J. Clozel

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Effects of Cilazapril on the Cerebral Circulation in Spontaneously Hypertensive Rats

J. Clozel, H. Kuhn, F. Hefti, 1989, Hypertension.

Time course of thrombolysis induced by intravenous bolus or infusion of tissue plasminogen activator in a rabbit jugular vein thrombosis model.

P. Holvoet, J. Clozel, T. Tschopp, 1989, Circulation.

Telemetry monitoring of pulmonary arterial pressure in freely moving rats.

J. Clozel, P. Hess, M. Clozel, 1996, Journal of applied physiology.

Renin inhibition by substituted piperidines: a novel paradigm for the inhibition of monomeric aspartic proteinases?

F. Winkler, A. D'arcy, C. Oefner, 1999, Chemistry & biology.

Functional and biochemical analysis of angiotensin II-forming pathways in the human heart.

W. Kiowski, J. Clozel, W. Fischli, 1997, Circulation research.

Angiotensin I-converting enzyme inhibition but not angiotensin II suppression alters angiotensin I-converting enzyme gene expression in vessels and epithelia.

J. Ménard, O. Costerousse, J. Clozel, 1998, The Journal of pharmacology and experimental therapeutics.

Increased vascular responsiveness to norepinephrine in rats with heart failure is endothelium dependent. Dissociation of basal and stimulated nitric oxide release.

G. Gray, J. Teerlink, J. Clozel, 1994, Circulation.

Vascular Protection with Cilazapril

H. Baumgartner, J. Clozel, H. Kuhn, 2012, Drugs.

Respective role of humoral factors and blood pressure in aortic remodeling of DOCA hypertensive rats.

D. Heudes, B. Löffler, J. Clozel, 1996, American journal of hypertension.

Decreases of vascular hypertrophy in four different types of arteries in spontaneously hypertensive rats.

J. Clozel, H. Kuhn, F. Hefti, 1989, The American journal of medicine.

Mibefradil (Ro 40-5967): the first selective T-type Ca2+ channel blocker.

S. Ertel, J. Clozel, 1997, Expert opinion on investigational drugs.

Discovery and main pharmacological properties of mibefradil (Ro 40‐5967), the first selective T‐type calcium channel blocker

S. Ertel, J. Clozel, E. A. Ertel, 1997, Journal of hypertension. Supplement : official journal of the International Society of Hypertension.

Increased survival after long-term treatment with mibefradil, a selective T-channel calcium antagonist, in heart failure.

F. Lallemand, P. Mulder, V. Richard, 1997, Journal of the American College of Cardiology.

Effects of endothelin on regional blood flows in squirrel monkeys.

J. Clozel, M. Clozel, Martine Clozel, 1989, The Journal of pharmacology and experimental therapeutics.

Ro 40–5967, in Contrast to Diltiazem, Does Not Reduce Left Ventricular Contractility in Rats with Chronic Myocardial Infarction

M. Véniant, J. Clozel, P. Hess, 1991, Journal of Cardiovascular Pharmacology.

Angiotensin I-Converting Enzyme Inhibition but Not Angiotensin II Suppression Alters Angiotensin I-Converting Enzyme Gene Expression in Vessels and Epithelia 1

J. Ménard, O. Costerousse, J. Clozel, 1998 .

Temporal evolution of endothelial dysfunction in a rat model of chronic heart failure.

J. Teerlink, J. Clozel, M. Clozel, 1993, Journal of the American College of Cardiology.

Pharmacology of the calcium antagonist mibefradil

T. Lüscher, G. Noll, J. Clozel, 1997 .

Local angiotensin II generation in the rat heart: role of renin uptake.

J. Ménard, D. Ganten, A. Busjahn, 1998, Circulation research.

Potent vasoconstriction mediated by endothelin ETB receptors in canine coronary arteries.

V. Breu, J. Teerlink, J. Clozel, 1994, Circulation research.

Effects of Diltiazem on Experimental Myocardial Ischemia and on Left Ventricular Performance

M. Bourassa, P. Théroux, J. Clozel, 1983, Circulation research.

Ro 42‐5892 Is a Potent Orally Active Renin Inhibitor in Primates

W. Neidhart, W. Wostl, J. Clozel, 1991, Hypertension.

Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries.

M. Turina, P. Vogt, V. Breu, 1996, Journal of cardiovascular pharmacology.

Short-term endothelin receptor blockade with tezosentan has both immediate and long-term beneficial effects in rats with myocardial infarction.

M. Clozel, J. Clozel, P. Hess, 2002, Journal of the American College of Cardiology.

Pharmacology of tezosentan, new endothelin receptor antagonist designed for parenteral use.

S. Roux, V. Breu, B. Löffler, 1999, The Journal of pharmacology and experimental therapeutics.

The role of endothelin in experimental cerebral vasospasm.

S. Roux, G. Gray, B. Löffler, 1995, Neurosurgery.

Voltage-gated T-type Ca2+ channels and heart failure.

S. Ertel, J. Clozel, E. A. Ertel, 1999, Proceedings of the Association of American Physicians.

Ro 40–5967: A New Nondihydropyridine Calcium Antagonist

J. Clozel, F. Hefti, H. Eggers, 1991 .

Effects of Cilazapril, a Novel Angiotensin Converting Enzyme Inhibitor, on the Structure of Pulmonary Arteries of Rats Exposed to Chronic Hypoxia

J. Clozel, W. Fischli, C. Saunier, 1991, Journal of cardiovascular pharmacology.

Nonlinear kinetics and pharmacologic response to mibefradil

J. Clozel, P. Souich, G. Caillé, 2000, Clinical pharmacology and therapeutics.

Renal proliferative and phenotypic changes in rats with two-kidney, one-clip Goldblatt hypertension.

J. Ménard, C. Alpers, J. Floege, 1994, American journal of hypertension.

A Ren in Inhibitor With Increasing Effects on Chronic Treatment

S. Mathews, V. Breu, W. Wostl, 2005 .

Pharmacokinetics of remikiren, a potent orally active inhibitor of human renin, in rat, dog and primates.

R. C. Chou, J. Clozel, P. Coassolo, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Hemodynamic Profile of Ro 40–5967 in Conscious Rats: Comparison with Diltiazem, Verapamil, and Amlodipine

M. Véniant, J. Clozel, P. Hess, 1991, Journal of cardiovascular pharmacology.

Effects of Ro 40-5967, a Novel Calcium Antagonist, on Myocardial Function During Ischemia Induced by Lowering Coronary Perfusion Pressure in Dogs: Comparison with Verapamil

J. Clozel, L. Banken, W. Osterrieder, 1989, Journal of cardiovascular pharmacology.

Prevention of neointima formation by mibefradil after vascular injury in rats: Comparison with ACE inhibition

F. Bühler, J. Clozel, N. Iberg, 1996, Cardiovascular Drugs and Therapy.

Influence of the status of the renin-angiotensin system on the effect of cilazapril on neointima formation after vascular injury in rats.

H. Baumgartner, S. Roux, J. Clozel, 1993, Circulation.

Effects of chronic heart failure on the responsiveness to angiotensin I and to angiotensin converting enzyme inhibition with cilazapril in rats.

J. Clozel, 1989, British journal of clinical pharmacology.

The structurally novel Ca2+ channel blocker Ro 40-5967, which binds to the [3H] desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts

M. Véniant, J. Clozel, W. Osterrieder, 1990, Cardiovascular Drugs and Therapy.

Combination of non-hypotensive doses of valsartan and enalapril improves survival of spontaneously hypertensive rats with endothelial dysfunction

P. Bruneval, B. Nuesslein-Hildesheim, J. Clozel, 2000, Journal of the renin-angiotensin-aldosterone system : JRAAS.

Additional hypotensive effect of endothelin-1 receptor antagonism in hypertensive dogs under angiotensin-converting enzyme inhibition.

J. Ketelslegers, J. Donckier, J. Clozel, 1997, Circulation.

Role of Angiotensin II in Injury‐Induced Neointima Formation in Rats

H. Baumgartner, J. Clozel, F. Hefti, 1991, Hypertension.

Effects of diltiazem on atrioventricular conduction and arterial blood pressure: correlation with plasma drug concentrations.

P. Théroux, J. Billette, R. Cartier, 1984, Canadian journal of physiology and pharmacology.

Chronic endothelin receptor blockade prevents renal vasoconstriction and sodium retention in rats with chronic heart failure.

M. Clozel, J. Clozel, P. Hess, 2002, Cardiovascular research.

Influence of congestive heart failure on endothelin levels and receptors in rabbits.

S. Roux, B. Kalina, B. Löffler, 1993, Journal of molecular and cellular cardiology.

Role of endothelin in the maintenance of blood pressure in conscious rats with chronic heart failure. Acute effects of the endothelin receptor antagonist Ro 47-0203 (bosentan).

B. Löffler, M. Clozel, J. Teerlink, 1994, Circulation.

Respective role of humoral factors and blood pressure in cardiac remodeling of DOCA hypertensive rats.

D. Heudes, B. Löffler, J. Clozel, 1996, Cardiovascular research.

Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism.

D. Heudes, P. Bruneval, B. Löffler, 1996, Hypertension.

Mibefradil, a selective calcium T-channel blocker, in stroke-prone spontaneously hypertensive rats.

Giudicelli, P. Fornés, J. Clozel, 1996, Journal of cardiovascular pharmacology.

Effects of nonpeptide endothelin receptor antagonists in rats with reduced renal mass.

D. Heudes, P. Bruneval, M. Clozel, 1999, Journal of cardiovascular pharmacology.

Prophylactic effect of intravenous tiapamil on methylergometrine-induced coronary artery spasm in patients with variant angina: randomized double-blind trial.

N. Danchin, F. Elkik, J. Clozel, 1985, American heart journal.

Decreased Coronary Vascular Reserve in Watanabe Heritable Hyperlipidemic Rabbits

H. Lengsfeld, H. Baumgartner, J. Clozel, 1988, Arteriosclerosis.

Experimental carotid thrombosis in the guinea pig.

S. Roux, L. Falivene, J. Clozel, 1994, Thrombosis and haemostasis.

Role of endothelin during reperfusion after ischemia in isolated perfused rat heart.

V. Breu, M. Clozel, J. Clozel, 1994, Journal of cardiovascular pharmacology.

Combination of Low-Dose Valsartan and Enalapril Improves Endothelial Dysfunction and Coronary Reserve in Nω-Nitro-l-Arginine Methyl Ester–Treated Spontaneously Hypertensive Rats

E. Persohn, P. Germann, M. Clozel, 2002, Journal of cardiovascular pharmacology.

Effects of the blockade of the renin–angiotensin system in cyclosporin-induced hypertension

J. Ménard, J. Clozel, W. Fischli, 1993, Journal of hypertension.

Piperidine renin inhibitors: from leads to drug candidates.

T Hartung, F C Luft, M. Kansy, 2001, Farmaco.

Endothelin plays a role in the maintenance of blood pressure in normotensive guinea pigs.

M. Véniant, J. Clozel, P. Hess, 1994, Life sciences.

Protective effects of endothelin receptor antagonists in dogs with aortic cross-clamping.

S. Roux, J. Clozel, C. Qiu, 1999, Journal of cardiovascular pharmacology.

Ro 61-1790, a new hydrosoluble endothelin antagonist: general pharmacology and effects on experimental cerebral vasospasm.

W. Neidhart, S. Roux, V. Breu, 1997, The Journal of pharmacology and experimental therapeutics.

Cilazapril Inhibits Wall Thickening of Vein Bypass Graft in the Rat

S. Roux, J. Clozel, H. Kuhn, 1991, Hypertension.

Effects of renin-angiotensin system blockade in guinea pigs.

M. Véniant, J. Clozel, P. Hess, 1992, Hypertension.

Hemodynamic effects of intravenous diltiazem in hypoxic pulmonary hypertension.

P. Battistella, J. Clozel, J. Polu, 1987, Chest.

Inhibition of Converting Enzyme and Neointima Formation After Vascular Injury in Rabbits and Guinea Pigs

J. Clozel, P. Hess, C. Michael, 1991, Hypertension.

Renal vascular and biochemical responses to systemic renin inhibition in dogs at low renal perfusion pressure.

M. Véniant, J. Clozel, W. Fischli, 1999, Journal of cardiovascular pharmacology.

Effects of calcium blockade on end‐organ damage in experimental hypertension

J. Ménard, D. Heudes, P. Bruneval, 1997 .

RoleofEndothelin intheMaintenance ofBlood Pressure inConscious RatsWith Chronic HeartFailure AcuteEffects oftheEndothelin Receptor Antagonist Ro47-0203 (Bosentan)

B. Löffler, M. Clozel, J. Clozel, 1994 .

Differential Effects of the Calcium Antagonist Mibefradil in Epicardial and Intramyocardial Coronary Arteries

T. Lüscher, G. Noll, J. Clozel, 1995, Journal of cardiovascular pharmacology.

Structural changes and cyclic GMP content of the aorta after calcium antagonism or angiotensin converting enzyme inhibition in renovascular hypertensive rats

J. Ménard, D. Heudes, M. Véniant, 1995, Journal of hypertension.

Effects of calcium channel blockade on the aortic intima in spontaneously hypertensive rats.

H. Baumgartner, G. Gray, J. Clozel, 1993, Hypertension.

Endothelin Mediates the Altered Renal Hemodynamics Associated with Experimental Congestive Heart Failure

M. Clozel, J. Clozel, P. Hess, 2001, Journal of cardiovascular pharmacology.

Contrasting effects of selective T- and L-type calcium channel blockade on glomerular damage in DOCA hypertensive rats.

J. Ménard, P. Bruneval, J. Clozel, 1999, Hypertension.

Low-voltage-activated T-type calcium channels : proceedings from the International Electrophysiology Meeting, Montpellier, 21-22 October 1996

R. Tsien, J. Clozel, J. Nargeot, 1998 .

Aprotinin: an antidote for recombinant tissue-type plasminogen activator (rt-PA) active in vivo.

S. Roux, J. Clozel, L. Banken, 1990, Journal of the American College of Cardiology.

Effects of acute and chronic cilazapril treatment in spontaneously hypertensive rats.

J. Clozel, F. Hefti, W. Fischli, 1989, British journal of clinical pharmacology.

Calcium blockade versus ACE inhibition in clipped and unclipped kidneys of 2K-1C rats.

J. Ménard, D. Heudes, P. Bruneval, 1994, Kidney international.

Effects of Ro 40-5967, a new calcium antagonist, and enalapril on cardiac remodeling in renal hypertensive rats.

J. Ménard, D. Heudes, M. Véniant, 1993, Journal of cardiovascular pharmacology.

Effects of chronic ACE inhibition on cardiac hypertrophy and coronary vascular reserve in spontaneously hypertensive rats with developed hypertension.

J. Clozel, H. Kuhn, F. Hefti, 1989, Journal of hypertension.

Major role of the renin angiotensin system in the neointima formation after vascular injury in guinea pigs.

H. Baumgartner, V. Breu, J. Clozel, 1994, Life sciences.

Role of endogenous endothelin in normal hemodynamic status of anesthetized dogs.

B. Löffler, J. Teerlink, J. Clozel, 1995, The American journal of physiology.

Effect of adenosine triphosphate on the accessory pathways.

J. Clozel, G. Faivre, B. Perrot, 1984, European heart journal.

Discovery of remikiren as the first orally active renin inhibitor.

J. Clozel, W. Fischli, 1993, Arzneimittel-Forschung.

Influence of low perfusion pressure on effect of endothelin on coronary vascular bed.

J. Clozel, U. Sprecher, 1991, The American journal of physiology.

Prostaglandin E1 increases myocardial contractility in the conscious dog.

M. Bourassa, S. Roux, J. Clozel, 1984, Canadian journal of physiology and pharmacology.

The influence of hypoxemia on tritiated digoxin plasma kinetics and tissue distribution in the conscious dog.

P. du Souich, J. Clozel, D. Hartemann, 1985, The American review of respiratory disease.

Reflex coronary vasodilation evoked by chemical stimulation of cardiac afferent vagal C fibres in dogs.

H. Coleridge, J. Coleridge, J. Clozel, 1990, The Journal of physiology.

Cimetidine inhibits the hypoxia‐induced increase in cerebral blood flow in dogs

J. Clozel, D. Hartemann, C. Saunier, 1985, Critical care medicine.

Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): Effects on intracellular calcium and platelet aggregation

V. Tkachuk, V. Bochkov, J. Clozel, 1995, Cardiovascular Drugs and Therapy.

Respiratory muscle length measured by sonomicrometry.

A. Grassino, F. Bellemare, J. Road, 1984, Journal of applied physiology: respiratory, environmental and exercise physiology.

High-performance liquid chromatographic determination of diltiazem and six of its metabolites in human urine.

P. Théroux, P. Biron, Y. Taeymans, 1984, Journal of pharmaceutical sciences.

Role of endogenous endothelin-1 in experimental renal hypertension in dogs.

J. Ketelslegers, J. Donckier, H. Pouleur, 1995, Circulation.

Effects of Two Angiotensin Converting Enzyme Inhibitors and Hydralazine on Coronary Circulation in Hypertensive Rats

M. Véniant, J. Clozel, P. Hess, 1991, Hypertension.

Inhibitors of angiotensin-converting enzyme prevent myointimal proliferation after vascular injury.

H. Baumgartner, J. Clozel, H. Kuhn, 1989, Science.

T-Type Ca2+ Channels and Pharmacological Blockade: Potential Pathophysiological Relevance

S. Ertel, J. Clozel, E. A. Ertel, 1997, Cardiovascular Drugs and Therapy.

Cilazapril prevents the development of cardiac hypertrophy and the decrease of coronary vascular reserve in spontaneously hypertensive rats.

J. Clozel, F. Hefti, 1988, Journal of cardiovascular pharmacology.

Mibefradil prevents neointima formation after vascular injury in rats. Possible role of the blockade of the T-type voltage-operated calcium channel.

F. Bühler, J. Clozel, N. Iberg, 1995, Arteriosclerosis, thrombosis, and vascular biology.

Chronic treatment with the CA2+ channel inhibitor RO 40-5967 potentiates endothelium-dependent relaxations in the aorta of the hypertensive salt sensitive Dahl rat.

P. Vanhoutte, J. Clozel, C. Boulanger, 1994, Blood pressure.

Antihypertensive properties of the novel calcium antagonist (1S,2S)-2-[2-[[3-(2-benzimidazolyl)propyl]methylamino] ethyl]-6- fluoro-1,2,3,4-tetrahydro-1-isopropyl-2-naphthyl methoxyacetate dihydrochloride in rat models of hypertension. Comparison with verapamil.

J. Clozel, F. Hefti, W. Osterrieder, 1990, Arzneimittel-Forschung.

Mechanism of the antiischemic effect of mibefradil, a selective T calcium channel blocker in dogs: comparison with amlodipine.

S. Roux, J. Clozel, M. Bühler, 1996, Journal of cardiovascular pharmacology.

Effects of propranolol and of verapamil on heart rate and blood pressure in hyperthyroidism

P. Genton, J. Clozel, N. Danchin, 1984, Clinical pharmacology and therapeutics.

Improved gas chromatographic determination of diltiazem and deacetyldiltiazem in human plasma.

P. Biron, Y. Taeymans, J. Clozel, 1984, Journal of Pharmacy and Science.

Effects of Endothelin on the Coronary Vascular Bed in Open-Chest Dogs

M. Clozel, J. Clozel, 1989, Circulation research.

A new model of chronic cardiac ischemia in rabbits.

S. Roux, L. Falivene, J. Clozel, 2000, Journal of applied physiology.

Hemodynamic variability and circadian rhythm in rats with heart failure: role of locomotor activity.

J. Teerlink, J. Clozel, Jean-Paul Clozel, 1993, The American journal of physiology.

Acute hemodynamic effects of ciprokiren, a novel renin inhibitor, in sodium-depleted dogs.

M. Véniant, J. Clozel, W. Fischli, 1995, Journal of cardiovascular pharmacology.

Cyclosporin‐Induced Hypertension in Marmosets: A New Model of Hypertension Sensitive to Angiotensin‐Converting Enzyme Inhibition

J. Clozel, W. Fischli, 1989, Journal of cardiovascular pharmacology.

Vagal chemoreflex coronary vasodilation evoked by stimulating pulmonary C-fibers in dogs.

J. Hoffman, H. Coleridge, J. Coleridge, 1985, Circulation research.

Role of endothelin in acute renal failure due to rhabdomyolysis in rats.

P. Bruneval, J. Bariéty, B. Löffler, 1995, The Journal of pharmacology and experimental therapeutics.

Ciprokiren (Ro 44-9375). A renin inhibitor with increasing effects on chronic treatment.

S. Mathews, V. Breu, W. Wostl, 1994, Hypertension.

Effects of chronic myocardial infarction on responsiveness to isoprenaline and the state of myocardial beta adrenoceptors in rats.

W. Burkard, M. da Prada, J. Clozel, 1987, Cardiovascular research.

Comparative effects of three different potent renin inhibitors in primates.

J. Clozel, W. Fischli, 1993, Hypertension.

Comparative evaluation of acute cerebral vasospasm by the microsphere and the angiography techniques

S. Roux, M. Clozel, J. Clozel, 1995, Journal of Neuroscience Methods.

Cardiovascular alterations in rat fetuses exposed to calcium channel blockers.

W. Scott, H. Buergin, J. Clozel, 1997, Reproductive toxicology.

Influence of hypoxemia and respiratory acidosis on the plasma kinetics and tissue distribution of digoxin in the conscious dog.

P. du Souich, J. Clozel, H. Ong, 1985, Canadian journal of physiology and pharmacology.

Nimodipine does not increase cerebral blood flow during subarachnoid hemorrhage in the rat.

J. Clozel, M. Clozel, J P Clozel, 1996, Pharmacology.

Effects of Chronic Therapy with Cilazapril, a New Angiotensin‐Converting Enzyme Inhibitor, on Regional Blood Flows in Conscious Spontaneously Hypertensive Rats

J. Clozel, F. Hefti, Jean-Paul Clozel, 1987, Journal of cardiovascular pharmacology.

Experimental Pulmonary Embolus in the Rat: A New in vivo Model to Test Thrombolytic Drugs

P. Holvoet, J. Clozel, T. Tschopp, 1988, Journal of cardiovascular pharmacology.