A. Engelsen

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Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

O. Straume, R. Brekken, J. Lorens, 2016 .

AXL Targeting Abrogates Autophagic Flux and Induces Immunogenic Cell Death in Drug-Resistant Cancer Cells

H. Ditzel, J. Minna, T. Tan, 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Inhibition of pyruvate dehydrogenase kinase redirects NSCLC cell metabolism and counteracts development of resistance to epidermal growth factor receptor tyrosine kinase inhibitors

T. Tan, J. Thiery, J. Lorens, 2020 .

Microenvironment-InducedNon-sporadicExpressionof the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

L. Akslen, M. Stampfer, J. Garbe, 2018 .

Dissecting the Role of AXL in Cancer Immune Escape and Resistance to Immune Checkpoint Inhibition

J. Thiery, S. Terry, S. Chouaib, 2022, Frontiers in Immunology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

S. Terry, O. Straume, S. Chouaib, 2018, Immunology.

Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

S. Chouaib, R. Brekken, J. Lorens, 2017 .

Animal Survival Efficiently Kill Glioblastoma and Prolong Have a Functional Activation Advantage to Nk Cells with Kir2ds2 Immunogenotype

Ø. Bruserud, J. Zimmer, L. Leiss, 2022 .

Induction of alveolar and bronchiolar phenotypes in human lung organoids

L. Hoareau, H. Raeder, M. Aanerud, 2021, Physiological reports.

AXL Is a Driver of Stemness in Normal Mammary Gland and Breast Cancer

T. Sørlie, T. Tan, J. Thiery, 2020, iScience.

Hypoxia-driven intratumor heterogeneity and immune evasion.

S. Terry, S. Chouaib, A. Engelsen, 2020, Cancer letters.

Microenvironment-Induced Non-sporadic Expression of the AXL and cKIT Receptors Are Related to Epithelial Plasticity and Drug Resistance

L. Akslen, M. Stampfer, J. Garbe, 2018, Front. Cell Dev. Biol..

Lawrence Berkeley National Laboratory Recent Work Title Microenvironment-induced non-sporadic expression of the AXL and cKIT receptors are related to epithelial plasticity and drug resistance Permalink

L. Akslen, M. Stampfer, J. Garbe, 2018 .

Role of Hypoxia-Mediated Autophagy in Tumor Cell Death and Survival

S. Chouaib, J. Thiery, C. Jamora, 2021, Cancers.

AXL Targeting Overcomes Human Lung Cancer Cell Resistance to NK- and CTL-Mediated Cytotoxicity

J. Thiery, S. Terry, P. Dessen, 2019, Cancer Immunology Research.

Autophagy mediated danger signaling regulates tumor immunosurveillance and may potentiate the effects of anti-cancer immunotherapy through increased adjuvanticity

S. Chouaib, J. Lorens, B. Baguley, 2020 .

Bortezomib administered prior to temozolomide depletes MGMT, chemosensitizes glioblastoma with unmethylated MGMT promoter and prolongs animal survival

B. Gjertsen, E. Bifulco, A. Simonsen, 2019, British Journal of Cancer.

Novel Points of Attack for Targeted Cancer Therapy

A. Engelsen, G. Røsland, 2014, Basic & clinical pharmacology & toxicology.

Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC

P. Lønning, H. Ditzel, T. Tan, 2019, Cancer & Metabolism.

Adaptive mechanisms of resistance to anti-neoplastic agents.

W. Link, Bibiana I Ferreira, Susana Machado, 2017, MedChemComm.

Bortezomib abrogates temozolomide-induced autophagic flux through an ATG5 dependent pathway

S. Knappskog, A. Simonsen, A. Engelsen, 2020, bioRxiv.

Decoding cancer’s camouflage: epithelial-mesenchymal plasticity in resistance to immune checkpoint blockade

J. Thiery, S. Terry, S. Chouaib, 2020, Cancer drug resistance.

Oxygen-dependent regulation of tumor growth and metastasis in human breast cancer xenografts

R. Reed, A. Engelsen, N. Lu, 2017, PloS one.

The Role of Axl Receptor Tyrosine Kinase in Tumor Cell Plasticity and Therapy Resistance

J. Lorens, Kjersti Davidsen, A. Engelsen, 2017 .

Intrinsic Differences in Spatiotemporal Organization and Stromal Cell Interactions Between Isogenic Lung Cancer Cells of Epithelial and Mesenchymal Phenotypes Revealed by High-Dimensional Single-Cell Analysis of Heterotypic 3D Spheroid Models

H. Ditzel, J. Thiery, L. Akslen, 2022, Frontiers in Oncology.

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

L. Akslen, Fan Zhou, J. Lorens, 2022, Frontiers in Cellular and Infection Microbiology.

Cancer Immunotherapy 2017 (Paris, France). Progress and challenges.

S. Terry, Stéphanie Corgnac, A. Engelsen, 2018, Bulletin du cancer.

Blocking Aerobic Glycolysis by Targeting Pyruvate Dehydrogenase Kinase in Combination with EGFR TKI and Ionizing Radiation Increases Therapeutic Effect in Non-Small Cell Lung Cancer Cells

T. Tan, J. Thiery, J. Lorens, 2021, Cancers.

A novel SRC-2-dependent regulation of epithelial-mesenchymal transition in breast cancer cells

G. Mellgren, J. Lorens, E. Janssen, 2019, The Journal of Steroid Biochemistry and Molecular Biology.

NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Ø. Bruserud, J. Zimmer, L. Leiss, 2014, The Journal of Immunology.

Epithelial to mesenchymal transition (EMT) is associated with attenuation of succinate dehydrogenase (SDH) in breast cancer through reduced expression of SDHC

P. Lønning, H. Ditzel, T. Tan, 2019, Cancer & metabolism.

Combination of bemcentinib (BGB324): A first-in-class selective oral AXL inhibitor, with pembrolizumab in patients with triple negative breast cancer and adenocarcinoma of the lung.

J. Thiery, S. Chouaib, R. Brekken, 2018 .

Adaptive mechanisms of resistance to anti-neoplastic agents.

W. Link, Susana Machado, J. Lorens, 2017, MedChemComm.

NK Cells with KIR2DS2 Immunogenotype Have a Functional Activation Advantage To Efficiently Kill Glioblastoma and Prolong Animal Survival

Ø. Bruserud, J. Zimmer, L. Leiss, 2014, The Journal of Immunology.