D. A. Abou El Ella

发表

Amido/ureidosubstituted benzenesulfonamides-isatin conjugates as low nanomolar/subnanomolar inhibitors of the tumor-associated carbonic anhydrase isoform XII.

C. Supuran, Mohamed Fares, H. Abdel‐Aziz, 2016, European journal of medicinal chemistry.

Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity.

Sameh Eid, Andrew G. Watts, K. Abouzid, 2013, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of novel quinazoline-based anti-inflammatory agents acting as PDE4B inhibitors.

D. A. Abou El Ella, N. S. Ismail, A. Esmat, 2015, Chemical & pharmaceutical bulletin.

A highly selective structure-based virtual screening model of Palm I allosteric inhibitors of HCV Ns5b polymerase enzyme and its application in the discovery and optimization of new analogues.

Amr H. Mahmoud, K. Abouzid, D. A. Abou El Ella, 2012, European journal of medicinal chemistry.

Design, synthesis, biological evaluation and dynamics simulation of indazole derivatives with antiangiogenic and antiproliferative anticancer activity.

Marawan Ahmed, K. Barakat, K. Abouzid, 2019, Bioorganic chemistry.

Molecular modeling study and synthesis of quinazolinone-arylpiperazine derivatives as α1-adrenoreceptor antagonists.

K. Abouzid, S. M. Abou-Seri, D. A. Abou El Ella, 2011, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of type-II VEGFR-2 inhibitors based on quinoxaline scaffold.

Nasser S. M. Ismail, K. Abouzid, D. A. Abou El Ella, 2014, Bioorganic chemistry.

Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.

C. Supuran, D. Vullo, D. A. Ibrahim, 2015, Bioorganic & medicinal chemistry.

Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.

D. A. Abou El Ella, Deena S. Lasheen, H. El-Subbagh, 2018, Bioorganic chemistry.

Synthesis of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety for evaluation as anticancer and radiosensitizing agents

D. A. Abou El Ella, M. Ghorab, H. Heiba, 2012, Medicinal Chemistry Research.

Design, synthesis and biological evaluation of some novel quinazolinone derivatives as potent apoptotic inducers.

S. M. Abou-Seri, D. A. Abou El Ella, Essam Eldin A Osman, 2018, Future medicinal chemistry.

Integrated structure-based activity prediction model of benzothiadiazines on various genotypes of HCV NS5b polymerase (1a, 1b and 4) and its application in the discovery of new derivatives.

Amr H. Mahmoud, K. Abouzid, D. A. Abou El Ella, 2012, Bioorganic & medicinal chemistry.

1-Piperazinylphthalazines as potential VEGFR-2 inhibitors and anticancer agents: Synthesis and in vitro biological evaluation.

Mamdouh M. Ali, Wagdy M. Eldehna, S. M. Abou-Seri, 2016, European journal of medicinal chemistry.

Analogue based drug design, synthesis, molecular docking and anticancer evaluation of novel chromene sulfonamide hybrids as aromatase inhibitors and apoptosis enhancers.

D. A. Abou El Ella, Ghada A Abdel-latif, M. Alsaid, 2016, European journal of medicinal chemistry.

Increasing the binding affinity of VEGFR-2 inhibitors by extending their hydrophobic interaction with the active site: Design, synthesis and biological evaluation of 1-substituted-4-(4-methoxybenzyl)phthalazine derivatives.

Mamdouh M. Ali, Wagdy M. Eldehna, S. M. Abou-Seri, 2016, European journal of medicinal chemistry.

Quinoxaline‐Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity

K. Abouzid, D. A. Abou El Ella, Nasser S M Ismail, 2016, Archiv der Pharmazie.

Molecular design and synthesis of certain new quinoline derivatives having potential anticancer activity.

D. A. Ibrahim, D. A. Abou El Ella, Amira M El-Motwally, 2015, European journal of medicinal chemistry.

Molecular modeling study and synthesis of novel pyrrolo[2,3-d]pyrimidines and pyrrolotriazolopyrimidines of expected antitumor and radioprotective activities.

D. A. Abou El Ella, E. Noaman, M. Ghorab, 2008, Bioorganic & medicinal chemistry.

Computer-Based Ligand Design and Synthesis of Some New Sulfonamides Bearing Pyrrole or Pyrrolopyrimidine Moieties Having Potential Antitumor and Radioprotective Activities

D. A. Abou El Ella, E. Noaman, M. Ghorab, 2007 .

Lonazolac analogues: molecular modeling, synthesis, and in vivo anti-inflammatory activity

K. Abouzid, J. Lehmann, D. A. Abou El Ella, 2009, Medicinal Chemistry Research.

Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.

D. A. Abou El Ella, Deena S. Lasheen, H. El-Subbagh, 2017, Bioorganic chemistry.

Novel series of 6-(2-substitutedacetamido)-4-anilinoquinazolines as EGFR-ERK signal transduction inhibitors in MCF-7 breast cancer cells.

F. Halaweish, Wagdy M. Eldehna, S. M. Abou-Seri, 2018, European journal of medicinal chemistry.

Design and Synthesis of New Quinoxaline Derivatives as Anticancer Agents and Apoptotic Inducers

K. Abouzid, Y. M. Nissan, D. A. Abou El Ella, 2019, Molecules.

Synthesis of some new thiazolopyrane and thiazolopyranopyrimidine derivatives bearing a sulfonamide moiety for evaluation as anticancer and radiosensitizing agents

D. A. Abou El Ella, M. Ghorab, H. Heiba, 2012, Medicinal Chemistry Research.

Novel quinoline-3-carboxamides (Part 2): Design, optimization and synthesis of quinoline based scaffold as EGFR inhibitors with potent anticancer activity.

S. Abbas, D. A. Abou El Ella, A. Esmat, 2017, Bioorganic chemistry.

ACE inhibitors hypothesis generation for selective design, synthesis and biological evaluation of 3-mercapto-2-methyl-propanoyl-pyrrolidine-3-imine derivatives as antihypertensive agents.

K. Abouzid, D. A. Abou El Ella, M. Ismail, 2009, Bioorganic & medicinal chemistry.

The natural isoflavone Biochanin‐A synergizes 5‐fluorouracil anticancer activity in vitro and in vivo in Ehrlich solid‐phase carcinoma model

S. Zada, M. Tolba, D. A. Abou El Ella, 2022, Phytotherapy research : PTR.

Indoline ureas as potential anti-hepatocellular carcinoma agents targeting VEGFR-2: Synthesis, in vitro biological evaluation and molecular docking.

S. Zada, Mohamed Fares, Mamdouh M. Ali, 2015, European journal of medicinal chemistry.

Novel 1,3-diaryl pyrazole derivatives bearing methylsulfonyl moiety: Design, synthesis, molecular docking and dynamics, with dual activities as anti-inflammatory and anticancer agents through selectively targeting COX-2.

D. A. Abou El Ella, Asmaa M. AboulMagd, H. Abdel-Rahman, 2022, Bioorganic chemistry.

Molecular modeling design, synthesis, and anti-hyprglycemic evaluation of certain 5-(aryl-alkoxy-benzylidine)-imidazolidine-2,4-dione derivatives as potential PPARγ agonists

K. Abouzid, D. A. Abou El Ella, M. Ismail, 2015, Medicinal Chemistry Research.

Molecular design and synthesis of HCV inhibitors based on thiazolone scaffold.

K. Abouzid, Sameh Eid, D. A. Abou El Ella, 2013, European journal of medicinal chemistry.

Discovery of potent thieno[2,3-d]pyrimidine VEGFR-2 inhibitors: Design, synthesis and enzyme inhibitory evaluation supported by molecular dynamics simulations.

K. Abouzid, D. A. Abou El Ella, R. Serya, 2021, Bioorganic chemistry.

Aromatase inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and molecular modeling studies of novel phenothiazine derivatives carrying sulfonamide moiety as hybrid molecules.

F. Ragab, D. A. Abou El Ella, M. Alsaid, 2017, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma.

N. Neamati, K. Abouzid, Y. Chai, 2018, European journal of medicinal chemistry.

Synthesis, docking studies and anti-inflammatory activity of some 2-amino-5,6,7,8-tetrahydroquinoline-3-carbonitriles and related compounds.

D. A. Abou El Ella, N. S. Ismail, M. Abdullah, 2009, Pharmazie.

Green analysis of newly approved binary omeprazole/aspirin mixture in presence of aspirin impurity using ultra-high-performance liquid chromatography and thin-layer chromatography methods.

D. A. Abou El Ella, Eglal A. Abdelaleem, Nessreen S. Abdelhamid, 2020, Biomedical chromatography : BMC.

Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

D. A. Abou El Ella, Deena S. Lasheen, A. Khalil, 2023, Scientific Reports.

Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells.

M. Henary, D. A. Abou El Ella, Eman Z Elrazaz, 2024, European journal of medicinal chemistry.

Molecular modeling design, synthesis, and anti-hyprglycemic evaluation of certain 5-(aryl-alkoxy-benzylidine)-imidazolidine-2,4-dione derivatives as potential PPARγ agonists

K. Abouzid, D. A. Abou El Ella, A. Lahham, 2014, Medicinal Chemistry Research.

FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives.

D. A. Abou El Ella, Deena S. Lasheen, Eman Z Elrazaz, 2024, European journal of medicinal chemistry.