Deena S. Lasheen

发表

Design, synthesis and 3D QSAR based pharmacophore study of novel imatinib analogs as antitumor-apoptotic agents.

Nasser S. M. Ismail, K. Abouzid, Iten M. Fawzy, 2018, Future medicinal chemistry.

Analogs design, synthesis and biological evaluation of peptidomimetics with potential anti-HCV activity.

Sameh Eid, Andrew G. Watts, K. Abouzid, 2013, Bioorganic & medicinal chemistry.

Phosphatidylinositol 3 kinase (PI3K) inhibitors as new weapon to combat cancer.

K. Abouzid, Deena S. Lasheen, Fatma M. Elmenier, 2019, European journal of medicinal chemistry.

Design and synthesis of benzothiazole-6-sulfonamides acting as highly potent inhibitors of carbonic anhydrase isoforms I, II, IX and XII.

C. Supuran, D. Vullo, D. A. Ibrahim, 2015, Bioorganic & medicinal chemistry.

Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.

D. A. Abou El Ella, Deena S. Lasheen, H. El-Subbagh, 2018, Bioorganic chemistry.

Design and synthesis of phthalazine-based compounds as potent anticancer agents with potential antiangiogenic activity via VEGFR-2 inhibition

Tamer M. Ibrahim, K. Abouzid, Deena S. Lasheen, 2019, Journal of enzyme inhibition and medicinal chemistry.

Molecular design, synthesis and biological evaluation of novel 1,2,5-trisubstituted benzimidazole derivatives as cytotoxic agents endowed with ABCB1 inhibitory action to overcome multidrug resistance in cancer cells

M. Wink, K. Abouzid, M. Sobeh, 2022, Journal of enzyme inhibition and medicinal chemistry.

Covalent EGFR Inhibitors: Binding Mechanisms, Synthetic Approaches, and Clinical Profiles

K. Abouzid, Deena S. Lasheen, M. Hossam, 2016, Archiv der Pharmazie.

Design, synthesis, molecular docking study, and biological evaluation of salicylaldimine derivatives as potential histone deacetylases inhibitors (HDACi) and anticancer agents

K. Abouzid, Deena S. Lasheen, Heba M Hesham, 2018 .

Click and Release: SO2 Prodrugs with Tunable Release Rates.

B. Wang, K. Abouzid, Deena S. Lasheen, 2017, Organic letters.

DESIGN AND SYNTHESIS OF PHTHALAZINE BASED DERIVATIVES AS POTENTIAL ANTICANCER AGENTS BY SalwaElmeligie

K. Abouzid, Deena S. Lasheen, Asmaa M. Aboul-Magd, 2018 .

Discovery of Potent VEGFR-2 Inhibitors based on Furopyrimidine and Thienopyrimidne Scaffolds as Cancer Targeting Agents

A. Mansour, K. Abouzid, Deena S. Lasheen, 2016, Scientific Reports.

Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.

D. A. Abou El Ella, Deena S. Lasheen, H. El-Subbagh, 2017, Bioorganic chemistry.

Toward discovery of mutant EGFR inhibitors; Design, synthesis and in vitro biological evaluation of potent 4-arylamino-6-ureido and thioureido-quinazoline derivatives.

P. Jänne, N. Farag, K. Abouzid, 2016, Bioorganic & medicinal chemistry.

Design and Synthesis of 4‐Anilinothieno[2,3‐d]pyrimidine‐Based Compounds as Dual EGFR/HER‐2 Inhibitors

K. Abouzid, Deena S. Lasheen, M. A. Hassan, 2016, Archiv der Pharmazie.

Identification of new pyrrolo[2,3-d]pyrimidines as potent VEGFR-2 tyrosine kinase inhibitors: Design, synthesis, biological evaluation and molecular modeling.

K. Abouzid, Deena S. Lasheen, R. Serya, 2018, Bioorganic chemistry.

3D-QSAR pharmacophore modelling, virtual screening and docking studies for lead discovery of a novel scaffold for VEGFR 2 inhibitors: Design, synthesis and biological evaluation.

N. Farag, K. Abouzid, Samar Mowafy, 2019, Bioorganic chemistry.

Pyrrolopyrimidine: A Versatile Scaffold for Construction of Targeted Anti-cancer Agents

K. Abouzid, Deena S. Lasheen, R. Serya, 2017 .

Selective Small Molecule Myeloid Cell Leukemia-1 (MCL-1) Inhibitors: Novel Agents in Cancer Therapy

Deena S. Lasheen, R. Serya, H. Ibrahim, 2019, Archives of Pharmaceutical Sciences Ain Shams University.

Synthesis, Characterization, and Evaluation of Cytotoxic Effects of Novel Hybrid Steroidal Heterocycles as PEG Based Nanoparticles

M. Zawrah, Deena S. Lasheen, S. Yahya, 2017, Asian Pacific journal of cancer prevention : APJCP.

Synthesis, ADMET Properties, and Biological Evaluation of Benzothiazole Compounds Targeting Chemokine Receptor 2 (CXCR2)

N. Neamati, Tiangong Lu, K. Abouzid, 2017, ChemMedChem.

Novel benzenesulfonamides aryl and arylsulfone conjugates adopting tail/dual tail approaches: Synthesis, carbonic anhydrase inhibitory activity and molecular modeling studies.

C. Supuran, A. Angeli, H. Abdel‐Aziz, 2021, European journal of medicinal chemistry.

How to train your inhibitor: Design strategies to overcome resistance to Epidermal Growth Factor Receptor inhibitors.

K. Abouzid, Deena S. Lasheen, R. Serya, 2017, European journal of medicinal chemistry.

Surmounting the resistance against EGFR inhibitors through the development of thieno[2,3-d]pyrimidine-based dual EGFR/HER2 inhibitors.

S. Minucci, K. Abouzid, Deena S. Lasheen, 2018, European journal of medicinal chemistry.

Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer

K. Abouzid, Deena S. Lasheen, Heba M Hesham, 2018, Medicinal research reviews.

Discovery of anilino-furo[2,3-d]pyrimidine derivatives as dual inhibitors of EGFR/HER2 tyrosine kinase and their anticancer activity.

A. Mansour, K. Abouzid, Deena S. Lasheen, 2018, European journal of medicinal chemistry.

Pyrrolopyrimidine, A Multifaceted Scaffold in Cancer Targeted Therapy

K. Abouzid, Deena S. Lasheen, R. Serya, 2018, Drug Research.

Elaborating piperazinyl-furopyrimidine based scaffolds as phosphoinositol-3-kinase enzyme alpha (PI3Kα) inhibitors to combat pancreatic cancer

K. Abouzid, Deena S. Lasheen, M. Mansour, 2020, RSC advances.

Identification of novel furo[2,3-d]pyrimidine based chalcones as potent anti-breast cancer agents: synthesis, in vitro and in vivo biological evaluation

K. Abouzid, Deena S. Lasheen, Zeinab A. Muhammad, 2022, RSC advances.

Synthesis and biological evaluation of novel 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives for the treatment of esophageal squamous cell carcinoma.

N. Neamati, K. Abouzid, Y. Chai, 2018, European journal of medicinal chemistry.

Apoptosis in cancer: from pathogenesis to discovery of advanced selective Bcl-2 family inhibitors

Deena S. Lasheen, N. Abdou, D. Ella, 2019, Archives of Pharmaceutical Sciences Ain Shams University.

A Fluorescence-Based Assay to Probe Inhibitory Effect of Fructose Mimics on GLUT5 Transport in Breast Cancer Cells

F. Wuest, K. Abouzid, Deena S. Lasheen, 2022, ACS bio & med chem Au.

Scaffold hopping and redesign approaches for quinazoline based urea derivatives as potent VEGFR-2 inhibitors.

K. Abouzid, D. Soliman, Deena S. Lasheen, 2020, Bioorganic chemistry.

Design, synthesis, and biological evaluation of new thieno[2,3-d] pyrimidine derivatives as targeted therapy for PI3K with molecular modelling study

K. Abouzid, Deena S. Lasheen, Fatma M. Elmenier, 2021, Journal of enzyme inhibition and medicinal chemistry.

Chimeric HDAC inhibitors: Comprehensive review on the HDAC‐based strategies developed to combat cancer

K. Abouzid, Deena S. Lasheen, Heba M Hesham, 2018, Medicinal research reviews.

Novel quinazolinone Derivatives: Design, synthesis and in vivo evaluation as potential agents targeting Alzheimer disease.

Hanan H. Georgey, Deena S. Lasheen, Eman Z Elrazaz, 2023, Bioorganic chemistry.

Design, molecular modelling and synthesis of novel benzothiazole derivatives as BCL-2 inhibitors

D. A. Abou El Ella, Deena S. Lasheen, A. Khalil, 2023, Scientific Reports.

FLT3-PROTACs for combating AML resistance: Analytical overview on chimeric agents developed, challenges, and future perspectives.

D. A. Abou El Ella, Deena S. Lasheen, Eman Z Elrazaz, 2024, European journal of medicinal chemistry.