Garth Powis

发表

Resistance to BRAF Inhibition in BRAF-Mutant Colon Cancer Can Be Overcome with PI3K Inhibition or Demethylating Agents

Michael A. Davies, Gordon B. Mills, John M. Mariadason, 2012, Clinical Cancer Research.

Molecular Pharmacology and Antitumor Activity of PHT-427, a Novel Akt/Phosphatidylinositide-Dependent Protein Kinase 1 Pleckstrin Homology Domain Inhibitor

Eugene A. Mash, Lei Du-Cuny, Emmanuelle J. Meuillet, 2010, Molecular Cancer Therapeutics.

The hypoxic inducible stress response as a target for cancer drug discovery.

G. Powis, S. Welsh, Garth Powis, 2006, Seminars in oncology.

HIF-1 regulation: not so easy come, easy go.

G. Powis, Garth Powis, Mei Yee Koh, 2008, Trends in biochemical sciences.

Synthesis of D-3-deoxy-3-phosphonomethyl-myo-inositol and its dimethyl ester - compounds of use in studying the ptdins-3′-kinase signalling pathway

G. Powis, A. Gallegos, A. Kozikowski, 1993 .

Discovery of a novel class of AKT pleckstrin homology domain inhibitors

Lei Du-Cuny, Benjamin George, Nikhil Shirahatti, 2008, Molecular Cancer Therapeutics.

Dynamic contrast-enhanced and diffusion MRI show rapid and dramatic changes in tumor microenvironment in response to inhibition of HIF-1alpha using PX-478.

Robert J Gillies, Natarajan Raghunand, R. Gillies, 2005, Neoplasia.

The hypoxia-associated factor switches cells from HIF-1α- to HIF-2α-dependent signaling promoting stem cell characteristics, aggressive tumor growth and invasion.

Xiuping Liu, G. Powis, Xiuping Liu, 2011, Cancer research.

Efficacy of the combination of MEK and CDK4/6 inhibitors in vitro and in vivo in KRAS mutant colorectal cancer models

L. Kwong, S. Kopetz, G. Powis, 2016, Oncotarget.

The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures

Kristiina Vuori, Robert T. Abraham, K. Vuori, 2007, Molecular Cancer Therapeutics.

Abstract 513: Stromal desmoplasia is induced by a hypoxia and HIF-1α mediated increase in sonic hedgehog formation in pancreatic cancer

Chengcheng Hu, Richard G. Posner, Geoffrey Bartholomeusz, 2011 .

In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Lei Du-Cuny, A. Skillman, Shuxing Zhang, 2009, Cancer research.

AMPKα modulation in cancer progression: multilayer integrative analysis of the whole transcriptome in Asian gastric cancer.

Jae Yong Cho, Hyun Cheol Chung, Jae Ho Cheong, 2012, Cancer research.

HNF4α is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer

Taesung Park, Seungyoon Nam, Dongwan Hong, 2014, Gut.

Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome.

John V Heymach, Kevin R Coombes, Lixia Diao, 2012, Journal of the National Cancer Institute.

From Bench to Bedside with Targeted Therapies

John Mendelsohn, J. Mendelsohn, G. Powis, 2008 .

Take your PIK: phosphatidylinositol 3-kinase inhibitors race through the clinic and toward cancer therapy

Nathan T. Ihle, G. Powis, Garth Powis, 2009, Molecular Cancer Therapeutics.

Identification of novel synergistic targets for rational drug combinations with PI3 kinase inhibitors using siRNA synthetic lethality screening against GBM.

Jing Wang, T. Liu, W. Yung, 2011, Neuro-oncology.

A versatile approach to PI(3,4)P2, PI(4,5)P2, and PI(3,4,5)P3 from L-(-)-Quebrachitol

F. Nan, G. Powis, L. Qiao, 2000 .

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Lei Du-Cuny, Sylvestor Moses, Zuohe Song, 2009, Bioorganic & medicinal chemistry.

Hypoxia inducible factor-1alpha as a cancer drug target.

G. Powis, Garth Powis, L. Kirkpatrick, 2004, Molecular cancer therapeutics.

Hypoxia-associated factor expression in low-grade and anaplastic gliomas: a marker of poor outcome.

David Taieb, Philippe Metellus, D. Figarella-Branger, 2016, Oncotarget.

The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men

S. Kopetz, G. Powis, Scott Kopetz, 2012, Clinical Cancer Research.

Passing the baton: the HIF switch.

G. Powis, Garth Powis, Mei Yee Koh, 2012, Trends in biochemical sciences.