J. Silverman

发表

Discovery and development of surotomycin for the treatment of Clostridium difficile

L. Chesnel, Victoria Knight-Connoni, Carmela T. M. Mascio, 2016, Journal of Industrial Microbiology & Biotechnology.

Perspective on Antibacterial Lead Identification Challenges and the Role of Hypothesis-Driven Strategies

J. Leeds, L. Silver, J. Silverman, 2019, SLAS discovery : advancing life sciences R & D.

Adenine nucleotide and lysine transport in Chlamydia psittaci

T. Hatch, J. Silverman, E. Al-Hossainy, 1982, Journal of bacteriology.

Daptomycin-Mediated Reorganization of Membrane Architecture Causes Mislocalization of Essential Cell Division Proteins

J. Pogliano, J. Silverman, Nicolas Pogliano, 2012, Journal of bacteriology.

Regulation of mprF by Antisense RNA Restores Daptomycin Susceptibility to Daptomycin-Resistant Isolates of Staphylococcus aureus

R. Haselbeck, M. Conrad, A. Rubio, 2010, Antimicrobial Agents and Chemotherapy.

VraSR Two-Component Regulatory System Contributes to mprF-Mediated Decreased Susceptibility to Daptomycin in In Vivo-Selected Clinical Strains of Methicillin-Resistant Staphylococcus aureus

R. Rosato, A. Rubio, J. Silverman, 2011, Antimicrobial Agents and Chemotherapy.

Daptomycin Exerts Bactericidal Activity without Lysis of Staphylococcus aureus

T. Beveridge, J. Silverman, Nicole Cotroneo, 2008, Antimicrobial Agents and Chemotherapy.

Staphylococcus aureus Reduced Susceptibility to Daptomycin in Genetic Changes That Correlate with

L. Friedman, J. Alder, J. Silverman, 2006 .

Bactericidal Action of Daptomycin against Stationary-Phase and Nondividing Staphylococcus aureus Cells

J. Alder, Carmela T. M. Mascio, J. Silverman, 2007, Antimicrobial Agents and Chemotherapy.

Mutational analysis of the helical hairpin region of diphtheria toxin transmembrane domain.

J. Mindell, R. Collier, A. Finkelstein, 1994, The Journal of biological chemistry.

Genetic Basis for Daptomycin Resistance in Enterococci (cid:1) †‡

M. Gilmore, K. Palmer, Kelli L. Palmer, 2011 .

Mutual inhibition through hybrid oligomer formation of daptomycin and the semisynthetic lipopeptide antibiotic CB-182,462.

Scott D. Taylor, M. Palmer, J. Silverman, 2013, Biochimica et biophysica acta.

Resistance Studies with Daptomycin

J. Silverman, Tongchuan Li, Ted Andrew, 2001, Antimicrobial Agents and Chemotherapy.

Analysis of Daptomycin Efficacy and Breakpoint Standards in a Murine Model of Enterococcus faecalis and Enterococcus faecium Renal Infection

Donghui Yu, J. Alder, J. Silverman, 2003, Antimicrobial Agents and Chemotherapy.

Locating a residue in the diphtheria toxin channel.

R. J. Collier, J. Mindell, A. Finkelstein, 1992, Biophysical journal.

Surotomycin Demonstrates Low In Vitro Frequency of Resistance and Rapid Bactericidal Activity in Clostridium difficile, Enterococcus faecalis, and Enterococcus faecium

L. Chesnel, Carmela T. M. Mascio, J. Silverman, 2014, Antimicrobial Agents and Chemotherapy.

Structure-function relationships in diphtheria toxin channels: I. Determining a minimal channel-forming domain

J. Mindell, R. Collier, H. Zhan, 2004, The Journal of Membrane Biology.

Array synthesis of novel lipodepsipeptide.

J. Finn, J. Silverman, I. Parr, 2003, Bioorganic & medicinal chemistry letters.

Transcriptional Proﬁling Reveals that Daptomycin Induces the Staphylococcus aureus Cell Wall Stress Stimulon and Genes Responsive to Membrane Depolarization (cid:1) †

R. Jayaswal, J. Silverman, B. Wilkinson, 2008 .

Bacteriophage K20 requires both the OmpF porin and lipopolysaccharide for receptor function

S. Benson, J. Silverman, 1987, Journal of bacteriology.

Correlation of Daptomycin Bactericidal Activity and Membrane Depolarization in Staphylococcus aureus

H. Shapiro, J. Silverman, N. Perlmutter, 2003, Antimicrobial Agents and Chemotherapy.

LC-MS/MS characterization of phospholipid content in daptomycin-susceptible and -resistant isolates of Staphylococcus aureus with mutations in mprF

M. Conrad, W. Shaw, A. Rubio, 2012, Molecular membrane biology.

Inhibition of daptomycin by pulmonary surfactant: in vitro modeling and clinical impact.

L. Mortin, J. Alder, J. Silverman, 2005, The Journal of infectious diseases.

Daptomycin forms cation- and size-selective pores in model membranes.

M. Palmer, J. Silverman, Tianhua Zhang, 2014, Biochimica et biophysica acta.

Cardiolipin Prevents Membrane Translocation and Permeabilization by Daptomycin*

Scott D. Taylor, M. Palmer, J. Silverman, 2014, The Journal of Biological Chemistry.

Oligomerization of daptomycin on membranes.

M. Palmer, J. Silverman, J. Muraih, 2011, Biochimica et biophysica acta.

Toxoplasma/host-cell interactions

S. Kaufmann, K. Joiner, J. Silverman, 1996 .

Discovery of Indazole Derivatives as a Novel Class of Bacterial Gyrase B Inhibitors.

R. Dolle, Qingyi Yang, T. Moy, 2015, ACS medicinal chemistry letters.

Additional Routes to Staphylococcus aureus Daptomycin Resistance as Revealed by Comparative Genome Sequencing, Transcriptional Profiling, and Phenotypic Studies

A. Rubio, R. Jayaswal, J. Silverman, 2013, PloS one.

A series of heterocyclic inhibitors of phenylalanyl-tRNA synthetases with antibacterial activity.

J. Finn, J. Silverman, D. Keith, 2004, Bioorganic & medicinal chemistry letters.

A series of spirocyclic analogues as potent inhibitors of bacterial phenylalanyl-tRNA synthetases.

J. Finn, J. Silverman, D. Keith, 2004, Bioorganic & medicinal chemistry letters.

A series of quinoline analogues as potent inhibitors of C. albicans prolyl tRNA synthetase.

P. Gallant, J. Finn, J. Silverman, 2001, Bioorganic & medicinal chemistry letters.

Genetic Basis for Daptomycin Resistance in Enterococci

M. Gilmore, K. Palmer, Kelli L. Palmer, 2011, Antimicrobial Agents and Chemotherapy.

In Vitro Bactericidal Activities of Daptomycin against Staphylococcus aureus and Enterococcus faecalis Are Not Mediated by Inhibition of Lipoteichoic Acid Biosynthesis

J. Alder, J. Silverman, V. Laganas, 2003, Antimicrobial Agents and Chemotherapy.

Alternatives to antibiotics-a pipeline portfolio review.

I. Henderson, R. Hancock, Christopher M Thomas, 2016, The Lancet. Infectious diseases.

In Vitro and In Vivo Characterization of CB-183,315, a Novel Lipopeptide Antibiotic for Treatment of Clostridium difficile

L. Mortin, A. V. Van Praagh, Carmela T. M. Mascio, 2012, Antimicrobial Agents and Chemotherapy.

Evaluating the activity of the RNA polymerase inhibitor myxopyronin B against Staphylococcus aureus.

T. Moy, J. Silverman, Anu Daniel, 2011, FEMS microbiology letters.

Characterization of anti-Toxoplasma activity of SDZ 215-918, a cyclosporin derivative lacking immunosuppressive and peptidyl-prolyl-isomerase-inhibiting activity: possible role of a P glycoprotein in Toxoplasma physiology

K. Joiner, B. Luft, J. Silverman, 1997, Antimicrobial agents and chemotherapy.

Genetically Engineered Lipopeptide Antibiotics Related to A54145 and Daptomycin with Improved Properties

Richard H. Baltz, L. Mortin, P. Brian, 2010, Antimicrobial Agents and Chemotherapy.

Transcriptional Profiling Reveals that Daptomycin Induces the Staphylococcus aureus Cell Wall Stress Stimulon and Genes Responsive to Membrane Depolarization

R. Jayaswal, J. Silverman, B. Wilkinson, 2007, Antimicrobial Agents and Chemotherapy.

Genetic Changes That Correlate with Reduced Susceptibility to Daptomycin in Staphylococcus aureus

L. Friedman, J. Alder, J. Silverman, 2006, Antimicrobial Agents and Chemotherapy.

Induced Activation of the Toxoplasma gondiiNucleoside Triphosphate Hydrolase Leads to Depletion of Host Cell ATP Levels and Rapid Exit of Intracellular Parasites from Infected Cells*

K. Joiner, C. Beckers, J. Silverman, 1998, The Journal of Biological Chemistry.

Cellular Architecture Mediates DivIVA Ultrastructure and Regulates Min Activity in Bacillus subtilis

K. Ramamurthi, K. Pogliano, J. Pogliano, 2011, mBio.

Synthesis and biological activity of N-Acylated ornithine analogues of daptomycin.

J. Finn, J. Silverman, I. Parr, 2003, Bioorganic & medicinal chemistry letters.

Structure-Activity Relationship Studies of a Series of Semisynthetic Lipopeptides Leading to the Discovery of Surotomycin, a Novel Cyclic Lipopeptide Being Developed for the Treatment of Clostridium difficile-Associated Diarrhea.

L. Mortin, M. Mesleh, D. Citron, 2015, Journal of medicinal chemistry.

Synthesis of protein in host-free reticulate bodies of Chlamydia psittaci and Chlamydia trachomatis

M. Miceli, T. Hatch, J. Silverman, 1985, Journal of bacteriology.

Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design.

M. Mesleh, J. Barker, R. Dolle, 2016, ACS medicinal chemistry letters.

Reduced pulmonary surfactant interaction of daptomycin analogs via tryptophan replacement with alternative amino acids.

Carmela T. M. Mascio, J. Silverman, D. Keith, 2012, Bioorganic & medicinal chemistry letters.

Daptomycin-reversible rifampicin resistance in vancomycin-resistant Enterococcus faecium.

K. Rand, J. Silverman, H. Houck, 2007, Journal of Antimicrobial Chemotherapy.

Bactericidal Activity in Clostridium difficile, Enterococcus faecalis and 2

L. Chesnel, Carmela T. M. Mascio, J. Silverman, 2014 .

Roles of Glu 349 and Asp 352 in membrane insertion and translocation by diphtheria toxin

A. Finkelstein, S. Blanke, P. D. Huynh, 1996, Protein science : a publication of the Protein Society.

ATP-DEPENDENT TRANSPORT OF AMPHIPHILIC CATIONS ACROSS THE CANALICULAR MEMBRANE MEDIATED BY P-GLYCOPROTEIN

D. Keppler, K. Mittenbuhler, S. Thorgeirsson, 1994 .