P. Sears

发表

Safety and Pharmacokinetic Study of Fidaxomicin in Children With Clostridium difficile–Associated Diarrhea: A Phase 2a Multicenter Clinical Trial

K. Kim, S. Kaplan, A. Otley, 2018, Journal of the Pediatric Infectious Diseases Society.

Synthesis and biological activity of new 5-O-sugar modified ketolide and 2-fluoro-ketolide antibiotics.

P. Sears, C. Liang, Sulan Yao, 2005, Bioorganic & medicinal chemistry letters.

Enzyme action in glycoprotein synthesis

Chi‐Huey Wong, P. Sears, Chi-Huey Wong, 1998, Cellular and Molecular Life Sciences CMLS.

Population Pharmacokinetics, Exposure-Response, and Probability of Target Attainment Analyses for Tedizolid in Adolescent Patients with Acute Bacterial Skin and Skin Structure Infections

M. Rizk, P. Sears, C. Hardalo, 2021, Antimicrobial agents and chemotherapy.

Intervention of carbohydrate recognition by proteins and nucleic acids.

C. Wong, P. Sears, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The murine homolog of the interleukin-8 receptor CXCR-2 is essential for the occurrence of neutrophilic inflammation in the air pouch model of acute urate crystal-induced gouty synovitis.

R. Terkeltaub, W. Boisvert, P. Sears, 1998, Arthritis and rheumatism.

Mechanism-based inhibition of carbohydrate-mediated biological recognitions

Chi‐Huey Wong, P. Sears, 1998 .

Acceptor Specificity and Inhibition of the Bacterial Cell‐Wall Glycosyltransferase MurG

Chi‐Huey Wong, Haitian Liu, Thomas K. Ritter, 2003, Chembiochem : a European journal of chemical biology.

Efficacy of Fidaxomicin Versus Vancomycin as Therapy for Clostridium difficile Infection in Individuals Taking Concomitant Antibiotics for Other Concurrent Infections

Mark A. Miller, T. Louie, S. Gorbach, 2011, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Safety, Tolerance, and Pharmacokinetic Studies of OPT-80 in Healthy Volunteers following Single and Multiple Oral Doses

R. Preston, S. Gorbach, P. Sears, 2008, Antimicrobial Agents and Chemotherapy.

Molecular epidemiology of Clostridioides (Clostridium) difficile strains recovered from clinical trials in the US, Canada and Europe from 2006-2009 to 2012-2015.

D. Gerding, E. Goldstein, S. Sambol, 2018, Anaerobe.

Fidaxomicin inhibits toxin production in Clostridium difficile.

A. Sonenshein, P. Sears, L. Bouillaut, 2013, The Journal of antimicrobial chemotherapy.

Effects of Inoculum, pH, and Cations on the In Vitro Activity of Fidaxomicin (OPT-80, PAR-101) against Clostridium difficile

P. Sears, J. Seddon, Y. Shue, 2010, Antimicrobial Agents and Chemotherapy.

Typing and susceptibility of bacterial isolates from the fidaxomicin (OPT-80) phase II study for C. difficile infection.

D. Gerding, E. Goldstein, S. Sambol, 2009, Anaerobe.

Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial.

D. Crook, S. Gorbach, O. Cornely, 2012, The Lancet. Infectious diseases.

Both Fidaxomicin and Vancomycin Inhibit Outgrowth of Clostridium difficile Spores

Joseph A. Sorg, P. Sears, Charlotte A. Allen, 2012, Antimicrobial Agents and Chemotherapy.

Enzymatic approaches to glycoprotein synthesis.

C. Wong, P. Sears, T. Tolbert, 2001, Genetic engineering.

Enzymatic Glycoprotein Synthesis: Preparation of Ribonuclease Glycoforms via Enzymatic Glycopeptide Condensation and Glycosylation

Chi‐Huey Wong, K. Witte, P. Sears, 1997 .

Fidaxomicin Inhibits Spore Production in Clostridium difficile

A. Sonenshein, P. Sears, L. Bouillaut, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Comparative Susceptibilities to Fidaxomicin (OPT-80) of Isolates Collected at Baseline, Recurrence, and Failure from Patients in Two Phase III Trials of Fidaxomicin against Clostridium difficile Infection

D. Gerding, E. Goldstein, S. Sambol, 2011, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics and Safety of Single-dose Tedizolid Phosphate in Children 2 to <12 Years of Age

J. Bradley, P. Sears, A. Arrieta, 2021, The Pediatric infectious disease journal.

Response to Surawicz et al.

S. Gorbach, P. Sears, C. DeRyke, 2014, The American Journal of Gastroenterology.

An efficient chemoenzymatic strategy for the synthesis of wild-type and vancomycin-resistant bacterial cell-wall precursors: UDP-N-acetylmuramyl-peptides.

Chi‐Huey Wong, Haitian Liu, C. Wong, 2001, Journal of the American Chemical Society.

Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents.

S. J. Sucheck, Changyong Hu, P. Sears, 2004, Bioorganic & medicinal chemistry letters.

Toward Automated Synthesis of Oligosaccharides and Glycoproteins

Chi‐Huey Wong, P. Sears, 2001, Science.

Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate‐Mediated Biological Recognition

Chi-Huey Wong, Pamela Sears, Chi‐Huey Wong, 1999 .

Synthesis and high-throughput screening of N-acetyl-beta-hexosaminidase inhibitor libraries targeting osteoarthritis.

Chi‐Huey Wong, Haitian Liu, Junjie Liu, 2004, The Journal of organic chemistry.

Fidaxomicin Is an Inhibitor of the Initiation of Bacterial RNA Synthesis

I. Artsimovitch, P. Sears, J. Seddon, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Engineering Subtilisin for Peptide Coupling: Studies on the Effects of Counterions and Site-Specific Modifications on the Stability and Specificity of the Enzyme

Chi‐Huey Wong, P. Wang, K. Witte, 1994 .

Breaking the low barrier hydrogen bond in a serine protease

Chi‐Huey Wong, G. Farber, K. Witte, 2008, Protein science : a publication of the Protein Society.

The effect of counterion, water concentration, and stirring on the stability of subtilisin BPN ' in organic solvents

Chi‐Huey Wong, K. Witte, P. Sears, 1999 .

Engineering Enzymes for Bioorganic Synthesis: Peptide Bond Formation

Chi‐Huey Wong, P. Sears, 1996 .

Enzymatic synthesis of N- and O-linked glycopeptides

Chi‐Huey Wong, P. Wang, P. Sears, 1993 .

Design and Synthesis of New Aminoglycoside Antibiotics Containing Neamine as an Optimal Core Structure: Correlation of Antibiotic Activity with in Vitro Inhibition of Translation

Chi‐Huey Wong, S. Hung, E. Priestley, 1999 .

Saccharide display on microtiter plates.

Chi‐Huey Wong, O. Plettenburg, M. Bryan, 2002, Chemistry & biology.

EXPLOITATION OF SUBTILISIN BPN' AS CATALYST FOR THE SYNTHESIS OF PEPTIDES CONTAINING NONCODED AMINO ACIDS, PEPTIDE MIMETICS AND PEPTIDE CONJUGATES

Chi‐Huey Wong, K. Kawashiro, P. Sears, 1997 .

Design of Bifunctional Antibiotics that Target Bacterial rRNA and Inhibit Resistance-Causing Enzymes

Chi-Huey Wong, Pamela Sears, A. L. Wong, 2000 .

Structure-activity relationships of bivalent aminoglycosides and evaluation of their microbiological activities.

Changyong Hu, P. Sears, David Rabuka, 2005, Bioorganic & medicinal chemistry letters.

Dimeric aminoglycosides as antibiotics.

Chi‐Huey Wong, P. Sears, Fu-Sen Liang, 2004, Angewandte Chemie.

Fidaxomicin versus vancomycin for Clostridium difficile infection.

Pamela Sears, Karl Weiss, Mark A. Miller, 2011, The New England journal of medicine.

Safety and Efficacy of Oral and/or Intravenous Tedizolid Phosphate From a Randomized Phase 3 Trial in Adolescents With Acute Bacterial Skin and Skin Structure Infections.

J. Butterton, J. Bradley, P. Sears, 2020, The Pediatric infectious disease journal.

Comparative Microbiological Studies of Transcription Inhibitors Fidaxomicin and the Rifamycins in Clostridium difficile

P. Sears, J. Seddon, F. Babakhani, 2014, Antimicrobial Agents and Chemotherapy.

Advances in the treatment of Clostridium difficile with fidaxomicin: a narrow spectrum antibiotic

S. Gorbach, P. Sears, Y. Ichikawa, 2013, Annals of the New York Academy of Sciences.

Fidaxomicin Attains High Fecal Concentrations With Minimal Plasma Concentrations Following Oral Administration in Patients With Clostridium difficile Infection

Mark A. Miller, T. Louie, D. Crook, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Killing kinetics of fidaxomicin and its major metabolite, OP-1118, against Clostridium difficile.

P. Sears, F. Babakhani, Abraham Gomez, 2011, Journal of medical microbiology.

Postantibiotic Effect of Fidaxomicin and Its Major Metabolite, OP-1118, against Clostridium difficile

P. Sears, F. Babakhani, Abraham Gomez, 2011, Antimicrobial Agents and Chemotherapy.

Derivation and validation of a simple clinical bedside score (ATLAS) for Clostridium difficile infection which predicts response to therapy

Mark A. Miller, T. Louie, K. Mullane, 2013, BMC Infectious Diseases.

Budget Impact Analysis of Fidaxomicin Versus Vancomycin for the Treatment of Clostridioides difficile Infection in the United States

E. Obi, P. Sears, Yiling Jiang, 2021, Infectious Diseases and Therapy.

Decreased cure and increased recurrence rates for Clostridium difficile infection caused by the epidemic C. difficile BI strain.

D. Gerding, S. Sambol, Stuart Johnson, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Population Pharmacokinetics, Exposure–Response, and Probability of Target Attainment 1 Analyses for Tedizolid in Adolescent Patients With Acute Bacterial Skin and Skin

M. Rizk, P. Sears, C. Hardalo, 2021 .

A Weak Calcium Binding Site in Subtilisin BPN‘ Has a Dramatic Effect on Protein Stability

Chi‐Huey Wong, G. Farber, H. Yennawar, 1996 .

751a Opt-80 Versus Vancomycin in Clostridium difficile Infection: Results of a Randomized Clinical Trial

T. Louie, S. Gorbach, K. Mullane, 2009 .

Comparison of soluble and immobilized trypsin kinetics: Implications for peptide synthesis

D. Clark, P. Sears, 1993, Biotechnology and bioengineering.

A Randomized, Placebo-controlled Trial of Fidaxomicin for Prophylaxis of Clostridium difficile–associated Diarrhea in Adults Undergoing Hematopoietic Stem Cell Transplantation

B. Alexander, E. Dubberke, A. Nooka, 2018, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Volunteers Following Single and Multiple Oral Doses

R. Preston, S. Gorbach, P. Sears, 2008 .

Biological and immunological characterization of cleaved and 16K forms of rat prolactin.

P. Sears, C. Clapp, B. Levay-Young, 1988, Endocrinology.

Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial.

D. Crook, S. Gorbach, O. Cornely, 2012, The Lancet. Infectious diseases.

Fidaxomicin inhibits toxin production in Clostridium difficile.

A. Sonenshein, P. Sears, L. Bouillaut, 2013, The Journal of antimicrobial chemotherapy.

A three-fluorophore FRET assay for high-throughput screening of small-molecule inhibitors of ribosome assembly.

Dagmar Klostermeier, David P. Millar, Chi-Huey Wong, 2004, Nucleic acids research.

Cell-wall engineering of living bacteria.

Chi‐Huey Wong, F. Tomita, Haitian Liu, 2002, Journal of the American Chemical Society.

Carbohydrate Mimetics: A New Strategy for Tackling the Problem of Carbohydrate-Mediated Biological Recognition.

Chi‐Huey Wong, P. Sears, 1999, Angewandte Chemie.