwald, 2021, Methods in molecular biology.

[The complement system: a double edge sword in tumor progression].

C. Sautès-Fridman, Rémi Noé, L. Roumenina, 2017, Medecine sciences : M/S.

Complement C1q‐target proteins recognition is inhibited by electric moment effectors

Alexander Kantardjiev, Robert Sim, Alexander A. Kantardjiev, 2007, Journal of molecular recognition : JMR.

The interaction between factor H and VWF increases factor H cofactor activity and regulates VWF prothrombotic status.

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2014, Blood.

ATVB IN FOCUS: Thromboinflammation and Infection

J. Dimitrov, K. Suzuki-Inoue, L. Roumenina, 2023 .

Complement activation during intravascular hemolysis: Implication for sickle cell disease and hemolytic transfusion reactions.

V. Frémeaux-Bacchi, N. Merle, L. Roumenina, 2019, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

Heme Interacts with C1q and Inhibits the Classical Complement Pathway*

B. Atanasov, S. Kaveri, S. Lacroix-Desmazes, 2011, The Journal of Biological Chemistry.

Intravascular hemolysis activates complement via cell-free heme and heme-loaded microvesicles.

S. Miescher, P. Houillier, J. Dimitrov, 2018, JCI insight.

Iron Ions and Haeme Modulate the Binding Properties of Complement Subcomponent C1q and of Immunoglobulins

J. Dimitrov, T. Vassilev, L. Roumenina, 2007, Scandinavian journal of immunology.

An Engineered Construct Combining Complement Regulatory and Surface-Recognition Domains Represents a Minimal-Size Functional Factor H

P. Sánchez-Corral, S. Reuter, T. Jokiranta, 2013, The Journal of Immunology.

Complement activation by heme as a secondary hit for atypical hemolytic uremic syndrome.

J. Dimitrov, V. Frémeaux-Bacchi, L. Halbwachs‐Mecarelli, 2013, Blood.

Complement factor B mutations in atypical hemolytic uremic syndrome-disease-relevant or benign?

L. Vergoz, M. Noris, C. Hue, 2014, Journal of the American Society of Nephrology : JASN.

A prevalent C3 mutation in aHUS patients causes a direct C3 convertase gain of function.

C. Sautès-Fridman, J. Atkinson, S. Satchell, 2012, Blood.

Renal Transplantation Under Prophylactic Eculizumab in Atypical Hemolytic Uremic Syndrome With CFH/CFHR1 Hybrid Protein

P. Niaudet, D. Beury, V. Frémeaux-Bacchi, 2012, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies.

J. Grünfeld, P. Niaudet, A. Servais, 2012, Kidney International.

A human FVIII inhibitor modulates FVIII surface electrostatics at a VWF‐binding site distant from its epitope

S. Kaveri, S. Lacroix-Desmazes, J. Dimitrov, 2010, Journal of thrombosis and haemostasis : JTH.

Clinical and functional consequences of anti‐properdin autoantibodies in patients with lupus nephritis

L. Roumenina, G. Mihaylova, M. Radanova, 2020, Clinical and experimental immunology.

Complement involvement in sickle cell disease.

L. Roumenina, M. Meuleman, Anne Grunenwald, 2023, Presse medicale.

Clinical Relevance of Anti-C3 and Anti-C4 Autoantibodies in Lupus Nephritis

L. Roumenina, G. Mihaylova, M. Radanova, 2024, Kidney international reports.