David R. Liu

发表

Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang, Kevin T. Zhao, Shannon M. Miller, 2019, Nature Biotechnology.

Analysis and comparison of genome editing using CRISPResso2

Luca Pinello, Matthew C. Canver, David R. Liu, 2018, bioRxiv.

Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Jennifer A. Doudna, Jing Zeng, Kevin T. Zhao, 2020, Nature Biotechnology.

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

David R. Liu, Luke W. Koblan, Andrew V. Anzalone, 2020, Nature Biotechnology.

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

David R. Liu, Gregory A. Newby, Jordan L. Doman, 2020, Nature Biotechnology.

Small-molecule discovery from DNA-encoded chemical libraries.

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2011, Chemical Society reviews.

Author Correction: Predictable and precise template-free CRISPR editing of pathogenic variants

David K. Gifford, Christopher A. Cassa, David R. Liu, 2019, Nature.

Development of new molecular functions

David R. Liu, Zev J. Gartner, Mattew W Kanan, 2002 .

Author Correction: Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors

Tony P. Huang, Kevin T. Zhao, Shannon M. Miller, 2019, Nature Biotechnology.

The developing toolkit of continuous directed evolution

David R. Liu, Mary S. Morrison, Christopher J. Podracky, 2020, Nature Chemical Biology.

Predictable and precise template-free CRISPR editing of pathogenic variants

David K. Gifford, Christopher A. Cassa, David R. Liu, 2018, Nature.

Generating New Molecular Function: A Lesson from Nature

David R. Liu, P. Schultz, 1999 .

Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity

Kevin T. Zhao, Nicole M. Gaudelli, David R. Liu, 2017, Science Advances.

Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage

David R. Liu, Alexis C. Komor, M. Packer, 2016, Nature.

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

David R. Liu, Gregory A. Newby, Luke W. Koblan, 2018, Nature Biotechnology.

High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells

Tony P. Huang, David R. Liu, Sungroh Yoon, 2020, Nature Biomedical Engineering.

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

David R. Liu, Alexis C. Komor, H. Rees, 2017, Nature Communications.

Improved base excision repair inhibition and bacteriophage

Kevin T. Zhao, Nicole M. Gaudelli, David R. Liu, 2017 .

Evolved Cas9 variants with broad PAM compatibility and high DNA specificity

David R. Liu, H. Rees, Johnny H. Hu, 2018, Nature.

Conversion of 5-Methylcytosine to 5- Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1

David R. Liu, William A. Pastor, L. Aravind, 2009 .

The Behaviour of 5-Hydroxymethylcytosine in Bisulfite Sequencing

David R. Liu, William A. Pastor, A. Rao, 2010, PloS one.

Determinants of Base Editing Outcomes from Target Library Analysis and Machine Learning

Christopher A. Cassa, David R. Liu, Christopher Wilson, 2020, Cell.

Sequence-Controlled Polymers

David R. Liu, Makoto Ouchi, Jean-François Lutz, 2013, Science.

Methods for the directed evolution of proteins

David R. Liu, M. Packer, 2015, Nature Reviews Genetics.

DNA-templated organic synthesis: nature's strategy for controlling chemical reactivity applied to synthetic molecules.

David R. Liu, David R Liu, Xiaoyu Li, 2004, Angewandte Chemie.

Broad Specificity Profiling of TALENs Results in Engineered Nucleases With Improved DNA Cleavage Specificity

J. Keith Joung, David R. Liu, John P. Guilinger, 2014, Nature Methods.

DNA-Templated Organic Synthesis and Selection of a Library of Macrocycles

David R. Liu, Thomas M. Snyder, Zev J. Gartner, 2004, Science.

Autonomous Multistep Organic Synthesis in a Single Isothermal Solution Mediated by a DNA Walker

David R. Liu, Yu He, Yu He, 2010, Nature nanotechnology.

Photoswitching Mechanism of Cyanine Dyes

David R. Liu, R. Tsien, Mark Bates, 2009, Journal of the American Chemical Society.

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

David R. Liu, Steven Lin, V. Pattanayak, 2013, Nature Biotechnology.

Revealing Off-Target Cleavage Specificities of Zinc Finger Nucleases by In Vitro Selection

David R. Liu, C. L. Ramirez, J. Joung, 2011, Nature Methods.

Base editing: precision chemistry on the genome and transcriptome of living cells

David R. Liu, H. Rees, 2018, Nature Reviews Genetics.

CRISPResso2 provides accurate and rapid genome editing sequence analysis

Matthew C. Canver, David R. Liu, Jason M. Gehrke, 2019, Nature Biotechnology.

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

David R. Liu, A. Badran, Alexis C. Komor, 2017, Cell.

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

David R. Liu, David B. Thompson, J. Guilinger, 2014, Nature Biotechnology.

Analysis of Active Site Residues in Escherichia coli Chorismate Mutase by Site-Directed Mutagenesis

David R. Liu, P. Schultz, S. Cload, 1996 .

Mutagenesis Study of Active Site Residues in Chorismate Mutase from Bacillus subtilis

David R. Liu, P. Schultz, S. Cload, 1996 .

Second-Generation DNA-Templated Macrocycle Libraries for the Discovery of Bioactive Small Molecules

David R. Liu, J. P. Maianti, D. Usanov, 2018, Nature Chemistry.

Continuous directed evolution of aminoacyl-tRNA synthetases

Dieter Söll, David R. Liu, David R Liu, 2017, Nature chemical biology.

Nucleic acid evolution and minimization by nonhomologous random recombination

David R. Liu, Joshua A. Bittker, Brian V. Le, 2002, Nature Biotechnology.

Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions

Kevin T. Zhao, David R. Liu, Alexis C. Komor, 2017, Nature Biotechnology.

Multimodal small-molecule screening for human prion protein binders

Jayme L. Dahlin, David R. Liu, S. Schreiber, 2020, The Journal of Biological Chemistry.

Multimodal small-molecule screening for human prion protein binders

Jayme L. Dahlin, David R. Liu, S. Schreiber, 2020, The Journal of Biological Chemistry.

A System for the Continuous Directed Evolution of Biomolecules

David R. Liu, Kevin M. Esvelt, K. Esvelt, 2011, Nature.

Small Molecule-Triggered Cas9 Protein with Improved Genome-Editing Specificity

David R. Liu, Vikram Pattanayak, David B. Thompson, 2015, Nature chemical biology.

Analysis and minimization of cellular RNA editing by DNA adenine base editors

David R. Liu, Holly A. Rees, Christopher Wilson, 2019, Science Advances.

Translation of DNA into a library of 13,000 synthetic small-molecule macrocycles suitable for in vitro selection.

David R. Liu, Thomas M. Snyder, T. Snyder, 2008, Journal of the American Chemical Society.

Continuous directed evolution of proteins with improved soluble expression

Tony P. Huang, David R. Liu, Tina Wang, 2018, Nature Chemical Biology.

Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo

J. Keith Joung, David R. Liu, John P. Guilinger, 2014, Nature Biotechnology.

An In Vitro Translation, Selection, and Amplification System for Peptide Nucleic Acids

David R. Liu, Michael E. Birnbaum, Ralph E. Kleiner, 2009, Nature chemical biology.

Potent Delivery of Functional Proteins into Mammalian Cells in Vitro and in Vivo Using a Supercharged Protein

David R. Liu, Kevin T. Beier, David B. Thompson, 2010, ACS chemical biology.

How pathogenic bacteria evade mammalian sabotage in the battle for iron

Hening Lin, David R. Liu, Michael A Fischbach, 2006, Nature chemical biology.

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Jennifer A. Doudna, Kevin T. Zhao, David R. Liu, 2020, Nature Biotechnology.

Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells.

David R. Liu, David R Liu, Irwin Chen, 2011, Chemistry & biology.

In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites

Bradley E. Bernstein, J. Keith Joung, David R. Liu, 2013, Nucleic acids research.

Directed evolution of ligand dependence: small-molecule-activated protein splicing.

David R. Liu, David R Liu, Zev J Gartner, 2004, Proceedings of the National Academy of Sciences of the United States of America.

In vivo evolution of an RNA-based transcriptional activator.

David R. Liu, David R Liu, Allen R. Buskirk, 2003, Chemistry & biology.

In vivo base editing of post-mitotic sensory cells

David R. Liu, Albert S. B. Edge, Holly A. Rees, 2018, Nature Communications.

Continuous evolution of SpCas9 variants compatible with non-G PAMs

Tony P. Huang, David R. Liu, Holly A. Rees, 2020, Nature Biotechnology.

DNA Ligase-Mediated Translation of DNA Into Densely Functionalized Nucleic Acid Polymers

David R. Liu, Jia Niu, R. Hili, 2012, Journal of the American Chemical Society.

A Biomolecule-Compatible Visible Light-Induced Azide Reduction from a DNA-Encoded Reaction Discovery System

David R. Liu, J. B. Steinman, Yiyun Chen, 2010, Nature chemistry.

Enhanced Functional Potential of Nucleic Acid Aptamer Libraries Patterned to Increase Secondary Structure

David R. Liu, Thomas M. Snyder, T. Snyder, 2010, Journal of the American Chemical Society.

Expanding the reaction scope of DNA-templated synthesis.

David R. Liu, Zev J. Gartner, Matthew W. Kanan, 2002, Angewandte Chemie.

Highly sensitive in vitro selections for DNA-linked synthetic small molecules with protein binding affinity and specificity.

David R. Liu, David R Liu, T. Snyder, 2003, Journal of the American Chemical Society.

In Vitro Selection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2010, Journal of the American Chemical Society.

Continuous evolution of Bacillus thuringiensis toxins overcomes insect resistance

Ping Wang, David R. Liu, A. Badran, 2016 .

Prime genome editing in rice and wheat

David R. Liu, Yanpeng Wang, Andrew V. Anzalone, 2020, Nature Biotechnology.

Inhibition of Bacterial Conjugation by Phage M13 and Its Protein g3p: Quantitative Analysis and Model

Irene A. Chen, David R. Liu, Michael L. Manapat, 2011, PloS one.

Small-Molecule Discovery from DNA-Encoded Chemical Libraries

David R. Liu, Ralph E. Kleiner, Christoph E. Dumelin, 2012 .

Reaction discovery enabled by DNA-templated synthesis and in vitro selection

David R. Liu, Thomas M. Snyder, Matthew W. Kanan, 2004, Nature.

Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

David R. Liu, Christoph E. Dumelin, L. M. McGregor, 2010, Journal of the American Chemical Society.

Enzyme-Free Translation of DNA into Sequence-Defined Synthetic Polymers Structurally Unrelated to Nucleic Acids

David R. Liu, Jia Niu, R. Hili, 2013, Nature chemistry.

Supercharging proteins can impart unusual resilience.

David R. Liu, Michael S. Lawrence, M. Lawrence, 2007, Journal of the American Chemical Society.

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Qiaobing Xu, David R. Liu, M. Charles Liberman, 2017, Nature.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

Hidenori Akutsu, Kevin Eggan, David R. Liu, 2009, Cell stem cell.

A population-based experimental model for protein evolution: effects of mutation rate and selection stringency on evolutionary outcomes.

Aaron M. Leconte, David R. Liu, Irene A Chen, 2013, Biochemistry.

DNA-Templated Organic Synthesis (DTS): A Novel Approach to the Discovery of Functional Small Molecules Based on Nature's Evolutionary Principles

David R. Liu, Kaori Sakurai, 2008 .

Continuous evolution of B. thuringiensis toxins overcomes insect resistance

David R. Liu, A. Badran, T. Malvar, 2016, Nature.

Phage-assisted continuous evolution of proteases with altered substrate specificity

David R. Liu, Holly A. Rees, M. Packer, 2017, Nature Communications.

A system for the continuous directed evolution of proteases rapidly reveals drug-resistance mutations

David R. Liu, A. Badran, M. Packer, 2014, Nature Communications.

Negative selection and stringency modulation in phage-assisted constinuous evolution

David R. Liu, A. Badran, Jacob C. Carlson, 2014, Nature chemical biology.

Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo.

David R. Liu, Yong Tao, David Thompson, 2015, Journal of the American Chemical Society.

Development of potent in vivo mutagenesis plasmids with broad mutational spectra

David R. Liu, A. Badran, Ahmed H. Badran, 2015, Nature Communications.

Reactivity-Dependent PCR: Direct, Solution-Phase in Vitro Selection for Bond Formation

David R. Liu, David J Gorin, Adam S. Kamlet, 2009, Journal of the American Chemical Society.

Aptazyme-embedded guide RNAs enable ligand-responsive genome editing and transcriptional activation

David R. Liu, Weixin Tang, Johnny H. Hu, 2017, Nature Communications.

A programmable Cas9-serine recombinase fusion protein that operates on DNA sequences in mammalian cells

David R. Liu, David B. Thompson, Johnny H. Hu, 2016, Nucleic acids research.

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

David R. Liu, Anna V. Kotrys, V. Mootha, 2020, Nature.

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

David R. Liu, Yong Zi Tan, B. Carragher, 2018, eLife.

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

David R. Liu, A. Badran, Alexis C. Komor, 2017, Cell.

Massively parallel assessment of human variants with base editor screens

David R. Liu, Peter C. DeWeirdt, Kendall R. Sanson, 2020, Cell.

In Vivo Base Editing Rescues Hutchinson-Gilford Progeria Syndrome in Mice

David R. Liu, Gregory A. Newby, Luke W. Koblan, 2020, Nature.

Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses

David R. Liu, Luke W. Koblan, Luke W Koblan, 2019, Nature Biomedical Engineering.

Stereoselectivity in DNA-templated organic synthesis and its origins.

David R. Liu, Xiaoyu Li, 2003, Journal of the American Chemical Society.

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

David R. Liu, Gregory A. Newby, Carl G. de Boer, 2022, Nature Genetics.

Sequence Determinants of Intracellular Phase Separation by Complex Coacervation of a Disordered Protein.

David R. Liu, R. Pappu, A. Holehouse, 2016, Molecular cell.

Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity

David R. Liu, G. Minasov, M. Packer, 2021, Science.

Proteolysis Targeting Chimeras With Reduced Off-targets

David R. Liu, B. Ebert, Vedagopuram Sreekanth, 2021, bioRxiv.

In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A

David R. Liu, E. Chaikof, Wookhyun Kim, 2016, Nature Communications.

Prime editing in mice reveals the essentiality of a single base in driving tissue-specific gene expression

David R. Liu, Gregory A. Newby, S. Tsai, 2020, bioRxiv.

In vitro characterization of IroB, a pathogen-associated C-glycosyltransferase.

David R. Liu, M. Fischbach, C. Walsh, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Glucose Response by Stem Cell-Derived β Cells In Vitro Is Inhibited by a Bottleneck in Glycolysis

David R. Liu, D. Melton, R. Kibbey, 2020, Cell reports.

Therapeutic in vivo delivery of gene editing agents

David R. Liu, Aditya Raguram, Samagya Banskota, 2022, Cell.

( ) charge density promote phase separation d Disordered regions with NICD-like sequence features are common in human proteome

David R. Liu, R. Pappu, A. Holehouse, 2016 .

Reprogramming the specificity of sortase enzymes

David R. Liu, E. Chaikof, H. Ham, 2014, Proceedings of the National Academy of Sciences.

Two enabling architectures for DNA-templated organic synthesis.

David R. Liu, Zev J. Gartner, Z. Gartner, 2003, Angewandte Chemie.

Green fluorescent proteins engineered for cartilage-targeted drug delivery: Insights for transport into highly charged avascular tissues.

David R. Liu, A. Grodzinsky, H. Rees, 2018, Biomaterials.

Development of a formaldehyde biosensor with application to synthetic methylotrophy

David R. Liu, G. Stephanopoulos, B. Woolston, 2018, Biotechnology and bioengineering.

Base editor treats progeria in mice.

David R. Liu, Luke W Koblan, M. Erdos, 2021, Nature.

Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning

David R. Liu, Max W. Shen, Wei-Hsi Yeh, 2022, Nature Communications.

-glycosyltransferase C characterization of IroB, a pathogen-associated In vitro From The Cover:

David R. Liu, M. Fischbach, C. Walsh, 2006 .

In vitro characterization of salmochelin and enterobactin trilactone hydrolases IroD, IroE, and Fes.

David R. Liu, M. Fischbach, C. Walsh, 2005, Journal of the American Chemical Society.

Templated Synthesis of Peptide Nucleic Acids via Sequence-Selective Base-Filling Reactions

David R. Liu, J. Heemstra, 2009, Journal of the American Chemical Society.

Targeted antithrombotic protein micelles.

David R. Liu, K. Peter, E. Chaikof, 2015, Angewandte Chemie.

A Sequential Strand-Displacement Strategy Enables Efficient Six-Step DNA-Templated Synthesis

David R. Liu, Yu He, 2011, Journal of the American Chemical Society.

Discovery of widespread GTP-binding motifs in genomic DNA and RNA.

David R. Liu, E. Curtis, 2013, Chemistry & biology.

DNA‐Templated Synthesis in Organic Solvents

David R. Liu, Mary M. Rozenman, David R. Liu, 2006, Chembiochem : a European journal of chemical biology.

Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells

David R. Liu, H. Rees, 2018, Nature Reviews Genetics.

Localized protein interaction surfaces on the EntB carrier protein revealed by combinatorial mutagenesis and selection.

David R. Liu, M. Fischbach, C. Walsh, 2006, Journal of the American Chemical Society.

DNA-templated polymerization of side-chain-functionalized peptide nucleic acid aldehydes.

David R. Liu, Ralph E. Kleiner, Y. Brudno, 2008, Journal of the American Chemical Society.

Translation of DNA into synthetic N-acyloxazolidines.

David R. Liu, Z. Gartner, Xiaoyu Li, 2004, Journal of the American Chemical Society.

Directing otherwise incompatible reactions in a single solution by using DNA-templated organic synthesis.

David R. Liu, Z. Gartner, C. Calderone, 2002, Angewandte Chemie.

Analytical Devices Based on Direct Synthesis of DNA on Paper.

David R. Liu, George M Whitesides, Chao-Min Cheng, 2016, Analytical chemistry.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

David R. Liu, Ava C. Carter, K. Eggan, 2009, Cell stem cell.

The Methyl Group at C(10) of 2,3-Oxidosqualene is Crucial to the Correct Folding of This Substrate in the Cyclization-Rearrangement Step of Sterol Biosynthesis

David R. Liu, E. Corey, S. Sarshar, 1992 .

First demonstration of a carbocation-olefin cyclization route to the lanosterol series

David R. Liu, E. Corey, Jaemoon Lee, 1994 .

In vivo continuous directed evolution.

David R. Liu, A. Badran, 2015, Current opinion in chemical biology.

Expanding the Genetic Code in Vitro and in Vivo

David R. Liu, T. Magliery, 2004 .

DNA-templated functional group transformations enable sequence-programmed synthesis using small-molecule reagents.

David R. Liu, T. Snyder, K. Sakurai, 2005, Journal of the American Chemical Society.

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, David R. Liu, Jose A Navas-Molina, 2017, Nature.

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Tony P. Huang, David R. Liu, Anna V. Kotrys, 2022, Nature Biotechnology.

Control of transcription factor activity and osteoblast differentiation in mammalian cells using an evolved small-molecule-dependent intein.

David R. Liu, S. Vokes, A. McMahon, 2006, Journal of the American Chemical Society.

Development and initial application of a hybridization-independent, DNA-encoded reaction discovery system compatible with organic solvents.

David R. Liu, David R Liu, Matthew W Kanan, 2007, Journal of the American Chemical Society.

A High-Throughput Platform to Identify Small-Molecule Inhibitors of CRISPR-Cas9

David R. Liu, P. Clemons, V. Dancík, 2019, Cell.

Solving chemical problems through the application of evolutionary principles.

David R. Liu, Brian R. McNaughton, Mary M. Rozenman, 2007, Current opinion in chemical biology.

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

David R. Liu, David B. Thompson, Brian R. McNaughton, 2009, Proceedings of the National Academy of Sciences.

Bromoenterobactins as potent inhibitors of a pathogen-associated, siderophore-modifying C-glycosyltransferase.

David R. Liu, M. Fischbach, C. Walsh, 2006, Journal of the American Chemical Society.

Evolution of Sequence-Defined Highly Functionalized Nucleic Acid Polymers

David R. Liu, Phillip A Lichtor, Jonathan C. Chen, 2017, Nature Chemistry.

Nucleic Acid‐Templated Synthesis of Sequence‐Defined Synthetic Polymers

David R. Liu, Zhen Chen, 2017 .

Using DNA to Program Chemical Synthesis, Discover New Reactions, and Detect Ligand Binding

David R. Liu, L. M. McGregor, 2014 .

Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes.

David R. Liu, David R Liu, D. Rosenbaum, 2003, Journal of the American Chemical Society.

Recent progress toward the templated synthesis and directed evolution of sequence-defined synthetic polymers.

David R. Liu, David R Liu, Y. Brudno, 2009, Chemistry & biology.

A New Functional Suppressor tRNA/ Aminoacyl-tRNA Synthetase Pair for the in Vivo Incorporation of Unnatural Amino Acids into Proteins

David R. Liu, P. Schultz, Lei Wang, 2000 .

In vivo somatic cell base editing and prime editing.

David R. Liu, Gregory A. Newby, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Disruption of HIV-1 Co-Receptors CCR5 and CXCR4 in Primary Human T Cells and Hematopoietic Stem and Progenitor Cells Using Base Editing.

David R. Liu, Gregory A. Newby, Anton P. McCaffrey, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

Site-specific incorporation of photoisomerizable azobenzene groups into ribonuclease S

David R. Liu, J. Karanicolas, G. Woolley, 1997 .

Immobilization of Actively Thromboresistant Assemblies on Sterile Blood‐Contacting Surfaces

David R. Liu, E. Chaikof, Sawan Hurst, 2014, Advanced healthcare materials.

Prime genome editing in rice and wheat

David R. Liu, Andrew V. Anzalone, Jordan L. Doman, 2020, Nature Biotechnology.

Electrophilic activity-based RNA probes reveal a self-alkylating RNA for RNA labeling

David R. Liu, S. Mukherji, J. Guilinger, 2014, Nature chemical biology.

Enhanced prime editing systems by manipulating cellular determinants of editing outcomes

David R. Liu, Jeffrey A. Hussmann, Gregory A. Newby, 2021, Cell.

PrimeDesign software for rapid and simplified design of prime editing guide RNAs

Kin Chung Lam, David R. Liu, Andrew V. Anzalone, 2020, Nature Communications.

Genome editing with CRISPR–Cas nucleases, base editors, transposases and prime editors

David R. Liu, Luke W. Koblan, Andrew V. Anzalone, 2020, Nature Biotechnology.

Search-and-replace genome editing without double-strand breaks or donor DNA

David R. Liu, Gregory A. Newby, Christopher Wilson, 2019, Nature.

Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, David R. Liu, A. Badran, 2017, Nature.

Effects of template sequence and secondary structure on DNA-templated reactivity.

David R. Liu, T. Snyder, Brian N. Tse, 2008, Journal of the American Chemical Society.

Discovery and biological characterization of geranylated RNA in bacteria

Aaron M. Leconte, David R. Liu, Christoph E. Dumelin, 2012, Nature chemical biology.

A chemical screen for biological small molecule–RNA conjugates reveals CoA-linked RNA

David R. Liu, Yinghua Shen, Walter E. Kowtoniuk, 2009, Proceedings of the National Academy of Sciences.

Recent advances in the in vitro evolution of nucleic acids.

Joshua A Bittker, David R. Liu, Joshua A. Bittker, 2002, Current opinion in chemical biology.

In vivo evolution of an RNA-based transcriptional silencing domain in S. cerevisiae.

David R. Liu, David R Liu, P. Kehayova, 2007, Chemistry & biology.

Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase

David R. Liu, Christopher Wilson, Z. Miao, 2020, Nature Biotechnology.

CRISPResso2 provides accurate and rapid genome editing sequence analysis

Matthew C. Canver, David R. Liu, Jason M. Gehrke, 2019, Nature Biotechnology.

Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells

David R. Liu, Gregory A. Newby, Carl G. de Boer, 2021, bioRxiv.

Rewritable multi-event analog recording in bacterial and mammalian cells

David R. Liu, David R Liu, Weixin Tang, 2018, Science.

Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal

David R. Liu, F. Yi, Laura Pereira, 2011, Nature Cell Biology.

The NIH Somatic Cell Genome Editing program

David R. Liu, Benjamin S. Freedman, Daniel G. Anderson, 2021, Nature.

Chemical Biology Approaches to Genome Editing: Understanding, Controlling, and Delivering Programmable Nucleases.

David R. Liu, David R Liu, Johnny H. Hu, 2016, Cell chemical biology.

Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination

David R. Liu, J. Doyon, Jeffrey B. Doyon, 2007, Nucleic acids research.

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

David R. Liu, Andrzej T. Foik, Gregory A. Newby, 2022, Nature Communications.

Genetic architecture of smoking: Evaluating rare variant contribution from deep whole-genome sequencing of up to 26,000 individuals

Ivana V. Yang, David R. Liu, Lisa J. Martin, 2021 .

Predictable and precise template-free CRISPR editing of pathogenic variants

David R. Liu, Jonathan Y. Hsu, Sannie J. Culbertson, 2018, Nature.

Reconstruction of evolving gene variants and fitness from short sequencing reads

Kevin T. Zhao, David R. Liu, Max W. Shen, 2021, Nature Chemical Biology.

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

David R. Liu, Gregory A. Newby, Elliot H. Choi, 2022, Cell.

Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing

David R. Liu, Andrzej T. Foik, Gregory A. Newby, 2020, Nature Biomedical Engineering.

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

Kevin T. Zhao, David R. Liu, Benjamin W. Thuronyi, 2020, Nature Biotechnology.

Mammalian Cell Penetration,siRNA Transfection, and DNA Transfection by Supercharged Green Fluorescent Proteins

David R. Liu, David B. Thompson, Brian R. McNaughton, 2009 .

Functional correction of CFTR mutations in human airway epithelial cells using adenine base editors

David R. Liu, Gregory A. Newby, S. Krishnamurthy, 2021, Nucleic acids research.

Continuous evolution of base editors with expanded target compatibility and improved activity

David R. Liu, J. R. Holt, Benjamin W. Thuronyi, 2019, Nature Biotechnology.

A general strategy for the evolution of bond-forming enzymes using yeast display

David R. Liu, Irwin Chen, Brent M. Dorr, 2011, Proceedings of the National Academy of Sciences.

A DNA-based molecular probe for optically reporting cellular traction forces

David R. Liu, Brendon M. Baker, Colin K. Choi, 2014, Nature Methods.

Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning

David R. Liu, Jeffrey A. Hussmann, Gregory A. Newby, 2021, Nature Biotechnology.

Highly Specific, Bi-substrate-Competitive Src Inhibitors from DNA-Templated Macrocycles

David R. Liu, Ralph E. Kleiner, M. Seeliger, 2011, Nature chemical biology.

A protein interaction surface in nonribosomal peptide synthesis mapped by combinatorial mutagenesis and selection.

David R. Liu, M. Fischbach, C. Walsh, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Determining the specificities of TALENs, Cas9, and other genome-editing enzymes.

David R. Liu, V. Pattanayak, J. Guilinger, 2014, Methods in enzymology.

A naturally occurring, noncanonical GTP aptamer made of simple tandem repeats

David R. Liu, E. Curtis, 2014, RNA Biology.

LC/MS analysis of cellular RNA reveals NAD-linked RNA

David R. Liu, Yinghua Shen, Walter E. Kowtoniuk, 2009, Nature chemical biology.

Precision genome editing using cytosine and adenine base editors in mammalian cells

Tony P. Huang, David R. Liu, Gregory A. Newby, 2021, Nature Protocols.

Efficient and Scalable Process to Produce Novel and Highly Bioactive Purified Cytosolic Crystals from Bacillus thuringiensis

David R. Liu, Mary S. Morrison, F. Rus, 2022, Microbiology spectrum.

Purified cytosolic crystals from Bacillus thuringiensis as a novel active pharmaceutical ingredient (API)

David R. Liu, Mary S. Morrison, F. Rus, 2022, bioRxiv.

Editing the Genome Without Double-Stranded DNA Breaks.

David R. Liu, Ahmed H Badran, David R Liu, 2017, ACS chemical biology.

Novel selection methods for DNA-encoded chemical libraries.

David R. Liu, Alix I. Chan, L. M. McGregor, 2015, Current opinion in chemical biology.

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

David R. Liu, Ralph E. Kleiner, M. García-Díaz, 2016, Cell chemical biology.

Efficient Delivery of Genome-Editing Proteins In Vitro and In Vivo

David R. Liu, Morgan L. Maeder, David B. Thompson, 2015 .

Engineered pegRNAs improve prime editing efficiency

Simon P. Shen, David R. Liu, Gregory A. Newby, 2021, Nature Biotechnology.

Base editing of haematopoietic stem cells rescues sickle cell disease in mice

Kevin T. Zhao, David R. Liu, Gregory A. Newby, 2021, Nature.

Laboratory Evolution of a Sortase Enzyme that Modifies Amyloid β-protein

David R. Liu, Christopher J. Podracky, D. Walsh, 2020, Nature Chemical Biology.

A de novo protein binding pair by computational design and directed evolution.

David Baker, Orly Dym, Tamar Unger, 2011, Molecular cell.

Creating small-molecule-dependent switches to modulate biological functions.

David R. Liu, Allen R. Buskirk, 2005, Chemistry & biology.

Nucleic-acid-templated synthesis as a model system for ancient translation.

David R. Liu, C. Calderone, 2004, Current opinion in chemical biology.

Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

David R. Liu, Jeffry D Sander, J Keith Joung, 2015, Nature Methods.

Experimental interrogation of the path dependence and stochasticity of protein evolution using phage-assisted continuous evolution

Aaron M. Leconte, David R. Liu, Benjamin Allen, 2013, Proceedings of the National Academy of Sciences.

A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.

Tina N. Davis, David R. Liu, Jen-Chieh Tseng, 2011, Chemistry & biology.

Crystal structures reveal an elusive functional domain of pyrrolysyl-tRNA synthetase

David R. Liu, D. Söll, Yane-Shih Wang, 2017, Nature chemical biology.

In vivo continuous directed evolution The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters

David R. Liu, A. Badran, 2015 .

Cellular uptake mechanisms and endosomal trafficking of supercharged proteins.

David R. Liu, David B. Thompson, M. Zerial, 2012, Chemistry & biology.

Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells.

David R. Liu, David R Liu, David B. Thompson, 2012, Methods in enzymology.

Directed evolution can rapidly improve the activity of chimeric assembly-line enzymes

David R. Liu, Michael A Fischbach, David R Liu, 2007, Proceedings of the National Academy of Sciences.

Programmable deletion, replacement, integration, and inversion of large DNA sequences with twin prime editing

David R. Liu, Luke W. Koblan, Andrew V. Anzalone, 2021, Nature Biotechnology.

Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors

David R. Liu, Gregory A. Newby, Jordan L. Doman, 2020, Nature Biotechnology.

Dissecting protein structure and function using directed evolution

David R. Liu, David R Liu, Courtney M Yuen, 2007, Nature Methods.

Simultaneous targeting of linked loci in mouse embryos using base editing

David R. Liu, L. Hennighausen, Shannon M. Miller, 2019, Scientific Reports.

Targeting fidelity of adenine and cytosine base editors in mouse embryos

David R. Liu, L. Hennighausen, Sojung Kim, 2018, Nature Communications.

Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2

David R. Liu, G. Stephanopoulos, B. Woolston, 2019, ACS synthetic biology.

Continuous evolution of SpCas9 variants compatible with non-G PAMs

Tony P. Huang, David R. Liu, Gregory A. Newby, 2020, Nature Biotechnology.

Comprehensive Analysis of CRISPR Base Editing Outcomes for Multimeric Protein

David R. Liu, Gregory A. Newby, Krishanu Saha, 2022, bioRxiv.

Adenosine Base Editing of γ-Globin Promoters Induces Fetal Hemoglobin and Inhibit Erythroid Sickling

David R. Liu, Gregory A. Newby, S. Tsai, 2020, Blood.

Base Editing Eliminates the Sickle Cell Mutation and Pathology in Hematopoietic Stem Cells Derived Erythroid Cells

David R. Liu, Gregory A. Newby, S. Tsai, 2020 .

Development of hRad51–Cas9 nickase fusions that mediate HDR without double-stranded breaks

David R. Liu, David R Liu, Wei-Hsi Yeh, 2019, Nature Communications.

Functional dissection of sRNA translational regulators by nonhomologous random recombination and in vivo selection.

David R. Liu, Joshua A. Bittker, Jane M. Liu, 2005, Chemistry & biology.

Synthesis of Acyclic α,β-Unsaturated Ketones via Pd(II)-Catalyzed Intermolecular Reaction of Alkynamides and Alkenes

David R. Liu, M. Kanan, N. Momiyama, 2007 .

Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles

Irene Georgakoudi, Qiaobing Xu, Shuo Sun, 2016, Proceedings of the National Academy of Sciences.

Global-scale CRISPR gene editor specificity profiling by ONE-seq identifies population-specific, variant off-target effects

Martin J. Aryee, Matthew C. Canver, David R. Liu, 2021, bioRxiv.

Directed evolution of protein enzymes using nonhomologous random recombination.

Joshua A Bittker, David R. Liu, Joshua A. Bittker, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Engineering a ligand-dependent RNA transcriptional activator.

David R. Liu, David R Liu, Allen R. Buskirk, 2004, Chemistry & biology.

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

David R. Liu, Gregory A. Newby, Daniel G. Anderson, 2020, Nature Communications.

Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs.

David R. Liu, Gregory A. Newby, Beau R. Webber, 2020, The Journal of investigative dermatology.

Generating New Molecular Function: A Lesson from Nature

David R. Liu, P. Schultz, 1999 .

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

David R. Liu, H. Ploegh, J. Tam, 2018, Bioconjugate chemistry.

Publisher Correction: Programmable base editing of A•T to G•C in genomic DNA without DNA cleavage

Nicole M. Gaudelli, David R. Liu, A. Badran, 2018, Nature.

Enzyme Mechanisms for Polycyclic Triterpene Formation

David R. Liu, G. Schulz, E. Corey, 2000 .

DNA capture by a CRISPR-Cas9–guided adenine base editor

David R. Liu, J. Doudna, G. Knott, 2020, Science.

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

David R. Liu, Ralph E. Kleiner, A. Saghatelian, 2014, Nature.

Directed evolution and substrate specificity profile of homing endonuclease I-SceI.

David R. Liu, V. Pattanayak, J. Doyon, 2006, Journal of the American Chemical Society.

An in vivo selection system for homing endonuclease activity.

David R. Liu, I. Serbanescu, M. Gruen, 2002, Nucleic acids research.

Phage-assisted continuous and non-continuous evolution

David R. Liu, David R Liu, Shannon M Miller, 2020, Nature Protocols.

Mechanisms of angiogenic incompetence in Hutchinson–Gilford progeria via downregulation of endothelial NOS

David R. Liu, Luke W. Koblan, J. Fisher, 2021, Aging cell.

An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells

David R. Liu, David B. Thompson, Y. B. Kim, 2019, Nature Communications.

Massively parallel base editing to map variant effects in human hematopoiesis

David R. Liu, Gregory A. Newby, E. Lander, 2023, Cell.

Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition.

David R. Liu, M. Fischbach, C. Walsh, 2006, ACS chemical biology.

Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

David R. Liu, Mary S. Morrison, Aditya Raguram, 2021, Nature Communications.

DNA-enabled self-assembly of plasmonic nanoclusters.

Federico Capasso, Gennady Shvets, David R. Liu, 2011, Nano letters.

The pathogen-associated iroA gene cluster mediates bacterial evasion of lipocalin 2

David R. Liu, M. Fischbach, A. Aderem, 2006, Proceedings of the National Academy of Sciences.

Massively parallel base editing to map variant effects in human hematopoiesis

David R. Liu, Gregory A. Newby, E. Lander, 2023, Cell.

Nanoparticle mediated in vitro and in vivo CRISPR base correction of LCA16 causing nonsense mutation rescues Kir7.1 channel function

David R. Liu, Krishanu Saha, Yuyuan Wang, 2022 .

Abstract CT050: Expansion cohort of Phase I study of oral sapacitabine and oral seliciclib in patients with metastatic breast cancer andBRCA1/2mutations

David R. Liu, E. Winer, G. Shapiro, 2019, Clinical Trials.

In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness

David R. Liu, J. R. Holt, Gregory A. Newby, 2020, Science Translational Medicine.

Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic

David R. Liu, M. García-Díaz, M. Seeliger, 2016 .

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

David R. Liu, L. M. McGregor, T. Jain, 2014, Journal of the American Chemical Society.

Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection.

David R. Liu, Alix I. Chan, L. M. McGregor, 2017, Journal of the American Chemical Society.

Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme

David R. Liu, B. Wagner, A. Vetere, 2019, Nature Chemical Biology.

A rechargeable anti-thrombotic coating for blood-contacting devices.

David R. Liu, E. Chaikof, H. Ham, 2021, Biomaterials.

Multistep small-molecule synthesis programmed by DNA templates.

David R. Liu, Zev J. Gartner, Matthew W. Kanan, 2002, Journal of the American Chemical Society.

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

David R. Liu, Benjamin W. Thuronyi, Gregory A. Newby, 2020, Nature Biotechnology.

Author Correction: Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

David R. Liu, Benjamin W. Thuronyi, Gregory A. Newby, 2020, Nature Biotechnology.

Small-molecule discovery through DNA-encoded libraries

David R. Liu, Alexander A. Peterson, 2023, Nature Reviews Drug Discovery.

Discovery of a mRNA mitochondrial localization element in Saccharomyces cerevisiae by nonhomologous random recombination and in vivo selection

David R. Liu, Jane M. Liu, 2007, Nucleic acids research.

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

David R. Liu, Luke W. Koblan, David B. Thompson, 2019, Nature Communications.

Programmable large DNA deletion, replacement, integration, and inversion with twin prime editing and site-specific recombinases

David R. Liu, Luke W. Koblan, Andrew V. Anzalone, 2021, bioRxiv.

Identification of eukaryotic promoter regulatory elements using nonhomologous random recombination

David R. Liu, J. Doyon, Omid Omidi-Arjenaki, 2007, Nucleic acids research.

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

David R. Liu, William A. Pastor, L. Aravind, 2009 .

Development of improved tRNAs for in vitro biosynthesis of proteins containing unnatural amino acids.

David R. Liu, P. Schultz, D. R. Liu, 1996, Chemistry & biology.

A communal catalogue reveals Earth’s multiscale microbial diversity

Rick L. Stevens, William A. Walters, Nicole M. Gaudelli, 2017, Nature.

Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme

David R. Liu, Yong Zi Tan, B. Carragher, 2018, eLife.

Opposing Effects of Tcf3 and Tcf1 Control Wnt-Stimulation of Embryonic Stem Cell Self Renewal

David R. Liu, David, F. Yi, 2011, Nature Cell Biology.

Translating DNA into Synthetic Molecules

David R. Liu, David R Liu, 2004, PLoS biology.

Massively parallel base editing to map variant effects in human hematopoiesis

David R. Liu, Gregory A. Newby, E. Lander, 2023, Cell.

Simultaneous targeting of linked loci in mouse embryos using base editing

David R. Liu, L. Hennighausen, Chengyu Liu, 2019, Scientific Reports.

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

David R. Liu, Luke W. Koblan, David B. Thompson, 2019, Nature Communications.

Chemical modifications of adenine base editor mRNA and guide RNA expand its application scope

David R. Liu, Gregory A. Newby, Anton P. McCaffrey, 2020, Nature Communications.

Reprogramming the Specificity of Sortase Enzymes by Directed Evolution

David R. Liu, E. Chaikof, H. Ham, 2014 .

Ordered multistep synthesis in a single solution directed by DNA templates.

David R. Liu, T. Snyder, 2005, Angewandte Chemie.

Small-molecule diversification from iterated branching reaction pathways enabled by DNA-templated synthesis.

David R. Liu, C. Calderone, 2005, Angewandte Chemie.

Side-chain determinants of biopolymer function during selection and replication

David R. Liu, Phillip A Lichtor, Nadine H. Elowe, 2019, Nature Chemical Biology.

In vivo continuous directed evolution.

David R. Liu, A. Badran, 2015, Current Opinion in Chemical Biology.

Determining the specificities of TALENs, Cas9, and other genome-editing enzymes.

David R. Liu, V. Pattanayak, J. Guilinger, 2014, Methods in enzymology.

Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1

David R. Liu, William A. Pastor, L. Aravind, 2009, Science.

A small-molecule inhibitor of tgf-Beta signaling replaces sox2 in reprogramming by inducing nanog.

David R. Liu, Ava C. Carter, K. Eggan, 2009, Cell stem cell.

A chemical screen for biological small molecule–RNA conjugates reveals CoA-linked RNA

David R. Liu, Yinghua Shen, Walter E. Kowtoniuk, 2009, Proceedings of the National Academy of Sciences.

Mammalian Cell Penetration,siRNA Transfection, and DNA Transfection by Supercharged Green Fluorescent Proteins

David R. Liu, Brian R. McNaughton, James J. Cronican, 2009 .

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

David R. Liu, J. Guilinger, David B. Thompson, 2014, Nature Biotechnology.

A class of human proteins that deliver functional proteins into mammalian cells in vitro and in vivo.

Tina N. Davis, David R. Liu, Kevin T. Beier, 2011, Chemistry & biology.

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity

David R. Liu, Benjamin W. Thuronyi, Gregory A. Newby, 2020, Nature Biotechnology.

Discovery and characterization of a peptide that enhances endosomal escape of delivered proteins in vitro and in vivo.

David R. Liu, A. Schepartz, D. Thompson, 2015, Journal of the American Chemical Society.

Engineering and identifying supercharged proteins for macromolecule delivery into mammalian cells.

David R. Liu, James J. Cronican, David B. Thompson, 2012, Methods in enzymology.

Continuous evolution of B. thuringiensis toxins overcomes insect resistance

David R. Liu, A. Badran, T. Malvar, 2016, Nature.

Directed evolution of a small-molecule-triggered intein with improved splicing properties in mammalian cells.

David R. Liu, Sun H. Peck, Irwin Chen, 2011, Chemistry & biology.

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

David R. Liu, H. Ploegh, J. Tam, 2018, Bioconjugate chemistry.

Negative selection and stringency modulation in phage-assisted constinuous evolution

David R. Liu, A. Badran, Jacob C. Carlson, 2014, Nature chemical biology.

Abstract 4350: Integrative and multiregional molecular analysis of localized, high grade prostate cancer treated with neoadjuvant androgen deprivation treatment

David R. Liu, G. Getz, D. Livitz, 2018, Molecular and Cellular Biology / Genetics.

Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection.

David R. Liu, T. Jain, Alix I. Chan, 2017, Journal of the American Chemical Society.