T. Maier

发表

Inhibition of microsomal prostaglandin E2 synthase‐1 as a molecular basis for the anti‐inflammatory actions of boswellic acids from frankincense

O. Werz, H. Northoff, F. Bernhard, 2011, British journal of pharmacology.

Antibody response to SARS-CoV-2 for more than one year − kinetics and persistence of detection are predominantly determined by avidity progression and test design

H. Scheiblauer, V. Mahler, C. Stephan, 2021, Journal of Clinical Virology.

5-Lipoxygenase contributes to PPARγ activation in macrophages in response to apoptotic cells.

D. Steinhilber, B. Brüne, A. von Knethen, 2013, Cellular signalling.

Inhibition of prostaglandin E2 synthesis by SC‐560 is independent of cyclooxygenase 1 inhibition

P. Jakobsson, C. Brenneis, K. Scholich, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

An Aberrant Phosphorylation of Amyloid Precursor Protein Tyrosine Regulates Its Trafficking and the Binding to the Clathrin Endocytic Complex in Neural Stem Cells of Alzheimer's Disease Patients

J. Enghild, E. T. Poulsen, C. Matrone, 2017, Front. Mol. Neurosci..

Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416.

O. Werz, D. Steinhilber, S. George, 2012, Biochimica et biophysica acta.

Pharmacological Inhibition of Platelet-Tumor Cell Cross-Talk Prevents Platelet-Induced Overexpression of Cyclooxygenase-2 in HT29 Human Colon Carcinoma Cells

B. Suess, D. Steinhilber, E. Marcantoni, 2013, Molecular Pharmacology.

Drug-Mediated Intracellular Donation of Nitric Oxide Potently Inhibits 5-Lipoxygenase: A Possible Key to Future Antileukotriene Therapy.

O. Werz, D. Steinhilber, E. Proschak, 2017, Antioxidants & redox signaling.

Effects of Celecoxib on Prostanoid Biosynthesis and Circulating Angiogenesis Proteins in Familial Adenomatous Polyposis

G. FitzGerald, D. Steinhilber, E. Ricciotti, 2012, Journal of Pharmacology and Experimental Therapeutics.

The Emerging Therapeutic Potential of Nitro Fatty Acids and Other Michael Acceptor-Containing Drugs for the Treatment of Inflammation and Cancer

D. Steinhilber, K. Zacharowski, C. Matrone, 2020, Frontiers in Pharmacology.

Sulindac sulfide suppresses 5-lipoxygenase at clinically relevant concentrations

O. Werz, D. Steinhilber, S. George, 2010, Cellular and Molecular Life Sciences.

Anti‐inflammatory nitro‐fatty acids suppress tumor growth by triggering mitochondrial dysfunction and activation of the intrinsic apoptotic pathway in colorectal cancer cells

D. Steinhilber, K. Zacharowski, C. Matrone, 2018, Biochemical pharmacology.

p53 is important for the anti-proliferative effect of ibuprofen in colon carcinoma cells.

S. Grösch, G. Geisslinger, I. Wobst, 2008, Biochemical and biophysical research communications.

TLR2 ligands augment cPLA2α activity and lead to enhanced leukotriene release in human monocytes

D. Steinhilber, U. Köhl, T. Maier, 2009, Journal of leukocyte biology.

The SARS-CoV-2 Variant Omicron Is Able to Escape Vaccine-Induced Humoral Immune Responses, but Is Counteracted by Booster Vaccination

E. Hildt, B. Schnierle, D. Oberle, 2022, Vaccines.

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

O. Werz, H. Northoff, S. Laufer, 2017, The Journal of clinical investigation.

Busulfan induces activin A expression in vitro and in vivo: a possible link to venous occlusive disease

H. Kroemer, T. Klingebiel, D. Dressel, 2003, Clinical pharmacology and therapeutics.

Insight on the impacts of free amino acids and their metabolites on the immune system from a perspective of inborn errors of amino acid metabolism

T. Vorup-Jensen, T. Maier, M. Pakula, 2017, Expert opinion on therapeutic targets.

The Fibrin Cleavage Product Bβ15-42 Channels Endothelial and Tubular Regeneration in the Post-acute Course During Murine Renal Ischemia Reperfusion Injury

B. Scheller, K. Zacharowski, P. Baer, 2018, Front. Pharmacol..

Nitro-fatty acids are formed in response to virus infection and are potent inhibitors of STING palmitoylation and signaling

A. Thielke, J. Rehwinkel, H. Arai, 2018, Proceedings of the National Academy of Sciences.

Expression of the anti-inflammatory suppressor of cytokine signaling 3 (SOCS3) in human clear cell renal cell carcinoma

J. Hänze, T. Maier, A. Hegele, 2016, Tumor Biology.

Quantitative assays reveal cell fusion at minimal levels of SARS-CoV-2 spike protein and fusion from without

E. Flory, K. Cichutek, C. Buchholz, 2020, bioRxiv.

Red Blood Cell-Derived Microparticles Exert No Cancer Promoting Effects on Colorectal Cancer Cells In Vitro

P. Meybohm, K. Zacharowski, M. Müller, 2022, International journal of molecular sciences.

Structural Modifications Yield Novel Insights Into the Intriguing Pharmacodynamic Potential of Anti-inflammatory Nitro-Fatty Acids

D. Steinhilber, S. George, K. Zacharowski, 2021, Frontiers in Pharmacology.

5-Lipoxygenase is a candidate target for therapeutic management of stem cell-like cells in acute myeloid leukemia.

D. Steinhilber, E. Proschak, I. Fleming, 2014, Cancer research.

Systemic TLR2 Antibody Application in Renal Ischaemia and Reperfusion Injury Decreases AKT Phosphorylation and Increases Apoptosis in the Mouse Kidney

B. Scheller, K. Zacharowski, P. Baer, 2018, Basic & clinical pharmacology & toxicology.

Fyn Tyrosine Kinase Elicits Amyloid Precursor Protein Tyr682 Phosphorylation in Neurons from Alzheimer’s Disease Patients

L. Annunziato, R. Sirabella, C. Matrone, 2020, Cells.

Systemic LPS induces toll-like receptor 3 (TLR3) expression and apoptosis in testicular mouse tissue

R. Kinscherf, M. Fijak, L. N. Nejsum, 2019, Cell and Tissue Research.

Michael acceptor containing drugs are a novel class of 5‐lipoxygenase inhibitor targeting the surface cysteines C416 and C418

D. Steinhilber, M. Karas, M. Parnham, 2017, Biochemical pharmacology.

Quantitative and Qualitative Difference in Antibody Response against Omicron and Ancestral SARS-CoV-2 after Third and Fourth Vaccination

E. Hildt, D. Oberle, T. Maier, 2022, Vaccines.

Combined Proteomic and In Silico Target Identification Reveal a Role for 5-Lipoxygenase in Developmental Signaling Pathways.

Herbert Waldmann, Gisbert Schneider, Claudia Pommerenke, 2018, Cell chemical biology.

Inhibitors of Human 5-Lipoxygenase Potently Interfere With Prostaglandin Transport

D. Steinhilber, K. Zacharowski, Florian Rörsch, 2022, Frontiers in Pharmacology.

An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation

R. Sirabella, Alessia Romano, C. Matrone, 2022, Cell & Bioscience.

management of stem cell-like cells in acute myeloid leukemia 5-lipoxygenase is a candidate target for therapeutic

D. Steinhilber, E. Proschak, I. Fleming, 2014 .

Tumor and Stem Cell Biology 5-Lipoxygenase Is a Candidate Target for Therapeutic Management of Stem Cell–like Cells in Acute Myeloid Leukemia

D. Steinhilber, E. Proschak, I. Fleming, 2014 .

Streamlined One‐Pot Synthesis of Nitro Fatty Acids

M. Raslan, T. Maier, G. Manolikakes, 2021 .

Sphingosine‐1‐phosphate (S1P) induces potent anti‐inflammatory effects in vitro and in vivo by S1P receptor 4‐mediated suppression of 5‐lipoxygenase activity

O. Werz, D. Steinhilber, P. Meybohm, 2018, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

O. Werz, D. Steinhilber, S. Fulda, 2016, Pharmacology & therapeutics.

Ion Channel Function During Oocyte Maturation and Fertilization

T. Maier, I. Carvacho, K. Machaca, 2018, Front. Cell Dev. Biol..

Novel insights into the regulation of cyclooxygenase-2 expression by platelet-cancer cell cross-talk

D. Steinhilber, P. Patrignani, M. Dovizio, 2015, Biochemical Society transactions.

Cyclooxygenase-2 (COX-2)-independent anticarcinogenic effects of selective COX-2 inhibitors.

S. Grösch, G. Geisslinger, T. Maier, 2006, Journal of the National Cancer Institute.

Activation of c‐Jun‐N‐terminal‐kinase is crucial for the induction of a cell cycle arrest in human colon carcinoma cells caused by flurbiprofen enantiomers

S. Grösch, G. Geisslinger, E. Niederberger, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Induction of apoptosis by R-flurbiprofen in human colon carcinoma cells: involvement of p53.

S. Grösch, G. Geisslinger, E. Niederberger, 2005, Biochemical pharmacology.

Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse.

D. Steinhilber, K. Alitalo, Z. Bago-Horvath, 2011, The Journal of clinical investigation.

The FASEB Journal express article 10.1096/fj.04-3274fje. Published online June 9, 2005.

S. Grösch, G. Geisslinger, T. Maier, 2022 .

Cysteinyl leukotriene-receptor-1 antagonists interfere with PGE2 synthesis by inhibiting mPGES-1 activity.

D. Steinhilber, Florian Rörsch, S. Grösch, 2013, Biochemical pharmacology.

Sulindac Sulfide Reverses Aberrant Self-Renewal of Progenitor Cells Induced by the AML-Associated Fusion Proteins PML/RARα and PLZF/RARα

T. Maier, M. Ruthardt, E. Puccetti, 2011, PloS one.

Toponomics analysis of drug-induced changes in arachidonic acid-dependent signaling pathways during spinal nociceptive processing.

Gerd Geisslinger, Dieter Steinhilber, D. Steinhilber, 2009, Journal of proteome research.

A. Larsen, Yichen Shi, C. Matrone, 2017, Neural plasticity.

Cellular membranes function as a storage compartment for celecoxib

D. Steinhilber, C. Glaubitz, S. Grösch, 2009, Journal of Molecular Medicine.

Role of Lipoxygenases in Pathogenesis of Cancer

D. Steinhilber, C. Matrone, T. Vorup-Jensen, 2016 .

The anti-proliferative potency of celecoxib is not a class effect of coxibs.

S. Grösch, G. Geisslinger, I. Wobst, 2008, Biochemical pharmacology.

Zafirlukast Is a Dual Modulator of Human Soluble Epoxide Hydrolase and Peroxisome Proliferator-Activated Receptor γ

Sandra K. Wittmann, D. Steinhilber, M. Schubert-Zsilavecz, 2019, Front. Pharmacol..

Targeting the 5-Lipoxygenase as a Novel Principle of Stem Cell Therapy In Acute Myeloid Leukemia

D. Steinhilber, H. Serve, O. Ottmann, 2010 .

Celecoxib inhibits 5-lipoxygenase.

O. Werz, D. Steinhilber, G. Geisslinger, 2008, Biochemical pharmacology.

Cyclooxygenase-2 (COX-2)-dependent and -independent anticarcinogenic effects of celecoxib in human colon carcinoma cells.

S. Grösch, G. Geisslinger, T. Maier, 2004, Biochemical pharmacology.

Persistence of infectious SARS‐CoV‐2 particles for up to 37 days in patients with mild COVID‐19

S. Vieths, E. Hildt, Z. Ivics, 2021, Allergy.

Electrophilic fatty acid species inhibit 5-lipoxygenase and attenuate sepsis-induced pulmonary inflammation.

D. Steinhilber, I. Fleming, B. Freeman, 2014, Antioxidants & redox signaling.

Elucidation of chemical modifier reactivity towards peptides and proteins and the analysis of specific fragmentation by matrix-assisted laser desorption/ionization collision-induced dissociation tandem mass spectrometry.

Benjamin Kühn, Dieter Steinhilber, Michael Karas, 2019, Rapid communications in mass spectrometry : RCM.

5-Lipoxygenase: Underappreciated Role of a Pro-Inflammatory Enzyme in Tumorigenesis

D. Steinhilber, T. Maier, J. Metzner, 2010, Front. Pharmacol..

Dimethylcelecoxib inhibits prostaglandin E2 production.

S. Grösch, G. Geisslinger, I. Wobst, 2008, Biochemical pharmacology.

5-Lipoxygenase is a direct p53 target gene in humans.

S. V. van Heeringen, B. Groner, D. Steinhilber, 2015, Biochimica et biophysica acta.

Evidence of COX-2 independent induction of apoptosis and cell cycle block in human colon carcinoma cells after S- or R-ibuprofen treatment.

S. Grösch, G. Geisslinger, T. Maier, 2006, European journal of pharmacology.

Endogenous anti-tumorigenic nitro-fatty acids inhibit the ubiquitin-proteasome system by directly targeting the 26S proteasome.

D. Steinhilber, C. Münch, T. Maier, 2023, Cell chemical biology.

Modular Regiospecific Synthesis of Nitrated Fatty Acids

T. Maier, D. Göbel, G. Manolikakes, 2016, Synthesis.

Effects of Celecoxib on Prostanoid Biosynthesis and Circulating Angiogenesis Proteins in Familial Adenomatous Polyposis

G. FitzGerald, D. Steinhilber, E. Ricciotti, 2012, Journal of Pharmacology and Experimental Therapeutics.

D. Steinhilber, M. Karas, T. Maier, 2018, Rapid communications in mass spectrometry : RCM.