S. Alsford

发表

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

Alejandro Sanchez-Flores, Christiane Hertz-Fowler, David Horn, 2011, Genome research.

Chemogenomic Profiling of Antileishmanial Efficacy and Resistance in the Related Kinetoplastid Parasite Trypanosoma brucei

D. Horn, S. Alsford, Clare F Collett, 2019, Antimicrobial Agents and Chemotherapy.

Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs

D. Horn, Joanna Szular, K. Seifert, 2017, Molecular microbiology.

University of Dundee Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging

D. Horn, Joanna Szular, K. Seifert, 2017 .

Receptor-mediated endocytosis for drug delivery in African trypanosomes: fulfilling Paul Ehrlich's vision of chemotherapy.

Mark C. Field, D. Horn, S. Alsford, 2013, Trends in parasitology.

Correction: Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

Mark C. Field, D. Horn, M. Zoltner, 2015, PLoS pathogens.

Epigenetic mechanisms, nuclear architecture and the control of gene expression in trypanosomes

Mark C. Field, D. Horn, S. Alsford, 2012, Expert Reviews in Molecular Medicine.

Elongator Protein 3b Negatively Regulates Ribosomal DNA Transcription in African Trypanosomes

D. Horn, S. Alsford, 2011, Molecular and Cellular Biology.

A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation

D. Horn, S. Alsford, Taemi Kawahara, 2007, Molecular microbiology.

Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei

D. Horn, Rachel B Currier, D. Rentsch, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cyclic AMP Effectors in African Trypanosomes Revealed by Genome-Scale RNA Interference Library Screening for Resistance to the Phosphodiesterase Inhibitor CpdA

A. Schnaufer, H. D. de Koning, D. Horn, 2013, Antimicrobial Agents and Chemotherapy.

NUP-1 Is a Large Coiled-Coil Nucleoskeletal Protein in Trypanosomes with Lamin-Like Functions

Mark C. Field, M. Rout, A. Ratushny, 2012, PLoS biology.

Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei

J. Mottram, D. Horn, R. McCulloch, 2017, PLoS pathogens.

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei

D. Horn, S. Alsford, 2012, Nucleic acids research.

Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF 1 A and CAF-1 b in Trypanosoma brucei

D. Horn, S. Alsford, 2012 .

Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms.

K. Gull, K. Ersfeld, S. Alsford, 1998, Trends in microbiology.

Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei.

B. Wickstead, K. Gull, K. Ersfeld, 2001, Molecular and biochemical parasitology.

Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression

Mark C. Field, B. Chait, M. Rout, 2016, Nucleic acids research.

VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes

D. Horn, S. Alsford, L. Glover, 2016, Proceedings of the National Academy of Sciences.

Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control

Mark C. Field, D. Horn, R. McCulloch, 2013, Cellular microbiology.

DNA breaks as triggers for antigenic variation in African trypanosomes

D. Horn, S. Alsford, L. Glover, 2009, Genome Biology.

Molecular forms of tegumental and muscle acetylcholinesterases of Schistosoma

S. Alsford, A. Agnew, M. Camacho, 1996, Parasitology.

Nicotinic acetylcholine receptors on the surface of the blood fluke Schistosoma.

A. Jones, S. Alsford, A. Agnew, 1995, Molecular and biochemical parasitology.

RNA polymerase I transcription stimulates homologous recombination in T. brucei

D. Horn, S. Alsford, 2013 .

RNA polymerase I transcription stimulates homologous recombination in Trypanosoma brucei.

D. Horn, S. Alsford, 2007, Molecular and biochemical parasitology.

RNA interference, growth and differentiation appear normal in African trypanosomes lacking Tudor staphylococcal nuclease

D. Horn, S. Alsford, Louise E. Kemp, 2010, Molecular and biochemical parasitology.

High-throughput decoding of anti-trypanosomal drug efficacy and resistance

Mark C. Field, D. Turner, M. Berriman, 2011, Nature.

Subverting lysosomal function in Trypanosoma brucei

S. Alsford, 2015, Microbial cell.

Insights into antitrypanosomal drug mode-of-action from cytology-based profiling

D. Horn, S. Alsford, L. Glover, 2018, PLoS neglected tropical diseases.

Genetic dissection of drug resistance in trypanosomes

D. Horn, J. Kelly, S. Alsford, 2013, Parasitology.

Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects.

D. Horn, S. Alsford, L. Glover, 2005, Molecular and biochemical parasitology.

Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6

D. Horn, S. Alsford, N. Baker, 2011, Molecular and biochemical parasitology.

A fluorescence in situ hybridisation study of the regulation of histone mRNA levels during the cell cycle of Trypanosoma brucei.

K. Gull, K. Ersfeld, S. Alsford, 1996, Molecular and biochemical parasitology.

Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei.

David Horn, D. Horn, S. Alsford, 2008, Molecular and biochemical parasitology.

Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest

D. Horn, S. Alsford, L. Glover, 2007, Nucleic acids research.

Telomeres, tethers and trypanosomes

Mark C. Field, M. Rout, D. Horn, 2012, Nucleus.

TbSAP is a novel chromatin protein repressing metacyclic variant surface glycoprotein expression sites in bloodstream form Trypanosoma brucei

B. Wickstead, G. Rudenko, B. Hall, 2021, Nucleic acids research.

Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes

Mark C. Field, D. Horn, M. Zoltner, 2015, PLoS pathogens.

Decoding the network of Trypanosoma brucei proteins that determines sensitivity to apolipoprotein-L1

A. MacLeod, Rachel B Currier, S. Alsford, 2018, PLoS pathogens.

Two essential MYST-family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes

G. Cross, D. Horn, S. Alsford, 2008, Molecular Microbiology.

DNA Break Site at Fragile Subtelomeres Determines Probability and Mechanism of Antigenic Variation in African Trypanosomes

D. Horn, S. Alsford, L. Glover, 2013, PLoS pathogens.

Cathepsin-L Can Resist Lysis by Human Serum in Trypanosoma brucei brucei

T. Clark, J. A. Guerra-Assunção, D. Horn, 2014, PLoS pathogens.

Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes

D. Turner, M. Berriman, C. Hertz-Fowler, 2014, Nature Protocols.

Multiplex analysis of RNA interference defects in Trypanosoma brucei.

D. Horn, S. Alsford, L. Glover, 2005, Molecular and biochemical parasitology.

Synthetic biology tools for engineering Goodwin oscillation in Trypanosoma brucei brucei

D. Nesbeth, Y. Borg, S. Alsford, 2022, Heliyon.

High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome.

D. Turner, M. Berriman, C. Hertz-Fowler, 2011, Genome research.