K. Clinch

发表

A Novel Mechanism for Desulfation of Mucin: Identification and Cloning of a Mucin-Desulfating Glycosidase (Sulfoglycosidase) from Prevotella Strain RS2

R. Furneaux, D. Christie, A. M. Roberton, 2005, Journal of bacteriology.

Synthesis of cyclic pyranopterin monophosphate, a biosynthetic intermediate in the molybdenum cofactor pathway.

A. Belaidi, G. Schwarz, A. Tiwari, 2013, Journal of medicinal chemistry.

Biofilm Inhibition via Delivery of Novel Methylthioadenosine Nucleosidase Inhibitors from PVA-Tyramine Hydrogels while Supporting Mesenchymal Stromal Cell Viability.

G. Evans, T. Woodfield, C. Sheen, 2018, ACS biomaterials science & engineering.

Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases

V. Schramm, P. Tyler, T. Meek, 2022, Biochemistry.

Combined Infection Control and Enhanced Osteogenic Differentiation Capacity on Additive Manufactured Ti‐6Al‐4V are Mediated via Titania Nanotube Delivery of Novel Biofilm Inhibitors

G. Evans, G. Hooper, K. Lim, 2020, Advanced Materials Interfaces.

Trichomonas vaginalis: detection of nucleoside hydrolase activity as a potential screening procedure.

R. Furneaux, A. M. Gero, K. Clinch, 2000, Experimental parasitology.

A novel and simple colorimetric method for screening Giardia intestinalis and anti-giardial activity in vitro

Joanne E. Harvey, R. Furneaux, A. M. Gero, 1998, Parasitology.

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase.

V. Schramm, P. Tyler, S. Cahill, 2022, ACS chemical biology.

Synthesis of (2R,4S,5S)-5-Acetamido-4-hydroxypipecolinic Acid (II) as a Potential Inhibitor of Sialidases.

A. Vasella, R. Schauer, K. Clinch, 1988 .

A route to spiroketals using radical translocation

K. Clinch, N. Simpkins, Chris Brown, 1993 .

Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase.

Andrew S Murkin, G. Evans, R. Furneaux, 2009, Journal of medicinal chemistry.

New Antibiotic Candidates against Helicobacter pylori.

G. Evans, V. Schramm, P. Tyler, 2015, Journal of the American Chemical Society.

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics.

G. Evans, V. Schramm, P. Tyler, 2012, Bioorganic & medicinal chemistry.

A practical synthesis of (3R,4R)-N-tert-butoxycarbonyl-4-hydroxymethylpyrrolidin-3-ol.

G. Evans, R. Furneaux, P. Tyler, 2007, Organic & biomolecular chemistry.

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis

G. Evans, V. Schramm, P. Tyler, 2015, PLoS neglected tropical diseases.

Transition State Analogues of Plasmodium falciparum and Human Orotate Phosphoribosyltransferases*

G. Evans, V. Schramm, P. Tyler, 2013, The Journal of Biological Chemistry.

Synthesis of analogues of monic acids A and C: Potential herbicides and inhibitors of isoleucyl tRNA synthetase

K. Clinch, 1996 .

Syntheses of 5-Chlorouracils/Thymines with 1-[Phosphono(Methyl/Difluoromethyl)]-1,2-Unsaturated-Moiety-Substituted Methyl Groups at N(1) and Human Thymidine Phosphorylase Inhibitory Activity

V. Schramm, P. Tyler, G. Gainsford, 2009 .

Synthesis of (2R,4S,5S)-5-acetamido-4-hydroxy-pipecolinic acid as a potential inhibitor of sialidases

A. Vasella, R. Schauer, K. Clinch, 1987 .

Syntheses and bio-activities of the L-enantiomers of two potent transition state analogue inhibitors of purine nucleoside phosphorylases.

G. Evans, R. Furneaux, V. Schramm, 2006, Organic & biomolecular chemistry.

Synthesis and utility of sulfated chromogenic carbohydrate model substrates for measuring activities of mucin-desulfating enzymes.

G. Evans, R. Furneaux, P. Tyler, 2002, Carbohydrate research.

Synthesis of substituted tetrahydropyridines and M-hydroxybenzoic acids

K. Clinch, C. Marquez, R. Ramage, 1989 .

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

G. Evans, V. Schramm, P. Tyler, 2013, Bioorganic & medicinal chemistry.

Reducing the Toxicity of Designer Aminoglycosides as Nonsense Mutation Readthrough Agents for Therapeutic Targets.

M. Roberge, A. Baradaran‐Heravi, Z. Gan, 2021, ACS medicinal chemistry letters.

Acyclic immucillin phosphonates: second-generation inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase.

V. Schramm, P. Tyler, S. Almo, 2012, Chemistry & biology.

L-Enantiomers of transition state analogue inhibitors bound to human purine nucleoside phosphorylase.

G. Evans, R. Furneaux, A. S. Murkin, 2008, Journal of the American Chemical Society.

Conformational heterogeneity within the Michaelis complex of lactate dehydrogenase.

R. Dyer, R. Callender, H. Deng, 2011, The journal of physical chemistry. B.

On the pathway of forming enzymatically productive ligand-protein complexes in lactate dehydrogenase.

R. Dyer, R. Callender, H. Deng, 2008, Biophysical journal.

Structural transformations in the dynamics of Michaelis complex formation in lactate dehydrogenase.

R. Dyer, R. Callender, K. Clinch, 2005, Biophysical journal.

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro

G. Evans, V. Schramm, P. Tyler, 2015, PloS one.

Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase.

G. Evans, V. Schramm, P. Tyler, 2009, Biochemistry.

Four generations of transition-state analogues for human purine nucleoside phosphorylase

Steven C. Almo, G. Evans, V. Schramm, 2010, Proceedings of the National Academy of Sciences.

Femtomolar Transition State Analogue Inhibitors of 5′-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase from Escherichia coli*

G. Evans, R. Furneaux, V. Schramm, 2005, Journal of Biological Chemistry.

(4R,5S)-4-Hydroxymethyl-5-[(methylsulfanyl)methyl]-1,3-oxazolidin-2-one

G. Gainsford, K. Clinch, 2012, Acta crystallographica. Section E, Structure reports online.

3-Benzoyl-5-chlorouracil

G. Gainsford, K. Clinch, 2009, Acta crystallographica. Section E, Structure reports online.

Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases.

G. Evans, V. Schramm, P. Tyler, 2007, Journal of the American Chemical Society.

tert-Butyl (2R,4aR,5aR,11aS,12R,12aR)-8-[bis(tert-butoxycarbonyl)amino]-12-hydroxy-2-methoxy-2,10-dioxo-4,4a,5a,6,9,10,11,11a,12,12a-decahydro-2H-1,3,5-trioxa-6,7,9,11-tetraaza-2λ5-phosphatetracene-6-carboxylate methanol monosolvate monohydrate

A. Tiwari, G. Gainsford, K. Clinch, 2012, Acta crystallographica. Section E, Structure reports online.

Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors

P. Tyler, A. Lamb, T. Meek, 2023, Biochemistry.

3-Benzoyl-5-chlorouracil

G. Gainsford, K. Clinch, 2009, Acta crystallographica. Section E, Structure reports online.

Immucillins in custom catalytic-site cavities.

A. S. Murkin, V. Schramm, P. Tyler, 2008, Bioorganic & medicinal chemistry letters.