R. Žalubovskis

发表

6-Substituted sulfocoumarins are selective carbonic anhdydrase IX and XII inhibitors with significant cytotoxicity against colorectal cancer cells.

C. Supuran, C. Ghelardini, L. di Cesare Mannelli, 2015, Journal of medicinal chemistry.

The antibiotic furagin and its derivatives are isoform-selective human carbonic anhydrase inhibitors

C. Supuran, A. Nocentini, R. Žalubovskis, 2020, Journal of enzyme inhibition and medicinal chemistry.

3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

C. Supuran, D. Vullo, A. Kazaks, 2017, Journal of enzyme inhibition and medicinal chemistry.

Flexible Entry into 3-Arylpent-2-enedioic Acids via Heck–Matsuda Arylation of Dimethyl Glutaconate with Arenediazonium Tosylates

R. Žalubovskis, M. Krasavin, O. Bakulina, 2019, Synthesis.

Novel electrophilic amides amenable by the Ugi reaction perturb thioredoxin system via thioredoxin reductase 1 (TrxR1) inhibition: Identification of DVD-445 as a new lead compound for anticancer therapy.

M. Pešić, S. Glišić, V. Sharoyko, 2019, European journal of medicinal chemistry.

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

S. Carradori, C. Supuran, J. Winum, 2021, Journal of enzyme inhibition and medicinal chemistry.

Stereochemical Control of Chirally Flexible Phosphepines

C. Moberg, R. Žalubovskis, Z. Szabó, 2007 .

Benzoxepinones: A new isoform-selective class of tumor associated carbonic anhydrase inhibitors.

C. Supuran, A. Nocentini, T. Werner, 2020, Bioorganic & medicinal chemistry.

4-Cyanamidobenzenesulfonamide derivatives: a novel class of human and bacterial carbonic anhydrase inhibitors

C. Supuran, R. Žalubovskis, Alessandro Bonardi, 2022, Journal of enzyme inhibition and medicinal chemistry.

Reactivity of Aziridine-2-Carboxamide (Leakadine) with Nucleophiles in Aqueous Solutions*

E. Liepinsh, I. Kalvinsh, R. Žalubovskis, 2014, Chemistry of Heterocyclic Compounds.

Selected strategies to fight pathogenic bacteria

C. Supuran, J. Yli-Kauhaluoma, A. Sobolev, 2023, Journal of enzyme inhibition and medicinal chemistry.

In a search for selective inhibitors of carbonic anhydrases: coumarin and its bioisosteres – synthesis and derivatization

R. Žalubovskis, 2015, Chemistry of Heterocyclic Compounds.

N-Substituted and ring opened saccharin derivatives selectively inhibit transmembrane, tumor-associated carbonic anhydrases IX and XII.

C. Supuran, D. Vullo, A. Kazaks, 2017, Bioorganic & medicinal chemistry.

Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment

S. Carradori, C. Supuran, S. Dedhar, 2020, Metabolites.

Facile synthesis of coumarin bioisosteres—1,2-benzoxathiine 2,2-dioxides

S. Belyakov, P. Trapencieris, A. Grandane, 2012 .

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of medicinal chemistry.

Recent advances in sultone synthesis (microreview)

R. Žalubovskis, Aleksandrs Pustenko, 2017, Chemistry of Heterocyclic Compounds.

Synthesis of 6-tetrazolyl-substituted sulfocoumarins acting as highly potent and selective inhibitors of the tumor-associated carbonic anhydrase isoforms IX and XII.

C. Supuran, M. Tanc, A. Grandane, 2014, Bioorganic & medicinal chemistry.

Enantioselective silicon–boron additions to cyclic 1,3-dienes catalyzed by the platinum group metal complexes

Martin Gerdin, C. Moberg, R. Žalubovskis, 2008 .

Influence of steric symmetry and electronic dissymmetry on the enantioselectivity in palladium-catalyzed allylic substitutions.

C. Moberg, R. Žalubovskis, J. Vasse, 2003, The Journal of organic chemistry.

Synthetic Methods toward Phosphacoumarins (microreview)

R. Žalubovskis, Anastasija Balašova, 2022, Chemistry of Heterocyclic Compounds.

Derivatives of 4-methyl-1,2,3-benzoxathiazine 2,2-dioxide as selective inhibitors of human carbonic anhydrases IX and XII over the cytosolic isoforms I and II

C. Supuran, A. Nocentini, R. Žalubovskis, 2023, Journal of enzyme inhibition and medicinal chemistry.

1,2,3-Benzoxathiazine-2,2-dioxides – effective inhibitors of human carbonic anhydrases

C. Supuran, A. Nocentini, R. Žalubovskis, 2022, Journal of enzyme inhibition and medicinal chemistry.

4-(3-Alkyl/benzyl-guanidino)benzenesulfonamides as selective carbonic anhydrase VII inhibitors

C. Supuran, R. Žalubovskis, M. Abdoli, 2022, Journal of enzyme inhibition and medicinal chemistry.

Development of oxathiino[6,5-b]pyridine 2,2-dioxide derivatives as selective inhibitors of tumor-related carbonic anhydrases IX and XII.

C. Supuran, A. Nocentini, A. Grandane, 2020, European journal of medicinal chemistry.

7-Acylamino-3H-1,2-benzoxathiepine 2,2-dioxides as new isoform-selective carbonic anhydrase IX and XII inhibitors

C. Supuran, A. Nocentini, R. Žalubovskis, 2020, Journal of enzyme inhibition and medicinal chemistry.

5-Substituted-benzylsulfanyl-thiophene-2-sulfonamides with effective carbonic anhydrase inhibitory activity: Solution and crystallographic investigations.

C. Supuran, D. Vullo, A. Kazaks, 2017, Bioorganic & medicinal chemistry.

Synthesis of 6-aryl-substituted sulfocoumarins and investigation of their carbonic anhydrase inhibitory action.

C. Supuran, M. Tanc, A. Grandane, 2015, Bioorganic & medicinal chemistry.

5-Substituted-(1,2,3-triazol-4-yl)thiophene-2-sulfonamides strongly inhibit human carbonic anhydrases I, II, IX and XII: solution and X-ray crystallographic studies.

C. Supuran, K. Tārs, M. Tanc, 2013, Bioorganic & medicinal chemistry.

Base-Free Catalytic Wittig-/Cross-Coupling Reaction Sequence as Short Synthetic Strategy for the Preparation of Highly Functionalized Arylbenzoxepinones

T. Werner, A. Grandane, R. Žalubovskis, 2021, Synthesis.

Self-adaptable catalysts: substrate-dependent ligand configuration.

C. Moberg, D. Linder, A. Fischer, 2008, Journal of the American Chemical Society.

Inhibitors of Selected Bacterial Metalloenzymes.

J. Winum, R. Žalubovskis, 2019, Current medicinal chemistry.

3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII

C. Supuran, A. Nocentini, R. Žalubovskis, 2022, Journal of enzyme inhibition and medicinal chemistry.

6-Triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrases IX and XII.

C. Supuran, M. Tanc, A. Grandane, 2014, Bioorganic & medicinal chemistry letters.

Investigation of novel alkyl/benzyl (4-sulphamoylphenyl)carbamimidothioates as carbonic anhydrase inhibitors

C. Supuran, R. Žalubovskis, Alessandro Bonardi, 2023, Journal of enzyme inhibition and medicinal chemistry.

Benzenesulfonamides Incorporating Hydantoin Moieties Effectively Inhibit Eukaryoticand Human Carbonic Anhydrases

C. Supuran, V. De Luca, C. Capasso, 2022, International journal of molecular sciences.

Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.

C. Supuran, A. Kazaks, K. Tārs, 2015, Journal of medicinal chemistry.

2-((1H-Benzo[d]imidazol-2-yl)amino)benzo[d]thiazole-6-sulphonamides: a class of carbonic anhydrase II and VII-selective inhibitors

C. Supuran, R. Žalubovskis, M. Abdoli, 2023, Journal of enzyme inhibition and medicinal chemistry.

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases

C. Supuran, V. De Luca, C. Capasso, 2023, Journal of enzyme inhibition and medicinal chemistry.

Combining carbonic anhydrase and thioredoxin reductase inhibitory motifs within a single molecule dramatically increases its cytotoxicity

C. Supuran, V. Sharoyko, T. Tennikova, 2020, Journal of enzyme inhibition and medicinal chemistry.

Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase

C. Supuran, A. Grandane, R. Žalubovskis, 2020, Journal of enzyme inhibition and medicinal chemistry.

Sulfocoumarins, specific carbonic anhydrase IX and XII inhibitors, interact with cancer multidrug resistant phenotype through pH regulation and reverse P-glycoprotein mediated resistance.

M. Pešić, J. Dinić, Tijana Stankovic, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

X-ray crystallographic and kinetic investigations of 6-sulfamoyl-saccharin as a carbonic anhydrase inhibitor.

V. Alterio, A. Di Fiore, G. De Simone, 2015, Organic & biomolecular chemistry.

6‐Triazolyl‐Substituted Sulfocoumarins Are Potent, Selective Inhibitors of the Tumor‐Associated Carbonic Anhydrases IX and XII.

C. Supuran, M. Tanc, A. Grandane, 2014 .

Response to Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.

S. Carradori, C. Supuran, S. Dedhar, 2020, Biophysical journal.

Aryl derivatives of 3H-1,2-benzoxathiepine 2,2-dioxide as carbonic anhydrase inhibitors

C. Supuran, A. Alafeefy, A. Nocentini, 2019, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, and biological evaluation of novel derivatives of dithiodiglycolic acid prepared via oxidative coupling of thiols

M. Pešić, R. Žalubovskis, M. Krasavin, 2019, Journal of enzyme inhibition and medicinal chemistry.

X-ray crystallography-promoted drug design of carbonic anhydrase inhibitors.

C. Supuran, A. Kazaks, K. Tārs, 2015, Chemical communications.

Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A

A. Alafeefy, R. Žalubovskis, M. E. El Shikh, 2017, Journal of enzyme inhibition and medicinal chemistry.

Further exploration of DVD-445 as a lead thioredoxin reductase (TrxR) inhibitor for cancer therapy: Optimization of potency and evaluation of anticancer potential.

M. Pešić, V. Sharoyko, T. Tennikova, 2020, European journal of medicinal chemistry.

Novel method for the preparation of 2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxides via a Curtius rearrangement

P. Trapencieris, R. Žalubovskis, E. M. Ivanova, 2012, Chemistry of Heterocyclic Compounds.

Novel Method for the Preparation of 2H‐1,2,4‐Benzothiadiazin‐3(4H)‐one 1,1‐Dioxides via a Curtius Rearrangement.

D. Borovika, P. Trapencieris, R. Žalubovskis, 2013 .

Synthesis of 6-sulfamoylsaccharin and study of its reactivity in alkylation reactions

P. Trapencieris, R. Žalubovskis, I. Vozny, 2012, Chemistry of Heterocyclic Compounds.

Hydrophobic Substituents of the Phenylmethylsulfamide Moiety Can Be Used for the Development of New Selective Carbonic Anhydrase Inhibitors

C. Supuran, P. Trapencieris, V. Alterio, 2014, BioMed research international.

Atropo/Tropo Flexibility: A Tool for Design and Synthesis of Self-Adaptable Inhibitors of Carbonic Anhydrases and Their Antiproliferative Effect.

C. Supuran, A. Kazaks, A. Nocentini, 2023, Journal of medicinal chemistry.

5-Membered cyclic hydroxamic acids as HDAC inhibitors

D. Borovika, P. Trapencieris, R. Žalubovskis, 2015, Journal of enzyme inhibition and medicinal chemistry.

4-Cyanamido-substituted benzenesulfonamides act as dual carbonic anhydrase and cathepsin inhibitors.

C. Supuran, M. Gütschow, R. Žalubovskis, 2023, Bioorganic chemistry (Print).

Synthesis of an 8-Membered Heterocycle from Saccharin and Leakadine

R. Žalubovskis, I. Vozny, A. Mishnev, 2012, Chemistry of Heterocyclic Compounds.

Inhibition Studies on Human and Mycobacterial Carbonic Anhydrases with N-((4-Sulfamoylphenyl)carbamothioyl) Amides

C. Supuran, S. Parkkila, A. Aspatwar, 2023, Molecules.

Sulfocoumarins (1,2-benzoxathiine-2,2-dioxides): a class of potent and isoform-selective inhibitors of tumor-associated carbonic anhydrases.

C. Supuran, A. Scozzafava, D. Vullo, 2013, Journal of medicinal chemistry.

May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

R. Žalubovskis, I. Kaņepe-Lapsa, A. Ņikitjuka, 2023, Molecules.