K. Vandyck

发表

A DFT conformational analysis and VCD study on methyl tetrahydrofuran-2-carboxylate.

T. Kuppens, P. Bultinck, W. Herrebout, 2007, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Characterization of a dengue NS4B inhibitor originating from an HCV small molecule library

Peggy Geluykens, M. Van Loock, B. Devogelaere, 2017, Antiviral research.

1a/1b Subtype Profiling of Nonnucleoside Polymerase Inhibitors of Hepatitis C Virus

M. Cummings, B. Devogelaere, F. Pauwels, 2010, Journal of Virology.

Novel Potent Capsid Assembly Modulators Regulate Multiple Steps of the Hepatitis B Virus Life Cycle

F. Zoulim, F. Pauwels, D. Durantel, 2018, Antimicrobial Agents and Chemotherapy.

Considerations for the discovery and development of 3-chymotrypsin-like cysteine protease inhibitors targeting SARS-CoV-2 infection

J. Deval, K. Vandyck, Koen Vandyck, 2021, Current Opinion in Virology.

Chiral imidates as a new class of nitrogen-based chiral ligands: synthesis and catalytic activity in asymmetric aziridinations and diethylzinc additions

K. Robeyns, L. V. Meervelt, T. Noël, 2009 .

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH)

J. Deval, J. Symons, D. Misner, 2020, bioRxiv.

Nucleotide prodrugs of 2'-deoxy-2'-spirooxetane ribonucleosides as novel inhibitors of the HCV NS5B polymerase.

B. Samuelsson, Lili Hu, L. Leclercq, 2014, Journal of medicinal chemistry.

Development of a cellular high-content, immunofluorescent HBV core assay to identify novel capsid assembly modulators that induce the formation of aberrant HBV core structures.

Emmanuel Gustin, F. Pauwels, D. Peeters, 2021, Journal of virological methods.

Antiviral Properties and Mechanism of Action Studies of the Hepatitis B Virus Capsid Assembly Modulator JNJ-56136379

F. Pauwels, Karen Vergauwen, K. Vandyck, 2020, Antimicrobial Agents and Chemotherapy.

Capsid Assembly Modulators Have a Dual Mechanism of Action in Primary Human Hepatocytes Infected with Hepatitis B Virus

Ellen Van Damme, F. Pauwels, Karen Vergauwen, 2017, Antimicrobial Agents and Chemotherapy.

Discovery of 4'-azido-2'-deoxy-2'-C-methyl cytidine and prodrugs thereof: a potent inhibitor of Hepatitis C virus replication.

L. Vrang, B. Samuelsson, Magnus Nilsson, 2012, Bioorganic & medicinal chemistry letters.

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model

A. Marchand, C. Liu, J. Neyts, 2021, bioRxiv.

Synthesis and Evaluation of N-Phenyl-3-sulfamoyl-benzamide Derivatives as Capsid Assembly Modulators Inhibiting Hepatitis B Virus (HBV).

Bing Huang, Ann Vos, Karen Vergauwen, 2018, Journal of medicinal chemistry.

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir

P. Maes, A. Marchand, J. Neyts, 2022, bioRxiv.

Practical synthesis of (2'R)-2'-deoxy-2'-C-methyluridine by highly diastereoselective homogeneous hydrogenation.

T. Jonckers, R. Wechselberger, I. Houpis, 2011, The Journal of organic chemistry.

1,5-Benzodiazepine inhibitors of HCV NS5B polymerase.

M. Cummings, Lili Hu, F. Pauwels, 2009, Bioorganic & medicinal chemistry letters.

D-Isomannide in synthesis: asymmetric Diels-Alder reactions with novel homochiral bis-imine Cu2+-catalysts.

E. V. D. Eycken, K. Vandyck, J. V. D. Eycken, 2002 .

Structure-based design of a benzodiazepine scaffold yields a potent allosteric inhibitor of hepatitis C NS5B RNA polymerase.

Lili Hu, Maxwell D Cummings, M. Cummings, 2009, Journal of medicinal chemistry.

Rhodium-Catalyzed Asymmetric Conjugate Additions of Boronic Acids to enones using DIPHONANE: a novel chiral bisphosphine ligand.

K. Robeyns, L. Van Meervelt, K. Vandyck, 2006, Organic letters.

2'-Deoxy-2'-spirocyclopropylcytidine revisited: a new and selective inhibitor of the hepatitis C virus NS5B polymerase.

B. Samuelsson, M. Cummings, Christophe Buyck, 2010, Journal of Medicinal Chemistry.

Synthesis and absolute configuration of (1S,8S)-as-hydrindacene-1,8-diol as determined by the circular dichroism exciton chirality method

K. Vandyck, J. V. D. Eycken, B. Matthys, 2005 .

Vibrational circular dichroism DFT study on bicyclo[3.3.0]octane derivatives

T. Kuppens, P. Bultinck, W. Herrebout, 2006 .

Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry

M. Scholle, C. Liu, J. Neyts, 2020, Antiviral Research.

Some new C2-symmetric bicyclo[2.2.1]heptadiene ligands: synthesis and catalytic activity in rhodium(I)-catalyzed asymmetric 1,4- and 1,2-additions

T. Noël, K. Vandyck, J. V. D. Eycken, 2007 .

Some New C2‐Symmetric Bicyclo[2.2.1]heptadiene Ligands: Synthesis and Catalytic Activity in Rhodium(I)‐Catalyzed Asymmetric 1,4‐ and 1,2‐Additions.

T. Noël, K. Vandyck, J. V. D. Eycken, 2008 .

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development

M. Scholle, A. Marchand, J. Deval, 2021, Antiviral Research.