T. Leone

发表

Energy Metabolic Reprogramming in the Hypertrophied and Early Stage Failing Heart: A Multisystems Approach

Rick B. Vega, A. Attie, A. Broman, 2014, Circulation. Heart failure.

A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders.

D. Kelly, C. Weinheimer, T. Leone, 1999, Proceedings of the National Academy of Sciences of the United States of America.

The cardiac phenotype induced by PPARalpha overexpression mimics that caused by diabetes mellitus.

Xianlin Han, M. Welch, R. Gross, 2002, The Journal of clinical investigation.

Role of adiponectin in the protective action of dietary saturated fat against alcoholic fatty liver in mice

D. Crabb, R. Considine, D. Kelly, 2005, Hepatology.

Increased ketone body oxidation provides additional energy for the failing heart without improving cardiac efficiency.

K. Gopal, D. Muoio, G. Lopaschuk, 2019, Cardiovascular research.

A Role for Peroxisome Proliferator-activated Receptor γ Coactivator 1 (PGC-1) in the Regulation of Cardiac Mitochondrial Phospholipid Biosynthesis*♦

Rick B. Vega, Xianlin Han, Miao Wang, 2013, The Journal of Biological Chemistry.

Toll-like Receptor-mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-activated Receptor ␥ Coactivator-1 Signaling Clinical Perspective on P 482 Methods Animal Experiments and Generation Results Lps Stimulation Suppresses Cardiac Mitochondrial

D. Kelly, J. Schilling, Ling Lai, 2022 .

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

J. Stamler, C. Hoppel, Fanghua Ye, 2015, The Journal of clinical investigation.

Skeletal muscle PGC-1β signaling is sufficient to drive an endurance exercise phenotype and to counteract components of detraining in mice.

Rick B. Vega, R. Fitts, J. Ayala, 2017, American journal of physiology. Endocrinology and metabolism.

Chronic Inhibition of Pyruvate Dehydrogenase in Heart Triggers an Adaptive Metabolic Response*

G. Lopaschuk, D. Kelly, B. Finck, 2011, The Journal of Biological Chemistry.

Decreased Contractile and Metabolic Reserve in Peroxisome Proliferator–Activated Receptor-&agr;–Null Hearts Can Be Rescued by Increasing Glucose Transport and Utilization

J. Balschi, R. Tian, D. Kelly, 2005, Circulation.

PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice.

C. Semenkovich, D. Kelly, K. Tordjman, 2001, The Journal of clinical investigation.

PGC1α Plays a Critical Role in TWEAK–Induced Cardiac Dysfunction

Mohit M. Jain, R. Liao, L. Burkly, 2013, PloS one.

Mitochondrial protein hyperacetylation in the failing heart.

Rick B. Vega, J. Coon, D. Pagliarini, 2016, JCI insight.

Interaction between the UCP2 -866 G>A polymorphism, diabetes, and β-blocker use among patients with acute coronary syndromes

J. Spertus, M. Province, I. Zineh, 2010, Pharmacogenetics and genomics.

Ketone Ester Treatment Improves Cardiac Function and Reduces Pathologic Remodeling in Preclinical Models of Heart Failure

R. D. de Boer, E. Verdin, H. Silljé, 2020, Circulation. Heart failure.

Liver-Specific PGC-1beta Deficiency Leads to Impaired Mitochondrial Function and Lipogenic Response to Fasting-Refeeding

S. Burgess, D. Kelly, B. Finck, 2012, PloS one.

Calcineurin and Calcium/Calmodulin-dependent Protein Kinase Activate Distinct Metabolic Gene Regulatory Programs in Cardiac Muscle*

J. Neilson, F. Chen, D. Kelly, 2004, Journal of Biological Chemistry.

The nuclear receptor PPARβ/δ programs muscle glucose metabolism in cooperation with AMPK and MEF2.

J. Ayala, J. Holloszy, D. Kelly, 2011, Genes & development.

Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPAR&agr;

E. Lewandowski, E. Abel, D. Kelly, 2010, Circulation Research.

Transcriptional Control of Mitochondrial Biogenesis and Maturation

Rick B. Vega, D. Kelly, R. Vega, 2014 .

The Human Medium Chain Acyl-CoA Dehydrogenase Gene Promoter Consists of a Complex Arrangement of Nuclear Receptor Response Elements and Sp1 Binding Sites (*)

D. Kelly, S. Cresci, D. Lala, 1995, The Journal of Biological Chemistry.

Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: role for nuclear receptors in cardiac and brown adipose expression

P. A. Wood, Richard Vega, P. Wood, 1996, Molecular and cellular biology.

Mitochondrial transcription factor A is increased but expression of ATP synthase beta subunit and medium-chain acyl-CoA dehydrogenase genes are decreased in hearts of copper-deficient rats.

D. Kelly, T. Leone, D. Medeiros, 2000, The Journal of nutrition.

Ketone body metabolism declines with age in mice in a sex-dependent manner

B. Schilling, D. Kelly, John C Newman, 2022, bioRxiv.

Diminished hepatic gluconeogenesis via defects in tricarboxylic acid cycle flux in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha)-deficient mice.

S. Burgess, A. Sherry, C. Malloy, 2006, The Journal of biological chemistry.

Ketone body metabolism declines with age in mice in a sex-dependent manner

B. Schilling, D. Kelly, John C Newman, 2022, bioRxiv.

Energy Metabolic Re-Programming in the Hypertrophied and Early Stage Failing Heart: A Multi-systems Approach Lai et al: Metabolic Remodeling in Heart Failure

Rick B. Vega, A. Attie, A. Broman, 2014 .

Response to Handschin and Spiegelman

C. Zechner, D. Kelly, T. Leone, 2011 .

The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism.

F. Gonzalez, D. Kelly, F. Djouadi, 1999, Prostaglandins, leukotrienes, and essential fatty acids.

Response to Letter Regarding Article, “Toll-like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor γ Coactivator-I Signaling”

D. Kelly, J. Schilling, Ling Lai, 2011 .

Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs

H. Calkins, D. Judge, Huei-Sheng Vincent Chen, 2012, Nature.

Lipin 1 is an inducible amplifier of the hepatic PGC-1α/PPARα regulatory pathway

T. Harris, J. Lawrence, D. Kelly, 2006 .

The Failing Heart Relies on Ketone Bodies as a Fuel

Rick B. Vega, E. Lewandowski, C. Hoppel, 2016, Circulation.

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Rick B. Vega, J. Auwerx, E. Olson, 2013, The Journal of clinical investigation.

PGC-1α Deficiency Causes Multi-System Energy Metabolic Derangements: Muscle Dysfunction, Abnormal Weight Control and Hepatic Steatosis

Michael Courtois, E. Dale Abel, R. Schmidt, 2005, PLoS Biology.

A Role for Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

A. Attie, A. Zorzano, D. Muoio, 2014, Circulation research.

The transcriptional coactivator PGC-1alpha is essential for maximal and efficient cardiac mitochondrial fatty acid oxidation and lipid homeostasis.

Xianlin Han, E. Lewandowski, E. Abel, 2008, American journal of physiology. Heart and circulatory physiology.

PGC-1β and ChREBP partner to cooperatively regulate hepatic lipogenesis in a glucose concentration-dependent manner.

H. Towle, B. Finck, Ling Lai, 2013, Molecular metabolism.

Transcriptional control of cardiac fuel metabolism and mitochondrial function.

D. Kelly, T. Leone, 2011, Cold Spring Harbor symposia on quantitative biology.

Total skeletal muscle PGC-1 deficiency uncouples mitochondrial derangements from fiber type determination and insulin sensitivity.

C. Zechner, D. Wozniak, Zhen Yan, 2010, Cell metabolism.

Ubiquitin Proteasome-dependent Degradation of the Transcriptional Coactivator PGC-1α via the N-terminal Pathway*

A. Schwartz, D. Kelly, J. Trausch-Azar, 2010, The Journal of Biological Chemistry.

Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.

C. Zechner, D. Kelly, S. Kelly, 2008, Genes & development.

Diminished Hepatic Gluconeogenesis via Defects in Tricarboxylic Acid Cycle Flux in Peroxisome Proliferator-activated Receptor γ Coactivator-1α (PGC-1α)-deficient Mice*

S. Burgess, A. Sherry, C. Malloy, 2006, Journal of Biological Chemistry.

Deactivation of peroxisome proliferator-activated receptor-alpha during cardiac hypertrophic growth.

D. Kelly, C. Weinheimer, T. Leone, 2000, The Journal of clinical investigation.

Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathway.

T. Harris, J. Lawrence, D. Kelly, 2006, Cell metabolism.

Effect of endurance training on lipid metabolism in women: a potential role for PPARalpha in the metabolic response to training.

J. Horowitz, S. Klein, D. Kelly, 2000, American journal of physiology. Endocrinology and metabolism.

The role of the peroxisome proliferator-activated receptor α (PPARα) in the control of cardiac lipid metabolism

F. Gonzalez, D. Kelly, F. Djouadi, 1999 .

Dexamethasone induction of hypertension and diabetes is PPAR-α dependent in LDL receptor–null mice

R. Knutsen, R. Mecham, C. Semenkovich, 2003, Nature Medicine.

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.

D. Bers, T. Flagg, C. Nichols, 2009, American journal of physiology. Heart and circulatory physiology.

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

G. Knott, D. Kelly, B. Schneider, 2015, Acta neuropathologica communications.

PPARα suppresses insulin secretion and induces UCP2 in insulinoma cells

C. Semenkovich, D. Kelly, K. Tordjman, 2002 .

MondoA coordinately regulates skeletal myocyte lipid homeostasis and insulin signaling.

Rick B. Vega, Xianlin Han, G. Roth, 2016, The Journal of clinical investigation.

PGC-1α activity in nigral dopamine neurons determines vulnerability to α-synuclein

G. Knott, D. Kelly, B. Schneider, 2015, Acta Neuropathologica Communications.

Mitochondrial Dynamics During Postnatal Cardiac Growth Coactivator-1 in the Control of γ A Role for Peroxisome Proliferator-Activated Receptor

A. Attie, A. Zorzano, D. Muoio, 2014 .

wheel running in the mouse Cardiac and skeletal muscle adaptations to voluntary

Rick B. Vega, B. LaFleur, B. Harrison, 2015 .

PPARalpha suppresses insulin secretion and induces UCP2 in insulinoma cells.

C. Semenkovich, D. Kelly, K. Tordjman, 2002, Journal of lipid research.

Fueling Cardiac Hypertrophy.

D. Kelly, T. Leone, T. Matsuura, 2020, Circulation research.

PPAR signaling in the control of cardiac energy metabolism.

J. Huss, D. Kelly, C. Weinheimer, 2000, Trends in cardiovascular medicine.

A Role for Peroxisome Proliferator-Activated Receptor γ Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth

A. Attie, A. Zorzano, D. Muoio, 2022 .

Kruppel-like factor 4 is critical for transcriptional control of cardiac mitochondrial homeostasis.

J. Stamler, C. Hoppel, Fanghua Ye, 2015, The Journal of clinical investigation.

Toll-Like Receptor-Mediated Inflammatory Signaling Reprograms Cardiac Energy Metabolism by Repressing Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 Signaling

D. Kelly, J. Schilling, Ling Lai, 2011, Circulation. Heart failure.

Preferential Oxidation of Triacylglyceride-Derived Fatty Acids in Heart Is Augmented by the Nuclear Receptor PPAR&agr;

E. Lewandowski, E. Abel, D. Kelly, 2010, Circulation research.