R. Tomlinson

发表

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Marc W. Kirschner, Feng Cong, Craig Mickanin, 2009, Nature.

EED-Targeted PROTACs Degrade EED, EZH2, and SUZ12 in the PRC2 Complex.

David M. Wilson, Fiona Pachl, S. Fawell, 2019, Cell chemical biology.

Chemistry‐Driven Target Identification

J. A. Hendricks, O. Engkvist, I. Cornella-Taracido, 2016 .

Structure‐Based Design of Selective Noncovalent CDK12 Inhibitors

Toan B. Nguyen, M. Haddrick, A. Ferguson, 2018, ChemMedChem.

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

D. Curtis, M. Hild, Yiping Shen, 2018, Journal of medicinal chemistry.

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers.

Q. Gao, I. Cornella-Taracido, C. García-echeverría, 2018, Cell chemical biology.

Rapid identification of novel allosteric PRC2 inhibitors.

A. Bloecher, K. Jones, P. Rawlins, 2019, ACS chemical biology.

PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.

John A. Tallarico, Jeffrey A. Porter, P. De Camilli, 2013, Chemistry & biology.

Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors.

David M. Wilson, Peng-Fei Wang, S. Fawell, 2009, Bioorganic & medicinal chemistry letters.

DOSCHEDA: a web application for interactive chemoproteomics data analysis

Piero Ricchiuto, Bruno Contrino, Eric Miele, 2017, PeerJ Comput. Sci..

Chemical Biology Approaches Confirm MCT4 as the Therapeutic Target of a Cellular Optimized Hit.

G. Lamont, M. P. Castaldi, Andrew X. Zhang, 2023, ACS chemical biology.

Mechanistic Insights into a CDK9 Inhibitor Via Orthogonal Proteomics Methods.

J. A. Hendricks, L. Reiter, D. M. Molina, 2021, ACS chemical biology.

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

D. Chin, B. Lagu, B. Firestone, 2013, Journal of medicinal chemistry.