Huahua Zhu

发表

The GLI1 splice variant TGLI1 promotes glioblastoma angiogenesis and growth.

Hu Zhu, R. Carpenter, H. Lo, 2014, Cancer letters.

The NCATS Pharmaceutical Collection: a 10-year update.

Ruili Huang, Paul Shinn, Anton Simeonov, 2019, Drug discovery today.

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

Ruili Huang, Anton Simeonov, Menghang Xia, 2018, Scientific Reports.

EGFR and EGFRvIII undergo stress- and EGFR kinase inhibitor-induced mitochondrial translocalization: A potential mechanism of EGFR-driven antagonism of apoptosis

F. Ali-Osman, H. Lo, Huahua Zhu, 2011, Molecular Cancer.

Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening

Olivia W. Lee, A. Jadhav, M. Hall, 2019, bioRxiv.

The Human Glioma-Associated Oncogene Homolog 1 (GLI1) Family of Transcription Factors in Gene Regulation and Diseases

H. Lo, Huahua Zhu, 2010, Current genomics.

Mining of high throughput screening database reveals AP-1 and autophagy pathways as potential targets for COVID-19 therapeutics

Ruili Huang, Anton Simeonov, Menghang Xia, 2020, Scientific Reports.

The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis

K. Watabe, R. Carpenter, H. Lo, 2015, OncoTarget.

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

F. Ali-Osman, H. Lo, Huahua Zhu, 2010, Molecular Cancer Research.

Constitutively Activated STAT3 Frequently Coexpresses with Epidermal Growth Factor Receptor in High-Grade Gliomas and Targeting STAT3 Sensitizes Them to Iressa and Alkylators

F. Ali-Osman, H. Lo, Huahua Zhu, 2008, Clinical Cancer Research.

Biological activity-based modeling identifies antiviral leads against SARS-CoV-2

Emily M. Lee, Catherine Z. Chen, Ruili Huang, 2021, Nature Biotechnology.

Pyrazole-Based Lactate Dehydrogenase (LDH) Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties.

D. Urban, A. Jadhav, C. Dang, 2020, Journal of medicinal chemistry.

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.

F. Ali-Osman, H. Lo, A. Aldrich, 2009, Cancer research.

Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice.

Alissa M. Hummer, Mitchell Ho, M. Hall, 2020, Gastroenterology.

Expanding biological space coverage enhances the prediction of drug adverse effects in human using in vitro activity profiles

Ruili Huang, C. Austin, M. Xia, 2018, Scientific Reports.

Human GPR17 missense variants identified in metabolic disease patients have distinct downstream signaling profiles

Jason M. Conley, M. Hall, Hongmao Sun, 2021, The Journal of biological chemistry.

EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.

S. Keir, F. Ali-Osman, H. Lo, 2010, Cancer letters.

Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH).

D. Urban, A. Jadhav, C. Dang, 2017, Journal of medicinal chemistry.

Massive-scale biological activity-based modeling identifies novel antiviral leads against SARS-CoV-2

Christopher P. Austin, Wei Zheng, Anton Simeonov, 2020, bioRxiv.

An electrophilic fragment screening for the development of small molecules targeting caspase-2.

K. Ashe, M. Hall, Hongmao Sun, 2023, European journal of medicinal chemistry.

Cyclooxygenase-2 Is a Novel Transcriptional Target of the Nuclear EGFR-STAT3 and EGFRvIII-STAT3 Signaling Axes

F. Ali-Osman, H. Lo, Huahua Zhu, 2010, Molecular Cancer Research.

A novel splice variant of GLI1 that promotes glioblastoma cell migration and invasion.

F. Ali-Osman, H. Lo, A. Aldrich, 2009, Cancer research.