A. Akdemir

发表

Discovery of novel isatin-based sulfonamides with potent and selective inhibition of the tumor-associated carbonic anhydrase isoforms IX and XII.

C. Supuran, N. Karalı, Özlen Güzel-Akdemir, 2015, Organic & biomolecular chemistry.

Synthesis of coumarin-sulfonamide derivatives and determination of their cytotoxicity, carbonic anhydrase inhibitory and molecular docking studies.

C. Supuran, A. Angeli, B. Zengin Kurt, 2019, European journal of medicinal chemistry.

Use of acetylcholine binding protein in the search for novel alpha7 nicotinic receptor ligands. In silico docking, pharmacological screening, and X-ray analysis.

D. Bertrand, T. Sixma, I. D. de Esch, 2009, Journal of medicinal chemistry.

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

D. Bertrand, T. Sixma, I. D. de Esch, 2011, Bioorganic & medicinal chemistry.

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

I. D. de Esch, C. de Graaf, A. J. Thompson, 2012, Bioorganic & medicinal chemistry.

The neutralization effect of montelukast on SARS-CoV-2 is shown by multiscale in silico simulations and combined in vitro studies

S. Durdağı, Ş. Tekin, M. Guzel, 2020, bioRxiv.

A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.

E. Novellino, G. De Rosa, C. Supuran, 2016, Chemistry.

Aromatase inhibition by 2-methyl indole hydrazone derivatives evaluated via molecular docking and in vitro activity studies

A. Akdemir, E. Ince, H. Gurer-Orhan, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Development of Thiazolidinones as Fungal Carbonic Anhydrase Inhibitors

S. Carradori, C. Supuran, R. Grande, 2020, International journal of molecular sciences.

Design and synthesis of novel peptidomimetics for cancer immunotherapy

G. Esendagli, Sevgi Gulyuz, A. Akdemir, 2020, Organic Communications.

Synthesis of a new series of dithiocarbamates with effective human carbonic anhydrase inhibitory activity and antiglaucoma action.

C. Supuran, A. Scozzafava, E. Masini, 2015, Bioorganic & medicinal chemistry.

The Structure, Physiological Role, and Potential Medicinal Applications of Carbonic Anhydrase V

Özlen Güzel-Akdemir, A. Akdemir, 2015 .

o-Benzenedisulfonimido-sulfonamides are potent inhibitors of the tumor-associated carbonic anhydrase isoforms CA IX and CA XII.

C. Supuran, D. Vullo, Özlen Güzel-Akdemir, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and biological activity of selective hCAs inhibitors based on 2-(benzylsulfinyl)benzoic acid scaffold

C. De Monte, S. Carradori, C. Supuran, 2019, Journal of enzyme inhibition and medicinal chemistry.

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.

S. Carradori, A. Mollica, C. Supuran, 2015, Bioorganic & medicinal chemistry.

Isatin analogs as novel inhibitors of Candida spp. β-carbonic anhydrase enzymes.

C. Supuran, N. Karalı, Özlen Güzel-Akdemir, 2016, Bioorganic & medicinal chemistry.

A Gq/11-coupled Mutant Histamine H1 Receptor F435A Activated Solely by Synthetic Ligands (RASSL)*

R. Leurs, A. Jongejan, A. Akdemir, 2005, Journal of Biological Chemistry.

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII

C. Supuran, A. Angeli, F. Carta, 2022, Molecules.

Novel 2-indolinones containing a sulfonamide moiety as selective inhibitors of candida β-carbonic anhydrase enzyme

C. Supuran, A. Angeli, N. Karalı, 2019, Journal of enzyme inhibition and medicinal chemistry.

Novel Indole-Based Hydrazones as Potent Inhibitors of the α-class Carbonic Anhydrase from Pathogenic Bacterium Vibrio cholerae

C. Supuran, A. Angeli, Özlen Güzel-Akdemir, 2020, International journal of molecular sciences.

A Study On Synthesis, Biological Activities and Molecular Modelling of Some Novel Trisubstituted 1,2,4-Triazole Derivatives

O. Bekircan, Y. Şirin, A. Akdemir, 2018, ChemistrySelect.

A class of sulfonamides with strong inhibitory action against the α-carbonic anhydrase from Trypanosoma cruzi.

C. Supuran, A. Scozzafava, C. Capasso, 2013, Journal of medicinal chemistry.

Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

S. Carradori, A. Mollica, C. Supuran, 2016, Journal of enzyme inhibition and medicinal chemistry.

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

S. Carradori, C. Supuran, S. Dedhar, 2020, Metabolites.

rac‐ and meso‐Cyclohexanoids: Their α‐, β‐glycosidases, antibacterial, antifungal activities, and molecular docking studies

A. Akdemir, Emel Karakılıç, A. Baran, 2020, Archiv der Pharmazie.

New 1H‐indole‐2,3‐dione 3‐thiosemicarbazones with 3‐sulfamoylphenyl moiety as selective carbonic anhydrase inhibitors

C. Supuran, N. Karalı, A. Akdemir, 2022, Archiv der Pharmazie.

Synthesis and biological evaluation of new chloro/acetoxy substituted isoindole analogues as new tyrosine kinase inhibitors.

M. Kaya, E. Şahin, A. Akdemir, 2019, Bioorganic chemistry.

Mandelic acid-based spirothiazolidinones targeting M. tuberculosis: Synthesis, in vitro and in silico investigations

Kerem Kaya, Özlen Güzel-Akdemir, A. Akdemir, 2022, Bioorganic Chemistry.

Synthesis of new 1,2,4‐triazole–(thio)semicarbazide hybrid molecules: Their tyrosinase inhibitor activities and molecular docking analysis

O. Bekircan, A. Akdemir, Y. Kolcuoğlu, 2021, Archiv der Pharmazie.

Synthesis, anti‐TB activities, and molecular docking studies of 4‐(1,2,3‐triazoyl)arylmethanone derivatives

A. Akdemir, Aysenur Gunaydin Akyildiz, A. Altundas, 2022, Journal of biochemical and molecular toxicology.

Anti-Candida activity and cytotoxicity of a large library of new N-substituted-1,3-thiazolidin-4-one derivatives.

C. De Monte, S. Carradori, A. Mollica, 2016, European journal of medicinal chemistry.

Structure-based design, synthesis and structure-activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein.

I. D. de Esch, O. Zuiderveld, R. Leurs, 2012, Bioorganic & medicinal chemistry letters.

Fragment growing induces conformational changes in acetylcholine-binding protein: a structural and thermodynamic analysis.

Rob Leurs, Iwan J P de Esch, Ewald Edink, 2011, Journal of the American Chemical Society.

Indole-Based Hydrazones Containing A Sulfonamide Moiety as Selective Inhibitors of Tumor-Associated Human Carbonic Anhydrase Isoforms IX and XII

C. Supuran, Silvia Bua, Özlen Güzel-Akdemir, 2019, International journal of molecular sciences.

Synthesis and Functional Investigations of Computer Designed Novel Cladribine‐Like Compounds for the Treatment of Multiple Sclerosis

A. Akdemir, Serkan Yavuz, A. Dişli, 2017, Archiv der Pharmazie.

Anticholinesterase and Antioxidant Activities of Natural Abietane Diterpenoids with Molecular Docking Studies.

M. Öztürk, F. Bahadori, M. Boğa, 2020, Current Alzheimer research.

Xanthates and trithiocarbonates strongly inhibit carbonic anhydrases and show antiglaucoma effects in vivo.

C. Supuran, A. Scozzafava, E. Masini, 2013, Journal of medicinal chemistry.

Azole-Based Compounds That Are Active against Candida Biofilm: In Vitro, In Vivo and In Silico Studies

S. Carradori, G. Simonetti, B. De Filippis, 2022, Antibiotics.

A novel library of saccharin and acesulfame derivatives as potent and selective inhibitors of carbonic anhydrase IX and XII isoforms.

C. De Monte, S. Carradori, A. Mollica, 2016, Bioorganic & medicinal chemistry.

Quinoline-sulfamoyl carbamates/sulfamide derivatives: Synthesis, cytotoxicity, carbonic anhydrase activity, and molecular modelling studies.

C. Supuran, A. Angeli, B. Zengin Kurt, 2021, Bioorganic chemistry.

Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis.

A. Akdemir, Serkan Yavuz, A. Dişli, 2017, Bioorganic & medicinal chemistry.

Selective inhibition of human carbonic anhydrases by novel amide derivatives of probenecid: synthesis, biological evaluation and molecular modelling studies.

S. Carradori, C. Supuran, D. Vullo, 2014, Bioorganic & medicinal chemistry.

New Pyridinium Salt Derivatives of 2-(Hydrazinocarbonyl)-3-phenyl-1H-indole-5-sulfonamide as Selective Inhibitors of Tumour-Related Human Carbonic Anhydrase Isoforms IX and XII.

C. Supuran, D. Vullo, A. Akdemir, 2022, Anti-Cancer Agents in Medicinal Chemistry.

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents

C. Supuran, A. Angeli, B. Zengin Kurt, 2023, ACS omega.

Five- and Six-Membered Nitrogen-Containing Compounds as Selective Carbonic Anhydrase Activators

S. Carradori, A. Mollica, C. Supuran, 2017, Molecules.

The extremo-α-carbonic anhydrase (CA) from Sulfurihydrogenibium azorense, the fastest CA known, is highly activated by amino acids and amines.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Bioorganic & medicinal chemistry letters.

Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme

C. De Monte, S. Carradori, C. Supuran, 2015, Journal of enzyme inhibition and medicinal chemistry.

Inhibition of tumor-associated human carbonic anhydrase isozymes IX and XII by a new class of substituted-phenylacetamido aromatic sulfonamides.

Clemente Capasso, Andrea Scozzafava, Claudiu T Supuran, 2013, Bioorganic & medicinal chemistry.

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors

C. Supuran, A. Angeli, Özlen Güzel-Akdemir, 2018, Journal of enzyme inhibition and medicinal chemistry.

New amide derivatives of Probenecid as selective inhibitors of carbonic anhydrase IX and XII: biological evaluation and molecular modelling studies.

C. De Monte, S. Carradori, A. Mollica, 2015, Bioorganic & medicinal chemistry.

Design and synthesis of new heterocyclic compounds containing 5-[(1H-1,2,4-triazol-1-yl)methyl]-3H-1,2,4-triazole-3-thione structure as potent hEGFR inhibitors.

O. Bekircan, A. Akdemir, Y. Kolcuoğlu, 2023, Journal of biomolecular structure & dynamics.

Novel sulfonamide-containing 2-indolinones that selectively inhibit tumor-associated alpha carbonic anhydrases.

C. Supuran, A. Angeli, N. Karalı, 2017, Bioorganic & medicinal chemistry.

Dithiocarbamates and dithiocarbonates containing 6-nitrosaccharin scaffold: Synthesis, antimycobacterial activity and in silico target prediction using ensemble docking-based reverse virtual screening

Kerem Kaya, Özlen Güzel-Akdemir, A. Akdemir, 2022, Journal of Molecular Structure.

In vitro evaluation of estrogenic, antiestrogenic and antitumor effects of amentoflavone

A. Akdemir, H. Gurer-Orhan, S. Ozcan-Sezer, 2021, Human & experimental toxicology.

Fibrate-based N-acylsulphonamides targeting carbonic anhydrases: synthesis, biochemical evaluation, and docking studies

S. Carradori, C. Supuran, A. Angeli, 2019, Journal of enzyme inhibition and medicinal chemistry.

The Synthesis, Anticancer Activity, Structure-Activity Relationships and Molecular Modelling Studies of Novel Isoindole-1,3(2H)-dione Compounds Containing Different Functional Groups.

A. Akdemir, Yunus Kara, A. Tan, 2020, Anti-cancer agents in medicinal chemistry.

Exploring new Probenecid-based carbonic anhydrase inhibitors: Synthesis, biological evaluation and docking studies.

S. Carradori, A. Mollica, C. Supuran, 2015, Bioorganic & medicinal chemistry.

Computational investigation of the selectivity of salen and tetrahydrosalen compounds towards the tumor-associated hCA XII isozyme

S. Carradori, C. Supuran, A. Akdemir, 2015, Journal of enzyme inhibition and medicinal chemistry.

Synthesis of Naproxen Thiadiazole Urea Hybrids and Determination of their Anti-melanoma, Anti-migration, Tyrosinase Inhibitory Activity, and Molecular Docking Studies

A. Akdemir, B. Z. Kurt, Fatih Sönmez, 2023, Journal of Molecular Structure.

Synthesis of flurbiprofen thiadiazole urea derivatives and assessment of biological activities and molecular docking studies.

B. Zengin Kurt, A. Akdemir, Fatih Sönmez, 2023, Chemical biology & drug design.

New azolyl-derivatives as multitargeting agents against breast cancer and fungal infections: synthesis, biological evaluation and docking study

S. Carradori, A. Cataldi, B. De Filippis, 2021, Journal of enzyme inhibition and medicinal chemistry.

Computer design, synthesis, and bioactivity analyses of drugs like fingolimod used in the treatment of multiple sclerosis.

A. Akdemir, Serkan Yavuz, A. Dişli, 2017, Bioorganic & medicinal chemistry.

Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors.

D. Bertrand, T. Sixma, I. D. de Esch, 2011, Bioorganic & medicinal chemistry.

Anti-SARS-CoV-2 and cytotoxic activity of two marine alkaloids from green alga Caulerpa cylindracea Sonder in the Dardanelles

A. Akdemir, M. D. Orhan, E. Erol, 2022, RSC advances.

A Divalent PAMAM-Based Matrix Metalloproteinase/Carbonic Anhydrase Inhibitor for the Treatment of Dry Eye Syndrome.

E. Novellino, C. Supuran, D. Vullo, 2016, Chemistry.

Design, Synthesis, and Investigation of Anticancer and Antioxidant Potential of Novel Indole‐Based Melatonin Analogues in Breast Cancer

A. Akdemir, H. Gurer-Orhan, S. Suzen, 2024, ChemistrySelect.