D. Sillence

发表

Accumulation of Glycosphingolipids in Niemann-Pick C Disease Disrupts Endosomal Transport*

R. Dwek, W. V. van Blitterswijk, F. Platt, 2004, Journal of Biological Chemistry.

Treatment with miglustat reverses the lipid-trafficking defect in Niemann–Pick disease type C

R. Dwek, R. Lachmann, F. Platt, 2004, Neurobiology of Disease.

Relative acidic compartment volume as a lysosomal storage disorder-associated biomarker.

Anneliese O. Speak, A. Speak, H. Runz, 2014, The Journal of clinical investigation.

Niemann–Pick type C disease: cellular pathology and pharmacotherapy

D. Sillence, Simon Wheeler, 2019, Journal of neurochemistry.

Analysis of fluorescently labeled glycosphingolipid-derived oligosaccharides following ceramide glycanase digestion and anthranilic acid labeling.

R. Dwek, D. Priestman, Danielle Te Vruchte, 2004, Analytical biochemistry.

Glucosylceramide modulates endolysosomal pH in Gaucher disease.

D. Sillence, 2013, Molecular genetics and metabolism.

Article Title: the Association of Shiga-like Toxin with Detergent-resistant Membranes Is Modulated by Glucosylceramide and Is an Essential Requirement in the Endoplasmic Reticulum for a Cytotoxic Effect the Association of Shiga-like Toxin with Detergent- Resistant Membranes Is Modulated by Glucosylc

L. Johannes, F. Platt, Daniel C. Smith, 2022 .

Storage diseases: new insights into sphingolipid functions.

F. Platt, D. Sillence, 2003, Trends in cell biology.

Glucosylceramide modulates membrane traffic along the endocytic pathway Published, JLR Papers in Press, August 16, 2002. DOI 10.1194/jlr.M200232-JLR200

R. Dwek, F. Platt, V. Puri, 2002, Journal of Lipid Research.

New insights into glycosphingolipid functions--storage, lipid rafts, and translocators.

D. Sillence, 2007, International review of cytology.

Ceramide changes during FAS (CD95/APO-1) mediated programmed cell death are blocked with the ICE protease inhibitor zVAD.FMK

M. Jacobson, D. Sillence, D. Allan, 1997 .

Transport of (Glyco)Sphingolipids in and Between Cellular Membranes; Multidrug Transporters and Lateral Domains

G. van Meer, H. Sprong, R. Raggers, 1999, Bioscience reports.

The subcellular sites of sphingomyelin synthesis in BHK cells.

D. Sillence, D. Allan, S. Howitt, 1997, Biochimica et biophysica acta.

Glycosphingolipid storage leads to the enhanced degradation of the B cell receptor in Sandhoff disease mice

Danielle Te Vruchte, F. Platt, D. Sillence, 2010, Journal of Inherited Metabolic Disease.

Evidence against an early signalling role for ceramide in Fas-mediated apoptosis.

D. Sillence, D. Allan, 1997, The Biochemical journal.

Glycosphingolipids in endocytic membrane transport.

F. Platt, D. Sillence, 2004, Seminars in cell & developmental biology.

Utilization of phosphatidylcholine and production of diradylglycerol as a consequence of sphingomyelin synthesis.

D. Sillence, D. Allan, 1998, The Biochemical journal.

Apoptosis and signalling in acid sphingomyelinase deficient cells

D. Sillence, 2001, BMC Cell Biology.

Assays for transmembrane movement of sphingolipids.

G. van Meer, R. Raggers, D. Sillence, 2000, Methods in enzymology.

The Metabolic Fates and Cellular Functions of Myoinositol

I. Batty, C. Downes, C. Vaziri, 1993 .

Mechanisms of Gaucher disease pathogenesis.

D. Sillence, Simon Wheeler, 2015, Annals of translational medicine.

Repair of BHK cell surface ganglioside GM3 after its degradation by extracellular sialidase.

D. Sillence, D. Allan, 1998, Molecular membrane biology.

Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calcium

A. Galione, G. Churchill, F. Platt, 2008, Nature Medicine.

Cytosolic glucosylceramide regulates endolysosomal function in Niemann-Pick type C disease

P. Haberkant, D. Sillence, Simon Wheeler, 2019, Neurobiology of Disease.

Role of Multiple Drug Resistance Protein 1 in Neutral but Not Acidic Glycosphingolipid Biosynthesis*

C. Ackerley, C. Lingwood, D. Sillence, 2004, Journal of Biological Chemistry.

Assay for the transbilayer distribution of glycolipids. Selective oxidation of glucosylceramide to glucuronylceramide by TEMPO nitroxyl radicals.

G. van Meer, D. C. Neville, D. Harvey, 2000, Journal of lipid research.

Resynthesis of the Cell Surface Pool of Phosphatidylinositol

D. Sillence, M. G. Low, 1996 .

Hydrolysis of cell surface inositol phospholipid leads to the delayed stimulation of phosphatidylinositol synthesis in bovine aortic endothelial cells.

D. Sillence, M. G. Low, 1994, Biochimica et biophysica acta.

Lipid–Protein Interactions in Niemann–Pick Type C Disease: Insights from Molecular Modeling

R. Schmid, D. Sillence, Simon Wheeler, 2019, International journal of molecular sciences.

Subcellular distribution of agonist-stimulated phosphatidylinositol synthesis in 1321 N1 astrocytoma cells.

C. Downes, D. Sillence, 1993, The Biochemical journal.

1H NMR-Linked Urinary Metabolic Profiling of Niemann-Pick Class C1 (NPC1) Disease: Identification of Potential New Biomarkers using Correlated Component Regression (CCR) and Genetic Algorithm (GA) Analysis Strategies

R. M. Luque-Baena, D. Elizondo, P. Clayton, 2014 .

Lithium treatment of affective disorders: effects of lithium on the inositol phospholipid and cyclic AMP signalling pathways.

C. Downes, D. Sillence, 1992, Biochimica et biophysica acta.

Introduction: Glycosphingolipids in cell biology and disease.

F. Platt, D. Sillence, 2004, Seminars in cell & developmental biology.

Effect of antidepressant drugs on the brain sphingolipid system

E. Masiero, J. Masania, D. Sillence, 2020, Journal of psychopharmacology.

Glucosylceramide depletion disrupts endolysosomal function in GBA-linked Parkinson’s fibroblasts?

D. Sillence, M. Bhardwaj, Z. Kula, 2023, bioRxiv.