Mukesh K. Jain

发表

Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells

Zhiyong Lin, Hiranmoy Das, Sucharita Sen-Banerjee, 2005, Circulation.

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

David S. Rosenbaum, Jeffrey Robbins, Saptarsi M. Haldar, 2012, Nature.

Kruppel-Like Factors and Vascular Inflammation: Implications for Atherosclerosis

Mukesh K. Jain, Yuan Lu, M. Alaiti, 2012, Current Atherosclerosis Reports.

Essential Role for Smad3 in Regulating MCP-1 Expression and Vascular Inflammation

Richard N. Mitchell, Peter Libby, P. Libby, 2004, Circulation Research.

Fatty Acid-binding Protein 5 and PPARβ/δ Are Critical Mediators of Epidermal Growth Factor Receptor-induced Carcinoma Cell Growth*

Padmamalini Kannan-Thulasiraman, N. Noy, D. Seachrist, 2010, The Journal of Biological Chemistry.

Kruppel-like Factor 4 Is a Mediator of Proinflammatory Signaling in Macrophages*

Sucharita SenBanerjee, M. Lebedeva, Mukesh K. Jain, 2005, Journal of Biological Chemistry.

Corrigendum: Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

Xudong Liao, Lilei Zhang, Jonathan A. Epstein, 2015, Nature Communications.

Inhibition of ARNT severely compromises endothelial cell viability and function in response to moderate hypoxia

Mukesh K. Jain, A. Proweller, D. Ramirez-Bergeron, 2012, Angiogenesis.

Kruppel-Like Factor 2 Regulates Endothelial Barrier Function

Ganapati H. Mahabeleshwar, Mukesh K. Jain, Daiji Kawanami, 2010, Arteriosclerosis, thrombosis, and vascular biology.

Aryl Hydrocarbon Receptor Nuclear Translocator in Vascular Smooth Muscle Cells Is Required for Optimal Peripheral Perfusion Recovery

A. Alaiti, Mukesh K. Jain, A. Proweller, 2018, Journal of the American Heart Association.

Krüppel-like Factor 15 (KLF15) Is a Key Regulator of Podocyte Differentiation*

Avi Ma’ayan, V. D’Agati, G. Narla, 2012, The Journal of Biological Chemistry.

Cardiovascular Basic Helix Loop Helix Factor 1, a Novel Transcriptional Repressor Expressed Preferentially in the Developing and Adult Cardiovascular System*

S. Fukumoto, Masafumi Watanabe, C. Hsieh, 2000, The Journal of Biological Chemistry.

Thrombospondin‐4 regulates fibrosis and remodeling of the myocardium in response to pressure overload

Z. Popović, M. Penn, N. Sopko, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression profiling identifies Klf15 as a glucocorticoid target that regulates airway hyperresponsiveness.

Saptarsi M. Haldar, D. Jeyaraj, A. Gerber, 2011, American journal of respiratory cell and molecular biology.

Kruppel-Like Factors in Monocyte–Macrophage Biology

Mukesh K. Jain, Derin Tugal, L. Nayak, 2014 .

Metabolic effects of air pollution exposure and reversibility.

K. Hansen, S. Rajagopalan, S. Biswal, 2020, The Journal of clinical investigation.

Regulation of Vein Graft Hyperplasia by Survivin, an Inhibitor of Apoptosis Protein

D. Altieri, Mukesh K. Jain, M. Conte, 2005, Arteriosclerosis, thrombosis, and vascular biology.

Inhibition of Vascular Permeability Factor/Vascular Endothelial Growth Factor-mediated Angiogenesis by the Kruppel-like Factor KLF2*

D. Mukhopadhyay, Ping Wang, Resham Bhattacharya, 2005, Journal of Biological Chemistry.

Fatty acid-binding protein 5 and PPARβ/δ are critical mediators of epidermal growth factor receptor-induced carcinoma cell growth.

Padmamalini Kannan-Thulasiraman, N. Noy, D. Seachrist, 2011, The Journal of Biological Chemistry.

The Krüppel-like Factor KLF15 Regulates the Insulin-sensitive Glucose Transporter GLUT4*

C. T. Kuo, Masafumi Watanabe, Mukesh K. Jain, 2002, The Journal of Biological Chemistry.

Prolylcarboxypeptidase promotes angiogenesis and vascular repair.

Evi X. Stavrou, A. Schmaier, D. Simon, 2013, Blood.

Mitophagy is required for brown adipose tissue mitochondrial homeostasis during cold challenge

S. Chiu, C. Croniger, Jiyun Zhu, 2018, Scientific Reports.

Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension.

H. Champion, Rongli Zhang, Mukesh K. Jain, 2014, American journal of respiratory cell and molecular biology.

The myeloid transcription factor KLF2 regulates the host response to polymicrobial infection and endotoxic shock.

Ross McManus, Saptarsi M. Haldar, Zhiyong Lin, 2011, Immunity.

Cardiac macrophages regulate isoproterenol-induced Takotsubo-like cardiomyopathy

R. Adams, Rongli Zhang, Mukesh K. Jain, 2022, JCI insight.

Evolutionary Protection of Krüppel-Like Factors 2 and 4 in the Development of the Mature Hemovascular System

Mukesh K. Jain, David R. Sweet, C. Lam, 2021, Frontiers in Cardiovascular Medicine.

Induction of Krüppel‐like factor 2 reduces K/BxN serum‐induced arthritis

M. Joseph, Mukesh K. Jain, D. Laha, 2018, Journal of cellular and molecular medicine.

Kruppel-like factor 4 regulates neutrophil activation.

Mukesh K. Jain, H. Hong, L. Nayak, 2017, Blood advances.

THROMBOSIS AND HEMOSTASIS The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 ( KLF 2 )

A. Schmaier, Mukesh K. Jain, Zhiyong Lin, 2014 .

The thromboprotective effect of bortezomib is dependent on the transcription factor Kruppel-like factor 2 (KLF2).

A. Schmaier, Mukesh K. Jain, Zhiyong Lin, 2014, Blood.

Myeloid Kruppel-like factor 2 deficiency exacerbates neurological dysfunction and neuroinflammation in a murine model of multiple sclerosis

Mukesh K. Jain, Chao Zhang, Zhiyong Lin, 2014, Journal of Neuroimmunology.

Kruppel-like Transcription Factor 6 Regulates Inflammatory Macrophage Polarization*

Dipali A. Date, G. Narla, D. Simon, 2014, The Journal of Biological Chemistry.

Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation.

Y. Takami, Ganapati H. Mahabeleshwar, Mukesh K. Jain, 2013, The American journal of pathology.

Kruppel-like factor 2 protects against ischemic stroke by regulating endothelial blood brain barrier function.

S. Jameson, Feng Zhang, Kui Xu, 2013, American journal of physiology. Heart and circulatory physiology.

Apelin/APJ Signaling Is a Critical Regulator of Statin Effects in Vascular Endothelial Cells—Brief Report

H. Chun, Mukesh K. Jain, Jongmin Kim, 2012, Arteriosclerosis, thrombosis, and vascular biology.

A Myeloid Hypoxia-inducible Factor 1α-Krüppel-like Factor 2 Pathway Regulates Gram-positive Endotoxin-mediated Sepsis*

J. Lingrel, Y. Takami, Ganapati H. Mahabeleshwar, 2011, The Journal of Biological Chemistry.

Tumor Necrosis Factor Alpha-Mediated Reduction of KLF2 Is Due to Inhibition of MEF2 by NF-κB and Histone Deacetylases

Mukesh K. Jain, Zhiyong Lin, S. Senbanerjee, 2005, Molecular and Cellular Biology.

Kruppel-Like Factor 2 Inhibits Protease Activated Receptor-1 Expression and Thrombin-Mediated Endothelial Activation

R. Jain, Mukesh K. Jain, A. Hamik, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Hemizygous Deficiency of Krüppel-Like Factor 2 Augments Experimental Atherosclerosis

D. Simon, Yunmei Wang, Huiyun Gao, 2008, Circulation research.

Kruppel-like Factor 2 Inhibits Hypoxia-inducible Factor 1α Expression and Function in the Endothelium*

Saptarsi M. Haldar, J. LaManna, K. Maemura, 2009, The Journal of Biological Chemistry.

Investigating mechanisms underpinning the detrimental impact of a high-fat diet in the developing and adult hypermuscular myostatin null mouse

K. Patel, A. Matsakas, J. Swann, 2015, Skeletal Muscle.

Endothelial differentiation: molecular mechanisms of specification and heterogeneity.

Mukesh K. Jain, A. Hamik, G. Atkins, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Conditional deletion of Cited2 results in defective corneal epithelial morphogenesis and maintenance.

Eric C. Carlson, S. Dunwoodie, Yu-Chung Yang, 2009, Developmental biology.

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

J. Stamler, C. Hoppel, Fanghua Ye, 2015, The Journal of clinical investigation.

Beating against the clock

Mukesh K. Jain, Lilei Zhang, 2016, Proceedings of the National Academy of Sciences.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Christoph D. Rau, Svati H Shah, X. Xiao, 2016, Circulation.

An ATF6-tPA pathway in hepatocytes contributes to systemic fibrinolysis and is repressed by DACH1.

R. Pestell, Wei Wang, R. Ramakrishnan, 2019, Blood.

Targeting Proteases in Atherosclerosis

D. Simon, Mukesh K. Jain, 2011 .

Reduced Krüppel-Like Factor 2 Aggravates Glomerular Endothelial Cell Injury and Kidney Disease in Mice with Unilateral Nephrectomy.

Kyung Lee, J. He, F. Salem, 2016, The American journal of pathology.

Molecular mechanisms of diabetic vasculopathy

Mukesh K. Jain, A. Hamik, G. Atkins, 2005 .

Low-protein diet supplemented with ketoacids reduces the severity of renal disease in 5/6 nephrectomized rats: a role for KLF15.

C. Mei, Li-li Fu, F. Grosjean, 2011, Kidney international.

KLF 15 is a molecular link between endoplasmic reticulum stress and insulin resistance

F. Urano, R. Friedline, Jason K. Kim, 2013 .

BRG1 and BRM function antagonistically with c-MYC in adult cardiomyocytes to regulate conduction and contractility.

Hyoung-Gon Lee, D. Jeyaraj, B. Jensen, 2017, Journal of molecular and cellular cardiology.

APEG-1, a Novel Gene Preferentially Expressed in Aortic Smooth Muscle Cells, Is Down-regulated by Vascular Injury*

C. Hsieh, W. Endege, M. Yoshizumi, 1996, The Journal of Biological Chemistry.

Adipose KLF15 Controls Lipid Handling to Adapt to Nutrient Availability.

Benlian Wang, Rongli Zhang, Mukesh K. Jain, 2017, Cell reports.

Circadian control of bile acid synthesis by a KLF15-Fgf15 axis

J. Epstein, Rajan Jain, P. Tso, 2015, Nature Communications.

The Krüppel-like Factor KLF2 Inhibits Peroxisome Proliferator-activated Receptor-γ Expression and Adipogenesis*

H. Hauner, Masafumi Watanabe, Mukesh K. Jain, 2003, The Journal of Biological Chemistry.

Kruppel-like Factor 15 Is a Critical Regulator of Cardiac Lipid Metabolism*

Saptarsi M. Haldar, T. Tuschl, C. Hoppel, 2014, The Journal of Biological Chemistry.

Kruppel-like Factor 15 Regulates Smooth Muscle Response to Vascular Injury—Brief Report

Saptarsi M. Haldar, D. Jeyaraj, D. Simon, 2010, Arteriosclerosis, thrombosis, and vascular biology.

KLF 15 regulates smooth muscle response to vascular injury Supplemental Table I

Saptarsi M. Haldar, D. Jeyaraj, D. Simon, 2010 .

KLF15 Is a Molecular Link between Endoplasmic Reticulum Stress and Insulin Resistance

F. Urano, R. Friedline, Jason K. Kim, 2013, PloS one.

Macrophage Gene Expression and Foam Cell Formation Are Regulated by Plasminogen

M. Febbraio, E. Plow, R. Das, 2013, Circulation.

KLF15 and PPARα Cooperate to Regulate Cardiomyocyte Lipid Gene Expression and Oxidation

Rongli Zhang, Mukesh K. Jain, Domenick A. Prosdocimo, 2015, PPAR research.

Krüppel-like Factors in the Heart

Saptarsi M. Haldar, Mukesh K. Jain, Daiji Kawanami, 2009 .

Multiple layers of metabolism

Mukesh K. Jain, 2008, Nature Medicine.

The Kruppel-like factor KLF15 inhibits connective tissue growth factor (CTGF) expression in cardiac fibroblasts.

Saptarsi M. Haldar, A. Leask, Mukesh K. Jain, 2006, Journal of molecular and cellular cardiology.

Krüppel-like factor 4 regulates pressure-induced cardiac hypertrophy.

Saptarsi M. Haldar, K. Kaestner, D. Jeyaraj, 2010, Journal of molecular and cellular cardiology.

An emerging role for Krüppel-like factors in vascular biology.

Mukesh K. Jain, M. Feinberg, Sudeshna Fisch, 2004, Trends in cardiovascular medicine.

Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.

O. Ilkayeva, C. Newgard, Vinesh Vinayachandran, 2021, The Journal of clinical investigation.

Ionic bases for electrical remodeling of the canine cardiac ventricle.

Y. Rudy, D. Jeyaraj, D. Rosenbaum, 2013, American journal of physiology. Heart and circulatory physiology.

Kruppel-like factor 15 regulates skeletal muscle lipid flux and exercise adaptation

Saptarsi M. Haldar, A. Russell, D. Jeyaraj, 2012, Proceedings of the National Academy of Sciences.

S-Nitrosylation of β-Arrestins Biases Receptor Signaling and Confers Ligand Independence.

J. Stamler, W. Koch, C. Milano, 2018, Molecular cell.

Krüppel-Like Factor 4 Regulation of Cholesterol-25-Hydroxylase and Liver X Receptor Mitigates Atherosclerosis Susceptibility

Hsi-Yuan Huang, Hsien-Da Huang, J. Li, 2017, Circulation.

The zinc finger transcription factor, KLF2, protects against COVID-19 associated endothelial dysfunction

P. Little, Yujie Liu, S. Luo, 2021, Signal Transduction and Targeted Therapy.

Interventions Targeting Glucocorticoid-Krüppel-like Factor 15-Branched-Chain Amino Acid Signaling Improve Disease Phenotypes in Spinal Muscular Atrophy Mice

Saptarsi M. Haldar, M. Bowerman, T. Gillingwater, 2018, EBioMedicine.

p53 Impairs Endothelial Function by Transcriptionally Repressing Kruppel-Like Factor 2

Cuk-Seong Kim, Saet-Byel Jung, A. Naqvi, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice.

A. Schmaier, D. Simon, S. Gerson, 2012, The Journal of clinical investigation.

Differential regulation of vascular endothelial growth factor receptors (VEGFR) revealed by RNA interference: interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling.

T. Michel, Ruqin Kou, Mukesh K. Jain, 2005, Biochemistry.

A targetable pathway in neutrophils mitigates both arterial and venous thrombosis

A. Schmaier, Vinesh Vinayachandran, N. Mackman, 2022, Science Translational Medicine.

KLF 4 Regulation of Ch 25 h and LXR Mitigates Atherosclerosis Susceptibility Running

Hsi-Yuan Huang, Hsien-Da Huang, S. Subramaniam, 2017 .

B and Histone Deacetylases κ MEF 2 by NF-Reduction of KLF 2 Is Due to Inhibition of Tumor Necrosis Factor Alpha-Mediated

Mukesh K. Jain, Zhiyong Lin, S. Senbanerjee, 2005 .

Enhancement of Serum-response Factor-dependent Transcription and DNA Binding by the Architectural Transcription Factor HMG-I(Y)*

Hong Wang, M. Chin, Mukesh K. Jain, 1998, The Journal of Biological Chemistry.

Megamitochondria in Cardiomyocytes of a Knockout (Klf15−/−) Mouse

Saptarsi M. Haldar, C. Hoppel, B. Tandler, 2015, Ultrastructural pathology.

String mitochondria in mouse soleus muscle

Saptarsi M. Haldar, C. Hoppel, B. Tandler, 2013, Microscopy research and technique.

Transcriptional repression of Kruppel like factor‐2 by the adaptor protein p66shc

A. Naqvi, T. A. Hoffman, J. Dericco, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Taking KLF9 to "Cort" for crimes against metabolism.

L. Fan, Mukesh K. Jain, David R. Sweet, 2019, The Journal of clinical investigation.

Angiogenesis: the HETE is on.

Mukesh K. Jain, L. Nayak, M. Jain, 2011, Blood.

KLF4 in Macrophages Attenuates TNFα-Mediated Kidney Injury and Fibrosis.

J. Privratsky, Jiafa Ren, B. Liu, 2019, Journal of the American Society of Nephrology : JASN.

Krüppel-like factor 15: Regulator of BCAA metabolism and circadian protein rhythmicity.

L. Fan, Mukesh K. Jain, David R. Sweet, 2017, Pharmacological research.

KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands

O. Ilkayeva, C. Newgard, Vinesh Vinayachandran, 2022, iScience.

Macrophage-restricted and Interferon γ-inducible Expression of the Allograft Inflammatory Factor-1 Gene Requires Pu.1*

N. Sibinga, Hongyuan Yang, Mukesh K. Jain, 2002, The Journal of Biological Chemistry.

Safeguarding the Vasculature: Redundant Transcriptional Machinery Ensures Endothelial Protection.

Mukesh K. Jain, David R. Sweet, M. Jain, 2021, Arteriosclerosis, thrombosis, and vascular biology.

KLF 4 is a key determinant in the development and progression of cerebral cavernous malformations

M. Corada, M. Lampugnani, E. Dejana, 2015 .

Endothelial cell activation by antiphospholipid antibodies is modulated by Kruppel-like transcription factors.

K. McCrae, Mukesh K. Jain, A. Hamik, 2011, Blood.

PLDing a case for angiogenesis.

Mukesh K. Jain, A. Hamik, M. Jain, 2010, Blood.

Molecular Cloning and Characterization of SmLIM, a Developmentally Regulated LIM Protein Preferentially Expressed in Aortic Smooth Muscle Cells (*)

E. Haber, N. Sibinga, C. Hsieh, 1996, The Journal of Biological Chemistry.

with hypertension and faster arterial thrombosis Murine prolylcarboxypeptidase depletion induces vascular dysfunction

Evi X. Stavrou, A. Schmaier, Y. Okada, 2012 .

Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

Evi X. Stavrou, Zia Shariat-Madar, Yoshio Okada, 2011, Blood.

A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells

L. Trudeau, K. Hirschi, Jinah Han, 2022, The Journal of cell biology.

Reducing acetylated tau is neuroprotective in brain injury

J. Stamler, D. Seth, L. McCullough, 2021, Cell.

Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms

P. Ridker, Mukesh K. Jain, M. Jain, 2005, Nature Reviews Drug Discovery.

Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1.

C. Ballantyne, D. Simon, Mukesh K. Jain, 2004, The Journal of clinical investigation.

KLF2 regulates neutrophil activation and thrombosis in cardiac hypertrophy and heart failure progression

Vinesh Vinayachandran, R. Adams, Rongli Zhang, 2021, The Journal of clinical investigation.