C. Thien

发表

Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell Functions

J. Penninger, W. Langdon, G. Baier, 2011, The Journal of Immunology.

Mini ReviewNegative regulation of PTK signalling by Cbl proteins

W. Langdon, C. Thien, 2005, Growth factors.

Cbl: many adaptations to regulate protein tyrosine kinases

W. Langdon, C. Thien, Wallace Y. Langdon, 2001, Nature Reviews Molecular Cell Biology.

SLP-76 in c-Cbl-Deficient Thymocytes Sustained Tyrosine Phosphorylation of LAT Perturbed Regulation of ZAP-70 and

D. Bowtell, C. Thien, Langdon, 1999 .

Perturbed regulation of ZAP-70 and sustained tyrosine phosphorylation of LAT and SLP-76 in c-Cbl-deficient thymocytes.

D. Bowtell, W. Langdon, C. Thien, 1999, Journal of immunology.

A TNF- and c-Cbl-dependent FLIPS-degradation pathway and its function in Mycobacterium tuberculosis–induced macrophage apoptosis

W. Langdon, H. Ichijo, J. Basu, 2009, Nature Immunology.

Myeloid leukemia development in c-Cbl RING finger mutant mice is dependent on FLT3 signaling.

R. Flavell, W. Langdon, C. Thien, 2010, Cancer cell.

Tumour induction by activated abl involves tyrosine phosphorylation of the product of the cbl oncogene.

W. Langdon, C. Andoniou, C. Thien, 1994, The EMBO journal.

3D uniaxial mechanical stimulation induces tenogenic differentiation of tendon‐derived stem cells through a PI3K/AKT signaling pathway

R. Tuan, Allan Wang, M. Ni, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Genetic Ablation of the c-Cbl Ubiquitin Ligase Domain Results in Increased Energy Expenditure and Improved Insulin Action

D. James, N. Turner, G. Cooney, 2006, Diabetes.

The Cbl Proto-Oncogene Product Negatively Regulates the Src-Family Tyrosine Kinase Fyn by Enhancing Its Degradation

D. Bowtell, H. Band, W. Langdon, 2000, Molecular and Cellular Biology.

Unaltered negative selection and Treg development of self‐reactive thymocytes in TCR transgenic Fyn‐deficient mice

W. Langdon, A. DeFranco, J. Lyandres, 2010, European journal of immunology.

to Type 1 Diabetes Islet-Reactive CD4 T Cells and Susceptibility Visualizing the Role of Cbl-b in Control of

C. Goodnow, W. Langdon, G. Hoyne, 2011 .

Loss of c‐Cbl RING finger function results in high‐intensity TCR signaling and thymic deletion

W. Langdon, A. Lew, C. Andoniou, 2005, The EMBO journal.

Incidence of c-Cbl mutations in human acute myeloid leukaemias in an Australian patient cohort

W. Langdon, C. Thien, R. Ghassemifar, 2011, Pathology.

A Mouse with a Loss-of-function Mutation in the c-Cbl TKB Domain Shows Perturbed Thymocyte Signaling without Enhancing the Activity of the ZAP-70 Tyrosine Kinase

D. Bowtell, W. Langdon, J. Papadimitriou, 2003, The Journal of experimental medicine.

Tyrosine kinase activity of the EGF receptor is enhanced by the expression of oncogenic 70Z-Cbl

W. Langdon, C. Thien, 1997, Oncogene.

EGF receptor binding and transformation by v-cbl is ablated by the introduction of a loss-of-function mutation from the Caenorhabditis elegans sli-1 gene

W. Langdon, C. Thien, 1997, Oncogene.

The two major sites of cbl tyrosine phosphorylation in abl-transformed cells select the crkL SH2 domain.

W. Langdon, C. Andoniou, C. Thien, 1996, Oncogene.

Cbl-b Is a Negative Regulator of Inflammatory Cytokines Produced by IgE-Activated Mast Cells1

W. Langdon, S. Gustin, C. Thien, 2006, The Journal of Immunology.

IgE-Activated Mast Cells Inflammatory Cytokines Produced by Cbl-b Is a Negative Regulator of

S. Gustin, C. Thien, 2006 .

The Cbl-b RING finger domain has a limited role in regulating inflammatory cytokine production by IgE-activated mast cells.

M. Oksvold, W. Langdon, C. Thien, 2008, Molecular immunology.

Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries

J. Snedeker, A. Traweger, R. Tuan, 2021, Science Translational Medicine.

c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses.

W. Langdon, C. Thien, Christine B F Thien, 2005, The Biochemical journal.

Tissue Hyperplasia and Enhanced T-Cell Signalling via ZAP-70 in c-Cbl-Deficient Mice

D. Bowtell, L. Barnett, W. Langdon, 1998, Molecular and Cellular Biology.

Cyclic mechanical stimulation rescues achilles tendon from degeneration in a bioreactor system

Jonas Rubenson, Bruce Gardiner, T. B. Kirk, 2015, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

c‐Cbl: A regulator of T cell receptor‐mediated signalling

W. Langdon, C. Thien, 1998, Immunology and cell biology.

Loss of c-Cbl E3 ubiquitin ligase activity enhances the development of myeloid leukemia in FLT3-ITD mutant mice.

Samuel J. Taylor, D. Gilliland, W. Langdon, 2015, Experimental hematology.

Dasatinib Targets B-Lineage Cells but Does Not Provide an Effective Therapy for Myeloproliferative Disease in c-Cbl RING Finger Mutant Mice

Samuel J. Taylor, W. Langdon, H. Morse, 2014, PloS one.

Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling.

Samuel J. Taylor, W. Langdon, C. Thien, 2012, Blood.

Visualizing the Role of Cbl-b in Control of Islet-Reactive CD4 T Cells and Susceptibility to Type 1 Diabetes

C. Goodnow, W. Langdon, G. Hoyne, 2011, The Journal of Immunology.

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells.

R. Flavell, W. Langdon, C. Thien, 2008, Genes & development.

Flt 3 inhibitor AC 220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt 3 signaling

Samuel J. Taylor, W. Langdon, C. Thien, 2012 .

c-Cbl Promotes T Cell Receptor-induced Thymocyte Apoptosis by Activating the Phosphatidylinositol 3-Kinase/Akt Pathway*

C. Scott, W. Langdon, J. Steer, 2010, The Journal of Biological Chemistry.

RING finger mutations that abolish c-Cbl-directed polyubiquitination and downregulation of the EGF receptor are insufficient for cell transformation.

F. Walker, W. Langdon, C. Thien, 2001, Molecular cell.

A c-Cbl yeast two hybrid screen reveals interactions with 14-3-3 isoforms and cytoskeletal components.

D. Bowtell, W. Langdon, C. Thien, 1997, Biochemical and biophysical research communications.

Serine mutations that abrogate ligand-induced ubiquitination and internalization of the EGF receptor do not affect c-Cbl association with the receptor

M. Oksvold, H. Huitfeldt, W. Langdon, 2003, Oncogene.

c-Cbl-deficient mice have reduced adiposity, higher energy expenditure, and improved peripheral insulin action.

P. Withers, D. Bowtell, D. James, 2004, The Journal of clinical investigation.

UV-Radiation-Induced Internalization of the Epidermal Growth Factor Receptor Requires Distinct Serine and Tyrosine Residues in the Cytoplasmic Carboxy-Terminal Domain

M. Oksvold, H. Huitfeldt, W. Langdon, 2004, Radiation research.

Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling.

Samuel J. Taylor, W. Langdon, C. Thien, 2012, Blood.