P. Jansson

发表

P-glycoprotein Mediates Drug Resistance via a Novel Mechanism Involving Lysosomal Sequestration*

D. Richardson, S. Sahni, A. Arvind, 2013, The Journal of Biological Chemistry.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity*

D. Richardson, S. Sahni, C. Hawkins, 2016, The Journal of Biological Chemistry.

The role of NDRG1 in the pathology and potential treatment of human cancers

D. Richardson, C. S. Lee, D. Kalinowski, 2013, Journal of Clinical Pathology.

Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT).

D. Richardson, D. Kalinowski, S. Sahni, 2016, Biochimica et biophysica acta.

Role of ABCB1 in Mediating Chemo-resistance of Triple Negative Breast Cancers.

A. Spillane, S. Sahni, P. Jansson, 2021, Bioscience reports.

Molecular and functional alterations in a mouse cardiac model of Friedreich ataxia: activation of the integrated stress response, eIF2α phosphorylation, and the induction of downstream targets.

Daohai Zhang, D. Richardson, C. Semsarian, 2013, The American journal of pathology.

Effects of iron on Vitamin C/copper-induced hydroxyl radical generation in bicarbonate-rich water

T. Nordström, C. Lindqvist, P. Jansson, 2005, Free radical research.

The old and new biochemistry of polyamines.

D. Richardson, P. Jansson, D. Lane, 2018, Biochimica et biophysica acta. General subjects.

Vitamin C (Ascorbic Acid) Induced Hydroxyl Radical Formation in Copper Contaminated Household Drinking Water: Role of Bicarbonate Concentration

T. Nordström, C. Lindqvist, P. Jansson, 2003, Free radical research.

Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.

D. Richardson, D. Kalinowski, P. Bernhardt, 2016, Journal of medicinal chemistry.

Autophagy: A Key Player in Pancreatic Cancer Progression and a Potential Drug Target

N. Pavlakis, J. Samra, S. Sahni, 2022, Cancers.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Novel thiosemicarbazones of the ApT and DpT series and their copper complexes: identification of pronounced redox activity and characterization of their antitumor activity.

D. Richardson, P. Bernhardt, P. Jansson, 2010, Journal of medicinal chemistry.

Bonnie and Clyde: Vitamin C and iron are partners in crime in iron deficiency anaemia and its potential role in the elderly

D. Richardson, P. Jansson, D. Lane, 2016, Aging.

A mechanism for overcoming P-glycoprotein-mediated drug resistance: novel combination therapy that releases stored doxorubicin from lysosomes via lysosomal permeabilization using Dp44mT or DpC

D. Richardson, N. Seebacher, P. Jansson, 2016, Cell Death & Disease.

A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors

V. Namasivayam, P. Jansson, J. Pahnke, 2022, Scientific Data.

Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer's disease therapeutics.

O. Soukup, V. Namasivayam, L. Górecki, 2022, International journal of biological macromolecules.

Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.

D. Richardson, D. Kalinowski, P. Bernhardt, 2013, Journal of medicinal chemistry.

Halogenated 2'-benzoylpyridine thiosemicarbazone (XBpT) chelators with potent and selective anti-neoplastic activity: relationship to intracellular redox activity.

D. Richardson, D. Kalinowski, P. Bernhardt, 2011, Journal of medicinal chemistry.

Methemoglobin Formation by Triapine, Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT), and Other Anticancer Thiosemicarbazones: Identification of Novel Thiosemicarbazones and Therapeutics That Prevent This Effect

D. Richardson, D. Kalinowski, P. Bernhardt, 2012, Molecular Pharmacology.

The thiosemicarbazone, DpC, broadly synergizes with multiple anti-cancer therapeutics and demonstrates temperature- and energy-dependent uptake by tumor cells.

D. Richardson, P. Jansson, R. Afroz, 2022, Biochimica et biophysica acta. General subjects.

Making a case for albumin – a highly promising drug-delivery system.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Future medicinal chemistry.

Measurement of Ascorbic Acid (Vitamin C) Induced Hydroxyl Radical Generation in Household Drinking Water

T. Nordström, C. Lindqvist, P. Jansson, 2002, Free radical research.

Identification of differential phosphorylation and sub-cellular localization of the metastasis suppressor, NDRG1.

D. Richardson, K. Park, D. Kalinowski, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics.

T. Ganz, D. Richardson, S. Toyokuni, 2016, Biochimica et biophysica acta.

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

D. Richardson, Yu Yu, D. Kalinowski, 2009, Journal of medicinal chemistry.

Novel second-generation di-2-pyridylketone thiosemicarbazones show synergism with standard chemotherapeutics and demonstrate potent activity against lung cancer xenografts after oral and intravenous administration in vivo.

D. Richardson, D. Kalinowski, N. Seebacher, 2012, Journal of medicinal chemistry.

The Iron Chelator, Deferasirox, as a Novel Strategy for Cancer Treatment: Oral Activity Against Human Lung Tumor Xenografts and Molecular Mechanism of Action

D. Richardson, D. Kalinowski, Z. Kovacevic, 2013, Molecular Pharmacology.

Novel Mechanism of Cytotoxicity for the Selective Selenosemicarbazone, 2-Acetylpyridine 4,4-Dimethyl-3-selenosemicarbazone (Ap44mSe): Lysosomal Membrane Permeabilization.

D. Richardson, D. Kalinowski, S. Sahni, 2016, Journal of medicinal chemistry.

Cancer cell iron metabolism and the development of potent iron chelators as anti-tumour agents.

D. Richardson, D. Kalinowski, P. Jansson, 2009, Biochimica et biophysica acta.

Zinc(II)-Thiosemicarbazone Complexes Are Localized to the Lysosomal Compartment Where They Transmetallate with Copper Ions to Induce Cytotoxicity.

D. Richardson, D. Kalinowski, P. Bernhardt, 2016, Journal of medicinal chemistry.

Exploiting Cancer Metal Metabolism using Anti-Cancer Metal- Binding Agents.

D. Richardson, D. Kalinowski, S. Sahni, 2019, Current medicinal chemistry.

Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes.

D. Richardson, P. Ponka, U. Brunk, 2011, Cancer research.

Pharmacological targeting of mitochondria in cancer stem cells: An ancient organelle at the crossroad of novel anti‐cancer therapies

D. Richardson, R. Veselska, P. Jansson, 2019, Pharmacological research.

The novel iron chelator, 2-pyridylcarboxaldehyde 2-thiophenecarboxyl hydrazone, reduces catecholamine-mediated myocardial toxicity.

D. Richardson, D. Kalinowski, P. Mladěnka, 2009, Chemical research in toxicology.

The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "Triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Pharmacological research.

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

D. Richardson, C. Hawkins, P. Jansson, 2010, Journal of inorganic biochemistry.

Identification of differential anti-neoplastic activity of copper bis(thiosemicarbazones) that is mediated by intracellular reactive oxygen species generation and lysosomal membrane permeabilization.

D. Richardson, D. Kalinowski, P. Jansson, 2015, Journal of inorganic biochemistry.

Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Multidrug Resistance by a Novel Mechanism Involving the Hijacking of Lysosomal P-Glycoprotein (Pgp)*

D. Richardson, S. Sahni, N. Seebacher, 2015, The Journal of Biological Chemistry.

Tumour Microenvironment Stress Promotes the Development of Drug Resistance

N. Seebacher, P. Jansson, J. Skoda, 2021, Antioxidants.

Iron prevents ascorbic acid (vitamin C) induced hydrogen peroxide accumulation in copper contaminated drinking water

T. Nordström, C. Lindqvist, P. Jansson, 2005, Free radical research.

Molecular Pharmacology of ABCG2 and Its Role in Chemoresistance

D. Richardson, P. Jansson, Alexandra E. Stacy, 2013, Molecular Pharmacology.

Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling.

D. Richardson, D. Kalinowski, A. M. Merlot, 2016, Biochimica et biophysica acta.

Emerging Role of Autophagy in the Development and Progression of Oral Squamous Cell Carcinoma

S. Sahni, P. Jansson, Yomna S. Abd El-Aziz, 2021, Cancers.

Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy.

D. Richardson, K. Park, D. Kalinowski, 2012, Biochimica et biophysica acta.

Ascorbate and Tumor Cell Iron Metabolism: The Evolving Story and its Link to Pathology.

D. Richardson, D. Kalinowski, P. Jansson, 2020, Antioxidants & redox signaling.

The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: new therapeutic targets

M. Zheng, D. Richardson, Zhihai Peng, 2015, Oncotarget.

Turning the gun on cancer: Utilizing lysosomal P-glycoprotein as a new strategy to overcome multi-drug resistance.

D. Richardson, N. Seebacher, P. Jansson, 2016, Free radical biology & medicine.

Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2α, IRE1α, ATF6 and calmodulin kinase.

D. Richardson, Yu Yu, D. Kalinowski, 2016, Biochemical pharmacology.

An Innovative Non-Hormonal Strategy Targeting Redox Active Metals to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer

D. Richardson, Robin L. Anderson, Dinny Graham, 2023, bioRxiv.

Copper and conquer: copper complexes of di-2-pyridylketone thiosemicarbazones as novel anti-cancer therapeutics.

D. Richardson, K. Park, D. Kalinowski, 2016, Metallomics : integrated biometal science.

Thiosemicarbazones suppress expression of the c-Met oncogene by mechanisms involving lysosomal degradation and intracellular shedding

D. Richardson, K. Park, Z. Kovacevic, 2019, The Journal of Biological Chemistry.

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

M. Zheng, Daohai Zhang, D. Richardson, 2013, Carcinogenesis.

Tumor-induced neoangiogenesis and receptor tyrosine kinases - Mechanisms and strategies for acquired resistance.

D. Richardson, D. Kalinowski, Z. Kovacevic, 2019, Biochimica et biophysica acta. General subjects.

Tumor stressors induce two mechanisms of intracellular P-glycoprotein–mediated resistance that are overcome by lysosomal-targeted thiosemicarbazones

D. Richardson, K. Park, S. Sahni, 2018, The Journal of Biological Chemistry.

The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1

M. Zheng, D. Richardson, D. Kalinowski, 2015, Oncotarget.

Coupling of the polyamine and iron metabolism pathways in the regulation of proliferation: Mechanistic links to alterations in key polyamine biosynthetic and catabolic enzymes.

D. Richardson, Y. Suryo Rahmanto, R. Casero, 2018, Biochimica et biophysica acta. Molecular basis of disease.

Regulation of autophagy and apoptosis by Dp44mT-mediated activation of AMPK in pancreatic cancer cells.

D. Richardson, S. Sahni, P. Jansson, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Mitochondrial dysfunction in the neuro-degenerative and cardio-degenerative disease, Friedreich's ataxia

D. Richardson, D. Kalinowski, P. Jansson, 2017, Neurochemistry International.

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease.

D. Richardson, D. Kalinowski, S. Sahni, 2015, Biochimica et biophysica acta.

The mechanistic role of chemically diverse metal ions in the induction of autophagy

D. Richardson, S. Sahni, P. Jansson, 2017, Pharmacological research.

The Anticancer Agent Di-2-pyridylketone 4,4-Dimethyl-3-thiosemicarbazone (Dp44mT) Overcomes Prosurvival Autophagy by Two Mechanisms

D. Richardson, P. Jansson, Elaine Gutierrez, 2014, The Journal of Biological Chemistry.

Inhibiting mitochondrial translation overcomes multidrug resistance in MYC-driven neuroblastoma via OMA1-mediated integrated stress response

M. Hogarty, J. Neradil, P. Jansson, 2023, bioRxiv.

The Metastasis Suppressor, N-myc Downstream-regulated Gene 1 (NDRG1), Inhibits Stress-induced Autophagy in Cancer Cells

D. Richardson, D. Kalinowski, S. Sahni, 2014, The Journal of Biological Chemistry.

Autophagy: A Promising Target for Triple Negative Breast Cancers.

S. Sahni, P. Jansson, Yomna S. Abd El-Aziz, 2021, Pharmacological research.

NDRG1 suppresses basal and hypoxia-induced autophagy at both the initiation and degradation stages and sensitizes pancreatic cancer cells to lysosomal membrane permeabilization.

D. Richardson, K. Park, S. Sahni, 2020, Biochimica et biophysica acta. General subjects.

Targeting Wnt/tenascin C-mediated cross talk between pancreatic cancer cells and stellate cells via activation of the metastasis suppressor NDRG1

D. Richardson, M. Apte, S. Sahni, 2022, The Journal of biological chemistry.

Breaking the cycle: Targeting of NDRG1 to inhibit bi‐directional oncogenic cross‐talk between pancreatic cancer and stroma

M. Pajic, D. Richardson, K. Park, 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The biochemical and molecular mechanisms involved in the role of micro-tumor environment stress in development of drug resistance.

D. Richardson, P. Jansson, Lina Al-Akra, 2019, Biochimica et biophysica acta. General subjects.

During mitosis ZEB1 switches from being a chromatin-bound epithelial gene repressor, to become a microtubule-associated protein.

D. Richardson, Z. Kovacevic, P. Jansson, 2020, Biochimica et biophysica acta. Molecular cell research.

Melanotransferrin Functions as a Pro-Oncogenic WNT Agonist: A Yin-Yang Relationship in Melanoma with the WNT Antagonist and Metastasis Suppressor, NDRG1

J. Wilmott, X. Zhao, D. Richardson, 2023, bioRxiv.

IRON METABOLISM AND AUTOPHAGY: A POORLY EXPLORED RELATIONSHIP THAT HAS IMPORTANT CONSEQUENCES FOR HEALTH AND DISEASE

D. Richardson, S. Sahni, P. Jansson, 2015, Nagoya journal of medical science.

Acireductone dioxygenase 1 (ADI1) is regulated by cellular iron by a mechanism involving the iron chaperone, PCBP1, with PCBP2 acting as a potential co-chaperone.

D. Richardson, R. Sutak, P. Jansson, 2020, Biochimica et biophysica acta. Molecular basis of disease.

Gene of the month: BECN1

D. Richardson, S. Sahni, P. Jansson, 2014, Journal of Clinical Pathology.

Novel chelators based on adamantane-derived semicarbazones and hydrazones that target multiple hallmarks of Alzheimer's disease.

N. Braidy, D. Richardson, D. Kalinowski, 2018, Dalton transactions.

Oxidative Decomposition of Vitamin C in Drinking Water

T. Nordström, C. Lindqvist, Hye-Rim Jung, 2004, Free radical research.

Glucose modulation induces reactive oxygen species and increases P‐glycoprotein‐mediated multidrug resistance to chemotherapeutics

D. Richardson, N. Seebacher, P. Jansson, 2015, British journal of pharmacology.

Glucose Modulation Induces Lysosome Formation and Increases Lysosomotropic Drug Sequestration via the P-Glycoprotein Drug Transporter*

D. Richardson, N. Seebacher, P. Jansson, 2015, The Journal of Biological Chemistry.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Vesicular ATP-binding cassette transporters in human disease: relevant aspects of their organization for future drug development

P. Riss, V. Namasivayam, P. Jansson, 2020 .

The growing evidence for targeting P-glycoprotein in lysosomes to overcome resistance.

D. Richardson, D. Kalinowski, P. Jansson, 2020, Future medicinal chemistry.

Unique targeting of androgen‐dependent and ‐independent AR signaling in prostate cancer to overcome androgen resistance

D. Richardson, S. Assinder, Z. Kovacevic, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Overcoming tamoxifen resistance in oestrogen receptor‐positive breast cancer using the novel thiosemicarbazone anti‐cancer agent, DpC

D. Richardson, K. Park, Rumeza Hanif, 2020, British journal of pharmacology.

Innovative Thiosemicarbazones that Induce Multi-Modal Mechanisms to Down-Regulate Estrogen-, Progesterone-, Androgen- and Prolactin-Receptors in Breast Cancer.

D. Richardson, Robin L. Anderson, Dinny Graham, 2023, Pharmacological research.

Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors.

M. Zheng, Daohai Zhang, D. Richardson, 2013, Carcinogenesis.

Thiosemicarbazones from the old to new: iron chelators that are more than just ribonucleotide reductase inhibitors.

D. Richardson, Yu Yu, D. Kalinowski, 2009, Journal of medicinal chemistry.

Alkyl substituted 2'-benzoylpyridine thiosemicarbazone chelators with potent and selective anti-neoplastic activity: novel ligands that limit methemoglobin formation.

D. Richardson, D. Kalinowski, P. Bernhardt, 2013, Journal of medicinal chemistry.

Inhibition of autophagy initiation: A novel strategy for oral squamous cell carcinomas.

S. Sahni, P. Jansson, L. Sioson, 2023, Biochimica et biophysica acta. Molecular cell research.

Structure-Activity Relationships of Di-2-pyridylketone, 2-Benzoylpyridine, and 2-Acetylpyridine Thiosemicarbazones for Overcoming Pgp-Mediated Drug Resistance.

D. Richardson, D. Kalinowski, P. Bernhardt, 2016, Journal of medicinal chemistry.

Targeting autophagy in antitumor agent design: furthering the 'lysosomal love' strategy.

D. Richardson, D. Kalinowski, S. Sahni, 2016, Future medicinal chemistry.

NDRG1: A Novel Therapeutic Target against Metastatic Cancers

D. Richardson, D. Kalinowski, Z. Kovacevic, 2015 .

The redox-active, anti-cancer drug Dp44mT inhibits T-cell activation and CD25 through a copper-dependent mechanism

D. Richardson, D. Kalinowski, Z. Kovacevic, 2013, Redox report : communications in free radical research.

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

D. Richardson, C. Hawkins, P. Jansson, 2010, Journal of inorganic biochemistry.

Novel combinatorial autophagy inhibition therapy for triple negative breast cancers.

S. Sahni, P. Jansson, L. Sioson, 2024, European journal of pharmacology.