A. Rakhmilevich

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In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments.

P. Harari, A. Korman, S. Gillies, 2016, Cancer research.

Tumor-Specific Inhibition of In Situ Vaccination by Distant Untreated Tumor Sites

P. Harari, S. Busche, A. Korman, 2018, Cancer Immunology Research.

T-cell-independent Antitumor Effects of CD40 Ligation

A. Rakhmilevich, P. Sondel, K. Alderson, 2012, International reviews of immunology.

Intratumoral injection reduces toxicity and antibody-mediated neutralization of immunocytokine in a mouse melanoma model

A. Bates, Z. Morris, J. Hank, 2020, Journal for ImmunoTherapy of Cancer.

MUC16 suppresses human and murine innate immune responses.

M. Patankar, S. Gillies, J. Connor, 2019, Gynecologic oncology.

Human and murine IL2 receptors differentially respond to the human-IL2 component of immunocytokines

S. Gillies, L. Carmichael, J. Hank, 2016, Oncoimmunology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Manish R. Patel, Charles J. Vaske, Joe Y. Chang, 2016, Journal for Immunotherapy of Cancer.

Differential internalization of hu14.18‐IL2 immunocytokine by NK and tumor cell: impact on conjugation, cytotoxicity, and targeting

M. Patankar, S. Gillies, R. Reisfeld, 2011, Journal of leukocyte biology.

Effect of spaceflight on lymphocyte proliferation and interleukin-2 production.

I V Konstantinova, A. Mastro, A. Rakhmilevich, 1992, Journal of applied physiology.

Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors.

N. Yang, A. Rakhmilevich, P. Sondel, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Cytokine gene therapy of cancer using gene gun technology: superior antitumor activity of interleukin-12.

N. Yang, A. Rakhmilevich, J. Turner, 1997, Human gene therapy.

Synergistic Activation of Macrophages via CD40 and TLR9 Results in T Cell Independent Antitumor Effects1

A. Rakhmilevich, P. Sondel, G. Berke, 2006, The Journal of Immunology.

Granulocyte-macrophage colony-stimulating factor (GM-CSF) secreted by cDNA-transfected tumor cells induces a more potent antitumor response than exogenous GM-CSF

D. Mahvi, S. Weber, A. Rakhmilevich, 1999, Cancer Gene Therapy.

Anti‐tumour synergy of cytotoxic chemotherapy and anti‐CD40 plus CpG‐ODN immunotherapy through repolarization of tumour‐associated macrophages

J. Wigginton, A. Rakhmilevich, P. Sondel, 2011, Immunology.

Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma

P. L. Bergsagel, A. Broman, N. Callander, 2015, Cancer Immunology Research.

Radiation Augments the Local Anti-Tumor Effect of In Situ Vaccine With CpG-Oligodeoxynucleotides and Anti-OX40 in Immunologically Cold Tumor Models

Amy K. Erbe, A. Bates, Z. Morris, 2021, Frontiers in Immunology.

Melanoma-induced suppression of tumor antigen-specific T cell expansion is comparable to suppression of global T cell expansion.

Andrew J. Russ, M. Suresh, C. Cho, 2011, Cellular immunology.

Enhancement of the anti-melanoma response of Hu14.18K322A by αCD40 + CpG

S. Gillies, F. Navid, A. Rakhmilevich, 2013, Cancer Immunology, Immunotherapy.

Intratumoral treatment of smaller mouse neuroblastoma tumors with a recombinant protein consisting of IL-2 linked to the Hu14.18 antibody increases intratumoral CD8+ T and NK cells and improves survival

E. Ranheim, KyungMann Kim, S. Gillies, 2013, Cancer Immunology, Immunotherapy.

In situ Vaccine Plus Checkpoint Blockade Induces Memory Humoral Response

Amy K. Erbe, S. Gillies, Z. Morris, 2020, Frontiers in Immunology.

CD40 Ligation Activates Murine Macrophages via an IFN-γ-Dependent Mechanism Resulting in Tumor Cell Destruction In Vitro 1

A. Rakhmilevich, P. Sondel, G. Berke, 2005, The Journal of Immunology.

Suppression of T-Cell Expansion by Melanoma is Exerted on Resting Cells

Andrew J. Russ, M. Suresh, C. Cho, 2011, Annals of Surgical Oncology.

Interleukin-12 gene therapy of a weakly immunogenic mouse mammary carcinoma results in reduction of spontaneous lung metastases via a T-cell-independent mechanism

N. Yang, A. Rakhmilevich, P. Sondel, 2000, Cancer Gene Therapy.

Intratumoral Delivery of Low Doses of Anti-CD40 mAb Combined With Monophosphoryl Lipid A Induces Local and Systemic Antitumor Effects in Immunocompetent and T Cell-Deficient Mice

Richard K. Yang, A. Rakhmilevich, P. Sondel, 2013, Journal of immunotherapy.

Effective particle-mediated vaccination against mouse melanoma by coadministration of plasmid DNA encoding Gp100 and granulocyte-macrophage colony-stimulating factor.

M. Albertini, N. Yang, T. Roberts, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Anti-CD40 Antibody Induces Antitumor and Antimetastatic Effects: The Role of NK Cells1

Hua Yu, L. Burdelya, A. Rakhmilevich, 2001, The Journal of Immunology.

Antimetastatic Effects: The Role of NK Cells Anti-CD40 Antibody Induces Antitumor and

Hua Yu, A. Rakhmilevich, P. Sondel, 2000 .

The level of MHC class I expression on murine adenocarcinoma can change the antitumor effector mechanism of immunocytokine therapy.

S. Gillies, R. Xiang, R. Reisfeld, 2001, Cancer research.

Synergistic inhibition of tumor growth in a murine mammary adenocarcinoma model by combinational gene therapy using IL-12, pro-IL-18, and IL-1beta converting enzyme cDNA.

D. Mahvi, N. Yang, A. Rakhmilevich, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade

KyungMann Kim, K. O'Leary, L. Schuler, 2022, Nature Communications.

Lymphocytic Leukemia Macrophages in a Mouse Model of Chronic Tumoricidal Effects of Activated

E. Ranheim, A. Rakhmilevich, P. Sondel, 2009 .

Tumor-associated myeloid cells can be activated in vitro and in vivo to mediate antitumor effects

N. Rooijen, Nicholas A. Kalogriopoulos, Richard K. Yang, 2012, Cancer Immunology, Immunotherapy.

The Use of Particle-Mediated Gene Transfer for Immunotherapy of Cancer

M. Albertini, A. Rakhmilevich, D. King, 2002 .

The anti-tumor effect of resveratrol alone or in combination with immunotherapy in a neuroblastoma model

KyungMann Kim, S. Gillies, R. Reisfeld, 2011, Cancer Immunology, Immunotherapy.

Intratumoral injection of interleukin-12 plasmid DNA, either naked or in complex with cationic lipid, results in similar tumor regression in a murine model.

D. Mahvi, N. Yang, A. Rakhmilevich, 2002, Molecular cancer therapeutics.

Mechanism of Immunocytokine Therapy Adenocarcinoma Can Change the Antitumor Effector The Level of MHC Class I Expression on Murine Updated

S. Gillies, R. Xiang, R. Reisfeld, 2001 .

Treatment of experimental breast cancer using interleukin-12 gene therapy combined with anti-vascular endothelial growth factor receptor-2 antibody.

D. Hicklin, A. Rakhmilevich, P. Sondel, 2004, Molecular cancer therapeutics.

Antitumor effects of anti-CD40/CpG immunotherapy combined with gemcitabine or 5- fluorouracil chemotherapy in the B16 melanoma model

A. Rakhmilevich, P. Sondel, M. Felder, 2013, Journal of Immunotherapy for Cancer.

Neutrophils are essential for resolution of primary and secondary infection with Listeria monocytogenes

A. Rakhmilevich, 1995, Journal of leukocyte biology.

PREDICTORS OF RESPONSE TO IMMUNE CHECKPOINT INHIBITOR THERAPY IN METASTATIC SOLID TUMORS: REAL WORLD EVIDENCE

I. Ong, R. Pinapati, S. McIlwain, 2020 .

Enhanced T-cell-independent Antitumor Effect of Cyclophosphamide Combined With Anti-CD40 mAb and CpG in Mice

N. Van Rooijen, A. Rakhmilevich, P. Sondel, 2011, Journal of immunotherapy.

In vivo CD40 ligation can induce T cell‐independent antitumor effects that involve macrophages

A. Rakhmilevich, P. Sondel, G. Berke, 2006, Journal of leukocyte biology.

Interleukin-12 as an in situ cancer vaccine component: a review

A. Rakhmilevich, P. Sondel, Emily Cheng, 2022, Cancer Immunology, Immunotherapy.

CD40 ligation in vivo can induce T cell independent antitumor effects even against immunogenic tumors

A. Rakhmilevich, P. Sondel, M. Malkovský, 2008, Cancer Immunology, Immunotherapy.

Tumoristatic effects of anti‐CD40 mAb‐activated macrophages involve nitric oxide and tumour necrosis factor‐α

A. Rakhmilevich, P. Sondel, G. Berke, 2006, Immunology.

Cells via Concurrent Ligation of CD40, following Recognition of L5178Y Lymphoma Naive Mouse Macrophages Become Activated

E. Ranheim, A. Rakhmilevich, P. Sondel, 2013 .

Naive Mouse Macrophages Become Activated following Recognition of L5178Y Lymphoma Cells via Concurrent Ligation of CD40, NKG2D, and CD18 Molecules1

E. Ranheim, L. Lanier, A. Rakhmilevich, 2009, The Journal of Immunology.

Roles of CD4+ T cells as mediators of antitumor immunity

D. S. Kravtsov, Amy K. Erbe, A. Rakhmilevich, 2022, Frontiers in Immunology.

Macrophages are essential for antitumour effects against weakly immunogenic murine tumours induced by class B CpG‐oligodeoxynucleotides

J. Eickhoff, A. Rakhmilevich, P. Sondel, 2007, Immunology.

Ovarian Cancer Immunotherapy Using Redirected Endogenous Anti-Gal Antibody

A. Rakhmilevich, P. Sondel, 2009 .

Stimulation of interleukin-2 mediated activity of human peripheral blood monuclear cells by lipopolysaccharide and muramyl dipeptide in vitro

B. Fuks, A. Rakhmilevich, M. A. Pelevina, 1988, Bulletin of Experimental Biology and Medicine.

Depth of tumor implantation affects response to in situ vaccination in a syngeneic murine melanoma model

Amy K. Erbe, V. Subbotin, Z. Morris, 2021, Journal for ImmunoTherapy of Cancer.

Interleukin 12 gene transfer into skin distant from the tumor site elicits antimetastatic effects equivalent to local gene transfer.

D. Mahvi, N. Yang, A. Rakhmilevich, 2001, Human gene therapy.

Independent Antitumor Effects CD40 and TLR9 Results in T Cell Synergistic Activation of Macrophages via

A. Rakhmilevich, P. Sondel, G. Berke, 2005 .

Elimination of CD4+ T cells in mice bearing an advanced sarcoma augments the antitumor action of interleukin-2

R. North, A. Rakhmilevich, 1994, Cancer Immunology, Immunotherapy.

Synergy of anti-CD40, CpG and MPL in activation of mouse macrophages.

A. Rakhmilevich, P. Sondel, Yongyu Shi, 2015, Molecular Immunology.

Effective Combination of Innate and Adaptive Immunotherapeutic Approaches in a Mouse Melanoma Model

A. Korman, S. Gillies, A. Rakhmilevich, 2017, The Journal of Immunology.

Intratumoral immunocytokine treatment results in enhanced antitumor effects

S. Gillies, R. Reisfeld, D. Colcher, 2008, Cancer Immunology, Immunotherapy.

secondary infection with Listeria monocytogenes

A. Rakhmilevich, 1995 .

Presence of CD4+ T suppressor cells in mice rendered unresponsive to tumor antigens by intravenous injection of irradiated tumor cells

R. North, A. Rakhmilevich, E. Dye, 1993, International journal of cancer.

Activation and suppression of cellular immunity during reparative liver regeneration in mice

A. Rakhmilevich, O. N. Sidorenko, 1986, Bulletin of Experimental Biology and Medicine.

Intratumoral hu14.18–IL-2 (IC) Induces Local and Systemic Antitumor Effects That Involve Both Activated T and NK Cells As Well As Enhanced IC Retention

E. Ranheim, KyungMann Kim, S. Gillies, 2012, The Journal of Immunology.

Combined innate and adaptive immunotherapy overcomes resistance of immunologically cold syngeneic murine neuroblastoma to checkpoint inhibition

Jo Lynne Rokita, J. Maris, S. Gillies, 2019, Journal of Immunotherapy for Cancer.

Enhanced Activity of Hu14.18-IL2 Immunocytokine against Murine NXS2 Neuroblastoma when Combined with Interleukin 2 Therapy

S. Gillies, R. Reisfeld, H. Lode, 2004, Clinical Cancer Research.

Intratumoral injection of IL-12 plasmid DNA – results of a phase I/IB clinical trial

D. Mahvi, M. Albertini, S. Weber, 2007, Cancer Gene Therapy.

Rapid acquisition of an enhanced capacity to produce tumor necrosis factor, alpha/beta interferon, and interleukin 6 after implantation of tumor cells.

R. North, A. Rakhmilevich, 1991, Cytokine.

A study of the action of immunosuppressive factors from tumour cells on lymphocytes and macrophages in vitro and on the graft-versus-host reaction in mice.

A. Medvedev, A. Rakhmilevich, B. Fuchs, 1990, Biomedical science.

Mechanism of effective combination radio-immunotherapy against 9464D-GD2, an immunologically cold murine neuroblastoma

Amy K. Erbe, S. Gillies, Z. Morris, 2022, Journal for ImmunoTherapy of Cancer.

Combining Immunocytokine and Ex Vivo Activated NK Cells as a Platform for Enhancing Graft-Versus-Tumor Effects Against GD2+ Murine Neuroblastoma

Joanna M. Hales, R. Orentas, T. Fry, 2021, Frontiers in Immunology.

458 Antitumor mechanisms of local radiation and combination immunotherapy in an immunologically cold model of neuroblastoma

A. Rakhmilevich, P. Sondel, A. Erbe, 2020, Journal for ImmunoTherapy of Cancer.

Gene gun-mediated IL-12 gene therapy induces antitumor effects in the absence of toxicity: a direct comparison with systemic IL-12 protein therapy.

N. Yang, M. Sheehy, A. Rakhmilevich, 1999, Journal of immunotherapy.

Activation of cytotoxic factor production of mouse spleen cells through in-vitro stimulation by lipopolysaccharide and muramyl dipeptide

A. Rakhmilevich, M. Rakhimova, 1988, Bulletin of Experimental Biology and Medicine.

NXS2 murine neuroblastomas express increased levels of MHC class I antigens upon recurrence following NK-dependent immunotherapy

KyungMann Kim, S. Gillies, R. Reisfeld, 2003, Cancer Immunology, Immunotherapy.

Radiofrequency Ablation Combined with KS-IL2 Immunocytokine (EMD 273066) Results in an Enhanced Antitumor Effect against Murine Colon Adenocarcinoma

D. Mahvi, S. Gillies, Brett H. Yamane, 2009, Clinical Cancer Research.

Low-dose targeted radionuclide therapy renders immunologically cold tumors responsive to immune checkpoint blockade

Amy K. Erbe, B. Bednarz, KyungMann Kim, 2021, Science Translational Medicine.

Immunotherapy Bridge 2016 and Melanoma Bridge 2016: meeting abstracts

C. Croce, L. Fattore, R. Mancini, 2017, Journal of Translational Medicine.

Combination of radiation therapy, bempegaldesleukin, and checkpoint blockade eradicates advanced solid tumors and metastases in mice

D. Spiegelman, W. Overwijk, Z. Morris, 2021, Journal for ImmunoTherapy of Cancer.

Short-course neoadjuvant in situ vaccination for murine melanoma

Amy K. Erbe, S. Gillies, V. Subbotin, 2022, Journal for ImmunoTherapy of Cancer.

Radiation to all macroscopic sites of tumor permits greater systemic antitumor response to in situ vaccination

Amy K. Erbe, B. Bednarz, R. Hernandez, 2023, Journal for ImmunoTherapy of Cancer.

Immunocytokine augments local and abscopal response and animal survival when added to radiation and CTLA-4 checkpoint inhibition in a murine melanoma model

P. Harari, A. Korman, S. Gillies, 2015, Journal of Immunotherapy for Cancer.

Immunocytokine Augments the Local and Abscopal Response to Radiation and CTLA4 Checkpoint Inhibition in a Murine Melanoma Model

P. Harari, A. Korman, Z. Morris, 2015 .

Pharmacokinetics and stability of the ch14.18–interleukin-2 fusion protein in mice

S. Gillies, M. Super, J. Hank, 1999, Cancer Immunology, Immunotherapy.

Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy.

KyungMann Kim, S. Gillies, R. Reisfeld, 2011, International immunopharmacology.

Tumoricidal Effects of Activated Macrophages in a Mouse Model of Chronic Lymphocytic Leukemia1

E. Ranheim, A. Rakhmilevich, P. Sondel, 2009, The Journal of Immunology.

Abstract 2256: Low dose brain radiotherapy enhances the efficacy of an extracranialin situvaccine regimen against melanoma brain metastases in a pre-clinical murine model

A. Bates, P. Clark, Z. Morris, 2020 .

Evidence for a significant role of CD4+ T cells in adoptive immunity to Listeria monocytogenes in the liver.

A. Rakhmilevich, 1994, Immunology.

[Immunostimulating effects of muramyl dipeptide, glucosaminyl muramyl dipeptide and their synthetic derivatives in vitro].

N. Bovin, T. Andronova, A. Rakhmilevich, 1989, Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic].

[Activation of cellular immunity in mice under normal conditions and in tumor growth during treatment with glucosaminyl muramyl dipeptide].

B. Fuks, T. Andronova, A. Rakhmilevich, 1990, Voprosy meditsinskoi khimii.

500 INV322, a TME selective CD25 x CTLA4 bispecific antibody approach for depletion of tumor restricted Tregs

J. Russell, A. Rakhmilevich, P. Sondel, 2022, Regular and Young Investigator Award Abstracts.

Cyclophosphamide augments the efficacy of in situ vaccination in a mouse melanoma model

Z. Morris, A. Rakhmilevich, P. Sondel, 2023, Frontiers in oncology.

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two

Charles J. Vaske, Joe Y. Chang, Scott R. Presnell, 2016, Journal for ImmunoTherapy of Cancer.

Intratumoral Delivery of Low Doses of Anti-CD40 mAb Combined With Monophosphoryl Lipid A Induces Local and Systemic Antitumor Effects in Immunocompetent and T Cell-Deficient Mice

Richard K. Yang, A. Rakhmilevich, P. Sondel, 2013, Journal of immunotherapy.

Tumoricidal Effects of Macrophage-Activating Immunotherapy in a Murine Model of Relapsed/Refractory Multiple Myeloma

P. L. Bergsagel, A. Broman, N. Callander, 2015, Cancer Immunology Research.

NK cells propagate T cell immunity following in situ tumor vaccination.

Amy K. Erbe, M. Albertini, A. Rakhmilevich, 2023, Cell reports.