Snahel Patel

发表

Novel benzoxazole inhibitors of mPGES-1.

K. Hoffmaster, R. Nugent, M. Vazquez, 2013, Bioorganic & medicinal chemistry letters.

RIP1 kinase activity is critical for skin inflammation but not for viral propagation

Min Xu, J. Webster, Summer Park, 2020, Journal of leukocyte biology.

Phenotypic screening with deep learning identifies HDAC6 inhibitors as cardioprotective in a BAG3 mouse model of dilated cardiomyopathy

M. Maddah, F. Farshidfar, K. Loewke, 2022, Science Translational Medicine.

Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.

G. L. Hamilton, Adam R. Johnson, C. Eigenbrot, 2019, Bioorganic & medicinal chemistry letters.

Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12).

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015, Journal of medicinal chemistry.

Loss of dual leucine zipper kinase signaling is protective in animal models of neurodegenerative disease

E. Huang, K. Scearce-Levie, Z. Modrušan, 2017, Science Translational Medicine.

Deep learning detects cardiotoxicity in a high-content screen with induced pluripotent stem cell-derived cardiomyocytes

M. Maddah, F. Farshidfar, T. Hoey, 2021, eLife.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.

Structure of human RIPK1 kinase domain in complex with GNE684

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019 .

Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design.

A. Cheng, Natasha M. Kablaoui, Snahel Patel, 2009, Bioorganic & medicinal chemistry letters.

Sca ff old-Hopping and Structure-Based Discovery of Potent , Selective , And Brain Penetrant N ‐ ( 1 H ‐ Pyrazol-3-yl ) pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase ( DLK , MAP 3 K 12 )

K. Scearce-Levie, Jianping Yin, Xingrong Liu, 2015 .

From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors.

Jun Liang, P. Trojer, Y. Ran, 2017, Bioorganic & medicinal chemistry letters.

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

K. Scearce-Levie, K. Stark, C. Ly, 2015, Journal of medicinal chemistry.

Minimizing CYP2C9 Inhibition of Exposed-Pyridine NAMPT (Nicotinamide Phosphoribosyltransferase) Inhibitors.

N. Skelton, D. Sampath, K. Bair, 2016, Journal of medicinal chemistry.

Deep Learning Predicts Patterns of Cardiotoxicity in a High-Content Screen Using Induced Pluripotent Stem Cell–Derived Cardiomyocytes

M. Maddah, F. Farshidfar, T. Hoey, 2021, bioRxiv.

Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease.

Jianping Yin, Xingrong Liu, J. Lyssikatos, 2017, Journal of medicinal chemistry.

Bicyclic pyridone lactams and methods of use thereof

Snahel Patel, 2017 .

Structure-Based Design of Potent, Selective, and Orally Bioavailable VPS34 Kinase Inhibitors.

John G. Moffat, L. Salphati, Huifen Chen, 2021, Journal of medicinal chemistry.

Identification and SAR around N-{2-[4-(2,3-dihydro-benzo[1,4]dioxin-2-ylmethyl)-[1,4]diazepan-1-yl]-ethyl}-2-phenoxy-nicotinamide, a selective alpha2C adrenergic receptor antagonist.

Maura E. Charlton, Cheryl Li, Douglas S. Johnson, 2008, Bioorganic & medicinal chemistry letters.

RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases

Adam R. Johnson, M. van Lookeren Campagne, J. Webster, 2019, Cell Death & Differentiation.

Abstract 1142: Discovery of FMC-376 a novel orally bioavailable inhibitor of activated KRASG12C

Johannes C. Hermann, R. Neve, R. Everley, 2023, Cancer Research.

Quinazolin-4-piperidin-4-methyl sulfamide PC-1 inhibitors: alleviating hERG interactions through structure based design.

A. Cheng, Natasha M. Kablaoui, Snahel Patel, 2009, Bioorganic & medicinal chemistry letters.