Michael J McLeish

The reaction mechanism of phenylethanolamine N-methyltransferase: a density functional theory study.

Polina Georgieva, Fahmi Himo, F. Himo, 2009, Biochimica et biophysica acta.

Characterization of benzaldehyde lyase from Pseudomonas fluorescens: A versatile enzyme for asymmetric C-C bond formation.

Martina Pohl, M. Kneen, M. McLeish, 2006, Bioorganic chemistry.

Saturation mutagenesis of putative catalytic residues of benzoylformate decarboxylase provides a challenge to the accepted mechanism

George L Kenyon, G. L. Kenyon, M. McLeish, 2008, Proceedings of the National Academy of Sciences.

Enzyme adaptation to inhibitor binding: a cryptic binding site in phenylethanolamine N-methyltransferase.

Christine L Gee, Jennifer L. Martin, C. Gee, 2007, Journal of medicinal chemistry.

Structural and kinetic analysis of catalysis by a thiamin diphosphate-dependent enzyme, benzoylformate decarboxylase.

Frank Jordan, Asim K Bera, George L Kenyon, 2003, Biochemistry.

Mode of binding of methyl acceptor substrates to the adrenaline-synthesizing enzyme phenylethanolamine N-methyltransferase: implications for catalysis.

Christine L Gee, Qian Wu, Michael J McLeish, 2005, Biochemistry.

Fragment-based screening by X-ray crystallography, MS and isothermal titration calorimetry to identify PNMT (phenylethanolamine N-methyltransferase) inhibitors.

Hoan Vu, Sally-Ann Poulsen, Thomas E Prisinzano, 2010, The Biochemical journal.

Molecular recognition of physiological substrate noradrenaline by the adrenaline-synthesizing enzyme PNMT and factors influencing its methyltransferase activity.

Munish Puri, Christine L Gee, Jennifer L. Martin, 2009, The Biochemical journal.

Mechanism of benzaldehyde lyase studied via thiamin diphosphate-bound intermediates and kinetic isotope effects.

Frank Jordan, George L Kenyon, Sumit Chakraborty, 2008, Biochemistry.