K. Saito

发表

Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency.

M. Takemura, M. Seishima, M. Heyes, 2000, American journal of physiology. Renal physiology.

Highly sensitive ELISA for soluble Fas in serum: increased soluble Fas in the elderly.

M. Takemura, M. Seishima, S. Minatoguchi, 1996, Clinical chemistry.

4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells).

S. Markey, M. Masana, M. Heyes, 1993, The Biochemical journal.

Species Heterogeneity Between Gerbils and Rats: Quinolinate Production by Microglia and Astrocytes and Accumulations in Response to Ischemic Brain Injury and Systemic Immune Activation

K. Kawai, S. Markey, M. Proescholdt, 1997, Journal of neurochemistry.

Different kynurenine pathway enzymes limit quinolinic acid formation by various human cell types.

E. Major, Kuniaki Saito, M. Heyes, 1997, The Biochemical journal.

Sources of the neurotoxin quinolinic acid in the brain of HIV-1-infected patients and retrovirus-infected macaques.

A. Lackner, C. Achim, C. Wiley, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

DNA single-strand breaks by nitropyrenes and related compounds in Chinese hamster V79 cells.

T. Kamataki, R. Kato, K. Saito, 1984, Cancer letters.

IL-1 beta and TNF-alpha suppress apolipoprotein (apo) E secretion and apo A-I expression in HepG2 cells.

M. Seishima, H. Ishiguro, T. Nagatsu, 1998, Cytokine.

Metabolism of Cyanox in rat. II. Sex-related differences in oxidative dearylation and desulphuration

I. Nakatsuka, K. Saito, H. Kaneko, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Sex difference in the stereoselective metabolism of a new dihydropyridine calcium channel blocker, in rat studies in vivo and in vitro.

K. Shiratori, F. Takayama, Y. Ishii, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

Significant reduction of 125 I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease.

M. Takemura, H. Fujiwara, H. Takatsu, 2002, Nuclear medicine communications.

Metabolism of l‐Tryptophan to Kynurenate and Quinolinate in the Central Nervous System: Effects of 6‐Chlorotryptophan and 4‐Chloro‐3‐Hydroxyanthranilate

M. Heyes, K. Saito, Cai-yu Chen, 1995, Journal of neurochemistry.

Quinolinic Acid Levels in a Murine Retrovirus‐Induced Immunodeficiency Syndrome

P. Skolnick, I. Paul, M. Heyes, 1996, Journal of neurochemistry.

Mechanism of Delayed Increases in Kynurenine Pathway Metabolism in Damaged Brain Regions Following Transient Cerebral Ischemia

S. Markey, M. Heyes, T. Nowak, 1993, Journal of neurochemistry.

DNA-adduct formation in the forestomach of rats treated with 3-tert-butyl-4-hydroxyanisole and its metabolites as assessed by an enzymatic 32P-postlabeling method.

A. Yoshitake, M. Hirose, J. Miyamoto, 1989, Cancer letters.

Acetyl coenzyme A dependent activation of N-hydroxy derivatives of carcinogenic arylamines: mechanism of activation, species difference, tissue distribution, and acetyl donor specificity.

T. Kamataki, R. Kato, K. Saito, 1986, Cancer research.

Tumor necrosis factor-alpha (TNF-alpha) plays a protective role in acute viralmyocarditis in mice: A study using mice lacking TNF-alpha.

M. Seishima, Kuniaki Saito, T. Kanda, 2001, Circulation.

A mechanism of quinolinic acid formation by brain in inflammatory neurological disease. Attenuation of synthesis from L-tryptophan by 6-chlorotryptophan and 4-chloro-3-hydroxyanthranilate.

E. Major, S. Milstien, S. Markey, 1993, Brain : a journal of neurology.

Colitis in Mice Induced - 2,4,6-Trinitrobenzene Sulfate IDO1 Plays an Immunosuppressive Role in

H. Tomita, Y. Hatano, A. Hirata, 2013 .

Effects of immune activation on quinolinic acid and neuroactive kynurenines in the mouse

S. Markey, M. Heyes, K. Saito, 1992, Neuroscience.

3-Hydroxyanthranilic acid, an L-tryptophan metabolite, induces apoptosis in monocyte-derived cells stimulated by interferon- γ

M. Takemura, M. Seishima, Kuniaki Saito, 2001, Annals of clinical biochemistry.

A mechanism for increased quinolinic acid formation following acute systemic immune stimulation.

S. Markey, M. Heyes, K. Saito, 1993, The Journal of biological chemistry.

Spin-Trapping Study on the Hydroxyl Radical Formed from a Tea Catechin-Cu(II) System

Kieko Saito, H. Yoshioka, K. Saito, 2001, Bioscience, biotechnology, and biochemistry.

Increased serum soluble Fas (sFas) concentrations in HCV-positive patients with liver cirrhosis.

M. Takemura, M. Seishima, K. Saito, 1997, Journal of hepatology.

Significant reduction of 125I-meta-iodobenzylguanidine accumulation directly caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydroxypyridine, a toxic agent for inducing experimental Parkinson's disease

M. Takemura, H. Fujiwara, H. Takatsu, 2002 .

Modification of hepato- and renal carcinogenesis by catechol and its isomers in rats pretreated with N-ethyl-N-hydroxyethylnitrosamine.

M. Hirose, M. Futakuchi, K. Saito, 1993, Teratogenesis, carcinogenesis, and mutagenesis.

Age-related changes in metabolism of diethofencarb: relationship between metabolism in rat and hepatic drug-metabolizing enzyme activities.

A. Yoshitake, H. Yamada, K. Saito, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

The relationship between plasma and brain quinolinic acid levels and the severity of hepatic encephalopathy.

M. Heyes, R. Hughes, R. Williams, 1995, Gastroenterology.

Lipopolysaccharide induction of indoleamine 2,3‐dioxygenase is mediated dominantly by an IFN‐γ‐independent mechanism

M. Seishima, Kuniaki Saito, O. Takikawa, 2001, European journal of immunology.

Fast-atom bombardment and electron-impact mass spectrometry of N-hydroxyarylamines, active intermediates of mutagenic aromatic amines.

T. Kamataki, R. Kato, K. Saito, 1985, Xenobiotica; the fate of foreign compounds in biological systems.

Glutathione conjugation of arylnitroso compound: detection and monitoring labile intermediates in situ inside a fast atom bombardment mass spectrometer.

K. Saito, R. Kato, 1984, Biochemical and biophysical research communications.

Relationship between the level of serum L-tryptophan and its hepatic uptake and metabolism in rats with carbon tetrachloride-induced liver cirrhosis

K. Saito, Y. Ohta, I. Ishiguro, 1996, Amino Acids.

Viral Myocarditis in Mice Metabolites Regulate Type I IFNs of Acute Kynurenine Pathway - l-Tryptophan

Hiroyasu Ito, M. Seishima, Y. Osawa, 2012 .

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole (2- and 3-BHA) in the rat. (II): Metabolism in forestomach and covalent binding to tissue macromolecules.

A. Yoshitake, M. Hirose, J. Miyamoto, 1987, Toxicology.

A new assay for N-hydroxyarylamine O-acetyltransferase: reduction of N-hydroxyarylamines through N-acetoxyarylamines.

T. Kamataki, R. Kato, K. Saito, 1986, Analytical biochemistry.

ESR Imaging on a Solid-tumor-bearing Mouse Using Spin-labeled Dextran

H. Yoshioka, M. Tada, K. Saito, 2001, Bioscience, biotechnology, and biochemistry.

Nitric oxide formation during light-induced decomposition of phenyl N-tert-butylnitrone.

R. Mason, R. Cutler, W. Chamulitrat, 1993, The Journal of biological chemistry.

Hepatic UDP-glucuronyltransferase(s) activity toward thyroid hormones in rats: induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers.

A. Yoshitake, H. Yamada, K. Saito, 1991, Toxicology and applied pharmacology.

Species differences in L-tryptophan-kynurenine pathway metabolism: quantification of anthranilic acid and its related enzymes.

M. Takemura, M. Seishima, K. Saito, 1998, Archives of biochemistry and biophysics.

Quinolinic acid accumulation and functional deficits following experimental spinal cord injury.

A. Blight, Kuniaki Saito, M. Heyes, 1995, Brain : a journal of neurology.

Kynurenine 3-hydroxylase in brain: species activity differences and effect of gerbil cerebral ischemia.

S. Markey, M. Heyes, T. Nowak, 1993, Archives of biochemistry and biophysics.

Kynurenine Pathway Enzymes in Brain

M. Heyes, K. Saito, 1996 .

Quinolinic acid and kynurenine pathway metabolism in inflammatory and non-inflammatory neurological disease.

M. Demitrack, A. Lackner, W. Tourtellotte, 1992, Brain : a journal of neurology.

DNA binding of N-hydroxy-Trp-P-2 and N-hydroxy-Glu-P-1 by acetyl-CoA dependent enzyme in mammalian liver cytosol.

T. Kamataki, R. Kato, K. Saito, 1985, Carcinogenesis.

Dual Gas Treatment With Hydrogen and Carbon Monoxide Attenuates Oxidative Stress and Protects From Renal Ischemia-Reperfusion Injury.

T. Takai, H. Hirano, H. Azuma, 2018, Transplantation proceedings.

Generation of Nitric Oxide from Spin-trapping Agents under Oxidative Conditions.

H. Yoshioka, K. Saito, T. Ariga, 1998, Bioscience, biotechnology, and biochemistry.

PAF response to inflammatory and non-inflammatory stimuli.

K. Saito, 1996, Advances in experimental medicine and biology.

Interactions between the active metabolite of tryptophan pyrolysate mutagen, N-hydroxy-Trp-P-2, and lipids: the role of lipid peroxides in the conversion of N-hydroxy-Trp-P-2 to non-reactive forms.

T. Kamataki, R. Kato, K. Saito, 1983, Chemico-biological interactions.

Kynurenine pathway enzymes in brain. Properties of enzymes and regulation of quinolinic acid synthesis.

M. Heyes, K. Saito, 1996, Advances in experimental medicine and biology.

Kynurenine pathway metabolism in the galactosamine model of hepatic injury.

S. Markey, M. Seishima, M. Heyes, 1996, Advances in experimental medicine and biology.

Kynurenine Pathway Enzymes in Brain: Responses to Ischemic Brain Injury Versus Systemic Immune Activation

S. Markey, M. Heyes, T. Nowak, 1993, Journal of neurochemistry.

Metabolism of tetramethrin isomers in rat: IV. Tissues responsible for formation of reduced and hydrated metabolites.

I. Nakatsuka, K. Saito, H. Kaneko, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Metabolism of 2- and 3-tert-butyl-4-hydroxyanisole in the rat (III): Metabolites in the urine and feces.

A. Yoshitake, M. Hirose, J. Miyamoto, 1988, Toxicology.

Lack of significant estrogenic or antiestrogenic activity of pyrethroid insecticides in three in vitro assays based on classic estrogen receptor alpha-mediated mechanisms.

I. Nakatsuka, K. Saito, N. Ohe, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Mechanism of activation of proximate mutagens in Ames' tester strains: the acetyl-CoA dependent enzyme in Salmonella typhimurium TA98 deficient in TA98/1,8-DNP6 catalyzes DNA-binding as the cause of mutagenicity.

T. Kamataki, R. Kato, K. Saito, 1983, Biochemical and biophysical research communications.

An in vitro reporter gene assay method incorporating metabolic activation with human and rat S9 or liver microsomes.

K. Sumida, I. Nakatsuka, K. Saito, 2001, Biochemical and biophysical research communications.

Metabolism of imiprothrin isomers in rats: Biotransformation and excretion

I. Nakatsuka, K. Saito, H. Kaneko, 1995 .

Metabolism of Cyanox in the rat. I. Absorption, disposition, excretion and biotransformation.

H. Yamada, I. Nakatsuka, K. Saito, 1995, Xenobiotica; the fate of foreign compounds in biological systems.

Participation of cytochrome P-450 in reductive metabolism of 1-nitropyrene by rat liver microsomes.

T. Kamataki, R. Kato, K. Saito, 1984, Cancer research.

Human microglia convert l-tryptophan into the neurotoxin quinolinic acid.

E. Major, C. Achim, C. Wiley, 1992, The Biochemical journal.

Human macrophages convert L-tryptophan into the neurotoxin quinolinic acid.

S. Markey, M. Heyes, K. Saito, 1992, The Biochemical journal.

Evaluation of two different homogeneous assays for LDL-cholesterol in lipoprotein-X-positive serum.

M. Seishima, K. Saito, S. Fujigaki, 2000, Clinical chemistry.

Inter-relationships between quinolinic acid, neuroactive kynurenines, neopterin and beta 2-microglobulin in cerebrospinal fluid and serum of HIV-1-infected patients.

R. Price, B. Brew, S. Markey, 1992, Journal of neuroimmunology.

Cytokine and drug modulation of kynurenine pathway metabolism by blood mononuclear cells.

S. Markey, M. Seishima, M. Heyes, 1996, Advances in experimental medicine and biology.

Evaluation of in vitro methods for detecting the effects of various chemicals on the human progesterone receptor, with a focus on pyrethroid insecticides.

K. Sumida, I. Nakatsuka, K. Saito, 2001, Toxicology letters.

Species differences in the N-acetylation by liver cytosol of mutagenic heterocyclic aromatic amines in protein pyrolysates.

T. Kamataki, R. Kato, K. Saito, 1984, Carcinogenesis.

Metabolic activation of mutagenic N-hydroxyarylamines by O-acetyltransferase in Salmonella typhimurium TA98.

T. Kamataki, R. Kato, K. Saito, 1985, Archives of biochemistry and biophysics.

Inhibition of acetyl-coenzyme A dependent activation of N-hydroxyarylamines by phenolic compounds, pentachlorophenol and 1-nitro-2-naphthol.

T. Kamataki, R. Kato, K. Saito, 1986, Chemico-biological interactions.

Purification, properties and function of N-hydroxyarylamine O-acetyltransferase.

T. Kamataki, R. Kato, K. Saito, 1986, Advances in experimental medicine and biology.

Alpha 2u-globulins in the urine of male rats: a reliable indicator for alpha 2u-globulin accumulation in the kidney.

S. Uwagawa, I. Nakatsuka, K. Saito, 1996, Toxicology.

Catalysis of the covalent binding of 3-hydroxyamino-1-methyl-5H-pyrido[4,3-b]indole to DNA by a L-proline- and adenosine triphosphate-dependent enzyme in rat hepatic cytosol.

T. Kamataki, R. Kato, M. Shimada, 1985, Cancer research.

Activation and detoxication of N-hydroxy-Trp-P-2 by glutathione and glutathione transferases.

T. Kamataki, R. Kato, K. Saito, 1983, Carcinogenesis.

Metabolism of a new dihydropyridine calcium antagonist in rats and dogs.

Y. Iwasawa, K. Shiratori, F. Takayama, 1989, Xenobiotica; the fate of foreign compounds in biological systems.

N-hydroxyarylamine O-acetyltransferase in hamster liver: identity with arylhydroxamic acid N,O-acetyltransferase and arylamine N-acetyltransferase.

T. Kamataki, R. Kato, K. Saito, 1986, Journal of biochemistry.

Characterization of the L-tryptophan transport system in the liver of growing rats.

K. Saito, Y. Nagamura, Y. Ohta, 1991, Life sciences.

A spin trap, N-tert-butyl-alpha-phenylnitrone extends the life span of mice.

H. Yoshioka, R. Cutler, K. Saito, 1998, Bioscience, biotechnology, and biochemistry.

Increased human immunodeficiency virus (HIV) type 1 DNA content and quinolinic acid concentration in brain tissues from patients with HIV encephalopathy.

D. Kleiner, M. Heyes, P. Pizzo, 1995, The Journal of infectious diseases.

Quinolinic acid production is related to macrophage tropic isolates of HIV-1.

J. Corbeil, D. Cooper, B. Brew, 1995, Journal of neurovirology.

Induction of pterin synthesis is not required for cytokine-stimulated tryptophan metabolism.

S. Milstien, N. Sakai, S. Kaufman, 1993, The Biochemical journal.

Mode of L-tryptophan uptake into rat hepatocytes via trypsin-sensitive high-affinity transport system.

K. Saito, Y. Nagamura, Y. Ohta, 1986, Biochemistry international.

4-chloro-3-hydroxyanthranilate attenuate quinolinic acid accumulation in brain following transient cerebral ischemia in the gerbil.

S. Markey, M. Seishima, M. Heyes, 1996, Advances in experimental medicine and biology.

Relationship between L-tryptophan uptake and L-tryptophan 2,3-dioxygenase activity in rat hepatocytes.

K. Saito, Y. Nagamura, Y. Ohta, 1990, Biochemistry international.

L-tryptophan-kynurenine pathway metabolite 3-hydroxyanthranilic acid induces apoptosis in macrophage-derived cells under pathophysiological conditions.

M. Takemura, M. Seishima, K. Saito, 1999, Advances in experimental medicine and biology.

Increased serum soluble Fas, tumor necrosis factor alpha and interleukin 6 concentrations in generalized pustular psoriasis.

M. Takemura, M. Seishima, K. Saito, 1998, Dermatology.

Initial induction and subsequent reduction of alpha(2u)-globulin in urine and serum of mature male rats after repeated intraperitoneal injections of (anti)estrogen.

K. Saito, H. Kaneko, H. Nagahori, 2001, Toxicology.

Autonomic regulation after exercise evidenced by spectral analysis of heart rate variability in asthmatic children.

M. Seishima, N. Kondo, K. Saito, 2000, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

Role of tetrahydrobiopterin in cytokine-stimulated metabolism of tryptophan and hydroxylation of arginine.

S. Milstien, N. Sakai, S. Kaufman, 1993, Advances in experimental medicine and biology.

Quantification of anthranilic acid and its related enzyme activity in several different species.

M. Seishima, K. Saito, S. Fujigaki, 1999, Advances in experimental medicine and biology.

Release of nitric oxide from a spin trap, N-tert-butyl-alpha-phenylnitrone, under various oxidative conditions.

H. Yoshioka, R. Cutler, K. Saito, 1998, Biological & pharmaceutical bulletin.