Taijin Wang

发表

Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.

Fang Wang, Zhuang Yang, Taijin Wang, 2017, European journal of medicinal chemistry.

A Combined Pharmacophore-Based Virtual Screening, Docking Study and Molecular Dynamics (MD) Simulation Approach to Identify Inhibitors with Novel Scaffolds for Myeloid cell leukemia (Mcl-1)

Lu Zhou, Taijin Wang, Guangkai Bao, 2014 .

Design, synthesis, and SAR study of highly potent, selective, irreversible covalent JAK3 inhibitors

Lijuan Chen, Taijin Wang, Linhong He, 2018, Molecular Diversity.

Synthesis, in vitro and in vivo evaluation of novel substituted N-(4-(2-(4-benzylpiperazin-1-yl)ethoxy)phenyl)-N-methyl-quinazolin-4-amines as potent antitumor agents.

F. Wang, Liang Ma, Ming-hai Tang, 2016, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.

Chunyu Wang, F. Wang, Liang Ma, 2016, Journal of medicinal chemistry.

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Liang Ma, Taijin Wang, Min Shi, 2016, Drug design, development and therapy.

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis

Sheng-yong Yang, Mingli Xiang, Zhuang Yang, 2018, Scientific Reports.

Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.

M. Shen, F. Wang, Zhuang Yang, 2017, Bioorganic & medicinal chemistry letters.

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.

F. Wang, Hang Song, Zhuang Yang, 2016, Journal of medicinal chemistry.

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Yiguo Hu, Sheng-yong Yang, Peng Bai, 2018, Cellular Physiology and Biochemistry.

Synthesis, Activity, and Docking Study of Novel Phenylthiazole‐Carboxamido Acid Derivatives as FFA2 Agonists

Liang Ma, Heying Pei, P. Fu, 2016, Chemical biology & drug design.

Applications of 3D-QSAR and structure-based pharmacophore modeling, virtual screening, ADMET, and molecular docking of putative MAPKAP-K2 (MK2) inhibitors

Lu Zhou, Zicheng Li, Taijin Wang, 2013, Medicinal Chemistry Research.

Flavonoids and biphenylneolignans with anti-inflammatory activity from the stems of Millettia griffithii.

Heying Pei, Lijuan Chen, Huan Tang, 2016, Bioorganic & medicinal chemistry letters.

Pironetin reacts covalently with cysteine-316 of α-tubulin to destabilize microtubule

J. Naismith, C. Botting, Lijuan Chen, 2016, Nature Communications.

Identification of potent virtual leads to design novel PLK1 inhibitors: pharmacophore modelling, virtual screening and molecular docking studies

Lu Zhou, Zicheng Li, Taijin Wang, 2013 .

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Yuquan Wei, Lijuan Chen, Buyun Ma, 2016, Oncotarget.

Exploration of potential RSK2 inhibitors by pharmacophore modelling, structure-based 3D-QSAR, molecular docking study and molecular dynamics simulation

Xiaohong Zhu, Lu Zhou, Rong You, 2017 .

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

Mingli Xiang, Heying Pei, Lijuan Chen, 2018, European journal of medicinal chemistry.

Discovery of Selective Histone Deacetylase 6 Inhibitors Using the Quinazoline as the Cap for the Treatment of Cancer.

F. Wang, Liang Ma, Zhuang Yang, 2016, Journal of medicinal chemistry.

Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.

M. Shen, F. Wang, Zhuang Yang, 2017, European journal of medicinal chemistry.

Discovery of novel NAMPT inhibitors based on pharmacophore modeling and virtual screening techniques.

Xiaoli Li, Qianying Yi, Lu Zhou, 2015, Combinatorial chemistry & high throughput screening.

Design, synthesis, and SAR study of highly potent, selective, irreversible covalent JAK3 inhibitors

Lijuan Chen, Taijin Wang, Linhong He, 2018, Molecular Diversity.