E. Grimm

发表

Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.

N. Méthot, D. Riendeau, D. Éthier, 2005, Bioorganic & medicinal chemistry letters.

The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.

Christine Brideau, Yves Ducharme, Marc Ouellet, 2010, ACS medicinal chemistry letters.

The discovery and synthesis of potent zwitterionic inhibitors of renin.

J. Falgueyret, M. Percival, S. Gagné, 2011, Bioorganic & medicinal chemistry letters.

Impact of passive permeability and gut efflux transport on the oral bioavailability of novel series of piperidine-based renin inhibitors in rodents.

Yongxin Han, S. Gagné, Y. Ducharme, 2011, Bioorganic & medicinal chemistry letters.

3,4-Diarylpiperidines as potent renin inhibitors.

J. Falgueyret, Yongxin Han, E. Cauchon, 2012, Bioorganic & medicinal chemistry letters.

Addressing time-dependent CYP 3A4 inhibition observed in a novel series of substituted amino propanamide renin inhibitors, a case study.

S. Gagné, D. McKay, E. Grimm, 2010, Bioorganic & medicinal chemistry letters.

The discovery of a new structural class of potent orally active leukotriene D4 antagonists

R. Young, P. Prasit, A. Ford-hutchinson, 1992 .

Substituted coumarins as potent 5-lipoxygenase inhibitors.

J. Falgueyret, D. Riendeau, C. Brideau, 2006, Bioorganic & medicinal chemistry letters.

Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Bioorganic & medicinal chemistry letters.

Solid phase synthesis of selective caspase-3 peptide inhibitors.

C. Bayly, R. Zamboni, P. Tawa, 2004, Bioorganic & medicinal chemistry.

Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.

Yongxin Han, R. Zamboni, P. Tawa, 2007, Bioorganic & medicinal chemistry letters.

Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.

C. Bayly, Yongxin Han, R. Zamboni, 2005, Bioorganic & medicinal chemistry letters.

Nicotinyl aspartyl ketones as inhibitors of caspase-3.

C. Bayly, R. Zamboni, N. Thornberry, 2000, Bioorganic & medicinal chemistry letters.

A straightforward approach to the synthesis of the tricyclic core of taxol

M. Bernstein, H. Perrier, S. Warder, 1993 .

Design and synthesis of potent, isoxazole-containing renin inhibitors.

J. Falgueyret, M. Percival, Yongxin Han, 2012, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of tertiary alcohol-bearing piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Renin inhibitors for the treatment of hypertension: design and optimization of a novel series of pyridone-substituted piperidines.

J. Falgueyret, M. Percival, Yongxin Han, 2011, Bioorganic & medicinal chemistry letters.

Design and optimization of a substituted amino propanamide series of renin inhibitors for the treatment of hypertension.

C. Bayly, S. Gagné, S. Soisson, 2010, Bioorganic & medicinal chemistry letters.

Correlating the fractional inhibition of caspase-3 in NT2 cells with apoptotic markers using an active-caspase-3 enzyme-linked immunosorbent assay.

Yongxin Han, P. Tawa, D. Nicholson, 2006, Analytical biochemistry.

A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.

D. Riendeau, P. Prasit, C. Brideau, 1999, Bioorganic & medicinal chemistry letters.

SAR in the alkoxy lactone series: the discovery of DFP, a potent and orally active COX-2 inhibitor.

D. Riendeau, S. Boyce, P. Prasit, 1999, Bioorganic & medicinal chemistry letters.

Intramolecular Diels–Alder Reactions with Methyl 2‐Trimethylsiloxy‐2‐vinylcyclopropanecarboxylates as Key Building Blocks

H. Reissig, E. Grimm, R. Zschiesche, 1986 .

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).

D. Riendeau, R. Young, P. Prasit, 2000, Bioorganic & medicinal chemistry letters.

Total synthesis of (±)-parvifoline

E. Grimm, Sylvain Levac, Michel L. Coutu, 1994 .

Facile construction of the bicyclo[6.4.0]dodecane ring system via intramolecular cyclization of a sulfone stabilized carbanion

E. Grimm, L. Trimble, Michel L. Coutu, 1993 .

2-alkenyl-substituted methyl 2-siloxycyclopropanecarboxylates as masked vinyl ketones: efficient syntheses of highly functionalized Michael adducts

H. Reissig, E. Grimm, R. Zschiesche, 1985 .

The unsymmetrical silaketal as a neutral, removable tether for effecting intramolecular diels-alder reactions.

M. Bernstein, J. Gillard, R. Glaser, 1991 .

Total synthesis of (±)-Heliannuol A

E. Grimm, L. Trimble, Sylvain Levac, 1994 .

2-Alkeny1-Substituted Methyl 2-Siloxycyclopropanecarboxylates as Masked Vinyl Ketones: Efficient Syntheses of Highly Functionalized Michael Adducts.

H. Reissig, E. Grimm, R. Zschiesche, 1986 .

Stereoselectivity of Intramolecular Diels-Alder Reactions of 1,7,9-Decatrien-3-ones to Octalone Derivatives.

H. Reissig, Barbara Frey, E. Grimm, 1990 .

Symmetry-enhanced remote dicarbanion annulations for latent cycloalkenones: Applications to alkaloids and terpenes

C. Spagnuolo, E. Grimm, P. Lansbury, 1990 .

SYNTHESIS AND BIOLOGICAL EVALUATION OF BOTH ENANTIOMERS OF L-761,000 AS INHIBITORS OF CYCLOOXYGENASE 1 AND 2

Yves Leblanc, Daniel Guay, Petpiboon Prasit, 1996 .

Catalytic activity of caspase-3 is required for its degradation: stabilization of the active complex by synthetic inhibitors

P. Tawa, D. Nicholson, S. Xanthoudakis, 2004, Cell Death and Differentiation.

Facile Construction of Medium-Sized Carbocycles, Total Synthesis of (±)-Parvifoline

E. Grimm, Sylvain Levac, Michel L. Coutu, 1994 .

Reducing the peptidyl features of caspase-3 inhibitors: a structural analysis.

C. Bayly, Yongxin Han, R. Zamboni, 2004, Journal of medicinal chemistry.

In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.

Chun Xing Li, J. Yergey, J. Silva, 2001, Drug metabolism and disposition: the biological fate of chemicals.

3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.

D. Riendeau, P. Prasit, C. Brideau, 2003, Bioorganic & medicinal chemistry letters.

Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte

R. Hotchkiss, Yongxin Han, P. Swanson, 2000, Nature Immunology.