A. Treiber

发表

The pharmacokinetics and tissue distribution of the glucosylceramide synthase inhibitor miglustat in the rat

O. Morand, M. Clozel, A. Treiber, 2007, Xenobiotica; the fate of foreign compounds in biological systems.

Physiologically-Based Pharmacokinetic Modeling of Macitentan: Prediction of Drug–Drug Interactions

R. de Kanter, A. Treiber, P. Sidharta, 2016, Clinical Pharmacokinetics.

Design and optimization of new piperidines as renin inhibitors.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

Design and preparation of potent, nonpeptidic, bioavailable renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Journal of medicinal chemistry.

New classes of potent and bioavailable human renin inhibitors.

L. Prade, A. Treiber, S. Delahaye, 2009, Bioorganic & medicinal chemistry letters.

No influence of the endothelin receptor antagonist bosentan on basal and indomethacin‐induced reduction of cerebral blood flow in pigs

A. Gjedde, G. Cold, J. Astrup, 2003, Acta anaesthesiologica Scandinavica.

The Quest for the Best Dual Orexin Receptor Antagonist (Daridorexant) for the Treatment of Insomnia Disorders

C. Brotschi, A. Treiber, M. Raumer, 2020, ChemMedChem.

A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells.

M. Hafner, J. Huwyler, H. Kettiger, 2013, Toxicology in vitro : an international journal published in association with BIBRA.

Inhibitory and Inductive Effects of Rifampin on the Pharmacokinetics of Bosentan in Healthy Subjects

A. Treiber, J. Dingemanse, H. Dietrich, 2007, Clinical pharmacology and therapeutics.

Bosentan, a dual endothelin receptor antagonist, activates the pregnane X nuclear receptor.

U. Meyer, A. Treiber, J. Dingemanse, 2002, European journal of pharmacology.

Optimization of 2-phenyl-pyrimidine-4-carboxamides towards potent, orally bioavailable and selective P2Y(12) antagonists for inhibition of platelet aggregation.

M. Riederer, E. Meyer, A. Treiber, 2014, Bioorganic & medicinal chemistry letters.

Inhibition of Organic Anion Transporting Polypeptide-Mediated Hepatic Uptake Is the Major Determinant in the Pharmacokinetic Interaction between Bosentan and Cyclosporin A in the Rat

M. Clozel, A. Treiber, S. Delahaye, 2004, Journal of Pharmacology and Experimental Therapeutics.

Absorption, distribution, metabolism, and excretion of macitentan, a dual endothelin receptor antagonist, in humans

G. Hopfgartner, M. Seiberling, A. Treiber, 2012, Xenobiotica; the fate of foreign compounds in biological systems.

The endothelin receptor antagonist macitentan for the treatment of pulmonary arterial hypertension: A cross‐species comparison of its cytochrome P450 induction pattern

A. Treiber, S. Delahaye, C. Gnerre, 2020, Pharmacology research & perspectives.

Pharmacology of Macitentan, an Orally Active Tissue-Targeting Dual Endothelin Receptor Antagonist

M. Bolli, M. Iglarz, M. Clozel, 2008, Journal of Pharmacology and Experimental Therapeutics.

The discovery of N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-propylsulfamide (Macitentan), an orally active, potent dual endothelin receptor antagonist.

M. Bolli, M. Iglarz, M. Clozel, 2012, Journal of medicinal chemistry.

In vivo and in vitro studies exploring the pharmacokinetic interaction between bosentan, a dual endothelin receptor antagonist, and glyburide

M. Clozel, A. Treiber, J. Dingemanse, 2002, Clinical pharmacology and therapeutics.

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells.

M. Hafner, J. Huwyler, A. Treiber, 2011, Biochimica et biophysica acta.

Discovery of Highly Potent Dual Orexin Receptor Antagonists via a Scaffold‐Hopping Approach

M. Bolli, C. Brotschi, Stefan Abele, 2016, ChemMedChem.

Elucidation of the Metabolic Pathways and the Resulting Multiple Metabolites of Almorexant, a Dual Orexin Receptor Antagonist, in Humans

W. Wagner-Redeker, G. Hopfgartner, A. Treiber, 2013, Drug Metabolism and Disposition.

The metabolism and drug–drug interaction potential of the selective prostacyclin receptor agonist selexipag

R. de Kanter, A. Treiber, S. Delahaye, 2018, Xenobiotica; the fate of foreign compounds in biological systems.

Novel benzo[1,4]diazepin-2-one derivatives as endothelin receptor antagonists.

J. Marfurt, M. Bolli, É. Thorin, 2004, Journal of medicinal chemistry.

Novel S1P1 receptor agonists--part 1: From pyrazoles to thiophenes.

M. Bolli, Stefan Abele, A. Treiber, 2013, Journal of medicinal chemistry.

From Oxadiazole to Triazole Analogues: Optimization toward a Dual Orexin Receptor Antagonist with Improved in vivo Efficacy in Dogs

M. Bolli, C. Brotschi, A. Treiber, 2020, ChemMedChem.

Oxadiazole Derivatives as Dual Orexin Receptor Antagonists: Synthesis, Structure–Activity Relationships, and Sleep‐Promoting Properties in Rats

M. Bolli, C. Brotschi, A. Treiber, 2019, ChemMedChem.

Substituted pyrrolidin-2-ones: Centrally acting orexin receptor antagonists promoting sleep. Part 2.

C. Brotschi, A. Treiber, T. Sifferlen, 2015, Bioorganic & medicinal chemistry letters.

N-Glycine-sulfonamides as potent dual orexin 1/orexin 2 receptor antagonists.

A. Treiber, R. Koberstein, C. Boss, 2008, Bioorganic & medicinal chemistry letters.

The metabolism of the dual endothelin receptor antagonist macitentan in rat and dog

M. Bolli, A. Treiber, J. Segrestaa, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Piperidine-based renin inhibitors: upper chain optimization.

L. Prade, A. Treiber, D. Bur, 2010, Bioorganic & medicinal chemistry letters.

2-imino-thiazolidin-4-one derivatives as potent, orally active S1P1 receptor agonists.

M. Bolli, Stefan Abele, A. Treiber, 2010, Journal of medicinal chemistry.

The Use of Physiology-Based Pharmacokinetic and Pharmacodynamic Modeling in the Discovery of the Dual Orexin Receptor Antagonist ACT-541468

J. V. van Gerven, R. de Kanter, M. von Raumer, 2017, The Journal of Pharmacology and Experimental Therapeutics.

The use of physiology-based PK and PD modeling in the discovery of the dual orexin receptor antagonist ACT-541468

J. V. Gerven, A. Treiber, M. Raumer, 2017 .

4-((R)-2-{[6-((S)-3-Methoxypyrrolidin-1-yl)-2-phenylpyrimidine-4-carbonyl]amino}-3-phosphonopropionyl)piperazine-1-carboxylic Acid Butyl Ester (ACT-246475) and Its Prodrug (ACT-281959), a Novel P2Y12 Receptor Antagonist with a Wider Therapeutic Window in the Rat Than Clopidogrel.

D. Renneberg, M. Riederer, E. Meyer, 2015, Journal of medicinal chemistry.

Cross-species comparison of the metabolism and excretion of selexipag

A. Treiber, C. Gnerre, J. Segrestaa, 2019, Xenobiotica; the fate of foreign compounds in biological systems.

Surgical and pharmacological animal models used in drug metabolism and pharmacokinetics

A. Treiber, K. Landskroner, K.A. Landskroner, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

Bosentan Is a Substrate of Human OATP1B1 and OATP1B3: Inhibition of Hepatic Uptake as the Common Mechanism of Its Interactions with Cyclosporin A, Rifampicin, and Sildenafil

B. Stieger, A. Treiber, R. Schneiter, 2007, Drug Metabolism and Disposition.

Phase I and II metabolism and MRP2‐mediated export of bosentan in a MDCKII‐OATP1B1‐CYP3A4‐UGT1A1‐MRP2 quadruple‐transfected cell line

M. Mieth, J. König, A. Treiber, 2013, British journal of pharmacology.

ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor

S. Krähenbühl, M. Hafner, J. Huwyler, 2015, Pharmacology research & perspectives.

In vivo and in vitro disposition profile of tezosentan, an intravenous dual endothelin receptor antagonist, in humans

A. Treiber, J. Dingemanse, P. V. van Giersbergen, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Clinical Pharmacokinetics and Pharmacodynamics of the Endothelin Receptor Antagonist Macitentan

A. Treiber, J. Dingemanse, P. Sidharta, 2015, Clinical Pharmacokinetics.

Effect of Cyclosporine and Rifampin on the Pharmacokinetics of Macitentan, a Tissue-Targeting Dual Endothelin Receptor Antagonist

A. Treiber, J. Dingemanse, P. Sidharta, 2011, The AAPS Journal.

Discovery of substituted lactams as novel dual orexin receptor antagonists. Synthesis, preliminary structure-activity relationship studies and efforts towards improved metabolic stability and pharmacokinetic properties. Part 1.

Johannes Hoecker, C. Brotschi, A. Treiber, 2014, Bioorganic & medicinal chemistry letters.

Chemical and Biological Oxidation of Thiophene: Preparation and Complete Characterization of Thiophene S-Oxide Dimers and Evidence for Thiophene S-Oxide as an Intermediate in Thiophene Metabolism in Vivo and in Vitro

D. Mansuy, H. Amri, P. Dansette, 1997 .

Macitentan Does Not Interfere with Hepatic Bile Salt Transport

R. de Kanter, A. Treiber, P. Sidharta, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Structure–Activity Relationship, Biological, and Pharmacological Characterization of the Proline Sulfonamide ACT‐462206: a Potent, Brain‐Penetrant Dual Orexin 1/Orexin 2 Receptor Antagonist

C. Brotschi, A. Treiber, T. Sifferlen, 2014, ChemMedChem.

The metabolism of the dual orexin receptor antagonist daridorexant

A. Treiber, S. Delahaye, J. Gatfield, 2023, Xenobiotica; the fate of foreign compounds in biological systems.

Competitive epoxidation and quinone formation in the dimethyldioxirane oxidation of diazoquinones as ambident nucleophiles

W. Adam, A. Treiber, L. Hadjiarapoglou, 1994 .

CYP3A4 Catalyzes the Rearrangement of the Dual Orexin Receptor Antagonist Daridorexant to 4‐Hydroxypiperidinol Metabolites

A. Treiber, S. Delahaye, C. Boss, 2023, ChemMedChem.

Discovery and Characterization of ACT‐335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist

A. Treiber, C. Boss, J. Gatfield, 2013, ChemMedChem.

Tetrahydroisoquinolines as orexin receptor antagonists: Strategies for lead optimization by solution-phase chemistry

M. Clozel, A. Treiber, O. Nayler, 2003 .

Triphenylalkylidenephosphoranes into the Peroxide Bond of 1,2-Dioxetanes: Thermolysis, Hydrolysis, and Wittig Olefination

W. Adam, A. Treiber, H. M. Harrer, 1994 .

1,3-Dioxolane Formation by Nucleophilic Attack of Diazoalkanes on the Peroxide Bond of 1,2-Dioxetanes

W. Adam, A. Treiber, 1994 .

The SN2 Reactivity of 3,3-Disubstituted 1,2-Dioxetanes with Morpholine

W. Adam, A. Treiber, R. Stoessel, 1995 .

Mechanism of the aromatic hydroxylation of thiophene by acid-catalyzed peracid oxidation.

D. Mansuy, P. Dansette, A. Treiber, 2002, The Journal of organic chemistry.

Oxidation of 2-(4-chlorobenzoyl)-thiophene into 1-oxide Diels-Alder dimers, sesquioxide and a sulfone-water adduct

P. Dansette, A. Treiber, Man Tik Ho, 1998 .

In vitro and in vivo pharmacokinetic characteristics of clazosentan, an intravenous endothelin receptor antagonist, in humans.

A. Treiber, J. Dingemanse, P. V. van Giersbergen, 2009, International journal of clinical pharmacology and therapeutics.

Pharmacokinetic interactions between simvastatin and setipiprant, a CRTH2 antagonist

A. Halabi, A. Treiber, J. Dingemanse, 2014, European Journal of Clinical Pharmacology.