A. Shaffer

发表

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation.

Daniel P. Walker, J. Masferrer, Y. M. Fobian, 2013, Bioorganic & medicinal chemistry letters.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

J. Monahan, H. Ichijo, E. Welsh, 2010, International Immunopharmacology.

In vivo characterization of zymosan-induced mouse peritoneal inflammation.

P. Isakson, J. L. Currie, A. Shaffer, 1994, The Journal of pharmacology and experimental therapeutics.

A Novel, Highly Selective, Tight Binding IκB Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor-κB Pathway in Arthritis-Relevant Cells and Animal Models

D. Thompson, J. F. Schindler, J. Guzova, 2009, Journal of Pharmacology and Experimental Therapeutics.

Altered Arachidonic Acid Metabolism in Urate Crystal Induced Inflammation

P. Isakson, K. Duffin, S. Gregory, 1997, Inflammation.

Comparative evaluation of arachidonic acid (AA)- and tetradecanoylphorbol acetate (TPA)-induced dermal inflammation

P. Isakson, J. L. Currie, A. Shaffer, 1993, Inflammation.

Evaluation of 5-lipoxygenase inhibitors, zileuton, A-78773 and ICI-D-2138 in an ionophore (A-23187)-induced pleural inflammation model in the rat.

P. Isakson, J. L. Currie, A. Shaffer, 1993, Life sciences.

Calcium ionophore (A-23187) induced peritoneal eicosanoid biosynthesis: a rapid method to evaluate inhibitors of arachidonic acid metabolism in vivo

P. Isakson, J. L. Currie, A. Shaffer, 1993, Mediators of inflammation.

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.

R. S. Rogers, C. Koboldt, K. Seibert, 2000, Journal of medicinal chemistry.

Pharmacology of celecoxib in rat brain after kainate administration.

Yan Zhang, Karen Seibert, K. Seibert, 2002, The Journal of pharmacology and experimental therapeutics.

Age-Dependent Cognitive Deficits and Neuronal Apoptosis in Cyclooxygenase-2 Transgenic Mice

P. Worley, A. Savonenko, W. Kaufmann, 2001, The Journal of Neuroscience.

Distinction of microsomal prostaglandin E synthase-1 (mPGES-1) inhibition from cyclooxygenase-2 inhibition in cells using a novel, selective mPGES-1 inhibitor.

J. Gierse, J. Masferrer, J. Carter, 2010, Biochemical pharmacology.

Pharmacological analysis of cyclooxygenase-1 in inflammation.

C. Koboldt, K. Seibert, P. Isakson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of cyclooxygenase-2 rapidly reverses inflammatory hyperalgesia and prostaglandin E2 production.

K. Seibert, P. Isakson, Y. Zhang, 1997, The Journal of pharmacology and experimental therapeutics.

Role of mast cells in calcium ionophore (A23187)-induced peritoneal inflammation in mice

P. Isakson, J. L. Currie, A. Shaffer, 1994, Inflammation.

Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response

P. Isakson, J. Goellner, A. Shaffer, 2007, NeuroMolecular Medicine.

Synthesis and biological evaluation of substituted benzoxazoles as inhibitors of mPGES-1: use of a conformation-based hypothesis to facilitate compound design.

Daniel P. Walker, Y. M. Fobian, L. Xing, 2013, Bioorganic & medicinal chemistry letters.

Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.

J. Monahan, H. Ichijo, E. Welsh, 2010, International immunopharmacology.