G. Fossati

发表

The Mitochondrial Network of Human Neutrophils: Role in Chemotaxis, Phagocytosis, Respiratory Burst Activation, and Commitment to Apoptosis 1

R. Moots, D. Spiller, S. Edwards, 2003, The Journal of Immunology.

Pharmacological Inhibition of Histone Deacetylases ( HDACs ) by Suberoylanilide Hydroxamic Acid ( SAHA ) Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain

A. Chiarugi, F. Moroni, Tristano Pancani, 2006 .

Involvement of iron (ferric) reduction in the iron absorption mechanism of a trivalent iron-protein complex (iron protein succinylate).

R. Simpson, Á. Acebrón, D. Dickson, 2000, Pharmacology & toxicology.

Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo*

A. Abbate, C. Dinarello, G. Fossati, 2014, The Journal of Biological Chemistry.

Interaction in Vivo between Tumor Cells and Phagocytes

G. Fossati, A. Notario, I. Mazzucchelli, 1997, Annals of the New York Academy of Sciences.

HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19

S. Minucci, C. Ripamonti, B. Vergani, 2022, Frontiers in Immunology.

Changes in opioid receptor density on murine splenocytes induced by in vivo treatment with morphine and methadone.

G. Ricevuti, P. Massi, D. Parolaro, 1996, The Journal of pharmacology and experimental therapeutics.

Mechanism of action of certolizumab pegol (CDP870): In vitro comparison with other anti‐tumor necrosis factor &agr; agents

A. Nesbitt, S. Stephens, R. Foulkes, 2007, Inflammatory bowel diseases.

Lymphocyte subpopulations and intima media thickness in primary antiphospholipd syndrome

A. Saulino, E. Matsuura, V. Brancaccio, 2005, Lupus.

Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors

M. Adib, M. Amanlou, G. Fossati, 2020, Journal of biomolecular structure & dynamics.

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

C. Workman, S. Mandrup, C. Mathieu, 2014, Proceedings of the National Academy of Sciences.

Pharmacokinetics , Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF 2357 ( Givinostat )

C. Dinarello, A. Furlan, G. Fossati, 2011 .

An immediate transcriptional signature associated with response to the histone deacetylase inhibitor Givinostat in T acute lymphoblastic leukemia xenografts

G. Basso, S. Indraccolo, S. Minuzzo, 2016, Cell Death and Disease.

Plasma levels of interleukin 2, 6, 10 and phenotypic characterization of circulating T lymphocytes in ischemic heart disease.

G. Specchia, S. de Servi, A. Mussini, 1999, Atherosclerosis.

The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines

G. Fantuzzi, C. Dinarello, Soohyun Kim, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study

J. Morrow, V. Brancaccio, G. Fossati, 2000, Lupus.

Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.

B. Vergani, C. Steinkühler, G. Fossati, 2021, ACS medicinal chemistry letters.

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes

P. Tak, T. McKinsey, D. Baeten, 2016, Annals of the rheumatic diseases.

Immunocytochemical localization and identification of prosomatostatin gene products in medullary carcinoma of human thyroid gland.

J. Holst, J. Rehfeld, F. Rilke, 1990, Human pathology.

Triggering a Second T Cell Receptor on Diabetogenic T Cells Can Prevent Induction of Diabetes

A. Cooke, B. Stockinger, K. Haskins, 1999, The Journal of experimental medicine.

Mycobacterial Cpn10 promotes recognition of the mammalian homologue by a mycobacterium-specific antiserum.

P. Ghezzi, G. Legname, F. Marcucci, 1998, Biochimica et biophysica acta.

Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study

M. Cappellini, G. Fossati, L. Porretti, 2014, British journal of haematology.

Fcγ receptors in autoimmune diseases

G. Fossati, R. Bucknall, S. W. Edwards, 2001 .

Correlation between CD11b/CD18 and increase of aggregability of granulocytes in coronary artery disease

G. Ricevuti, S. Servi, A. Mazzone, 1992, Inflammation.

The effects of anti–TNF agents on the expansion of T helper-type 17 cells driven by lipopolysaccharide-stimulated monocytes

A. Nesbitt, G. Fossati, L. Healy, 2012, Journal of Translational Medicine.

Chaperonin 10 of Mycobacterium tuberculosis induces a protective immune response to foot-and-mouth disease virus

G. Fossati, M. Amadori, P. Mascagni, 1999, Archives of Virology.

Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes.

R. Moots, S. Edwards, G. Fossati, 2002, Arthritis and rheumatism.

Histone deacetylase 6 controls Notch3 trafficking and degradation in T-cell acute lymphoblastic leukemia cells

Y. Ciribilli, S. Indraccolo, S. Minuzzo, 2018, Oncogene.

The role of integrins in granulocyte dysfunction in myelodysplastic syndrome.

G. Ricevuti, A. Mazzone, G. Fossati, 1993, Leukemia research.

Commitment to Apoptosis Phagocytosis , Respiratory Burst Activation , Neutrophils : Role in Chemotaxis , The Mitochondrial Network of Human Edwards

R. Moots, D. Spiller, M. White, 2003 .

ITF1697, a Stable Lys-Pro-Containing Peptide, Inhibits Weibel-Palade Body Exocytosis Induced by Ischemia/Reperfusion and Pressure Elevation

J. Bhattacharya, S. Bertuglia, G. Fossati, 2007, Molecular medicine.

Expression of adhesion molecules and functional stimulation in human neutrophils: modulation by GM‐CSF and role of the Bcr gene

M. Cazzola, A. Mazzone, C. Canale, 1997, British journal of haematology.

Limited effect of rituximab on thrombocytopaenia and anticardiolipin antibodies in a patient with primary antiphospholipid syndrome

F. Ferrara, V. Brancaccio, G. Fossati, 2007, Annals of Hematology.

Monoclonal antibodies against calcitonin

G. Houen, G. Fossati, L. Scopsi, 2004, Histochemistry.

Effect of the Anti-TNF Agents, Adalimumab, Etanercept, Infliximab, and Certolizumab PEGOL (CDP870) on the Induction of Apoptosis in Activated Peripheral Blood Lymphocytes and Monocytes: 806

A. Nesbitt, G. Fossati, 2005 .

The histone deacetylase inhibitor ITF2357 has anti-leukemic activity in vitro and in vivo and inhibits IL-6 and VEGF production by stromal cells

L. Cuppini, A. Neri, P. Pagani, 2007, Leukemia.

The CD11/CD18 granulocyte adhesion molecules in myelodysplastic syndromes

G. Ricevuti, A. Mazzone, G. Fossati, 1993, British journal of haematology.

Phagocyte activation in coronary artery disease.

G. Ricevuti, A. Mazzone, G. Fossati, 1992, FEMS microbiology immunology.

Selective anti-leukaemic activity of low-dose histone deacetylase inhibitor ITF2357 on AML1/ETO-positive cells

M. Lübbert, A. Morandi, G. Fossati, 2008, Oncogene.

Neutrophil infiltration into human gliomas

G. Ricevuti, S. Edwards, C. Walker, 1999, Acta Neuropathologica.

Certolizumab pegol has a different profile from other anti-TNFs, including golimumab, in a variety of in vitro assays

A. Nesbitt, G. Fossati, 2010, Journal of Translational Medicine.

Novel Benzohydroxamate-based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis and Biological Evaluation.

C. Ripamonti, B. Vergani, E. Galbiati, 2019, Journal of medicinal chemistry.

Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice

G. Mező, C. Steinkühler, S. Schuster, 2019, International journal of molecular sciences.

Mycobacterium tuberculosis Chaperonin 10 Is Secreted in the Macrophage Phagosome: Is Secretion Due to Dissociation and Adoption of a Partially Helical Structure at the Membrane?

E. Gancia, F. Mangili, B. Casetta, 2003, Journal of bacteriology.

Use of Monospecific Antibodies for the Purification of D-Amino Acid Oxidases from Various Sources

E. Monti, G. Fossati, B. Curti, 1987 .

A facile preparation of Fmoc-Argω,ω′(Boc)2 -OH and Z-Argω,ω′ (Boc)2 -OH, new arginine derivatives for peptide synthesis.

G. Fossati, A. Verdini, P. Lucietto, 1992 .

Histone Deacetylase Inhibitors for Treating a Spectrum of Diseases Not Related to Cancer

C. Dinarello, G. Fossati, P. Mascagni, 2011, Molecular medicine.

Inhibition of the Autophagy Pathway Synergistically Potentiates the Cytotoxic Activity of Givinostat (ITF2357) on Human Glioblastoma Cancer Stem Cells

S. Comincini, I. Masiello, Roberto Würth, 2016, Front. Mol. Neurosci..

Pharmacological Inhibition of Histone Deacetylases by Suberoylanilide Hydroxamic Acid Specifically Alters Gene Expression and Reduces Ischemic Injury in the Mouse Brain

A. Chiarugi, F. Moroni, Tristano Pancani, 2006, Molecular Pharmacology.

The histone deacetylase inhibitor givinostat (ITF2357) exhibits potent anti-tumor activity against CRLF2-rearranged BCP-ALL

K. Davis, S. Izraeli, G. Cazzaniga, 2017, Leukemia.

Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b

A. Neri, M. Introna, A. Rambaldi, 2010, Haematologica.

Pleiotropic anti-myeloma activity of ITF 2357 : inhibition of IL-6 receptor signalling and repression of miR-19 a and miR-19 b by

A. Neri, M. Introna, A. Rambaldi, 2009 .

The TB structural genomics consortium: a resource for Mycobacterium tuberculosis biology.

A W Munro, M Wilmanns, E N Baker, 2003, Tuberculosis.

Mycobacterium tuberculosis Chaperonin 10 Stimulates Bone Resorption: A Potential Contributory Factor in Pott's Disease

J. Hunt, B. Henderson, P. White, 1997, The Journal of experimental medicine.

HDAC3 Regulates Gingival Fibroblast Inflammatory Responses in Periodontitis

J. Potempa, T. Kaczmarzyk, G. Fossati, 2019, Journal of dental research.

Granulocyte defects and opioid receptors in chronic exposure to heroin or methadone in humans.

G. Ricevuti, A. Mazzone, G. Fossati, 1994, International journal of immunopharmacology.

Inhibiting LSD1 suppresses coronavirus-induced inflammation but spares innate antiviral activity

R. Ravasio, S. Minucci, P. Pelicci, 2021, bioRxiv.

Histone deacetylase inhibitors prevent exocytosis of interleukin-1beta-containing secretory lysosomes: role of microtubules.

C. Dinarello, A. Rubartelli, G. Fossati, 2006, Blood.

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way

A. Rubartelli, A. Piccini, G. Fossati, 2008, Proceedings of the National Academy of Sciences.

The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene

C. Steinkühler, S. A. Licandro, G. Fossati, 2021, Skeletal muscle.

In vitro effects of GM-CSF on mature peripheral blood neutrophils.

G. Ricevuti, S. Edwards, D. Moulding, 1998, International journal of molecular medicine.

Iloprost effects on phagocytes in patients suffering from ischaemic diseases: in vivo evidence for down‐regulation of αMβ2 integrin

G. Ricevuti, C. Canale, A. Mazzone, 1996 .

Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases

L. Joosten, M. Netea, C. Dinarello, 2015, Annals of the rheumatic diseases.

The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo

G. Fantuzzi, C. Dinarello, P. Pagani, 2005, Molecular medicine.

Novel HDAC inhibitors exhibit pre-clinical efficacy in lymphoma models and point to the importance of CDKN1A expression levels in mediating their anti-tumor response

L. Cascione, A. Stathis, E. Gaudio, 2014, Oncotarget.

-containing secretory lysosomes: role of microtubules β Histone deacetylase inhibitors prevent exocytosis of interleukin-1

C. Dinarello, A. Rubartelli, G. Fossati, 2013 .

Engineered hexavalent Fc proteins with enhanced Fc-gamma receptor avidity provide insights into immune-complex interactions

F. Fallah-Arani, D. Humphreys, A. Ventom, 2018, Communications Biology.

The Histone Deacetylase Inhibitor ITF2357 Decreases Surface CXCR4 and CCR5 Expression on CD4+ T-Cells and Monocytes and is Superior to Valproic Acid for Latent HIV-1 Expression in Vitro

B. Palmer, C. Dinarello, M. Nold, 2010, Journal of acquired immune deficiency syndromes.

Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo

A. Chiarugi, F. Moroni, S. Fossati, 2009, Neurobiology of Disease.

Pharmacokinetics, Safety and Inducible Cytokine Responses during a Phase 1 Trial of the Oral Histone Deacetylase Inhibitor ITF2357 (Givinostat)

C. Dinarello, A. Furlan, G. Fossati, 2011, Molecular medicine.

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

P. Blackshear, T. Radstake, D. Baeten, 2018, Arthritis Research & Therapy.

Granulocyte dysplasia and dysfunction, and CD11/CD18 defects in myelodysplastic syndromes.

C. Porta, G. Ricevuti, A. Mazzone, 1996, Leukemia & lymphoma.

Granulocyte Dy splasia and Dysfunction, and CD1 KD18 Defects in Myelodysplas tic Syndromes

C. Porta, G. Ricevuti, A. Mazzone, 1996 .

Increased Expression of Neutrophil and Monocyte Adhesion Molecules in Unstable Coronary Artery Disease

G. Specchia, L. Angoli, E. Bramucci, 1993, Circulation.

The in Vitro Activity of Two Urinary Polypeptides Respect to G- and GM-CSF and IL3 on the Peripheral CFU of Normal and Leukemic Subjects

G. Fossati, A. Notario, I. Mazzucchelli, 1995 .

A PEGylated Fab’ Fragment against Tumor Necrosis Factor for the Treatment of Crohn Disease

A. Nesbitt, G. Fossati, T. Bourne, 2012, BioDrugs.

Crystallization, x-ray diffraction and preliminary structure analysis of Mycobacterium tuberculosis chaperonin 10.

A. Coker, S. Wood, G. Fossati, 1999, Acta crystallographica. Section D, Biological crystallography.

Reverse signalling of membrane TNF in human natural killer cells: a comparison of the effect of certolizumab pegol and other anti-TNF agents

A. Nesbitt, G. Fossati, 2011, Journal of Translational Medicine.

In Vitro Complement-Dependent Cytotoxicity and Antibody-Dependent Cellular Cytotoxicity by the Anti-TNF Agents Adalimumab, Etanercept, Infliximab, and Certolizumab Pegol (CDP870): 807

A. Nesbitt, G. Fossati, 2005 .

Clinical and angiographic correlates of leukocyte activation in unstable angina.

G. Specchia, S. de Servi, L. Angoli, 1995, Journal of the American College of Cardiology.

Mycobacterium tuberculosis Chaperonin 10 Heptamers Self-Associate through Their Biologically Active Loops

A. Coker, S. Wood, A. Coates, 2003, Journal of bacteriology.

Mycobacterium tuberculosis Chaperonin 10 Forms Stable Tetrameric and Heptameric Structures

G. Legname, H. Cölfen, A. Coates, 1995, The Journal of Biological Chemistry.

The Mycobacterium tuberculosis chaperonin 10 monomer exhibits structural plasticity

S. Harding, B. Henderson, A. Coates, 2004, Biopolymers.

Increased expression of CD11b/CD18 on phagocytes in ischaemic disease: a bridge between inflammation and coagulation

S. de Servi, G. Ricevuti, A. Mazzone, 1997, European journal of clinical investigation.

Expression of neutrophil and monocyte CD11B/CD18 adhesion molecules at different sites of the coronary tree in unstable angina pectoris.

G. Specchia, S. de Servi, L. Angoli, 1996, The American journal of cardiology.

The levels of TLR2, TLR4 and CD14 on LPS stimulated monocytes are reduced by membrane TNF signaling of certolizumab pegol, adalimumab and infliximab: O-0032.

A. Nesbitt, G. Fossati, 2008 .

Insoluble and soluble immune complexes activate neutrophils by distinct activation mechanisms: changes in functional responses induced by priming with cytokines

S. Edwards, G. Fossati, R. Bucknall, 2002, Annals of the rheumatic diseases.

Expression in Escherichia coli, purification and functional activity of recombinant human chaperonin 10

G. Legname, F. Marcucci, G. Gromo, 1995, FEBS letters.

Mycobacterium tuberculosis chaperonin 10 and N-truncated fragments. Their synthesis and purification by the isoelectric focusing technique carried out in solution.

H. Ball, G. Fossati, P. Mascagni, 2009, The journal of peptide research : official journal of the American Peptide Society.

Sequence and structural homologies between M. tuberculosis chaperonin 10 and the MHC class I/II peptide binding cleft.

A. Coates, G. Fossati, P. Mascagni, 1995, Biochemical and biophysical research communications.

Effect of certolizumab pegol, etanercept, adalimumab and infliximab on cytokine production: P-0029

A. Nesbitt, G. Fossati, D. Brown, 2007 .

Use of Z-Arg,ω,ω’ (Boc)2-OH and Fmoc-Argω,ω’ (Boc)2-OH in peptide synthesis: Dermorphin and deltorphin-C analogs with Arg residues in the address domain

S. Salvadori, R. Guerrini, G. Fossati, 1993 .

Fmoc-Argω,ω′ (Boc)2-OH and Z-Argω,ω′ (Boc) 2-OH: New arginine derivatives for peptide synthesis

G. Fossati, A. Verdini, P. Lucietto, 1992 .

Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity

B. Vergani, C. Steinkühler, G. Fossati, 2022, The Journal of biological chemistry.

The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression in CD4+ T-cells and monocytes and induces latent HIV-1 expression in vitro

B. Palmer, C. Dinarello, M. Nold, 2009 .

TNF Binding by Certolizumab Pegol, Adalimumab, and Infliximab-Stoichiometry, Complex Formation, and the Biologic Effects of Complexes

A. Nesbitt, Jeff Kennedy, G. Fossati, 2007 .

LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model

E. Conte, O. Cappellari, A. De Luca, 2023, Disease models & mechanisms.

Production of monoclonal antibodies to calcitonin and development of a two-site enzyme immunoassay.

G. Fossati, G. Racchetti, Y. Galante, 1987, Molecular immunology.