Linhong He

发表

Discovery of novel CDK8 inhibitors using multiple crystal structures in docking-based virtual screening.

Fang Wang, Zhuang Yang, Taijin Wang, 2017, European journal of medicinal chemistry.

Design, synthesis, and SAR study of highly potent, selective, irreversible covalent JAK3 inhibitors

Lijuan Chen, Taijin Wang, Linhong He, 2018, Molecular Diversity.

Synthesis and biological evaluation of 4-oxoquinoline-3-carboxamides derivatives as potent anti-fibrosis agents.

Yuquan Wei, Mingli Xiang, Liang Ma, 2014, Bioorganic & medicinal chemistry letters.

Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents.

Yuquan Wei, F. Wang, Mingli Xiang, 2014, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of a series of pyrano chalcone derivatives containing indole moiety as novel anti-tubulin agents.

Yuquan Wei, X. Liang, F. Wang, 2014, Bioorganic & medicinal chemistry.

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis

Sheng-yong Yang, Mingli Xiang, Zhuang Yang, 2018, Scientific Reports.

Structure-based design, synthesis and in vitro antiproliferative effects studies of novel dual BRD4/HDAC inhibitors.

M. Shen, F. Wang, Zhuang Yang, 2017, Bioorganic & medicinal chemistry letters.

Development of Purine-Based Hydroxamic Acid Derivatives: Potent Histone Deacetylase Inhibitors with Marked in Vitro and in Vivo Antitumor Activities.

F. Wang, Hang Song, Zhuang Yang, 2016, Journal of medicinal chemistry.

Scale-up purification for rutin hyrdrolysates by high-performance counter-current chromatography coupled with semi-preparative high-performance liquid chromatography

Tao Yang, Linhong He, Jinying Chen, 2016 .

Design, synthesis, and biological evaluation of quinazoline derivatives as dual HDAC1 and HDAC6 inhibitors for the treatment of cancer

Linhong He, Jinying Chen, Zitai Sang, 2018, Chemical biology & drug design.

Synthesis and Biological Evaluation of 5‐Nitropyrimidine‐2,4‐dione Analogues as Inhibitors of Nitric Oxide and iNOS Activity

X. Liang, Liang Ma, Zhuang Yang, 2015, Chemical biology & drug design.

Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations.

Kai Chen, Shucai Li, Lijuan Chen, 2014, Journal of chromatography. A.

Synthesis and biological evaluation of novel pyrazoline derivatives as potent anti-inflammatory agents.

Liang Ma, Ming-hai Tang, Lijuan Chen, 2015, Bioorganic & medicinal chemistry letters.

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.

X. Liang, Mingli Xiang, Liang Ma, 2015, European journal of medicinal chemistry.

Synthesis and lipid-lowering evaluation of 3-methyl-1H-purine-2,6-dione derivatives as potent and orally available anti-obesity agents.

Liang Ma, Ming-hai Tang, Heying Pei, 2014, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis.

Mingli Xiang, Heying Pei, Lijuan Chen, 2018, European journal of medicinal chemistry.

Discovery of (R)-5-(benzo[d][1,3]dioxol-5-yl)-7-((1-(vinylsulfonyl)pyrrolidin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (B6) as a potent Bmx inhibitor for the treatment of NSCLC.

Peng Bai, Lijuan Chen, Linhong He, 2017, Bioorganic & medicinal chemistry letters.

Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.

M. Shen, F. Wang, Zhuang Yang, 2017, European journal of medicinal chemistry.

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Yuquan Wei, Mingli Xiang, Liang Ma, 2013, Bioorganic & medicinal chemistry.

Design, synthesis, and SAR study of highly potent, selective, irreversible covalent JAK3 inhibitors

Lijuan Chen, Taijin Wang, Linhong He, 2018, Molecular Diversity.

Design and Synthesis of a Highly Selective JAK3 Inhibitor for the Treatment of Rheumatoid Arthritis

Ming-hai Tang, Heying Pei, Lijuan Chen, 2017, Archiv der Pharmazie.

Synthesis and biological evaluation of diarylthiazole derivatives as antimitotic and antivascular agents with potent antitumor activity.

F. Wang, Chunlai Nie, Liang Ma, 2015, Bioorganic & medicinal chemistry.

Discovery of 5-methyl-2-(4-((4-(methylsulfonyl)benzyl)oxy)phenyl)-4-(piperazin-1-yl)pyrimidine derivatives as novel GRP119 agonists for the treatment of diabetes and obesity

Liang Ma, Linhong He, Jinying Chen, 2017, Molecular Diversity.

Discovery of a Potent 9‐Deazaxanthine‐based Agent for the Treatment of Obesity‐Related Non‐alcoholic Fatty Liver Disease

Liang Ma, Heying Pei, Lijuan Chen, 2015, Chemical biology & drug design.

Discovery of a Potent 9‐Deazaxanthine‐based Agent for the Treatment of Obesity‐Related Non‐alcoholic Fatty Liver Disease

Liang Ma, Heying Pei, Lijuan Chen, 2015, Chemical biology & drug design.