D. Medinas

发表

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

Robert H. Brown, D. A. Bosco, C. Hetz, 2018, Proceedings of the National Academy of Sciences.

Proteostasis disturbance in amyotrophic lateral sclerosis

C. Hetz, D. Medinas, V. Valenzuela, 2017, Human molecular genetics.

Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model

C. Hetz, F. Court, D. Medinas, 2017, Scientific Reports.

Generation of singlet oxygen by the glyoxal-peroxynitrite system.

E. Bechara, P. Di Mascio, N. Assunção, 2011, Journal of the American Chemical Society.

Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis

C. Hetz, D. Medinas, J. V. Gonzalez, 2017, Front. Mol. Neurosci..

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

W. Schmidt-Heck, C. Hetz, J. Hengstler, 2014, Archives of Toxicology.

Critical roles of protein disulfide isomerases in balancing proteostasis in the nervous system

C. Hetz, D. Medinas, Pablo Rozas, 2022, The Journal of biological chemistry.

Emerging roles of endoplasmic reticulum proteostasis in brain development.

C. Hetz, H. Urra, D. Medinas, 2022, Cells & development.

Tempol diverts peroxynitrite/carbon dioxide reactivity toward albumin and cells from protein-tyrosine nitration to protein-cysteine nitrosation.

D. Fernandes, O. Augusto, D. Medinas, 2005, Free radical biology & medicine.

When the Good Turns Bad: Challenges in the Targeting of Autophagy in Neurodegenerative Diseases

C. Hetz, D. Medinas, K. Castillo, 2015 .

Control of mammalian brain aging by the unfolded protein response (UPR)

S. Lipton, C. Hetz, A. Palacios, 2020, bioRxiv.

ER Dysfunction and Protein Folding Stress in ALS

C. Hetz, D. Medinas, S. Matus, 2013, International journal of cell biology.

Oligomerization of Cu,Zn-Superoxide Dismutase (SOD1) by Docosahexaenoic Acid and Its Hydroperoxides In Vitro: Aggregation Dependence on Fatty Acid Unsaturation and Thiols

L. Netto, O. Augusto, D. Medinas, 2015, PloS one.

β-catenin aggregation in models of ALS motor neurons: GSK3β inhibition effect and neuronal differentiation

C. Hetz, A. F. Castro, Agustín D. Martínez, 2019, Neurobiology of Disease.

Control of mammalian brain ageing by the unfolded protein response transcription factor XBP1

S. Lipton, C. Hetz, B. Kennedy, 2020 .

A ditryptophan cross-link is responsible for the covalent dimerization of human superoxide dismutase 1 during its bicarbonate-dependent peroxidase activity.

F. Gozzo, O. Augusto, L. F. A. Santos, 2010, Free radical biology & medicine.

The unfolded protein response transcription factor XBP1s ameliorates Alzheimer’s disease by improving synaptic function and proteostasis

B. Morales, C. Hetz, C. Rozas, 2022, bioRxiv.

Unfolded protein response IRE1/XBP1 signaling is required for healthy mammalian brain aging

S. Lipton, B. Kennedy, C. Hetz, 2022, The EMBO journal.

Protein homeostasis: Modeling UPR adaptive responses.

C. Hetz, D. Medinas, Danilo B. Medinas, 2014, Nature chemical biology.

The carbonate radical and related oxidants derived from bicarbonate buffer

Giselle Cerchiaro, O. Augusto, D. Medinas, 2007, IUBMB life.

Peroxymonocarbonate and carbonate radical displace the hydroxyl-like oxidant in the Sod1 peroxidase activity under physiological conditions.

O. Augusto, D. Medinas, Alberto Malvezzi, 2009, Chemical research in toxicology.

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein*

C. Hetz, C. Soto, J. M. Matamala, 2015, The Journal of Biological Chemistry.

The ER proteostasis network in ALS: Determining the differential motoneuron vulnerability

C. Hetz, D. Medinas, Pablo Rozas, 2017, Neuroscience Letters.

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

M. Bertrand, C. Hetz, J. M. Matamala, 2019, Molecular Neurodegeneration.

IRE1 signaling exacerbates Alzheimer’s disease pathogenesis

W. Scheper, C. Hetz, C. Soto, 2017, Acta Neuropathologica.

Disruption of Endoplasmic Reticulum Proteostasis in Age-Related Nervous System Disorders.

C. Hetz, Younis Hazari, D. Medinas, 2021, Progress in molecular and subcellular biology.

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

A. Ciechanover, F. Urano, G. Kroemer, 2016, Brain Research.

ERp57 as a novel cellular factor controlling prion protein biosynthesis: Therapeutic potential of protein disulfide isomerases

C. Hetz, D. Medinas, Pablo Rozas, 2016, Prion.

ALS‐linked protein disulfide isomerase variants cause motor dysfunction

Robert H. Brown, P. Henny, M. Concha, 2016, The EMBO journal.

Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

C. Hetz, F. Osorio, U. Woehlbier, 2015, PloS one.

Common ground: stem cell approaches find shared pathways underlying ALS.

C. Hetz, D. Medinas, S. Matus, 2014, Cell stem cell.

Editorial: Restoring endoplasmic reticulum proteostasis to treat neurological disorders

V. Zambelli, D. Medinas, S. Miyamoto, 2023, Frontiers in Pharmacology.

Correction: Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

C. Hetz, F. Osorio, U. Woehlbier, 2015, PloS one.

Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS

C. Hetz, D. Medinas, Pablo Rozas, 2021, Acta neuropathologica communications.

Proteostasis impairment: at the intersection between Alzheimer's disease and diabetes.

C. Hetz, D. Medinas, Danilo B. Medinas, 2013, Cell metabolism.

The transcription factor CHOP, a central component of the transcriptional regulatory network induced upon CCl4 intoxication in mouse liver, is not a critical mediator of hepatotoxicity

W. Schmidt-Heck, C. Hetz, J. Hengstler, 2014, Archives of Toxicology.

Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis

C. Hetz, J. M. Matamala, C. Cortez, 2019, Molecular Neurodegeneration.

Editorial: Protein Misfolding and Proteostasis Impairment in Aging and Neurodegeneration: From Spreading Studies to Therapeutic Approaches

R. Morales, C. Durán-Aniotz, D. Medinas, 2022, Frontiers in Aging Neuroscience.

Mechanism of the peroxidase activity of superoxide dismutase 1.

O. Augusto, D. Medinas, 2010, Free radical biology & medicine.

ER stress links aging to sporadic ALS

C. Hetz, Felipe Cabral-Miranda, D. Medinas, 2019, Aging.