A. Hall

发表

Dynamics of Aβ42 Reduction in Plasma, CSF and Brain of Rats Treated with the γ-Secretase Modulator, GSM-10h

J. Richardson, Sharlin Ahmed, A. Medhurst, 2011, Neurodegenerative Diseases.

One-Pot, Three-Component Sulfonimidamide Synthesis Exploiting the Sulfinylamine Reagent N-Sulfinyltritylamine, TrNSO.

M. Willis, A. Hall, T. Davies, 2017, Angewandte Chemie.

Harnessing Sulfinyl Nitrenes: A Unified One-Pot Synthesis of Sulfoximines and Sulfonimidamides

M. Tilby, M. Willis, F. Duarte, 2020, Journal of the American Chemical Society.

Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO

M. Tilby, M. Willis, A. Hall, 2020, Organic letters.

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

M. Topf, T. Gonen, F. E. Reyes, 2017, Journal of the American Chemical Society.

Discovery of GSK345931A: An EP(1) receptor antagonist with efficacy in preclinical models of inflammatory pain.

A. Naylor, W. Winchester, A. Hall, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of 1,5-biaryl pyrroles as EP1 receptor antagonists.

I. Chessell, A. Naylor, S. Atkinson, 2006, Bioorganic & medicinal chemistry letters.

Pyridine-derived γ-secretase modulators.

J. D. Elliott, Zehong Wan, Wei Zhao, 2011, Bioorganic & medicinal chemistry letters.

Piperidine-derived gamma-secretase modulators.

I. Hussain, Alan Naylor, Beverley Smith, 2010, Bioorganic & medicinal chemistry letters.

TASTPM Mice Expressing Amyloid Precursor Protein and Presenilin-1 Mutant Transgenes Are Sensitive to γ-Secretase Modulation and Amyloid-β42 Lowering by GSM-10h

J. Richardson, L. Facci, S. Skaper, 2010, Neurodegenerative Diseases.

Contents Vol. 8, 2011

Jane S. Paulsen, Robert P. Davis, J. L. Mesa, 2011, Neurodegenerative Diseases.

Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition.

Mark D. Hopkin, D. O'connor, J. Ellard, 2015, Bioorganic & medicinal chemistry letters.

Discovery of sodium 6-[(5-chloro-2-{[(4-chloro-2-fluorophenyl)methyl]oxy}phenyl)methyl]-2-pyridinecarboxylate (GSK269984A) an EP(1) receptor antagonist for the treatment of inflammatory pain.

A. Naylor, W. Winchester, A. Hall, 2009, Bioorganic & medicinal chemistry letters.

Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy.

A. Naylor, A. Hall, A. Billinton, 2008, Bioorganic & medicinal chemistry letters.

Identification and optimization of novel 1,3,4-oxadiazole EP1 receptor antagonists.

A. Naylor, A. Hall, D. Livermore, 2007, Bioorganic & medicinal chemistry letters.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists. Structure-activity relationships of 6-substituted and 5,6-disubstituted benzoic acid derivatives.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel, non-acidic 1,5-biaryl pyrrole EP1 receptor antagonists.

I. Chessell, A. Naylor, S. Atkinson, 2007, Bioorganic & medicinal chemistry letters.

1,5-Biaryl pyrrole derivatives as EP1 receptor antagonists: Structure-activity relationships of 4- and 5-substituted benzoic acid derivatives.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

Discovery of novel biaryl heterocyclic EP1 receptor antagonists.

I. Chessell, A. Naylor, X. Lewell, 2006, Bioorganic & medicinal chemistry letters.

EP1 antagonists for the treatment of inflammatory pain.

A. Hall, A. Billinton, G. Giblin, 2007, Current opinion in drug discovery & development.

Primary Sulfonamide Synthesis Using the Sulfinylamine Reagent N-Sulfinyl-O-(tert-butyl)hydroxylamine, t-BuONSO

M. Tilby, M. Willis, A. Hall, 2020, Organic letters.

Targeting γ-Secretase for the Treatment of Alzheimer’s Disease

A. Hall, A. I. Velter, 2017 .

Novel 4-(aryloxy)tetrahydropyridine analogs of MPTP as monoamine oxidase A and B substrates.

A. Kalgutkar, A. Hall, K. Castagnoli, 1994, Journal of medicinal chemistry.

Discovery of a novel indole series of EP1 receptor antagonists by scaffold hopping.

A. Naylor, P. Theobald, A. Hall, 2008, Bioorganic & medicinal chemistry letters.

Copper-catalyzed coupling of hydroxylamines with aryl iodides.

Michael D. Woodrow, A. Hall, N. Tomkinson, 2008, Organic letters.

The discovery of a selective, small molecule agonist for the MAS-related gene X1 receptor.

M. Wigglesworth, P. Szekeres, A. Muir, 2009, Journal of medicinal chemistry.

Synthesis of BACE1 Inhibitors E2609/E2071 via Oxime–Olefin Cycloaddition Following a Process Risk Mitigation Strategy

Yoichi Kita, M. Bracke, A. Chanda, 2021, Organic Process Research & Development.

Identification of novel pyrazole acid antagonists for the EP1 receptor.

I. Chessell, X. Lewell, A. Hall, 2006, Bioorganic & medicinal chemistry letters.

Total synthesis and structural confirmation of the marine natural product Dysinosin A: a novel inhibitor of thrombin and Factor VIIa.

S. Hanessian, R. Margarita, L. Parlanti, 2002, Journal of the American Chemical Society.

Regioselectivity and Mechanism of Synthesizing N-Substituted 2-Pyridones and 2-Substituted Pyridines via Metal-Free C-O and C-N Bond-Cleaving of Oxazoline[3,2-a]pyridiniums

Weiliang Zhu, Jiye Shi, Zhijian Xu, 2017, Scientific Reports.

α-Chloronitroso compounds derived from carbohydrate ketones: cycloadditions with cyclic dienes, a synthesis of (–)-physoperuvine and a formal synthesis of (+)-epibatidine

D. Rees, G. Rosair, A. Hall, 2000 .

Access to Different Isomeric Dibenzoxazepinones through Copper-Catalyzed C-H Etherification and C-N Bond Construction with Controllable Smiles Rearrangement.

Weiliang Zhu, Jiye Shi, Yunfei Zhou, 2016, Organic letters.

Agents Acting on Prostanoid and Thromboxane Receptors

Simon Peace, A. Hall, M. Swarbrick, 2010 .

Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates

M. Tilby, M. Willis, A. Hall, 2022, ACS catalysis.

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism

Weiliang Zhu, Jiye Shi, Zhijian Xu, 2016 .

A General Method for the a-Acyloxylation of Carbonyl Compounds

Stephen P. Thomas, R. Jenkins, A. Hall, 2005 .

A new chiral diol derived from tetralone for the complexation of Lewis acids

D. Hibbs, R. Jenkins, A. Hall, 2003 .

Synthesis of Hydroxylated Pyrrolizidines Related to Alexine using Cycloaddition Reactions of Functionalized Cyclic Nitrones

A. Hall, R. Wightman, Kevin P. Meldrum, 2004 .

Synthesis of Hydroxylated Pyrrolizidines Related to Alexine Using Cycloaddition Reactions of Functionalized Cyclic Nitrones.

A. Hall, R. Wightman, Kevin P. Meldrum, 1997 .

1,2-Asymmetric induction in dianionic allylation reactions of amino acid derivatives-synthesis of functionally useful, enantiopure aspartates and constrained scaffolds

S. Hanessian, R. Margarita, A. Hall, 1998 .

Asymmetric cycloadditions of dienes to chloronitroso compounds derived from carbohydrate ketones: syntheses of (–)-physoperuvine and (+)-epibatidine

D. Rees, A. Hall, P. Bailey, 1998 .

A Simple Method for the a-Oxygenation of Aldehydes.

Stephen P. Thomas, R. Jenkins, A. Hall, 2005 .

A simple and versatile method to determine the enantiomeric purity of Diels-Alder adducts

R. Jenkins, A. Hall, N. Tomkinson, 2003 .

Discovery of GSK345931A: An EP1 Receptor Antagonist with Efficacy in Preclinical Models of Inflammatory Pain.

A. Hall, 2009 .

The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.

I. Chessell, A. Naylor, A. Hall, 2007, Bioorganic & medicinal chemistry letters.

Facile Synthesis of Substituted 4-Alkoxy-2-oxazolines and Exploration of the Reaction Mechanism

Weiliang Zhu, Jiye Shi, Zhijian Xu, 2016, Synthesis.

Designing Out PXR Activity on Drug Discovery Projects: A Review of Structure-Based Methods, Empirical and Computational Approaches.

A. Hall, M. Ledecq, H. Chanteux, 2021, Journal of medicinal chemistry.

The Role of Disulfide Bond Replacements in Analogues of the Tarantula Toxin ProTx-II and Their Effects on Inhibition of the Voltage-Gated Sodium Ion Channel Nav1.7

M. Topf, T. Gonen, K. Thalassinos, 2017, Journal of the American Chemical Society.

Identification of novel glycine sulfonamide antagonists for the EP1 receptor.

I. Chessell, A. Naylor, W. Winchester, 2007, Bioorganic & medicinal chemistry letters.

Novel Strategies To Activate the Dopamine D1 Receptor: Recent Advances in Orthosteric Agonism and Positive Allosteric Modulation.

A. Hall, L. Provins, Anne Valade, 2018, Journal of medicinal chemistry.

Targeting β-Secretase (BACE) for the Treatment of Alzheimer’s Disease

A. Hall, H. Gijsen, 2017 .

Discovery of a novel series of nonacidic benzofuran EP1 receptor antagonists.

A. Naylor, P. Theobald, A. Hall, 2011, Bioorganic & medicinal chemistry letters.

Discovery of brain penetrant, soluble, pyrazole amide EP1 receptor antagonists.

A. Naylor, L. Cutler, A. Hall, 2008, Bioorganic & medicinal chemistry letters.

γ‐Secretase modulators do not induce Aβ‐rebound and accumulation of β‐C‐terminal fragment

Zehong Wan, Y. Matsuoka, L. Lau, 2012, Journal of neurochemistry.

An Introduction to the CNS Section of Volume 7: Recent Approvals and Advances in CNS Drug Discovery

A. Hall, 2017 .

γ-Secretase modulators: current status and future directions.

A. Hall, T. Patel, 2014, Progress in medicinal chemistry.

4th Anglo-Swedish Medicinal Chemistry Symposium.

A. Hall, 2009, Future medicinal chemistry.

Piperidine-Derived γ-Secretase Modulators.

I. Hussain, Alan Naylor, Beverley Smith, 2010 .

Orally bioavailable and brain-penetrant pyridazine and pyridine-derived γ-secretase modulators reduced amyloidogenic Aβ peptides in vivo

Zehong Wan, Y. Matsuoka, D. Harrison, 2013, Neuropharmacology.

Reversible Inhibition of Human Carboxylesterases by Acyl Glucuronides

A. Hall, W. G. Lai, Eric T. Williams, 2013, Drug Metabolism and Disposition.

A general method for the alpha-acyloxylation of carbonyl compounds.

Stephen P. Thomas, R. Jenkins, A. Hall, 2005, Organic letters.

Exploiting Configurational Lability in Aza‐Sulfur Compounds for the Organocatalytic Enantioselective Synthesis of Sulfonimidamides

M. Tilby, M. Willis, A. Hall, 2021, Angewandte Chemie.