F. Rock

发表

An Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site

Vincent Hernandez, Stephen J Benkovic, Lucy Shapiro, 2007, Science.

A family of human receptors structurally related to Drosophila Toll.

G. Hardiman, R. Kastelein, J. Bazan, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Dual inhibition of αvβ6 and αvβ1 reduces fibrogenesis in lung tissue explants from patients with IPF

T. Desai, P. Wolters, L. Hooi, 2021, Respiratory Research.

Discovery of a Potent and Speci fi c M . tuberculosis Leucyl-tRNA Synthetase Inhibitor : ( S ) ‐ 3-( Aminomethyl )

David Barros, J. Plattner, Esther Pérez-Herrán, 2017 .

Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656).

David Barros, J. Plattner, Esther Pérez-Herrán, 2017, Journal of medicinal chemistry.

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

Malina A. Bakowski, A. Hoerauf, Laura J. Myhill, 2019, Journal of medicinal chemistry.

Overexpression and structure--function analysis of a bioengineered IL-2/IL-6 chimeric lymphokine.

M. Klein, F. Rock, M. Everett, 1992, Protein engineering.

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 2. Ketone Linked Analogs

J. McKerrow, S. Lustigman, J. Plattner, 2019, ACS infectious diseases.

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs

K. Jarnagin, A. Hoerauf, J. McKerrow, 2019, ACS infectious diseases.

Synthesis and SAR of novel benzoxaboroles as a new class of β-lactamase inhibitors.

Yi Xia, S. Baker, M. Meewan, 2011, Bioorganic & medicinal chemistry letters.

Molecular characterization and modular analysis of human MyD88.

G. Hardiman, R. Kastelein, J. Bazan, 1996, Oncogene.

Examining the Benefits of the Boron-Based Mechanism of Action and Physicochemical Properties of Tavaborole in the Treatment of Onychomycosis.

M. Ghannoum, Aditya K. Gupta, F. Rock, 2018, Journal of the American Podiatric Medical Association.

Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus.

Christopher F Stratton, T. Kirikae, P. Tonge, 2008, Biochemistry.

Roles of disulfide bonds in recombinant human interleukin 6 conformation.

M. Klein, P. Chong, F. Rock, 1994, Biochemistry.

The leptin haemopoietic cytokine fold is stabilized by an intrachain disulfide bond.

R. Kastelein, J. Bazan, S. Altmann, 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors

K. Jarnagin, F. Rock, Yong-Kang Zhang, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

R. Abagyan, K. Jarnagin, G. A. Lemieux, 2017, PLoS neglected tropical diseases.

Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase

Christopher B. Cooper, Lisa K. Woolhiser, J. Sacchettini, 2016, Antimicrobial Agents and Chemotherapy.

Design, synthesis, and structure-activity relationship of Trypanosoma brucei leucyl-tRNA synthetase inhibitors as antitrypanosomal agents.

Yaxue Zhao, B. Nare, Dawei Li, 2011, Journal of medicinal chemistry.

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013, Antimicrobial Agents and Chemotherapy.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

Binding of leptin to the soluble ectodomain of recombinant leptin receptor: a kinetic analysis by surface plasmon resonance.

R. Kastelein, B. Weig, J. Bazan, 1996, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

Structure-function analysis of the C-terminal segment of human interleukin-6.

M. Klein, S. Cockle, P. Chong, 1993, The Journal of biological chemistry.

Treatment of Skin Inflammation with Benzoxaborole Phosphodiesterase Inhibitors: Selectivity, Cellular Activity, and Effect on Cytokines Associated with Skin Inflammation and Skin Architecture Changes

K. Jarnagin, Olga Zemska, M. Meewan, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target

R. Abagyan, K. Jarnagin, G. A. Lemieux, 2017, PLoS neglected tropical diseases.

with Activity against Gram-negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013 .

Linking Phenotype to Kinase: Identification of a Novel Benzoxaborole Hinge-Binding Motif for Kinase Inhibition and Development of High-Potency Rho Kinase Inhibitors

K. Jarnagin, F. Rock, Yong-Kang Zhang, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Design, Synthesis, and Structure−Activity Relationship of Trypanosoma brucei Leucyl-tRNA Synthetase Inhibitors as Antitrypanosomal Agents

Yaxue Zhao, B. Nare, Dawei Li, 2011 .