J. Santos

发表

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

Tianyuan Wang, N. Chandel, Gonzalo Riadi, 2018, Life Science Alliance.

Telomerase Impinges on the Cellular Response to Oxidative Stress Through Mitochondrial ROS-Mediated Regulation of Autophagy

N. Sharma, J. Santos, Paula D. Green, 2019, International journal of molecular sciences.

Mitochondrial hTERT exacerbates free‐radical‐mediated mtDNA damage

B. Van Houten, Joel N. Meyer, M. Škorvaga, 2004, Aging cell.

Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

Tianyuan Wang, N. Chandel, Gonzalo Riadi, 2018, bioRxiv.

Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant

Sara A. Grimm, Tianyuan Wang, O. Lozoya, 2020, Cell reports.

Mitochondria signaling to the epigenome: a novel role for an old organelle.

J. Santos, 2020, Free radical biology & medicine.

Maternal exposure to a mitochondrial toxicant results in life-long alterations in DNA methylation and gene expression in the offspring

Sara A. Grimm, Tianyuan Wang, O. Lozoya, 2019, bioRxiv.

The Emerging Role of Telomerase Reverse Transcriptase in Mitochondrial DNA Metabolism

D. Gordon, J. Santos, 2010, Journal of nucleic acids.

A mutant telomerase defective in nuclear‐cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction

M. Bonini, M. Kimura, J. Santos, 2010, Aging cell.

The peroxidase activity of mitochondrial superoxide dismutase.

M. Bonini, R. Mason, D. Ganini, 2013, Free radical biology & medicine.

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

B. Van Houten, Joel N. Meyer, J. Santos, 2006, Methods in molecular biology.

Roles for the Human ATP-dependent Lon Protease in Mitochondrial DNA Maintenance*

C. Newlon, Tong Liu, B. Tian, 2007, Journal of Biological Chemistry.

Vanadium-induced HB-EGF expression in human lung fibroblasts is oxidant dependent and requires MAP kinases.

B. Van Houten, J. Bonner, A. Rice, 2003, American journal of physiology. Lung cellular and molecular physiology.

Emerging mitochondrial signaling mechanisms in cardio-oncology: beyond oxidative stress.

J. Santos, Andreas M Beyer, Jean C. Bikomeye, 2022, American journal of physiology. Heart and circulatory physiology.

Cell Sorting Experiments Link Persistent Mitochondrial DNA Damage with Loss of Mitochondrial Membrane Potential and Apoptotic Cell Death*

B. Van Houten, C. Bortner, J. Santos, 2003, The Journal of Biological Chemistry.

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase γ associated with progressive external ophthalmoplegia

G. R. Stuart, B. V. Houten, Micheline K. Strand, 2006 .

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase g associated with progressive external ophthalmoplegia

G. R. Stuart, B. V. Houten, Micheline K. Strand, 2006 .

Mitochondrial and nuclear DNA defects in Saccharomyces cerevisiae with mutations in DNA polymerase gamma associated with progressive external ophthalmoplegia.

G. R. Stuart, B. Van Houten, Micheline K. Strand, 2006, Human molecular genetics.

Mitochondrial DNA lesions and copy number are strain dependent in endurance‐trained mice

M. Massett, S. Kleeberger, J. T. Lightfoot, 2020, Physiological reports.

Mitochondria and telomeres: the promiscuous roles of TIN2.

Lucas B. Sullivan, N. Chandel, J. Santos, 2012, Molecular cell.

Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells.

B. Van Houten, Joel N. Meyer, J. Santos, 2014, Methods in molecular biology.

The peroxidase activity of mitochondrial superoxide dismutase (MnSOD/SOD2)

M. Bonini, R. Mason, D. Ganini, 2014 .

Intrinsic mitochondrial DNA repair defects in Ataxia Telangiectasia.

Jeffrey D. Stumpf, J. D. Stumpf, N. Sharma, 2014, DNA repair.

Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria

A. Reyes, N. Sharma, M. Bonini, 2011, Nucleic acids research.

Measuring oxidative mtDNA damage and repair using quantitative PCR.

B. Van Houten, J. Santos, B. Mandavilli, 2002, Methods in molecular biology.

Quantitative PCR: a sensitive biomarker of gene-specific DNA damage and repair

B. V. Houten, J. Santos, B. Mandavilli, 2002 .

A Novel Analytical Strategy to Identify Fusion Transcripts between Repetitive Elements and Protein Coding-Exons Using RNA-Seq

Tianyuan Wang, E. Nestler, D. Fargo, 2016, PloS one.

Mitochondrial DNA damage as driver of cellular outcomes.

J. Santos, S. Ayala‐Peña, C. Nadalutti, 2021, American journal of physiology. Cell physiology.

Menadione-Induced DNA Damage Leads to Mitochondrial Dysfunction and Fragmentation During Rosette Formation in Fuchs Endothelial Corneal Dystrophy.

J. Santos, U. Jurkunas, C. Hamill, 2016, Antioxidants & redox signaling.

Expression of NES-hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress

E. Azzam, J. Santos, U. Herbig, 2010, PloS one.

Mitochondrial localization of telomerase as a determinant for hydrogen peroxide-induced mitochondrial DNA damage and apoptosis.

B. Van Houten, Joel N. Meyer, J. Santos, 2006, Human molecular genetics.

TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions.

R. Deberardinis, M. Mehta, Yingming Zhao, 2016, Molecular cell.

Switch of Mitochondrial Superoxide Dismutase into a Prooxidant Peroxidase in Manganese-Deficient Cells and Mice.

M. Bonini, R. Mason, D. Ganini, 2017, Cell chemical biology.

MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signaling in cancer

Dede N. Ekoue, P. Hart, M. Bonini, 2014, Nature Communications.

Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration

Qingshan Wang, E. Oyarzabal, Jau-Shyong Hong, 2020, Brain, Behavior, and Immunity.

Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress

Thomas J. Begley, A. Baccarelli, T. Ideker, 2014, Environmental health perspectives.

Mitochondrial toxicity in hearts of CD‐1 mice following perinatal exposure to AZT, 3TC, or AZT/3TC in combination

K. Witt, B. Van Houten, D. L. Cook, 2007, Environmental and molecular mutagenesis.

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

K. Petersen, G. Shulman, P. Rabinovitch, 2010, Cell metabolism.

Role of mitochondrial DNA in toxic responses to oxidative stress.

B. Van Houten, J. Santos, Victoria M. Woshner, 2006, DNA repair.

Mitochondrial genome instability and ROS enhance intestinal tumorigenesis in APC(Min/+) mice.

W. D. Martin, N. Chandel, G. Shadel, 2012, The American journal of pathology.

Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation

P. Bushel, Jianying Li, N. Chandel, 2018, PLoS biology.

Neuroinflammation in Neurological Dysfunction and Degeneration

Qingshan Wang, Shih-Heng Chen, E. Oyarzabal, 2015 .

Mitochondrial DNA repair and aging.

B. Van Houten, J. Santos, B. Mandavilli, 2002, Mutation research.

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease

G. Porter, S. Tsaih, M. Flister, 2019, Scientific Reports.

Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.

B. Van Houten, J. Bonner, A. Rice, 2003, Free radical biology & medicine.

Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation

Julie K. Freed, D. Gutterman, M. Riedel, 2016, Circulation research.

DNA Damage and Its Cellular Response in Mother and Fetus Exposed to Hyperglycemic Environment

C. Rocha, E. Bevilacqua, J. Santos, 2014, BioMed research international.

Photochemical Targeting of Mitochondria to Overcome Chemoresistance in Ovarian Cancer †

U. Demirci, D. Kessel, I. Rizvi, 2022, Photochemistry and photobiology.

Reduction in frataxin causes progressive accumulation of mitochondrial damage.

B. Van Houten, M. Resnick, W. Copeland, 2003, Human molecular genetics.

Analysis of Oxidative Damage by Gene‐Specific Quantitative PCR

J. Santos, O. Kovalenko, 2009, Current protocols in human genetics.

Hyperglycemia Differentially Affects Maternal and Fetal DNA Integrity and DNA Damage Response

C. Rocha, E. Bevilacqua, J. Santos, 2016, International journal of biological sciences.

A brain-specific pgc1α fusion transcript affects gene expression and behavioural outcomes in mice

Gonzalo Riadi, A. Gruzdev, S. Moy, 2021, Life science alliance.

A Leveraged Signal-to-Noise Ratio (LSTNR) Method to Extract Differentially Expressed Genes and Multivariate Patterns of Expression From Noisy and Low-Replication RNAseq Data

Richard P. Woychik, Oswaldo A. Lozoya, Janine H. Santos, 2018, Front. Genet..

Mitochondrial Oxidative Phosphorylation defect in the Heart of Subjects with Coronary Artery Disease

G. Porter, S. Tsaih, M. Flister, 2019, Scientific Reports.

Methods to Evaluate Changes in Mitochondrial Structure and Function in Cancer

D. Akin, U. Demirci, S. Fenton, 2023, Cancers.

Selected mitochondrial DNA landscapes activate the SIRT3 axis of the UPRmt to promote metastasis

K. Eliceiri, T. LaFramboise, L. Papa, 2017, Oncogene.

NRF2 Alters Mitochondrial Gene Expression in Neonate Mice Exposed to Hyperoxia

Heather L. Vellers, Hye-Youn Cho, S. Kleeberger, 2022, Antioxidants.

Mutations on a novel brain-specific isoform of PGC1α leads to extensive upregulation of neurotransmitter-related genes and sexually dimorphic motor deficits in mice

Gonzalo Riadi, S. Moy, J. Cushman, 2020 .