J. Haendeler

A. Zeiher, S. Dimmeler, J. Haendeler, 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

The transcription factor Grainyhead like 3 (GRHL3) affects endothelial cell apoptosis and migration in a NO-dependent manner.

J. Altschmied, J. Haendeler, M. Lukosz, 2011, Biochemical and biophysical research communications.

A new kid on the block: PKD1: a promising target for antiangiogenic therapy?

J. Altschmied, J. Haendeler, 2008, Arteriosclerosis, thrombosis, and vascular biology.

c-Src-mediated activation of Erk1/2 is a reaction of epithelial cells to carbon nanoparticle treatment and may be a target for a molecular preventive strategy

K. Unfried, J. Haendeler, U. Sydlik, 2010, Biological chemistry.

Endothelial hyaluronan synthase 3 aggravates acute colitis in an experimental model of inflammatory bowel disease.

M. Grandoch, J. Fischer, U. Flögel, 2021, Matrix biology : journal of the International Society for Matrix Biology.

Mouse cardiac mitochondria do not separate in subsarcolemmal and interfibrillar subpopulations.

M. Totzeck, T. Rassaf, J. Altschmied, 2018, Mitochondrion.

Redox balance in the aged endothelium

J. Altschmied, J. Haendeler, L. L. Rabanter, 2013, Zeitschrift für Gerontologie und Geriatrie.

Cathepsin D and H2O2 Stimulate Degradation of Thioredoxin-1

A. Zeiher, S. Dimmeler, R. Popp, 2005, Journal of Biological Chemistry.

Differentiation of circulating endothelial progenitor cells to a cardiomyogenic phenotype depends on E‐cadherin

E. Chavakis, A. Zeiher, S. Dimmeler, 2005, FEBS letters.

Intra- and Interorgan Communication in the Cardiovascular System: A Special View on Redox Regulation.

A. Gödecke, J. Haendeler, 2017, Antioxidants & redox signaling.

Co‐expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions

G. Fraedrich, A. Zeiher, R. Hess, 1998, The Journal of pathology.

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

A. Zeiher, S. Dimmeler, I. Spyridopoulos, 2009, Arteriosclerosis, thrombosis, and vascular biology.

The role of near infrared radiation in photoaging of the skin

Jean Krutmann, P. Schroeder, J. Krutmann, 2008, Experimental Gerontology.

Protective Effects of Curcumin in Cardiovascular Diseases—Impact on Oxidative Stress and Mitochondria

M. Grandoch, J. Altschmied, J. Haendeler, 2022, Cells.

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

M. Nehls, A. Zeiher, S. Dimmeler, 1997, The Journal of experimental medicine.

Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2)

M. Denison, C. Vogel, T. Haarmann-Stemmann, 2015, Archives of Toxicology.

Inhibition of suicidal erythrocyte death by nitric oxide

R. Busse, F. Lang, Saisudha Koka, 2008, Pflügers Archiv - European Journal of Physiology.

Mitochondrial Telomerase Reverse Transcriptase Protects From Myocardial Ischemia/Reperfusion Injury by Improving Complex I Composition and Function

M. Grandoch, G. Heusch, K. Unfried, 2021, Circulation.

Cell-to-Cell Connection of Endothelial Progenitor Cells With Cardiac Myocytes by Nanotubes: A Novel Mechanism for Cell Fate Changes?

R. Brandes, A. Zeiher, S. Dimmeler, 2005, Circulation research.

Nuclear redox signaling.

J. Altschmied, J. Haendeler, M. Lukosz, 2010, Antioxidants & redox signaling.

MicroRNA-15b regulates mitochondrial ROS production and the senescence-associated secretory phenotype through sirtuin 4/SIRT4

Kai Stühler, Markus Uhrberg, Jean Krutmann, 2016, Aging.

Do we age on Sirt1 expression?

D. Sedding, J. Haendeler, 2007, Circulation research.

Aryl Hydrocarbon Receptor-Dependent and -Independent Pathways Mediate Curcumin Anti-Aging Effects

X. Coumoul, C. Esser, N. Ventura, 2022, bioRxiv.

Aryl hydrocarbon receptor-dependent and -independent pathways 1 mediate curcumin anti-aging effects 2

X. Coumoul, C. Esser, N. Ventura, 2022 .

Nitric Oxide Down-regulates MKP-3 mRNA Levels

A. Zeiher, S. Dimmeler, C. Urbich, 2000, The Journal of Biological Chemistry.

Nitric oxide and apoptosis.

A. Zeiher, S. Dimmeler, J. Haendeler, 1999, Vitamins and hormones.

SIRT1 controls endothelial angiogenic functions during vascular growth.

F. Alt, F. Dequiedt, E. Dejana, 2007, Genes & development.

Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR4-Dependent Signaling Pathway via the S1P3 Receptor

J. Chun, A. Zeiher, S. Dimmeler, 2006, Arteriosclerosis, thrombosis, and vascular biology.

Telomerase As a Therapeutic Target in Cardiovascular Disease.

I. Spyridopoulos, V. Andrés, J. Altschmied, 2021, Arteriosclerosis, thrombosis, and vascular biology.

Non-canonical functions of Telomerase Reverse Transcriptase – Impact on redox homeostasis

J. Rosen, J. Altschmied, J. Haendeler, 2020, Redox biology.

Well-known signaling proteins exert new functions in the nucleus and mitochondria.

G. Saretzki, J. Altschmied, J. Haendeler, 2010, Antioxidants & redox signaling.

Antioxidants Inhibit Nuclear Export of Telomerase Reverse Transcriptase and Delay Replicative Senescence of Endothelial Cells

Stefanie Dimmeler, Jörg Hoffmann, A. Zeiher, 2004, Circulation research.

Hydrogen Peroxide Triggers Nuclear Export of Telomerase Reverse Transcriptase via Src Kinase Family-Dependent Phosphorylation of Tyrosine 707

R. Brandes, A. Zeiher, S. Dimmeler, 2003, Molecular and Cellular Biology.

The hallmarks of fibroblast ageing

G. Reifenberger, J. Fischer, H. Reinke, 2014, Mechanisms of Ageing and Development.

Effects of physical exercise on myocardial telomere-regulating proteins, survival pathways, and apoptosis.

U. Laufs, M. Pfreundschuh, J. Bauersachs, 2008, Journal of the American College of Cardiology.

HMG-CoA Reductase Inhibitors Reduce Senescence and Increase Proliferation of Endothelial Progenitor Cells via Regulation of Cell Cycle Regulatory Genes

W. Hofmann, A. Zeiher, S. Dimmeler, 2003, Circulation research.

Aging Enhances the Sensitivity of Endothelial Cells Toward Apoptotic Stimuli: Important Role of Nitric Oxide

A. Zeiher, S. Dimmeler, L. Rössig, 2001, Circulation research.

Partial frataxin suppression in Caenorhabditis elegans reduces tumor formation by dampening the RAS/MAPk signaling

N. Ventura, J. Haendeler, Natascia Ventura, 2017 .

Physical Exercise Prevents Cellular Senescence in Circulating Leukocytes and in the Vessel Wall

Thomas Widmann, Wilfried Kindermann, U. Laufs, 2009, Circulation.

High Concentration of Low-Density Lipoprotein Results in Disturbances in Mitochondrial Transcription and Functionality in Endothelial Cells

W. Kaisers, J. Altschmied, H. Schaal, 2019, Oxidative medicine and cellular longevity.

The role of junctional adhesion molecule‐C (JAM‐C) in oxidized LDL‐mediated leukocyte recruitment

E. Chavakis, K. Preissner, R. Bohle, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Date of Patent : ( 54 ) USE OF ONION EXTRACTS TO PREVENT AND TREAT ACUTE AND CHRONIC CARDAC AND VASCULAR COMPLICATIONS AND THEIR SEQUELAE

E. Nabel, R. Westrick, D. Eitzman, 2017 .

Posttranslational Modification of Bcl-2 Facilitates Its Proteasome-Dependent Degradation: Molecular Characterization of the Involved Signaling Pathway

A. Zeiher, S. Dimmeler, J. Haendeler, 2000, Molecular and Cellular Biology.

Flavanol Consumption in Healthy Men Preserves Integrity of Immunological‐Endothelial Barrier Cell Functions: Nutri(epi)genomic Analysis

K. Köhrer, W. V. Berghe, A. Rodriguez-Mateos, 2022, Molecular Nutrition & Food Research.

Cellular functions of the dual-targeted catalytic subunit of telomerase, telomerase reverse transcriptase — Potential role in senescence and aging

J. Altschmied, J. Haendeler, Nadine Dyballa-Rukes, 2014, Experimental Gerontology.

Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis.

A. Zeiher, S. Dimmeler, B. Assmus, 1998, Circulation research.

Changes of MMP-1 and collagen type Iα1 by UVA, UVB and IRA are differentially regulated by Trx-1

P. Schroeder, J. Krutmann, J. Haendeler, 2008, Experimental Gerontology.

The Aryl Hydrocarbon Receptor (AhR) in the Aging Process: Another Puzzling Role for This Highly Conserved Transcription Factor

N. Ventura, J. Haendeler, N. Ale-Agha, 2020, Frontiers in Physiology.

Shear stress inhibits apoptosis of human endothelial cells

M. Nehls, A. Zeiher, S. Dimmeler, 1996, FEBS letters.

Mitochondrial respiratory states and rates

Sharma, Whiejong M. Han, Duchen, 2019 .

Fluid Shear Stress Attenuates Hydrogen Peroxide–Induced c-Jun NH2-Terminal Kinase Activation via a Glutathione Reductase–Mediated Mechanism

Yuji Saito, C. Baines, B. Berk, 2002, Circulation research.

Selenoprotein T Protects Endothelial Cells against Lipopolysaccharide-Induced Activation and Apoptosis

J. Altschmied, H. Schaal, J. Haendeler, 2021, Antioxidants.

Angiotensin II-induced upregulation of MAP kinase phosphatase-3 mRNA levels mediates endothelial cell apotosis

A. Zeiher, S. Dimmeler, L. Rössig, 2002, Basic Research in Cardiology.

CDKN1B/p27 is localized in mitochondria and improves respiration-dependent processes in the cardiovascular system—New mode of action for caffeine

K. Köhrer, M. Grandoch, J. Fischer, 2018, PLoS biology.

Molecular mechanisms involved in endothelial cell aging: role of telomerase reverse transcriptase

J. Haendeler, S. Jakob, 2007, Zeitschrift für Gerontologie und Geriatrie.

Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells From Patients With Coronary Artery Disease

Stefanie Dimmeler, Jörg Hoffmann, C. Heeschen, 2005, Circulation research.

Interacting with thioredoxin-1--disease or no disease?

J. Sadoshima, J. Altschmied, J. Haendeler, 2013, Antioxidants & redox signaling.

Redox modification of cell signaling in the cardiovascular system.

J. Sadoshima, P. Eaton, S. Oka, 2012, Journal of molecular and cellular cardiology.

Oxidative Stress–Induced Degradation of Thioredoxin-1 and Apoptosis Is Inhibited by Thioredoxin-1–Actin Interaction in Endothelial Cells

J. Altschmied, J. Haendeler, Tim-Christian Zschauer, 2011, Arteriosclerosis, thrombosis, and vascular biology.

Thioredoxin-1 and endothelial cell aging: role in cardiovascular diseases.

J. Altschmied, J. Haendeler, 2009, Antioxidants & redox signaling.

Thioredoxin-1 and posttranslational modifications.

J. Haendeler, 2006, Antioxidants & redox signaling.

Protective role of thioredoxin‐1 in cardiovascular systems

J. Haendeler, 2005 .

Shear stress increases the amount of S‐nitrosylated molecules in endothelial cells: important role for signal transduction

S. Dimmeler, J. Haendeler, J. Hoffmann, 2003, FEBS letters.

Sphingosine-1-Phosphate Stimulates the Functional Capacity of Progenitor Cells by Activation of the CXCR 4-Dependent Signaling Pathway via the S 1 P 3 Receptor

J. Chun, A. Zeiher, S. Dimmeler, 2006 .

TNFalpha and oxLDL reduce protein S-nitrosylation in endothelial cells.

A. Zeiher, S. Dimmeler, J. Haendeler, 2001, The Journal of biological chemistry.

GIT1 Mediates Src-dependent Activation of Phospholipase Cγ by Angiotensin II and Epidermal Growth Factor*

R. Aebersold, M. Heller, Yuji Saito, 2003, Journal of Biological Chemistry.

Angiotensin II mediated signal transduction Important role of tyrosine kinases

B. Berk, J. Haendeler, 2000, Regulatory Peptides.

GIT1 Mediates Thrombin Signaling in Endothelial Cells: Role in Turnover of RhoA-Type Focal Adhesions

A. Ridley, K. Fujiwara, V. V. van Hinsbergh, 2004, Circulation research.

Cyclophilin A is a secreted growth factor induced by oxidative stress.

C. Yan, Y. Suh, B. Berk, 2000, Circulation research.

Hypoxic Induction of the Hypoxia-Inducible Factor Is Mediated via the Adaptor Protein Shc in Endothelial Cells

A. Zeiher, S. Dimmeler, J. Haendeler, 2002, Circulation research.

Interventions to slow cardiovascular aging: Dietary restriction, drugs and novel molecules

I. Spyridopoulos, C. Heiss, J. Haendeler, 2017, Experimental Gerontology.

The imbalanced redox status in senescent endothelial cells is due to dysregulated Thioredoxin-1 and NADPH oxidase 4

A. Shah, J. Altschmied, J. Haendeler, 2014, Experimental Gerontology.

Two Isoforms of Sister-of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and In Vivo

K. Köhrer, F. Guardiola-Serrano, R. Deenen, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Downregulation of ETS Rescues Diabetes-Induced Reduction of Endothelial Progenitor Cells

I. Spyridopoulos, F. Seeger, J. Altschmied, 2009, PloS one.

Measurement of Endothelium-Dependent Vasodilation in Mice—Brief Report

J. Fischer, A. Rodriguez-Mateos, M. Kelm, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Accessing Mitochondrial Protein Import in Living Cells by Protein Microinjection

V. Gordeliy, A. Schulga, T. Gensch, 2020, bioRxiv.

Nuclear Redox-Signaling Is Essential for Apoptosis Inhibition in Endothelial Cells—Important Role for Nuclear Thioredoxin-1

P. Schroeder, J. Altschmied, J. Haendeler, 2007, Arteriosclerosis, thrombosis, and vascular biology.

growthcontrols endothelial angiogenic functions during vascular

F. Alt, F. Dequiedt, E. Dejana, 2007 .

Inhibition of the p38 MAP kinase in vivo improves number and functional activity of vasculogenic cells and reduces atherosclerotic disease progression

A. Langheinrich, A. Zeiher, S. Dimmeler, 2010, Basic Research in Cardiology.

Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity

Min S. Park, Matteo Ottolini, M. Kalani, 2020, Circulation.

Inseparably tied: functional and antioxidative capacity of endothelial progenitor cells.

S. Dimmeler, J. Haendeler, 2006, Circulation research.

Judith Haendeler and Stefanie Dimmeler Inseparably Tied : Functional and Antioxidative Capacity of Endothelial Progenitor Cells

S. Dimmeler, J. Haendeler, 2006 .

Unhealthy diet and ultrafine carbon black particles induce senescence and disease associated phenotypic changes

K. Unfried, J. Altschmied, J. Haendeler, 2013, Experimental Gerontology.

The vascular NADPH oxidase subunit p47phox is involved in redox-mediated gene expression.

S. Holland, R. Busse, R. Brandes, 2002, Free radical biology & medicine.

The aryl hydrocarbon receptor promotes aging phenotypes across species

A. Eckers, C. Esser, N. Ventura, 2016, Scientific Reports.

The protonmotive force and respiratory control : Building blocks of mitochondrial physiology Part 1

Tretter, D., M. J., 2017 .

4-Methylumbelliferone improves the thermogenic capacity of brown adipose tissue

M. Grandoch, J. Fischer, M. Kinzig, 2019, Nature Metabolism.

Endothelial cells in health and disease.

A. Eckers, J. Haendeler, 2015, Antioxidants & redox signaling.

Effects of redox-related congeners of NO on apoptosis and caspase-3 activity.

A. Zeiher, S. Dimmeler, U. Weiland, 1997, Nitric oxide : biology and chemistry.

Caffeine Enhances Endothelial Repair by an AMPK-Dependent Mechanism

A. Zernecke, C. Weber, S. Fichtlscherer, 2008, Arteriosclerosis, thrombosis, and vascular biology.

Silver ion‐induced suicidal erythrocyte death

F. Lang, M. Sopjani, M. Föller, 2009, Journal of applied toxicology : JAT.

Role of Mitochondria in Environmentally and Dietary Modulated Age-Associated Diseases

N. Ventura, J. Haendeler, 2023, Cells.

Downregulation of mitochondrial telomerase reverse transcriptase induced by H2O2 is Src kinase dependent

J. Altschmied, J. Haendeler, M. Lukosz, 2010, Experimental Gerontology.

Carbon nanoparticles induce ceramide- and lipid raft-dependent signalling in lung epithelial cells: a target for a preventive strategy against environmentally-induced lung inflammation

M. Gotic, K. Unfried, S. Grether-Beck, 2012, Particle and Fibre Toxicology.

Dephosphorylation Targets Bcl-2 for Ubiquitin-dependent Degradation: A Link between the Apoptosome and the Proteasome Pathway

A. Zeiher, S. Dimmeler, J. Haendeler, 1999, The Journal of experimental medicine.

GIT1 Functions as a Scaffold for MEK1-Extracellular Signal-Regulated Kinase 1 and 2 Activation by Angiotensin II and Epidermal Growth Factor

G. Yin, B. Berk, J. Haendeler, 2004, Molecular and Cellular Biology.

"Shping 2" different cellular localizations - a potential new player in aging processes

J. Altschmied, J. Haendeler, S. Jakob, 2009, Aging.

Co‐expression of p53 and MDM2 in human atherosclerosis: implications for the regulation of cellularity of atherosclerotic lesions

G. Fraedrich, A. Zeiher, R. Hess, 1998, The Journal of pathology.

Critical regulators of endothelial cell functions: for a change being alternative.

J. Altschmied, J. Haendeler, Sabrina Farrokh, 2015, Antioxidants & redox signaling.

The protonmotive force and respiratory control: Building blocks of mitochondrial physiology

B. Bakker, T. Pulinilkunnil, J. Calbet, 2017 .

Nuclear Factor (Erythroid-Derived 2)-Like 2 and Thioredoxin-1 in Atherosclerosis and Ischemia/Reperfusion Injury in the Heart.

A. Eckers, N. Leitinger, J. Haendeler, 2017, Antioxidants & redox signaling.

Fluid shear stress stimulates phosphorylation of Akt in human endothelial cells: involvement in suppression of apoptosis.

A. Zeiher, S. Dimmeler, B. Assmus, 1998, Circulation research.

Thioredoxin: A Key Regulator of Cardiovascular Homeostasis

H. Yamawaki, B. Berk, J. Haendeler, 2003, Circulation research.

The Anti-Apoptotic Properties of APEX1 in the Endothelium Require the First 20 Amino Acids and Converge on Thioredoxin-1.

A. Eckers, J. Altschmied, J. Haendeler, 2017, Antioxidants & redox signaling.

Interacting with thioredoxin-1--disease or no disease?

J. Sadoshima, J. Altschmied, J. Haendeler, 2013, Antioxidants & redox signaling.

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1 ␤ –converting Enzyme (ice)-like and Cysteine Protease Protein (cpp)-32–like Proteases

J. Haendeler, S. Dimmeler, A. Zeiher, 1997 .

A Key Regulator of Cardiovascular Homeostasis General Function of Thioredoxin (trx) System Regulation of Reduction/oxidation (redox) Status in Cell Activation of Transcription Factors (nuclear Factor-␬b, Nuclear Receptors, and Ap-1) Growth-promoting Effects Thioredoxin in Vascular Endothelium and Sm

J. Haendeler, Bradford C. Berk, Hideyuki Yamawaki, 2022 .

Activation of the aryl hydrocarbon receptor by the widely used Src family kinase inhibitor 4-amino-5-(4-chlorophenyl)-7-(dimethylethyl)pyrazolo[3,4-d]pyrimidine (PP2)

M. Denison, C. Vogel, T. Haarmann-Stemmann, 2014, Archives of Toxicology.

Dose-Dependent Effects of Lipopolysaccharide on the Endothelium—Sepsis versus Metabolic Endotoxemia-Induced Cellular Senescence

J. Altschmied, J. Haendeler, P. Jakobs, 2024, Antioxidants.

Caffeine Inhibits Oxidative Stress- and Low Dose Endotoxemia-Induced Senescence—Role of Thioredoxin-1

J. Altschmied, J. Haendeler, Nadine Dyballa-Rukes, 2023, Antioxidants.

Abstract 1383: Mitochondrial Tert Enhances Mitochondria Functions In Vivo by Protecting Mitochondrial DNA Integrity from Oxidative Damage

J. Altschmied, S. Dröse, J. Haendeler, 2008 .