N. Mutch

发表

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow.

J. Heemskerk, M. Lancé, C. Whyte, 2015, Blood.

Physiology of Haemostasis: Plasmin-Antiplasmin System

C. Whyte, N. Mutch, Claire S. Whyte, 2020 .

A. Sauaia, E. Moore, H. Moore, 2021, Nature Reviews Disease Primers.

Polyphosphate modifies thefibrin network and down-regulatesfibrinolysis by attenuating binding of tPAand plasminogen tofibrin

H. Philippou, N. Mutch, R. Engel, 2016 .

The use of the Chandler loop to examine the interaction potential of NXY‐059 on the thrombolytic properties of rtPA on human thrombi in vitro

N. Booth, N. Mutch, A. R. Green, 2008, British journal of pharmacology.

Fibrinogen Replacement Therapy for Traumatic Coagulopathy: Does the Fibrinogen Source Matter?

N. Curry, N. Mutch, G. Morrow, 2021, International journal of molecular sciences.

Insights into thrombin activatable fibrinolysis inhibitor function and regulation

A. Gils, J. Foley, N. Mutch, 2013, Journal of thrombosis and haemostasis : JTH.

Regulation of Fibrinolysis by Platelets

N. Mutch, 2019, Platelets.

Platelet-Mediated Modulation of Fibrinolysis

C. Whyte, N. Mutch, Joanne L. Mitchell, 2017, Seminars in Thrombosis and Hemostasis.

Polyphosphate as a haemostatic modulator.

N. Mutch, 2016, Biochemical Society transactions.

Polyphosphate Delays Fibrin Polymerisation and Alters the Mechanical Properties of the Fibrin Network

Marco M. Domingues, J. Weisel, I. Chernysh, 2016, Thrombosis and Haemostasis.

Polyphosphate colocalizes with factor XII on platelet-bound fibrin and augments its plasminogen activator activity.

A. S. Lionikiene, N. Mutch, P. Kim, 2016, Blood.

Single‐chain factor XII exhibits activity when complexed to polyphosphate

A. S. Lionikiene, N. Mutch, R. Engel, 2014, Journal of thrombosis and haemostasis : JTH.

Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation.

T. Renné, K. Nickel, N. Mutch, 2013, Blood.

The Role of Platelets in Fibrinolysis

N. Mutch, 2013 .

Polyphosphate scores a hat trick in regulating host defense mechanisms

N. Mutch, 2012, Journal of thrombosis and haemostasis : JTH.

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

M. Doherty, I. Megson, S. MacRury, 2014, Biochemical Society transactions.

An international study on the feasibility of a standardized combined plasma clot turbidity and lysis assay: communication from the SSC of the ISTH

H. Philippou, D. Rijken, M. Pieters, 2018, Journal of thrombosis and haemostasis : JTH.

Human Thrombi Contain an Abundance of Active Thrombin

N. Booth, N. Mutch, L. Robbie, 2001, Thrombosis and Haemostasis.

Trauma-induced coagulopathy

A. Sauaia, E. Moore, H. Moore, 2021, Nature Reviews Disease Primers.

A Serpin With a Finger in Many PAIs: PAI-1's Central Function in Thromboinflammation and Cardiovascular Disease

C. Whyte, N. Mutch, G. Morrow, 2021, Frontiers in Cardiovascular Medicine.

THROMBOSIS AND HEMOSTASIS Altered fi brinolysis in autosomal dominant thrombomodulin-associated coagulopathy

K. Stirrups, E. Turro, A. Mumford, 2016 .

Altered fibrinolysis in autosomal dominant thrombomodulin-associated coagulopathy.

K. Stirrups, E. Turro, A. Mumford, 2016, Blood.

Role of Shear Stress and tPA Concentration in the Fibrinolytic Potential of Thrombi

D. Newby, K. M. Baeten, A. Lucking, 2021, International journal of molecular sciences.

TAFIa, PAI‐1 and α2‐antiplasmin: complementary roles in regulating lysis of thrombi and plasma clots

N. Booth, N. Mutch, N. Moore, 2007, Journal of thrombosis and haemostasis : JTH.

Harmonisation of D-dimer - A call for action.

G. Lippi, J. Thachil, S. Kitchen, 2016, Thrombosis research.

Let's cross‐link: diverse functions of the promiscuous cellular transglutaminase factor XIII‐A

N. Mutch, J. Mitchell, Nicola J. Mutch, 2019, Journal of thrombosis and haemostasis : JTH.

The suboptimal fibrinolytic response in COVID‐19 is dictated by high PAI‐1

J. Knight, A. Mentzer, N. Curry, 2022, Journal of Thrombosis and Haemostasis.

Emerging roles for factor XII in vivo

N. Mutch, 2011, Journal of thrombosis and haemostasis : JTH.

Immobilized transition metal ions stimulate contact activation and drive factor XII‐mediated coagulation

N. Mutch, J. Morrissey, E. K. Waters, 2012, Journal of thrombosis and haemostasis : JTH.

Cryoprecipitate transfusion in trauma patients attenuates hyperfibrinolysis and restores normal clot structure and stability: Results from a laboratory sub-study of the FEISTY trial

Z. McQuilten, N. Curry, N. Mutch, 2022, Critical Care.

Exposure of plasminogen and the novel plasminogen receptor, Plg-RKT, on activated human and murine platelets.

L. Miles, N. Booth, C. Whyte, 2020, Blood.

Functional plasminogen activator inhibitor 1 is retained on the activated platelet membrane following platelet activation.

C. Whyte, N. Mutch, G. Morrow, 2019, Haematologica.

Defective α2antiplasmin cross‐linking and thrombus stability in a case of acquired factor XIII deficiency

H. Watson, N. Mutch, Joanne L. Mitchell, 2017, British journal of haematology.

THROMBOSIS AND HEMOSTASIS Polyphosphate colocalizes with factor XII on platelet-bound ﬁ brin and augments its plasminogen activator activity

A. S. Lionikiene, N. Mutch, P. Kim, 2016 .

Functional factor XIII-A is exposed on the stimulated platelet surface.

N. Booth, C. Whyte, A. S. Lionikiene, 2014, Blood.

Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis

H. Watson, N. Booth, N. Mutch, 2010, Journal of thrombosis and haemostasis : JTH.

Monocytes Expose Factor XIII-A and Stabilize Thrombi against Fibrinolytic Degradation

C. Whyte, N. Mutch, F. Alshehri, 2021, International journal of molecular sciences.

Factor XII and kininogen asymmetric assembly with gC1qR/C1QBP/P32 is governed by allostery.

J. Emsley, I. Dreveny, K. McCrae, 2020, Blood.

Theme 1: Pathogenesis of venous thromboembolism (and post-thrombotic syndrome).

S. Diamond, P. Reitsma, R. Nieuwland, 2015, Thrombosis research.

Basic science research opportunities in thrombosis and hemostasis: Communication from the SSC of the ISTH

O. McCarty, V. Schroeder, S. D. De Meyer, 2022, Journal of thrombosis and haemostasis : JTH.

Activation mechanism dependent surface exposure of cellular factor XIII on activated platelets and platelet microparticles

M. Antal, N. Mutch, G. Kis, 2022, Journal of thrombosis and haemostasis : JTH.

Novel aspects of platelet factor XIII function.

N. Mutch, Joanne L. Mitchell, 2016, Thrombosis research.

Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

N. Mutch, G. Morrow, 2022, Seminars in Thrombosis and Hemostasis.

S100A8/A9 drives the formation of procoagulant platelets through GPIbα

Natalie S. Poulter, S. Watson, N. Poulter, 2022, Blood.

uPA-mediated plasminogen activation is enhanced by polyphosphate

C. Whyte, N. Mutch, Claire S. Whyte, 2020, Haematologica.

Activation of single‐chain urokinase‐type plasminogen activator by platelet‐associated plasminogen: a mechanism for stimulation of fibrinolysis by platelets

K. M. Baeten, S. Kanse, J. Degen, 2010, Journal of thrombosis and haemostasis : JTH.

Polyphosphate modifies the fibrin network and down-regulates fibrinolysis by attenuating binding of tPA and plasminogen to fibrin.

H. Philippou, N. Mutch, R. Ariëns, 2010, Blood.

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

T. Renné, W. Gahl, Stefan Schmidbauer, 2009, Cell.

Polyphosphate modulates blood coagulation and fibrinolysis.

James H Morrissey, Peter Rohloff, P. Rohloff, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Thrombin-Anti-Thrombin Levels and Patency of Arterio-Venous Fistula in Patients Undergoing Haemodialysis Compared to Healthy Volunteers: A Prospective Analysis

J. Brittenden, I. Ford, N. Mutch, 2013, PloS one.

Defining trauma‐induced coagulopathy with respect to future implications for patient management: Communication from the SSC of the ISTH

E. Moore, M. Schreiber, R. Medcalf, 2020, Journal of thrombosis and haemostasis : JTH.

Location, location, location: Fibrin, cells, and fibrinolytic factors in thrombi

C. Whyte, N. Mutch, Anuj Narwal, 2023, Frontiers in Cardiovascular Medicine.

Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

C. Whyte, N. Mutch, F. Alshehri, 2021, International journal of molecular sciences.

Localization and Identification of Thrombin and Plasminogen Activator Activities in Model Human Thrombi by in situ Zymography

B. Bennett, S. Berry, N. Booth, 2002, Thrombosis and Haemostasis.

Polyphosphate binds with high affinity to exosite II of thrombin

L. Leung, T. Myles, N. Mutch, 2010, Journal of thrombosis and haemostasis : JTH.

Factor XIIa regulates the structure of the fibrin clot independently of thrombin generation through direct interaction with fibrin.

H. ten Cate, H. Philippou, N. Mutch, 2011, Blood.

thrombin generation through direct interaction with fibrin Factor XIIa regulates the structure of the fibrin clot independently of

H. Philippou, N. Mutch, R. Ariëns, 2012 .

Thrombus lysis by uPA, scuPA and tPA is regulated by plasma TAFI

N. Booth, N. Mutch, N. J. Mutch, 2003, Journal of thrombosis and haemostasis : JTH.

Fibrinolytic abnormalities in acute respiratory distress syndrome (ARDS) and versatility of thrombolytic drugs to treat COVID‐19

C. Whyte, N. Mutch, P. Chowdary, 2020, Journal of Thrombosis and Haemostasis.

Past, Present, and Future Perspectives of Plasminogen Activator Inhibitor 1 (PAI-1)

N. Mutch, G. Morrow, 2022, Seminars in Thrombosis and Hemostasis.

Determinants of Endogenous Fibrinolysis in Whole Blood Under High Shear in Patients With Myocardial Infarction

N. Mutch, D. Gorog, Y. Gue, 2022, JACC. Basic to translational science.

The antifibrinolytic function of factor XIII is exclusively expressed through α₂-antiplasmin cross-linking.

N. Booth, N. Mutch, S. Fraser, 2011, Blood.

The Efficacy of Fibrinogen Concentrates in Relation to Cryoprecipitate in Restoring Clot Integrity and Stability against Lysis

C. Whyte, N. Mutch, A. Rastogi, 2022, International journal of molecular sciences.

Removing plasmin from the equation - Something to chew on….

N. Mutch, G. Morrow, 2021, Journal of thrombosis and haemostasis : JTH.

Plasminogen activator inhibitor-1 and haemostasis in obesity

H. Wilson, N. Booth, N. Mutch, 2001, Proceedings of the Nutrition Society.

“Super” SERPINs—A stabilizing force against fibrinolysis in thromboinflammatory conditions

C. Whyte, N. Mutch, S. J. Humphreys, 2023, Frontiers in Cardiovascular Medicine.

A new pedigree with thrombomodulin‐associated coagulopathy in which delayed fibrinolysis is partially attenuated by co‐inherited TAFI deficiency

K. Downes, J. Stephens, E. Turro, 2020, Journal of thrombosis and haemostasis : JTH.

Plasmin and the thrombin–thrombomodulin complex both contribute to thrombin‐activatable fibrinolysis inhibitor activation in whole blood model thrombi

A. Gils, N. Mutch, P. Declerck, 2013, Journal of thrombosis and haemostasis : JTH.

Atorvastatin-mediated inhibition of prenylation of Rab27b and Rap1a in platelets attenuates their prothrombotic capacity and modulates clot structure.

F. Coxon, C. Whyte, N. Mutch, 2023, Platelets.

“Going with the flow” in modeling fibrinolysis

C. Whyte, N. Mutch, Claire S. Whyte, 2022, Frontiers in Cardiovascular Medicine.

Brief report The antifibrinolytic function of factor XIII is exclusively expressed through 2-antiplasmin cross-linking

N. Booth, N. Mutch, S. Fraser, 2017 .

Platelet factor XIII-A regulates platelet function and promotes clot retraction and stability

T. Sage, J. Gibbins, N. Curry, 2023, Research and practice in thrombosis and haemostasis.

Fibrinolytic pathophysiologies: still the poor cousin of hemostasis?

N. Mutch, 2023, Journal of thrombosis and haemostasis : JTH.

The antifibrinolytic function of factor XIII is exclusively expressed through a2-antiplasmin cross-linking. Blood. 2011;117(23):6371-6374.

N. Booth, N. Mutch, S. Fraser, 2011 .

Platelet Polyphosphates Are Proinflammatory and Procoagulant Mediators In Vivo

T. Renné, W. Gahl, Stefan Schmidbauer, 2009, Cell.

Cellular FXIII in Human Macrophage-Derived Foam Cells

J. Balla, É. Katona, N. Mutch, 2023, International journal of molecular sciences.

Time-dependent degradation and tissue factor addition mask the ability of platelet polyphosphates in activating factor XII-mediated coagulation.

T. Renné, N. Mutch, H. Spronk, 2013, Blood.

Endothelial cell oxidative stress in diabetes: a key driver of cardiovascular complications?

M. Doherty, I. Megson, S. MacRury, 2014, Biochemical Society transactions.

The antifibrinolytic function of factor XIII is exclusively expressed through α₂-antiplasmin cross-linking.

N. Booth, N. Mutch, S. Fraser, 2011, Blood.

Nebulized Recombinant Tissue Plasminogen Activator (rt-PA) for Acute COVID-19-Induced Respiratory Failure: An Exploratory Proof-of-Concept Trial

P. Watkinson, E. Raith, A. Riddell, 2023, Journal of clinical medicine.

Defective α2antiplasmin cross‐linking and thrombus stability in a case of acquired factor XIII deficiency

H. Watson, N. Mutch, Joanne L. Mitchell, 2017, British journal of haematology.

Fibrinogenolysis and ﬁ brinolysis in vaccine-induced immune thrombocytopenia and thrombosis

N. Mutch, Megan Simpson, Anuj Narwal, 2022 .