Steve Schneider

发表

Discovery of novel, induced-pocket binding oxazolidinones as potent, selective, and orally bioavailable tankyrase inhibitors.

Steve Schneider, Xin Huang, John Newcomb, 2013, Journal of medicinal chemistry.

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

Xin Huang, Klaus Michelsen, Xin Huang, 2015, Nature.

Structure-Based Design of Potent and Selective CK1γ Inhibitors.

H. Bregman, J. Newcomb, Xin Huang, 2012, ACS medicinal chemistry letters.

Development of a homogeneous AlphaLISA ubiquitination assay using ubiquitin binding matrices as universal components for the detection of ubiquitinated proteins.

P. Andrews, Steve Schneider, R. Emkey, 2012, Biochimica et biophysica acta.

Improvement of the synthesis and pharmacokinetic properties of chromenotriazolopyrimidine MDM2-p53 protein-protein inhibitors.

J. Oliner, S. Olson, Q. Ye, 2011, Bioorganic & medicinal chemistry letters.

Structure-guided design of aminopyrimidine amides as potent, selective inhibitors of lymphocyte specific kinase: synthesis, structure-activity relationships, and inhibition of in vivo T cell activation.

P. Gallant, A. Oliveira-dos-Santos, J. Newcomb, 2008, Journal of medicinal chemistry.

Development of novel dual binders as potent, selective, and orally bioavailable tankyrase inhibitors.

H. Bregman, J. Newcomb, P. Andrews, 2013, Journal of medicinal chemistry.

Discovery of a class of novel tankyrase inhibitors that bind to both the nicotinamide pocket and the induced pocket.

H. Bregman, Xin Huang, Cindy A. Wilson, 2013, Journal of medicinal chemistry.

Structure-based design of 2-aminopyridine oxazolidinones as potent and selective tankyrase inhibitors.

Steve Schneider, Xin Huang, Angel Guzman-Perez, 2013, ACS medicinal chemistry letters.

Discovery of novel 2,3-diarylfuro[2,3-b]pyridin-4-amines as potent and selective inhibitors of Lck: synthesis, SAR, and pharmacokinetic properties.

J. Newcomb, Xin Huang, Steve Schneider, 2007, Bioorganic & medicinal chemistry letters.

Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction.

Xin Huang, Klaus Michelsen, Michael D Bartberger, 2009, Journal of medicinal chemistry.

Discovery of aminoquinazolines as potent, orally bioavailable inhibitors of Lck: synthesis, SAR, and in vivo anti-inflammatory activity.

Xin Huang, David Powers, Daniela Metz, 2006, Journal of medicinal chemistry.

Rational design and binding mode duality of MDM2-p53 inhibitors.

Xin Huang, Paul Shaffer, Steve Schneider, 2013, Journal of medicinal chemistry.

N-(3-(phenylcarbamoyl)arylpyrimidine)-5-carboxamides as potent and selective inhibitors of Lck: structure, synthesis and SAR.

P. Gallant, A. Cheng, J. Newcomb, 2008, Bioorganic & medicinal chemistry letters.

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

J. Luther, H. Bregman, Xin Huang, 2016, Nature Structural &Molecular Biology.

Structure-based design of novel inhibitors of the MDM2-p53 interaction.

J. Canon, J. Oliner, Min Jiang, 2012, Journal of medicinal chemistry.

Virtual screening to identify potent sepiapterin reductase inhibitors.

P. Andrews, Xin Huang, Steve Schneider, 2019, Bioorganic & medicinal chemistry letters.

Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat

P. Andrews, W. McCarty, Steve Schneider, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Special Section on The Opioid Crisis Pharmacological Assessment of Sepiapterin Reductase Inhibition on Tactile Response in the Rat s

P. Andrews, W. McCarty, Steve Schneider, 2019 .

Identification of substrates of SMURF1 ubiquitin ligase activity utilizing protein microarrays.

P. Andrews, Steve Schneider, R. Emkey, 2010, Assay and drug development technologies.

Discovery of 4-amino-5,6-biaryl-furo[2,3-d]pyrimidines as inhibitors of Lck: development of an expedient and divergent synthetic route and preliminary SAR.

A. Cheng, J. Newcomb, Xin Huang, 2007, Bioorganic & medicinal chemistry letters.

Novel 2-aminopyrimidine carbamates as potent and orally active inhibitors of Lck: synthesis, SAR, and in vivo antiinflammatory activity.

P. Gallant, M. Morrison, D. Elbaum, 2006, Journal of medicinal chemistry.